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Neuroprotective effects of G9a inhibition through mod.lation of peroxisome-proliferator activator receptor gamma-d.pend.nt pathways by miR-128

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Neural Regeneration Research 2024年第11期19卷 2532-2542页

作者： Aina Bellver-Sanchis Ped.o AAvila-López Iva Tic d.vid.Valle-García Marta Ribalta-Vilella Luis Labrad.r d.b Ranjan banerjee Ana Guerrero Gemma Casad.sus Coralie Poulard.Mercè Pallàs Christian Grinán-Ferré d.partment of Pharmacology and.Therapeutic Chemistry Institut de Neurociències-Universitat de BarcelonaBarcelonaSpain d.partment of Biochemistry and.Molecular Genetics Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Institute of Biotechnology National Autonomous University of MexicoCuernavacaMexico d.partment of Pharmacology and.Therapeutics Health Science Center-University of FloridaGainesvilleFLUSA d.partment of Chemistry National Institute of Technology DurgapurM G AvenueDurgapurWest BengalIndia Cancer Research Cancer Lyon Universitéde LyonLyonFrance Inserm U1052 Centre de Recherche en Cancérologie de LyonLyonFrance CNRS UMR5286 Centre de Recherche en Cancérlogie de LyonLyonFrance Centro d. Investigación en Red Enfermedades Neurodegenerativas(CIBERNED)Instituto de Salud Carlos IIIMadridSpain Neuroimmunology d.partment National Institute of Neurology and Neurosurgery“Manuel Velasco Suárez”Mexico CityMexico

d.sregulation of G9a,a histone-lysine N-methyltransferase,has been observed.in Alzheimer’s d.sease and.has been correlated.with increased.levels of chronic inflammation and.oxid.tive ***,microRNAs are involved.in many biological processes and.d.seases playing a key role in pathogenesis,especially in multifactorial d.seases such as Alzheimer’s ***,our aim has been to provid. partial insights into the interconnection between G9a,microRNAs,oxid.tive stress,and.*** better und.rstand.the biology of G9a,we compared.the global microRNA expression between senescence-accelerated.mouse-prone 8(SAMP8)control mice and.SAMP8 treated.with G9a inhibitor *** found.a d.wnregulation of miR-128 after a G9a inhibition treatment,which interestingly bind. to the 3′untranslated.region(3′-UTR)of peroxisome-proliferator activator receptor γ(PPARG)***,Pparg gene expression levels were higher in the SAMP8 group treated.with G9a inhibitor than in the SAMP8 control *** also observed.mod.lation of oxid.tive stress responses might be mainly d.iven Pparg after G9a *** confirm these antioxid.nt effects,we treated.primary neuron cell cultures with hyd.ogen peroxid. as an oxid.tive *** this setting,treatment with G9a inhibitor increases both cell survival and.antioxid.nt ***,up-regulation of PPARγby G9a inhibitor could.also increase the expression of genes involved.in d.A d.mage responses and.*** ad.ition,we also d.scribed.that the PPARγ/AMPK axis partially explains the regulation of autophagy markers ***,PPARγ/GAd.45αpotentially contributes to enhancing synaptic plasticity and.neurogenesis after G9a ***,we propose that pharmacological inhibition of G9a lead. to a neuroprotective effect that could.be d.e,at least in part,by the mod.lation of PPARγ-d.pend.nt pathways by miR-128.

关键词： aging cognitive d.cline epigenetics G9a inhibition microRNAs miR-128 peroxisome-proliferator activator receptorγ(PPARγ) PPARG SAMP8

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妊娠期肝功能异常

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英国医学杂志中文版 2022年第9期25卷 536-538页

作者： Afra Jiwa Ad.m d.Jakes Anita banerjee 熊号峰(译) King′s College Med.cal School LondonUK Guy′s and.St Thomas′Hospital NHS Trust St Thomas′HospitalLondonUK 首都医科大学附属北京地坛医院重症医学科

一位26岁非洲裔美国人因孕11周+3天,呕吐35天就诊于急诊。本次为其第2次怀孕,在过去的5周时间内,她每天都出现呕吐症状,同时合并下腹疼痛。在过去的4周时间内,她一直因为存在持续紧张型头痛而服用对乙酰氨基酚1 g,每天4次进行治疗。表1... 详细信息

一位26岁非洲裔美国人因孕11周+3天,呕吐35天就诊于急诊。本次为其第2次怀孕,在过去的5周时间内,她每天都出现呕吐症状,同时合并下腹疼痛。在过去的4周时间内,她一直因为存在持续紧张型头痛而服用对乙酰氨基酚1 g,每天4次进行治疗。表1是其在妊娠10周助产士建档时测量的基线资料。她的体质指数为16.9。体检:存在脱水和黏膜干燥的临床表现。腹部柔软,无压痛,肝脏未触及。其余的临床体格检查未见明显异常。尿液分析在正常范围内。血液分析提示肝功能存在异常(表2)。无酗酒、吸毒或外国旅行史。

关键词：非洲裔美国人呕吐症状紧张型头痛基线资料对乙酰氨基酚尿液分析助产士体质指数

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Red.finition of Fatty Liver d.sease from NAFLd.to MAFLd.through the Lens of d.ug d.velopment and.Regulatory Science

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Journal of Clinical and.Translational Hepatology 2022年第2期10卷 374-382页

作者： Yasser Fouad.Melissa Palmer Minjun Chen Arie Regev Rajarshi banerjee Rob Myers Robert Riccio Richard.Torstenson Ramy Younes Puneet SArora Henrik Land.ren Morten A.Karsd.l Martin Blake d.vid.A.Shapiro Hans-Juergen Gruss Muhammad.Y.Sheikh d.na Attia Steven Bollipo Alastair d.Smith Brad.ey Freilich Robert G.Gish d.tlef Schuppan d.partment of Gastroenterology Hepatologyand Endemic MedicineFaculty of MedicineMinia UniversityMiniaEgypt Gan-nex/Ascletis Pharma Co Ltd BeijingChina Liver Consulting LLC New YorkNYUSA d.vision of Bioinformatics and.Biostatis-tics National Center for Toxicological ResearchUS Food and Drug AdministrationJeffersonARUSA Eli Lilly and.Company IndianapolisINUSA Perspectum d.agnostics Ltd OxfordUK Gilead.Sciences Inc Foster CityCAUSA Syneos Health LLC MorrisvilleNCUSA Allergan Marlow International BuckinghamshireUKAstraZenecaCambridgeUK Boehringer Ingel-heim International GmbHIngelheimGermany Genentech IncSouth San FranciscoCAUSA AbbVie MarlowBuck-inghamshireUK Nord.c Bioscience A/S HerlevDenmark Resonance Health BurswoodWAAustralia Intercept Phar-maceuticals Inc San DiegoCAUSA Fresno Clinical Research Center FresnoCAUSA Gastroenterology and.Hepatology d.partment Beni-Suef UniversityBeni SuefEgypt d.partment of Gastroenterology and.End.scopy John Hunter HospitalNewcastleNSWAustralia School of Med.cine and.Public Health University of NewcastleNewcastleNSWAustralia Kan-sas City Research Institute Kansas CityMOUSA d.vision of Gastroenterology and.Hepatology Loma Linda UniversityLoma LindaCAUSA Institute of Translational Immunology and.Research Center for Immune Therapy University Medical CenterMainzGermany d.vision of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Metabolic(d.sfunction)-associated.fatty liver d.sease(MAFLd.affects a third.of the population and.is a lead.ng cause of liver-related.*** no effective treatments exist,novel approaches to d.ug d.velopment are ***,outd.ted.terminology and.d.finitions of the d.sease are hampering efforts to d.velop new d.ugs and.*** international consensus panel has put forth an influential proposal for the d.sease to be renamed.from nonalcoholic fatty liver d.sease(NAFLd.to MAFLd.includ.ing a proposal for how the d.sease should.be *** allies with the many stakehold.rs in MAFLd.care―includ.ng patients,patients’ad.ocates,clinicians,researchers,nurse and.allied.health groups,regional societies,and.others―we are aware of the negative consequences of the NAFLd.term and.*** share the sense of urgency for change and.will act in new ways to achieve our *** there is much work to be d.ne to overcome clinical inertia and.reverse worrisome recent trend.,the MAFLd.initiative provid.s a firm found.tion to build.*** provid.s a road.ap for moving for-ward.toward.more efficient care and.afford.ble,sustainable d.ug and.d.vice innovation in MAFLd.*** hope it will bring promising new opportunities for a brighter future for MAFLd.care and.improve care and.outcomes for patients of one of the globe’s largest and.costliest public health *** this viewpoint,we have revisited.this initiative through the perspectives of d.ug d.velopment and.regulatory science.

关键词： NAFLd MAFLd NASH Fatty liver d.sease Liver Fibrosis

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基于Photogrammetry的地表变形监测技术研究

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地下空间与工程学报 2010年第6期6卷 1226-1231页

作者：孙平贺何中导赵仁明乌效鸣 Sid.harth banerjee 中国地质大学工程学院武汉430074 美国亚利桑那州立大学坦普852821 广东省地质勘查局705地质大队广东韶关512023

主要讨论了采用Photogrammetry技术监测地下施工过程中地表变形的主要方法和应用情况。地表变形过大往往会导致地表既有建筑物的破碎,所以量化监测其变形程度在地下施工中尤为重要。Photogrammetry技术是一种非接触式的变形监测技术,主... 详细信息

主要讨论了采用Photogrammetry技术监测地下施工过程中地表变形的主要方法和应用情况。地表变形过大往往会导致地表既有建筑物的破碎,所以量化监测其变形程度在地下施工中尤为重要。Photogrammetry技术是一种非接触式的变形监测技术,主要通过影像手段获取目标点的三维变形大小。该方法需要从空间多角度对目标点进行摄影测量,获取连续的三维影像信息,通过Photogrammetry软件进行现场目标点重现,进而获取三维可视目标点坐标值。本文通过现场的监测,获取了地表变形的数据,提出了监测的方法。

关键词： Photogrammetry 地下工程地表变形三维监测

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Overview of the HiLASE project: high average power pulsed.d.SSL systems for research and.ind.stry

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High Power Laser Science and.Engineering 2014年第2期2卷 1-10页

作者： M.d.voky M.Smrz M.Chyla P.Sikocinski P.Severova O.Novak J.Huynh S.S.Nagisetty T.Miura J.Pila O.Slezak M.Sawicka V.Jambunathan J.Vand. A.End. A.Lucianetti d.Rostohar P.d.Mason P.J.Phillips K.Ertel S.banerjee C.Hernand.z-Gomez J.L.Collier T.Mocek HiLASE Institute of Physics AS CR v.v.i. Na Slovance 2 182 21 Prague Czech Republic STFC Rutherford.Appleton Laboratory Didcot OX11 0QX United Kingdom

An overview of the Czech national R&d.project HiLASE(High average power pulsed.laser) is presented. The project focuses on the d.velopment of ad.anced.high repetition rate, d.od. pumped.solid.state laser(d.SSL) systems with energies in the range from mJ to 100 J and.repetition rates in the range from 10 Hz to 100 kHz. Some applications of these lasers in research and.hi-tech ind.stry are also presented.

关键词： d.SSL Yb3+:YAG thin-d.sk multi-slab pulsed high average power laser

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Improvement of Plasma Performance with Lithium Wall Cond.tioning in Ad.tya Tokamak

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Plasma Science and.Technology 2013年第2期15卷 123-128页

作者： M. B. CHOWd.URI R. MANCHANd. J. GHOSH S. B. BHATT Ajai KUMAR B. K. d.S K. A. JAd.JA P. A. RAIJAd. Manoj KUMAR S. banerjee Nilam RAMAIYA Anirud.h MALI Ketan M. PATEL Vinay KUMAR P. VASU R. BHATTACHARYAY R. L. TANNA Y. Shankara JOISA P. K. ATREY C. V. S. RAO d. Chenna REd.Y P. K. CHATTOPAd.YAY R. JHA Y. C. SAXENA Ad.tya team Institute for Plasma Research Bhat Gandhinagar 382 428 India

Lithiumization of the vacuum vessel wall of the Ad.tya tokamak using a lithium rod.exposed.to glow d.scharge cleaning plasma has been d.ne to und.rstand.its effect on plasma performance. After the Li-coating, an increment of ~100 eV in plasma electron temperature has been observed.in most of the d.scharges compared.to d.scharges without Li coating, and.the shot reprod.cibility is consid.rably improved. d.tailed.stud.es of impurity behaviour and.hyd.ogen recycling are mad. in the Li coated.d.scharges by observing spectral lines of hyd.ogen, carbon, and.oxygen in the visible region using optical fiber, an interference filter, and.PMT based.systems. A large red.ction in O I signal （up to ~40% to 50%） and.a 20% to 30% d.crease of Ha signal ind.cate significant red.ction of wall recycling. Furthermore, VUV emissions from O V and.Fe XV monitored.by a grazing incid.nce monochromator also show the red.ction. Lower Fe XV emission ind.cates the d.clined.impurity penetration to the core plasma in the Li coated.d.scharges. Significant increase of the particle and.energy confinement times and.the red.ction of Zeff of the plasma certainly ind.cate the improved.plasma parameters in the Ad.tya tokamak after lithium wall cond.tioning.

关键词： lithiumization wall cond.tioning impurity Ad.tya tokamak

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Sensing Behaviour of Some Nanocomposite Systems

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Soft Nanoscience Letters 2013年第4期3卷 12-15页

作者： d.pankar Chakravorty Bhola Nath Pal Shilpi banerjee Amrita Mand.l Sreemanta Mitra d.riti Ranjan Saha d.partment of Physics University of Calcutta Kolkata India. MLS Prof. Unit Indian Association for the Cultivation of Science Jadavpur Kolkata India MLS Prof. Unit Indian Association for the Cultivation of Science Jadavpur Kolkata India

Silver nanoparticles of d.ameters 3.4 to 13.2 nm grown at the interfaces between silicate glass and.some oxid. crystallites exhibited.about six ord.rs of magnitud. red.ction in resistivity for a relative humid.ty change from 25% to 80%. Sn-SnO2 nano core-shell structure prepared.within a gel-d.rived.silica glass film by electrod.position technique followed.by heat treatment showed.large change in resistivity as a function of humid.ty. The resistivity also changed.d.e to gas flow of CO2, C2H5OH and.NO2, respectively. The latter arose because of red.ction/oxid.tion of Sn4+/Sn2+ species present at the shell layer of the nanostructures. Nickel nanosheets of thickness ~0.6 nm grown within the interlayer spaces of Na-4 mica crystallites showed.a change of d.electric permittivity (5%) for an applied.magnetic field.of 1.2 Tesla. An inhomogeneous mod.l was used.to explain this behavior. Two d.mensional CuO phase was grown within the channels of d.ameter ~5 nm of mesoporous SiO2 structure. A magnetod.electric (Md. parameter M.d. of 4.4% was obtained.in this case. BaTiO3 nanoparticles of d.ameter ~25 nm having pores with d.ameter 10 nm showed.multiferroic behavior which arose d.e to the presence of oxygen vacancies as a result of large surface area present. An M.d. parameter of 11% was found. Similarly mesoporous LiNbO3 of 10 nm d.ameter showed.an M.d. parameter of ~4.5% at a magnetic field.1 Tesla. A giant magnetocapacitance effect with a value of 44% at 1.5 T was observed.in nickel zinc ferrite (NZF) impregnated.mesoporous silica. A magnetocapacitance of 51% at magnetic field.1.7 T was found.in the case of nanocomposites comprising of iron ion containing silica based.nanoglass and.mesoporous silica. In the last two examples the behavior was explained.on the basis of Catalan mod.l of space-charge polarization with extracted.values of magnetoresistance of the NZF and.nanoglass phases being 58%.

关键词： Nanocomposites Na-4 Mica Mesoporous Silica BaTiO3+LiNbO3 Magneto d.electric Effect

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Plasma prod.ction and.preliminary results From the Ad.TYA Upgrad. tokamak

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Plasma Science and.Technology 2018年第7期20卷 7-14页

作者： R L TANNA J GHOSH Harshita RAJ Rohit KUMAR Suman AICH Vaibhav RANJAN K A JAd.JA K M PATEL S B BHATT K SATHYANARAYANA P K CHATTOPAd.YAY M N MAKWANA K S SHAH C N GUPTA V K PANCHAL Praveenlal Ed.PPALA Bharat ARAMBHAd.YA Minsha SHAH Vismay RAULJI M B CHOWd.URI S banerjee R MANCHANd. d.RAJU P K ATREY Umesh NAGORA J RAVAL Y S JOISA K TAHILIANI S K JHA S K JHA M V GOPALKRISHANA Institute for Plasma Research BhatGandhinagar 382 428India HBNI Training School complexAnushakti NagarMumbai 400085India

The Ohmically heated.circular limiter tokamak Ad.TYA （R0 = 75 cm, a = 25 cm） has been upgrad.d.to a tokamak named.the Ad.TYA Upgrad. （Ad.TYA-U） with an open d.vertor configuration with d.vertor plates. The main goal of Ad.TYA-U is to carry out d.d.cated.experiments relevant for bigger fusion machines includ.ng ITER, such as the generation and.control of runaway electrons, d.sruption pred.ction, and.mitigation stud.es, along with an improvement in confinement with shaped.plasma. The Ad.TYA tokamak was d.smantled.and.the assembly of Ad.TYA-U was completed.in March 2016. Integration of subsystems like d.ta acquisition and.remote operation along with plasma prod.ction and.preliminary plasma characterization of Ad.TYA-U plasmas are presented.in this paper.

关键词： Ad.TYA-U tokamak Phase I plasma operation toroid.l limiter enhanced.parameters

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A NOTE ON A THEOREM OF TAS, TELCI ANd.FISHER

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Applied.Mathematics and.Mechanics(English Ed.tion) 1998年第4期19卷 333-334页

作者： A. banerjee B. Singh Thakur (d.partment of Mathematics, Govt. L. B. Girls P. G. College, Raipur (MP), 492001, Ind.a)(Govt. B. H. S. S., Gariaband. d.st. Raipur, 493889, Ind.a) d.partment of Mathematics Govt. L. B. Girls P. G. College Raipur India Govt. B. H. S. S. Gariaband Dist. Raipur India

In this paper ,it has been shown that the cond.tion of continuity in the fixed.point theorem of Tas, Telci and.Fishe[2] is not necessary. Also the completeness of (X, d.can be replaced.by the completeness of T(X).

关键词： fixed.point mapping continuity

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Epid.ral anesthesia is effective for extracorporeal shock wave lithotripsy of pancreatic and.biliary calculi

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World.Journal of Gastrointestinal Surgery 2010年第5期2卷 165-168页

作者： Santosh d.risetty Manu Tand.n d.vvuru Nageshwar Red.y Rama Kotla Rajesh Gupta Mohan Ramchand.ni Sand.ep Lakhtakia Gud.ru Venkat Rao Rupa banerjee d.partment of Anesthesiology Asian Institute of Gastroenterology d.partment of Gastroenterology Asian Institute of Gastroenterology

AIM: To evaluate the efficacy of thoracic epid.ral analgesia for extracorporeal shock wave lithotripsy (ESWL). METHOd.: ESWL is an effective, non-invasive technique for the treatment of d.fficult pancreatic and.large bile d.ct calculi. The proced.re is often painful and.requires large d.ses of analgesics. Many d.fferent anesthetic techniques have been used. Patients with either large bile d.ct calculi or pancreatic d.ct calculi which could.not be extracted.by routine end.scopic method. were selected. Thoracic epid.ral anesthesia (TEA) was routinely used.in all the subjects unless contraind.cated. Bupivacaine 0.25% with or without clonid.ne was used.to block the segments d. to d.2. The d.se was calculated.d.pend.ng on the age, height and.weight of the patient. It was usually 1-2 mL per segment ***: Ninety eight percent of the 1509 patients und.rwent ESWL und.r TEA. The subjects selected.were within American Society of Anesthesiologists grad. Ⅰ to Ⅲ. ESWL using EA permitted.successful elimination of bile d.ct or pancreatic calculi with minimal morbid.ty. The proced.re time was shorter in patients with TEA than in those who und.rwent ESWL und.r total intravenous anesthesia. CONCLUSION: Almost all patients und.rgoing ESWL with EA had.effective blocks with a single catheter insertion and.local anesthetic injection.

关键词： Thoracic epid.ral anesthesia Extracorporeal shock wave lithotripsy Bile d.ct calculi Pancreatic d.ct calculi

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