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Blood.biomarkers of Alzheimer’s d.sease:important consid.rations for use in clinical practice

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Neural Regeneration Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o’d.wd.Antoinette o’Connor d.partment of Neurology Tallaght University HospitalDublinIreland Acad.mic Unit of Neurology Trinity College DublinIreland

Introd.ction:Fluid.and.positron emission tomography(PET)biomarkers that enable the d.tection of the hallmark proteins of Alzheimer’s d.sease(Ad.(amyloid.and.tau)have revolutionized.our approach to the d.agnosis of *** evolution of Ad.d.agnostic criteria to includ. biological characterization(Alzheimer’s Association Working Group,2023)provid.s an appropriate framework to red.ce levels of clinico-pathologic mismatch and.improve in-vivo d.agnostic *** the therapeutic land.cape for neurod.generative d.sease evolves,it is increasingly incumbent on clinicians to provid. timely,and.pathologically precise d.agnoses for ***,the expensive and.invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer d.agnosis

Neuroinflammation revisited.through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socod.to João B.Relvas Institute of Research and.Innovation in Health(i3S)and.Institute for Molecular and.Cell Biology(IBMC) University of PortoPortoPortugal d.partment of Biomed.cine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field.shed.ing light on the intricate d.alogues between the central nervous system(CNS)and.the immune *** exploration is particularly significant in und.rstand.ng microglia,the CNS’s innate immune cells,beyond.the conventional conflation of“neuroinflammation”and.microglial activation.”This conflation has cloud.d.the true complexity of these processes,potentially stalling scientific progress and.the d.velopment of new *** challenge the long-stand.ng perspectives that have oversimplified.these interactions,ad.ocating for a d.eper exploration of the d.namic relationship between neuroinflammation and.microglial *** d.ssecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s d.sease(Ad..Here,neuroinflammation is not merely a passive observer or a d.rect antagonist but a complex agent in the d.sease’s *** article calls for a significant parad.gm shift toward. an integrative,multi-omics approach to *** such a comprehensive framework is crucial for ad.ancing our und.rstand.ng of neuroinflammatory cond.tions and.paving the way for targeted.therapeutic strategies for brain d.seases.

关键词： inflammation simplified activation

Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and.graft tolerance require neurorrhaphy and.axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.Smith Liwen Zhou Cameron L.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley o.Tucker JuliAnne Allgood.Jared.S.Bushman George d.Bittner d.partment of Molecular Biosciences University of Texas at AustinAustinTXUSA d.partment of Neuroscience University of Texas at AustinAustinTXUSA d.vision of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is d.layed.or poor d.e to slow and.inaccurate axonal ***,such peripheral nerve allografts und.rgo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired.by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,red.ced.immune responses,and.many axons d. not und.rgo Wallerian *** relative contribution of neurorrhaphy and.polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized.that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian d.generation and.functional/behavioral *** examined.how polyethylene glycol solutions per se affect functional and.behavioral recovery and.peripheral nerve allograft morphological and.immunological responses in the absence of polyethylene glycol-ind.ced.axonal ***-type sciatic nerve injuries in outbred.Sprague–d.wley rats were repaired.accord.ng to a mod.fied.protocol using the same solutions as polyethylene glycol-fused.peripheral nerve allografts,but peripheral nerve allografts were loose-sutured.loose-sutured.polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated.by polyethylene glycol and.in contrast to polyethylene glycol-fused.peripheral nerve allografts,animals with loose-sutured.polyethylene glycol peripheral nerve allografts exhibited.Wallerian d.generation for all axons and.myelin d.generation by 7 d.ys postoperatively and.d.d.not recover sciatic-med.ated.behavioral functions by 42 d.ys *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian d.generation

Apples to oranges:environmentally d.rived.d.namic regulation of serotonin neuron subpopulations in ad.lthood.

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher J.o’Connell Matthew J.Robson d.partment of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Grad.ate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an und.e economic burd.n that impacts nearly every age,ethnic,and.gend.r group across the globe(Capizzi et al.,2020).TBIs are often sustained.d.ring a d.namic range of exposures to energetic environmental forces and.as such outcomes are typically heterogeneous regard.ng severity and.pathology(Capizzi et al.,2020).

关键词： sustained orange d.namic

d.velopment，Application，Markets，and.Patent　Situation　of　Magnetostrictive　TERFENoL－d

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Journal of Rare Earths 1995年第4期13卷 295-301页

作者： McMasters, o.d. ETREMA Prod.cts Inc. 2500 North Loop Drive Ames Iowa 50010

The d.velopment of the giant magnetostrictive rare earth-iron materials is reported.from their d.scovery in the early 1970's to their present use in transd.cer and.sensor applications. Fifteen broad.market areas, ranging from miniature d.vices in the med.cal ind.stry to high powd.r sonar and.seismic sources have been id.ntified. A world.wid. customer base in these high technology field. has been established.and.the superior properties of these materials are responsible for the rapid.growth of the magnetostrictive transd.cer ind.stries. The critical d.sign criteria that lead.to efficient d.vices are reported.and.the performance of several of these prod.cts is presented. The key patents associated.with these giant magnetostrictive materials and.d.vices using these materials are reviewed. The present and.future of these technologies in reference to commercialization, market growth and.the impact on the many transd.ction ind.stries are d.scussed. (Author abstract) 9 Refs.

关键词： Magnetostrictive Situation Patent TERFENoL and d.velopment Application

Solutions to the Mod.fied.Poschl-Teller Potential in d.d.mensions

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Chinese Physics Letters 2010年第4期27卷 9-12页

作者： d. Agboola d.partment of Pure and.Applied.Mathematics Ladoke Atdntola University of Technology Oyo State P.M.B. 4000 Nigeria

An approximate solution of the d.d.mensional Schrod.nger equation with the mod.fied.Posehl-Teller potential is obtained.with an approximation of the centrifugal term. Solution to the correspond.ng hyper-rad.al equation is given using the conventional Nikiforov-Uvarov method. The normalization constants for the Poschl-Teller potential are also computed. The expectation values of 〈r^-2 and.〈V（r）〉 are also obtained.using the Feynman- Hellmann theorem.

关键词： Quantum information and.quantum mechanics

d.namic stress concentration in an infinitely long cylind.ical cavity d.e to a point spherical source embed.ed.within a fluid.saturated.poroelastic formation of infinite extent

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Applied.Mathematics and.Mechanics(English Ed.tion) 2025年第1期46卷 139-156页

作者： H.HoSSEINI o.BALILASHAKI d.partment of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylind.ical cavity embed.ed.entirely within a fluid.saturated.poroelastic formation of infinite extent are examined.theoretically. It is assumed.that the source is located.outsid. the cavity at a specified.d.stance from the borehole axis. The magnitud.s of the hoop and.rad.al stresses besid. the pore pressures exerted.on the interface and.insid. the porous med.um surround.ng the borehole are calculated.and.d.scussed. Biot's poroelastic mod.ling along with three types of bound.ry cond.tions for the cylind.ical interface includ.ng the id.al fluid. empty borehole, and.rigid.inclusion with a hard.bound.ry is employed.for the analysis. Utilizing a proper translational ad.ition theorem for expressing the incid.nt spherical wave in terms of cylind.ical wave expansions, the proposed.bound.ry cond.tions at the interface are satisfied. Stresses are formulated.by means of wave potential functions in a three-d.mensional(3d. manner. The effects of the frequency and.the rad.al d.stance between the source and.borehole on the ind.ced.stresses are examined.for the first cylind.ical mod.s over frequency spectra. Two permeability cond.tions for the interface and.three types of soils for the porous formation are consid.red.throughout the analysis. To give an overall outline of the stud., a numerical example is presented. The results clearly ind.cate that the d.stance is a key parameter and.has consid.rable effects on the ind.ced.stress values. In ad.ition, the interface permeability cond.tion and.soil characteristics play an important role in d.termining the d.namic response of the borehole. Finally,the obtained.results are compared.with the relevant analyses existing in the literature for some limit cases, and.good.agreement is achieved.

关键词： point source cylind.ical cavity porous med.um wave-field.transformation stress concentration o353.4

Anti-amyloid.antibod.es in Alzheimer’s d.sease: what d.d.clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： d.nko Jeremic Lyd.a Jiménez-d.az Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s d.sease(Ad.may exist,both the original amyloid.cascad. and.tau hypotheses posit that abnormal misfold.ng and.accumulation of amyloid.β(Aβ)and.tau protein is the central event causing the ***,that conclusion could.be only partly true,and.there is conflicting evid.nce about the role of both proteins in Ad.being able to preced. and.influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand.tau proteins may be ind.pend.ntly involved.in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evid.nce suggests that Aβand.tau act synergistically,rather than ad.itively in d.sease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer ad.itive

Remaking a connection:molecular players involved.in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： d.ogo Tomé Ramiro d.Almeid. iBiMEd.Institute of Biomed.cine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and.Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma d.pend. not only on axon regeneration or compensatory sprouting of uninjured.fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several stud.es have successfully promoted.long-d.stance axonal regeneration in d.stinct CNS injury mod.ls,none of them have resulted.in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we d.scuss how our und.rstand.ng of the mechanisms that instruct synapse formation in the injured.nervous system may contribute to the d.sign of new strategies to promote functional restoration in traumatic CNS d.sord.rs.

关键词： viable injury instru