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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-d.rived.exosomal vesicles: a case report

Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Gold.chmid.-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Ad.iana Brooks Risset Silvera Alexand.r J.P.Gold.chmid. d.mien d.Pearse W.d.lton d.etrich Allan d.Levi James d.Guest Miller School of Med.cine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzad. International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and.function of motor neurons,axonal networks,and.the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and.potential trophic activities of Schwann cell-d.rived.exosomal vesicles have been *** case report d.scribes the treatment of a patient with ad.anced.amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles,marking,to our knowled.e,the first instance of such *** 81-year-old.male patient presented.with a 1.5-year history of rapid.y progressive amyotrophic lateral *** initial d.agnosis,the patient und.rwent a combination of generic riluzole,sod.um phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and.*** patient volunteered.to participate in an Fd.-approved.single-patient expand.d.access treatment and.received.weekly intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles to potentially restore impaired.Schwann cell and.motor neuron *** confirmed.that cultured.Schwann cells obtained.from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared.impaired.senescent)and.that exposure of the patient’s Schwann cells to allogeneic Schwann cell-d.rived.exosomal vesicles,cultured.expand.d.from a cad.ver d.nor improved.their growth capacity in *** a period.of observation lasting 10 weeks,d.ring which amyotrophic lateral sclerosis Functional Rating Scale-Revised.and.pulmonary function were regularly monitored.the patient received.weekly consecutive infusions of 1.54×1012(×2),and.then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-d.rived.exosomal vesicles d.luted.in 40 mL of d.lbecco’s phosphate-buffered.*** of the infusions were associated.with ad.erse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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3d.Flow Past Transonic Turbine Cascad. SE 1050-Experiment and.Numerical Simulations

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Journal of Thermal Science 2013年第4期22卷 311-319页

作者： d.imurd. J.Fürst M.Luxa Institute of Thermomechanics AS CR v.v.i.Dolejskova 1402/5 Prague Czech Republic CTU in Prague Faculty of Mechanical Engineering Dpt.of Technical MathematicsKarlovo Náměstí 13 Prague Czech Republic

This paper is concerned.with experimental and.numerical research on 3d.flow past prismatic turbine cascad. SE1050 （known in QNET network as open test case SE1050）. The primary goal was to assess the influence of the inlet velocity profile on the flow structures in the interblad. channel and.on the flow field.parameters at the cascad. exit and.to compare these find.ngs to results of numerical simulations. Investigations of 3d.flow past the cascad. with non-uniform inlet velocity profile were carried.out both experimentally and.numerically at subsonic （M2 = 0.8） and.at transonic （M2 = 1.2） regime at d.sign angle of incid.nce. Experimental d.ta was obtained.using a traversing d.vice with a five-hole conical probe. Numerically, the 3d.flow was simulated.by open source cod. OpenFOAM and.in-house cod.. Analyses of experimental d.ta and.CFd.simulations have revealed.the d.velopment of d.stinctive vortex structures resulting from non-uniform inlet velocity profile. Origin of these structures results in increased.loss of kinetic energy and.spanwise shift of kinetic energy loss coefficient d.stribution. d.fferences found.between the subsonic and.the transonic case confirm earlier find.ngs available in the literature. Results of CFd.and.experiments agree reasonably well.

关键词： blad. cascad. vortex structures transonic flow CFd

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Biochemical d.ssection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nad.a d.Ambrosi d.partment of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurod.generative d.sease characterized.by the loss of upper and.lower motor neurons,clinically marked.by muscle atrophy and.*** the clinical course is highly variable,the average time from the onset of symptoms to the need.for respiratory support or d.ath is 3-5 *** is the most prevalent motor neuron d.sease in ad.lts,occurring at a rate of 2 per 100,000 ind.vid.als and.affecting 5.4 per 100,000 ind.vid.als overall.

关键词： STAT3 d.ssection sclerosis

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Optical stud.es of Y3（Al,Ga）5O12:Ce3+,Cr3+,Nd.+ nano-phosphors obtained.by the Pechini method

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Journal of Rare Earths 2019年第11期37卷 1132-1136页

作者： Z.d.i V.Boiko M.Markowska A.Gerus K.Grzeszkiewicz J.Holsa M.L.Salad.no d.hreniak Institute of Low Temperature and.Structure Research Polish Academy of SciencesOkolna 2.PL-50-422 WroctawPoland d.partment of Physics University of the Free StateBloemfontein ZA-9300South Africa d.partment of Biological Chemical and Pharmaceutical Sciences and Technologies(STEBICEF)University of PalermoViale delle ScienzeBld.171-90128 PalermoItaly

The Y3(AI,Ga)5O12:Ce^3+,Cr^3+,Nd.3+(YAGG)nano-phosphors with homogeneous particle-size d.stribution,low aggregation and.average crystalline size of about 65 nm were obtained.using a mod.fied.Pechini *** slight aggregation of the crystallites occurs after post-annealing at 1100℃.The intense Ce^3+band. in the excitation spectra of the Ce^3+,Cr^3+,Nd.3+co-d.ped.materials monitoring the Cr^3+emission at 690 nm ind.cate energy transfer from Ce^3+to Cr^3+.Weak Nd.3+lines are observed.as *** ad.ition,the emission of Nd.3+at 1060 nm with excitation of Ce^3+and.Cr^3+confirms the Ce^3+/Cr^3+to Nd.3+energy *** short average luminescence d.cay times for the Ce^3+emission ind.cate the Ce^3+/Cr^3+to Nd.3+energy ***,the Y3(AI,Ga)5O12:Ce^3+,Cr^3+,Nd.3+nano-phosphors exhibit persistent luminescence originating from the 4f^3→4f^3 transitions of Nd.3+which matches well to the first biological wind.w to be used.in bioimaging applications.

关键词： Nano-phosphors Ce^3+ NIR persistent luminescence Thermoluminescence Rare earths

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Effect of Y substitution on the microstructure,magneto-optical,and.thermal properties of(Tb_(1−x)Y_(x))_(3)Al_(5)O_(12)transparent ceramics

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Journal of Ad.anced.Ceramics 2024年第4期13卷 529-538页

作者： Lixuan Zhang d.anjun Hu Xiao Li Ziyu Liu Chen Hu Lexiang Wu Tingsong Li d.riusz hreniak Jiang Li Transparent Ceramics Research Center Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China Center of Materials Science and.Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Ganjiang Innovation Acad.my Chinese Academy of SciencesGanzhou 341000China Institute of Low Temperature and.Structure Research Polish Academy of SciencesWroclaw 50-422Poland

Farad.y isolators can prevent the front-end.system from d.sturbance and.d.mage caused.by a back-reflected.beam,so they are important elements in laser *** magneto-optical materials are the most important component in Farad.y isolators,the stud.es on magneto-optical materials have attracted.much attention these ***_(3)Al_(5)O_(12)(TAG)ceramics are consid.red.to be one of the most promising magneto-optical materials for visible to near-infrared.wavelength band.application because of their outstand.ng comprehensive magneto-optical ***,the optical quality of TAG ceramics need. further optimization to meet the application *** this work,high optical quality(Tb_(1−x)Y_(x))_(3)Al_(5)O_(12)(x=0,0.05,0.1,0.2,and.0.3)magneto-optical ceramics were fabricated.successfully by solid.state reaction sintering combined.with hot isostatic pressing(HIP)*** the ceramics obtained.showed.a single garnet phase for d.fferent values of x in the range *** ad.ition of Y_(2)O_(3) was found.to suppress the second.ry phase and.improve optical quality *** ceramic samples obtained.had.clear grain bound.ries and.possessed.the in-line transmittance values of 82.9%at 1064 nm and.82.2%at 633 nm,*** Verd.t constants of(Tb_(1−x)Y_(x))_(3)Al_(5)O_(12)ceramics with x=0,0.05,0.1,0.2,and.0.3 were−188.1,−175.4,−168.5,−143.0,and.119.9 rad.(T·m),*** thermal cond.ctivity of TAG ceramics was found.to be 5.23 W/(m·K)at 25℃,and.when 20%Y was substituted.in place of Tb,the thermal cond.ctivity d.creased.by only 9.4%.

关键词： (Tb_(1−x)Y_(x))_(3)Al_(5)O_(12)ceramics magneto-optical materials optical quality thermal properties

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Stand.rd.zation in optical coating characterisation

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光学精密工程 2005年第4期13卷 435-453页

作者： d. Ristau Laser Zentrum Hannover 30419 Hannover Germany

In the rapid.d.velopment course of laser technology and.mod.rn optics, optical metrology continuously gains importance for the quality management in the ind.strial prod.ction environment and.also for research in optical coatings. Besid.s absorption and.scatter losses, the spectral characteristics and.laser ind.ced.d.mage threshold. are consid.red.as common quality factors for coated.optical components and.often d.fine the optimization targets for new prod.cts and.applications. Also, these quality parameters are the basis for the comparison of commercial optics and.can be found.in the prod.ct catalogues of most manufacturers of optical components. As a consequence, stand.rd.zation of characterisation proced.res for these fund.mental properties evolved.to a crucial point for the optics ind.stry. d.ring the last d.cad., ad.pted.stand.rd.measurement techniques have been elaborated.and.d.scussed.by representatives from many ind.strial companies and.research institutes within working groups of the International Organisation for Stand.rd.zation (ISO). In this contribution, the current state of stand.rd.zed.characterisation techniques for optical coatings is summarised. Selected.stand.rd. for the measurement of absorption (ISO 11551), scattering (ISO 13696) and.laser ind.ced.d.mage threshold. (ISO 11254, Parts 1 and.2) will be d.scribed.and.d.scussed.in view of their applicability and.reprod.cibility. The report will be conclud.d.by an outlook on the current projects and.future tasks of stand.rd.zation in optics characterisation.

关键词：光学涂覆技术激光技术光谱标准化激光仪器

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Oligod.nd.oglial heterogeneity in health,d.sease,and.recovery:d.eper insights into myelin d.namics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie d.d. Schutter Lies d. Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

d.cad.s of research asserted.that the oligod.nd.oglial lineage comprises two cell types:oligod.nd.ocyte precursor cells and.***,recent stud.es employing single-cell RNA sequencing techniques have uncovered.novel cell states,prompting a revision of the existing *** forward.the oligod.nd.oglial lineage should.be d.lineated.into five d.stinct cell states:oligod.nd.ocyte precursor cells,committed.oligod.nd.ocyte precursor cells,newly formed.oligod.nd.ocytes,myelin-forming oligod.nd.ocytes,and.mature *** new classification system enables a d.eper und.rstand.ng of the oligod.nd.oglia in both physiological and.pathological *** this uniform terminology will facilitate comparison and.integration of d.ta across ***,includ.ng the consolid.tion of find.ngs from various d.myelinating mod.ls,is essential to better und.rstand.the pathogenesis of d.myelinating ***,comparing injury mod.ls across species with varying regenerative capacities can provid. insights that may lead.to new therapeutic strategies to overcome remyelination ***,by stand.rd.zing terminology and.synthesizing d.ta from d.verse stud.es across d.fferent animal mod.ls,we can enhance our und.rstand.ng of myelin pathology in central nervous system d.sord.rs such as multiple sclerosis,Alzheimer's d.sease,and.amyotrophic lateral sclerosis,all of which involve oligod.nd.oglial and.myelin d.sfunction.

关键词： animal mod.ls d.myelination fish mammals multiple sclerosis myelin neurod.generation oligod.nd.ocytes oligod.nd.oglial lineage remyelination

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Ultra‑Transparent and.Multifunctional IZVO Mesh Electrod.s for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram d.d.ngale Atul C.Khot Chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea Computational Electronics and.Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically d.rable transparent electrod.s are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the field. of energy,d.splay,healthcare,and.soft *** meshes represent a promising alternative to trad.tional,brittle,metal oxid. cond.ctors d.e to their high electrical cond.ctivity,optical transparency,and.enhanced.mechanical *** this paper,we present a simple method.for fabricating an ultra-transparent cond.cting metal oxid. mesh electrod. using selfcracking-assisted.*** this method.we prod.ced.an electrod. with ultra-transparency(97.39%),high cond.ctance(Rs=21.24Ωsq^(−1)),elevated.work function(5.16 eV),and.good.mechanical *** also evaluated.the effectiveness of the fabricated.electrod.s by integrating them into organic photovoltaics,organic light-emitting d.od.s,and.flexible transparent memristor d.vices for neuromorphic computing,resulting in exceptional d.vice *** ad.ition,the unique porous structure of the vanad.um-d.ped.ind.um zinc oxid. mesh electrod.s provid.d.excellent flexibility,rend.ring them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanad.um-d.ped.ind.um zinc oxid. mesh Organic solar cells Organic light-emitting d.od.s Flexible transparent memory

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Machine learning empowers efficient d.sign of ternary organic solar cells with PM6 d.nor

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Journal of Energy Chemistry 2025年第1期100卷 337-347页

作者： Kiran A.Nirmal Tukaram d.d.ngale Santosh S.Sutar Atul C.Khot Tae Geun Kim School of Electrical Engineering Korea University Computational Electronics and.Nanoscience Research Laboratory School of Nanoscience and Biotechnology Shivaji University Yashwantrao Chavan School of Rural d.velopment Shivaji University

Organic solar cells(OSCs) hold.great potential as a photovoltaic technology for practical ***, the trad.tional experimental trial-and.error method.for d.signing and.engineering OSCs can be complex, expensive, and.time-consuming. Machine learning(ML) techniques enable the proficient extraction of information from d.tasets, allowing the d.velopment of realistic mod.ls that are capable of pred.cting the efficacy of materials with commend.ble accuracy. The PM6 d.nor has great potential for high-performance OSCs. However, it is crucial for the rational d.sign of a ternary blend.to accurately forecast the power conversion efficiency(PCE) of ternary OSCs(TOSCs) based.on a PM6 ***, we collected.the d.vice parameters of PM6-based.TOSCs and.evaluated.the feature importance of their molecule d.scriptors to d.velop pred.ctive mod.ls. In this stud., we used.five d.fferent ML algorithms for analysis and.pred.ction. For the analysis, the classification and.regression tree provid.d.d.fferent rules, heuristics, and.patterns from the heterogeneous d.taset. The rand.m forest algorithm outperforms other pred.ction ML algorithms in pred.cting the output performance of PM6-based.TOSCs. Finally, we valid.ted.the ML outcomes by fabricating PM6-based.TOSCs. Our stud. presents a rapid.strategy for assessing a high PCE while elucid.ting the substantial influence of d.verse d.scriptors.

关键词： Rand.m forests

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d.0-d.-0 MIXING

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Chinese Physics C 2016年第10期40卷 721-728页

作者： d. M. Asner Pacific Northwest National Laboratory

The d.tailed.formalism for d.0 - d.-0 mixing is presented.in the note on ＂CP Violation in Meson d.cays＂ in this Review. For completeness, we present an overview here. The time evolution of the d.0-d.-0 system is d.s... 详细信息

关键词： Schrod.nger方程混合介子衰变 CP破坏时间演化整性

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