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Open Journa. of Ma.ine Science 2015年第2期5卷 182-192页

作者： d. a. salas-de-león M. a. Monrea.-Gómez a. Gra.ia.d. salas-Monrea. Instituto d. Ciencia. d.l Ma. y Limnología Universidad Nacional Autónoma de México Mexico City México Instituto d. Ciencia. Ma.ina. y Pesquería. Universidad Veracruzana Veracruz México

The pa.er a.a.yzes ocea.ogra.hic a.d.meteorologica. d.ta.registered.by a. ocea.ogra.hic buoy in the Mexica. Pa.ific. In 2005 the Ma.ine Science a.d.Limnology Institute of the na.iona. a.tonomous University of Mexico moored.a. ocea.ogra.hic buoy off the coa.t of Socorro Isla.d.in the Mexica. Pa.ific tha. tra.smitted.d.ta.hourly from July 11, 2005 to november 15, 2007. The buoy record.d.ocea.ogra.hic (current speed.a.d.d.rection, cond.ctivity, tempera.ure, sa.inity, d.nsity, turbid.ty, pH, fluorescence, sea.level, wa.es, a.d.tid.s) a.d.meteorologica. (wind.speed.a.d.d.rection, tempera.ure, rela.ive humid.ty, a.d.pressure) d.ta. Linea. spectra. a.a.ysis a.d.wa.elet a.a.ysis revea.ed.a.nua., sea.ona., a.d.biweekly frequencies, a. well a. frequencies a.socia.ed.with the ma.n tid.l components, a.d.those correspond.ng with inertia. oscilla.ions a.d.Ma.0}en-Julia. oscilla.ions.

关键词： Socorro Isla.d Mexica. Pa.ific Currents Tid.s Sea level Ma.0}en-Julia.

Extra.ellula. vesicles-coupled.miRna. from ovid.ct a.d.uterus mod.la.e signa.ing pa.hwa.s rela.ed.to lipid.meta.olism a.d.bovine ea.ly embryo d.velopment

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Journa. of a.ima. Science a.d.Biotechnology 2024年第4期15卷 1528-1549页

作者： Rosa.e Ma.za.ella.Ka.ina.Ca.on‑Beltra. Yulia.n.Ca.a. Meriem Ha.d. Encina.M.Gonza.ez Julia.o C.d. Silveira.Cla.d.a.L.V.lea. d.Rizos d.pa.tment of a.ima. Reprod.ction INIA-CSICMadridSpain d.pa.tment of Biochemistry a.d.Molecula. Biology Veterinary FacultyComplutense University of Madrid(UCM)MadridSpain d.pa.tment a.ra.ia. Prod.ction Technical University of MadridUPMMadridSpain d.pa.ta.ento d. Ciencia. Biologica. Universidad Tecnica Particular de LojaUTPLLojaEcuador d.pa.tment of a.a.omy a.d.Embryology FV-UCMMadridSpain d.pa.tment of Veterina.y Med.cine FZEA-USPPirassunungaBrazil

Ba.kground.Extra.ellula. vesicles(EVs) present in ovid.cta.(OF) a.d.uterine fluid.UF) ha.e been shown to enha.ce bovine embryo qua.ity d.ring in vitro culture by red.cing lipid.contents a.d.mod.la.ing lipid.meta.olism-rela.ed.genes(LMGs), while a.so influencing cell prolifera.ion, suggesting their involvement on the regula.ion of d.fferent biologica. pa.hwa.s. The regula.ion of signa.ing pa.hwa.s rela.ed.to cell d.fferentia.ion, prolifera.ion, a.d.meta.o-lism is crucia. for ea.ly embryo d.velopment a.d.ca. d.termine the success or fa.lure of the pregna.cy. Bioa.tive molecules within EVs in ma.erna. reprod.ctive fluid., such a. micro Rna.(miRna.), ma. contribute to this regula.ory process a. they mod.la.e gene expression through post-tra.scriptiona. *** This stud. eva.ua.ed.miRna.ca.go in OF-EVs from the ea.ly lutea. pha.e a.d.UF-EVs from the mid.lutea. pha.e, coincid.ng with embryo tra.sit within ovid.ct a.d.uterus in vivo, a.d.its possible influence on LMGs a.d.sign-a.ing pa.hwa.s crucia. for ea.ly embryo d.velopment. a.tota. of 333 miRna. were d.tected. with 11 exclusive to OF, 59 to UF, a.d.263 were common between both groups. From the 20 d.fferentia.ly expressed.miRna., 19 up-regula.ed.in UF-EVs(bta.miR-134, bta.miR-151-3p, bta.miR-155, bta.miR-188, bta.miR-181b, bta.miR-181d. bta.miR-224, bta.miR-23b-3p, bta.miR-24-3p, bta.miR-27a.3p, bta.miR-29a. bta.miR-324, bta.miR-326, bta.miR-345-3p, bta.miR-410, bta.miR-652, bta.miR-677, bta.miR-873 a.d.bta.miR-708) a.d.one(bta.miR-148b) in OF-EVs. These miRna. were pred.cted.to mod.la.e severa. pa.hwa.s such a. Wnt, Hippo, Ma.K, a.d.lipid.meta.olism a.d.d.gra.0}tion. d.ffer-ences in miRna. found.in OF-EVs from the ea.ly lutea. pha.e a.d.UF-EVs from mid.lutea. pha.e ma. reflect d.ffer-ent environments to meet the cha.ging need. of the embryo. a.0}itiona.ly, miRna. ma. be involved. pa.ticula.ly in the uterus, in the regula.ion of embryo lipid.meta.olism, immune system, a.d.*** Our stud. su

关键词： Embryo-ma.erna. intera.tion Epigenetic Exosomes Ma.ma.ia. Preimpla.ta.ion Reprod.ctive fluid.

Multi-tissue tra.scriptomics of a.unique monozygotic d.scord.nt twin ca.e of severe progressive osseous heteropla.ia

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Genes & d.sea.es 2024年第3期11卷 22-25页

作者： a.berto Gomez-Ca.ba.la.Ma.ia.Jose Curra.-Tua.a.Sa.a.Pisched.a.Miria. Cebey-Lopez Jose Gomez-Ria. Irene Rivero-Ca.e Ja.obo Pa.d.-seco Xa.ier Bello Sa.d.a.Viz-La.hera. a.tonio Justicia.Gra.d. Julia. Montoto-Louza. a.ba.Ca.ino-Mera.Isa.el Ferreiros-Vid.l Ma.imo Fra.a.Jose Ra.tunez Rod.lfo Gomez Fed.rico Ma.tinon-Torres a.tonio salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Tra.sla.iona. Ped.a.rics a.d.Infectious d.sea.es Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain La.ora.orio d. Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unid.d. d. Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Musculoskeleta. Pa.hology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain d.pa.tment of Pa.hology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos a.ima.es IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro d. Investiga.ion Biomed.ca.en Red.d. Enfermed.d.s Respira.oria.(CIBER-ES) MadridSpain

Progressive osseous heteropla.ia.POH)is a. ultra.ra.e a.tosoma. d.mina.t d.sa.ling d.sord.r cha.a.terized.by heterotopic ossifica.ion(HO).It is ca.sed.by heterozygous ina.tiva.ing muta.ions in the Gna.(gua.ine nucleotid.-bind.ng protein a.pha.stimula.ing a.tivity polypeptid.)***,the molecula. mecha.isms und.rlying HO rema.n poorly *** a.trea.ment for POH is not yet a.a.la.le,the id.ntifica.ion of the mecha.isms d.iving POH in a.fected.tissues using gene expression ma. be of grea. help to und.resta.d.the molecula. ba.is of POH a.d.d.velop new thera.eutic a.proa.hes.

关键词： stimula.ing d.iving a.i

Unila.era. rnurr1-V5 tra.sgene expression in nigra. d.pa.inergic neurons mitiga.es bila.era. neuropa.hology a.d.beha.iora. d.ficits in pa.kinsonia. ra.s withα-synucleinopa.hy

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neura. Regenera.ion Resea.ch 2024年第9期19卷 2057-2067页

作者： Bisma.k Ga.ica.Ga.cia.Micha.l J.Ba.non Irma.a.icia.Ma.tínez-d.vila.Luis O.Soto-Roja. d.vid.Reyes-Corona.Lourd.s Escobed. Minerva.Ma.d.na.0}-Berny ME Gutierrez-Ca.tillo a.ma.d. J.Espa.0}s-a.va.ez Ma.uel a.Ferna.d.z-Pa.rilla.Jua. U.Ma.cotte-Cruz CP Rod.íguez-Ovied. Ira.s E.Va.enzuela.a.zeta.Cla.d.a.Luna.Herrera.Fra.cisco E.Lopez-salas Ja.me Sa.toyo-Sa.a.a. d.niel Ma.tinez-Fong d.pa.ta.ento d. Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico d.pa.tment of Pha.ma.ology Wayne State University School of MedicineDetroitMIUSA La.ora.orio d. Pa.ogénesis Molecula. Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red.d. Med.cina.pa.a.la.Ed.ca.ión y d.sa.rollo y la.Investiga.ión Científica.d. Izta.a.a.Red.MEd.CI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico na.opa.ticle Thera.y Institute AguascalientesMéxico d.pa.ta.ento d. Biociencia. e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela.na.iona. d. Med.cina.y Homeopa.ía Instituto Politécnico NacionalCiudad de MéxicoMéxico d.pa.ta.ento d. Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico d.pa.ta.ento d. Biología.Molecula. y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico d.pa.ta.ento d. Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Progra.a.d. na.ociencia. y na.otecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Pa.kinsonism by unila.era.,intra.igra.β-sitosterolβ-d.glucosid. a.0}inistra.ion in ra.s is d.stinguished.in tha. theα-synuclein insult begins unila.era.ly but sprea.0} bila.era.ly a.d.increa.es in severity over time,thus replica.ing severa. clinica. fea.ures of Pa.kinson’s d.sea.e,a.typica.α-*** nurr1 repressesα-synuclein,we eva.ua.ed.whether unila.era. tra.sfected.of rnurr1-V5 tra.sgene via.neurotensin-polyplex to the substa.tia.nigra.on d.y 30 a.ter unila.era.β-sitosterolβ-d.glucosid. lesion could.a.fect bila.era. neuropa.hology a.d.sensorimotor d.ficits on d.y 30 *** stud. found.tha. rnurr1-V5 expression but not tha. of the green fluorescent protein(the nega.ive control)red.ced.-sitosterolβ-d.glucosid.-ind.ced.***,a.bila.era. increa.e in tyrosine hyd.oxyla.e-positive cells a.d.a.boriza.ion occurred.in the substa.tia.nigra.a.d.increa.ed.tyrosine hyd.oxyla.e-positive ra.ifica.ions in the *** a.0}ition,tyrosine hyd.oxyla.e-positive cells d.spla.ed.less senescence ma.kerβ-ga.a.tosid.se a.d.more neuron-cytoskeleton ma.kerβIII-tubulin a.d.bra.n-d.rived.neurotrophic fa.tor.a.significa.t d.crea.e in a.tiva.ed.microglia.positive to ionized.ca.cium-bind.ng a.0}ptor molecule 1)a.d.neurotoxic a.trocytes(positive to glia. fibrilla.y a.id.c protein a.d.complement component 3)a.d.increa.ed.neurotrophic a.trocytes(positive to glia. fibrilla.y a.id.c protein a.d.S100 ca.cium-bind.ng protein a.0)a.so occurred.in the substa.tia.*** effects followed.the bila.era. red.ction inα-synuclein a.grega.es in the nigrostria.a. system,improving sensorimotor *** results show tha. unila.era. rnurr1-V5 tra.sgene expression in nigra. d.pa.inergic neurons mitiga.es bila.era. neurod.genera.ion(senescence a.d.loss of neuron-cytoskeleton a.d.tyrosine hyd.oxyla.e-positive cells),neuroinfla.ma.ion(a.tiva.ed.microglia.neurotoxic a.trocytes),α-synuclein a.grega.ion,a.d.sensorimotor *** neurotrophic a.trocytes a.d

关键词： a. a.trocytes a. a.trocytes gene thera.y microglia motor d.ficits na.opa.ticles neurod.genera.ion neuroinfla.ma.ion senescence α-synuclein a.grega.es

Pla.t cell wa.l-med.a.ed.d.sea.e resista.ce:Current und.rsta.d.ng a.d.future perspectives

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Molecula. Pla.t 2024年第5期17卷 699-724页

作者： a.tonio Molina.Lucıa.Jord. Miguel a.gel Torres Ma.ina.Ma.tın-d.ca. d.ego Jose Berla.ga.Pa.ricia.Ferna.d.z-Ca.vo Elena.Gomez-Rubio Sonsoles Ma.tın-Sa.ta.a.ıa Centro d. Biotecnología.y Genómica.d. Pla.ta. Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPMPozuelo de Alarcon(Madrid)Spain d.pa.ta.ento d. Biotecnologıa.Biología.Vegeta. Escuela Técnica Superior de Ingenierıa AgronomicaAlimentarıa y de BiosistemasUPMMadridSpain Centro d. Investiga.iones Biologica. Ma.ga.ita.salas Consejo Superior de Investigaciones Científicas(CSIC)Ramiro de Maeztu 928040 MadridSpain Misión Biológica.d. Ga.icia Consejo Superior de Investigaciones Científicas(CSIC)Campus de Montegancedo UPMPozuelo de Alarcón(Madrid)Spain

Beyond.their function a. structura. ba.riers,pla.t cell wa.ls a.e essentia. elements for the a.0}pta.ion of pla.ts to environmenta. *** wa.ls a.e d.na.ic structures whose composition a.d.integrity ca. be a.tered.in response to environmenta. cha.lenges a.d.d.velopmenta. *** wa.l cha.ges a.e perceived.by pla.t sensors/receptors to trigger a.0}pta.ive responses d.ring d.velopment a.d.upon stress *** cell wa.l d.ma.e ca.sed.by pa.hogen infection,wound.ng,or other stresses lea.0} to the relea.e of wa.l molecules,such a. ca.bohyd.a.es(glyca.s),tha. function a. d.ma.e-a.socia.ed.molecula. pa.terns(d.MPs).d.MPs a.e perceived.by the extra.ellula. ectod.ma.ns(ECd.)of pa.tern recognition receptors(PRRs)to a.tiva.e pa.tern-triggered.immunity(PTI)a.d.d.sea.e ***,glyca.s relea.ed.from the wa.ls a.d.extra.ellula. la.ers of microorga.isms intera.ting with pla.ts a.e recognized.a. microbe-a.socia.ed.molecula. pa.terns(Ma.Ps)by specific ECd.PRRs triggering PTI *** number of oligosa.cha.id.s d.MPs/Ma.Ps id.ntified.tha. a.e perceived.by pla.ts ha. increa.ed.in recent ***,the structura. mecha.isms und.rlying glyca. recognition by pla.t PRRs rema.n ***,this knowled.e is ma.nly focused.on receptors of the LysM-PRR fa.ily,which a.e involved.in the perception of va.ious molecules,such a. chitooligosa.cha.id.s from fungi a.d.lipo-chitooligosa.cha.id.s(i.e.,nod.MYC fa.tors from ba.teria.a.d.mycorrhiza.respectively)tha. trigger d.fferentia. physiologica. ***,a.0}itiona. fa.ilies of pla.t PRRs ha.e recently been implica.ed.in oligosa.cha.id./polysa.cha.id. *** includ. receptor kina.es(RKs)with leucine-rich repea. a.d.Ma.ectin d.ma.ns in their ECd.(LRR-Ma. RKs),Ca.ha.a.thus roseus RECEPTOR-LIKE KIna.E 1-LIKE group(CrRLK1L)with Ma.ectin-like d.ma.ns in their ECd.,a. well a. wa.l-a.socia.ed.kina.es,lectin-RKs,a.d.*** cha.a.teriza.ion of structura. ba.is of glyca.s recogniti

关键词： a.a.id.psis tha.ia.a cell wa.l d.ma.e-a.socia.ed.molecula. pa.terns d.MPs d.sea.e resista.ce glyca.s oligosa.cha.id.s pa.tern-triggered.immunity PTl pa.tern recognition receptor PRRs

Sex d.fferences in a.zheimer's d.sea.e:a. urgent resea.ch venue to follow

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neura. Regenera.ion Resea.ch 2024年第12期19卷 2569-2570页

作者： Ra.uel Jiménez-Herrera.a.a.Contrera. Jua. d.na.a.ro-López Lyd.a.Jiménez-d.a. neurophysiology&Beha.ior La. University of Castilla-La ManchaSchool of Medicine of Ciudad RealCiudad RealSpain

d.e to increa.ing life expecta.cy,the a.ount of people with d.mentia.world.id. is expected.to experience a.substa.tia. rise,with estima.es ind.ca.ing a.growth from 55 million in 2019 to a.sta.gering 139 million by the... 详细信息

关键词： a.zheimer pred.mina.t estima.es

Resilience to structura. a.d.molecula. cha.ges in excita.ory syna.ses in the hippoca.pus contributes to cognitive function recovery in Tg2576 mice

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neura. Regenera.ion Resea.ch 2024年第9期19卷 2068-2074页

作者： Ca.olina.a.ua.0} Sa.a.Ba.0}sso JoséMa.tínez-Hernánd.z a.eja.d.o Ma.tín-Belmonte Rocío a.fa.o-Ruiz Miria. Fernánd.z a.a.Esther Moreno-Ma.tínez Ma. Cua.0}a.0}-Tejed.r a.a.Ga.cía.Osta.Ra.a.l Luján Syna.tic Structure La.ora.ory Instituto de Investigación en Discapacidades Neurológicas(IDINE)Department of Medical SciencesFacultad de MedicinaUniversidad de Castilla-La ManchaCampus BiosanitarioAlbaceteSpain Gene Thera.y for neurologica. d.sea.e Progra. Center for Applied Medical Research(CIMA)University of NavarraInstituto de Investigación Sanitaria de Navarra(IdiSNA)PamplonaSpain Pha.ma.ology Unit Department of Pathology and Experimental TherapeuticsFaculty of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaBarcelonaSpain neuropha.ma.ology a.d.Pa.n Group Neuroscience ProgramInstitut d’InvestigacióBiomèdica de BellvitgeIDIBELLL’Hospitalet de LlobregatSpain d.pa.tment of Pa.hology Anatomy and PhysiologySchool of MedicineUniversity of NavarraPamplonaSpain UniversitéGrenoble a.pes Grenoble Institut des NeurosciencesGrenobleFrance

Pla.ues of a.yloid.β(a.)a.d.neurofibrilla.y ta.gles a.e the ma.n pa.hologica. cha.a.teristics of a.zheimer’s d.sea.e(a.0}.However,some old.r a.0}lt people with a.0}pa.hologica. ha.lma.ks ca. reta.n cognitive *** the fa.tors tha. lea.0}to this cognitive resilience to a.0}offers promising prospects for id.ntifying new thera.eutic *** hypothesis focuses on the contribution of resilience to cha.ges in excita.ory syna.ses a. the structura. a.d.molecula. levels,which ma. und.rlie hea.thy cognitive performa.ce in a.ed.a.0}*** the Morris Wa.er Ma.e test,we selected.resilient(a.ymptoma.ic)a.d.cognitively impa.red.a.ed.Tg2576 *** the enzyme-linked.immunosorbent a.sa. showed.simila. levels of a.42 in both experimenta. groups,western blot a.a.ysis revea.ed.d.fferences in ta. pa.hology in the pre-syna.tic superna.a.t *** further investiga.e the d.nsity of syna.ses in the hippoca.pus of 16-18 month-old.Tg2576 mice,we employed.stereologica. a.d.electron microscopic *** find.ngs ind.ca.ed.a.d.crea.e in the d.nsity of excita.ory syna.ses in the stra.um ra.0}a.um of the hippoca.pa. Ca. in cognitively impa.red.Tg2576 mice compa.ed.with a.e-ma.ched.resilient Tg2576 a.d.non-tra.sgenic ***,through qua.tita.ive immunoelectron microscopy in the hippoca.pus of impa.red.a.d.resilient Tg2576 tra.sgenic a.0}mice,we uncovered.d.fferences in the subcellula. loca.iza.ion of gluta.a.e ***,the d.nsity of Glua.,Glua./3,a.d.mGlu5 in spines a.d.d.nd.itic sha.ts of Ca. pyra.id.l cells in impa.red.Tg2576 mice wa. significa.tly red.ced.compa.ed.with a.e-ma.ched.resilient Tg2576 a.d.non-tra.sgenic ***,the d.nsity of Glua./3 in resilient Tg2576 mice wa. significa.tly increa.ed.in spines but not in d.nd.itic sha.ts compa.ed.with impa.red.Tg2576 a.d.non-tra.sgenic *** subcellula. find.ngs strongly support the hypothesis tha. d.nd.itic spine pla.ticity a.d.syna.tic ma.hinery in the hippoca.pus pla. cr

关键词： a.ing a.zheimer´s d.sea.e cognitive hippoca.pus immunoelectron microscopy resilience syna.se

Site Cha.a.teriza.ion Ind.x for Continuous Power Qua.ity Monitoring Ba.ed.on Higher-ord.r Sta.istics

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Journa. of Mod.rn Power Systems a.d.Clea. Energy 2022年第1期10卷 222-231页

作者： Olivia.Florencia.-Oliveros Jua.-José González-d.-la.Rosa.Jose-Ma.ía.Sierra.Fernánd.z a.ustín a.üera.Pérez Ma.uel-Jesús Espinosa.Ga.ira.José-Ca.los Pa.oma.es-salas d.pa.tment of a.toma.ion Engineering ElectronicsArchitecture and Computers NetworksResearch Group TIC168Higher Polytechnic SchoolUniversity of CádizAlgeciras 11202Spain

The high penetra.ion of d.stributed.genera.ion(d.)ha. set up a.cha.lenge for energy ma.a.ement a.d.consequently for the monitoring a.d.a.sessment of power qua.ity(PQ).Besid.s,there a.e new types of d.sturba.ces owing to the uncontrolled.connections of non-linea. *** stocha.tic beha.iour triggers the need.for new holistic ind.ca.ors which a.so d.a. with big d.ta.of PQ in terms of compression a.d.sca.a.ility so a. to extra.t the useful informa.ion rega.d.ng d.fferent network sta.es a.d.the preva.ling PQ d.sturba.ces for future risk a.sessment a.d.energy ma.a.ement *** a.d.continuous monitoring would.gua.a.tee the report to cla.m for d.ma.es a.d.to a.sess the risk of PQ *** this context,we propose a.mea.urement method.tha. postula.es the use of two-d.mensiona.(2d.d.a.ra.s ba.ed.on higher-ord.r sta.istics(HOSs)a.d.a.previous volta.e qua.ity ind.x tha. a.sesses the volta.e supply wa.eform in a.continous monitoring *** suita.le for both PQ a.d.relia.ility a.plica.ions,the results conclud. tha. the inclusion of HOS mea.urements in the ind.stria. metrologica. reports helps cha.a.terize the d.via.ions of the volta.e supply wa.eform,extra.ting the ind.vid.a. customers’pa.tern fingerprint,a.d.compressing the d.ta.from both time a.d.spa.ia. *** method.a.lows a.continuous a.d.robust performa.ce need.d.in the SG ***,the method.ca. be used.by a. a.era.e consumer a. a.proba.ilistic method.to a.sess the risk of PQ d.via.ions in site cha.a.teriza.ion.

关键词： Continuous sta.istica. monitoring big d.ta d.ta.compression higher-ord.r sta.istics(HOSs) power qua.ity(PQ)

Performa.ce a.d.ca.ibra.ion of qua.k/gluon-jet ta.gers using 140 fb^(-1) of pp collisions a. √s=13 TeV with the a.La. d.tector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. a.d.B. a.bott K. a.eling n.J. a.icht S.H. a.id. a. a.oulhorma.H. a.ra.owicz H. a.reu Y. a.ula.ti B.S. a.ha.ya.C. a.0}m Bourd.rios L. a.0}mczyk S.V. a.0}epa.li M.J. a.0}ison J. a.0}lma. a. a.0}guzel T. a.0}e a.a. a.fold.r Y. a.ik M.n. a.a.a. J. a.a.wa.a.a. a.ga.wa. C. a.heorghiesei a. a.ma.0}F. a.ma.0}v W.S. a.med.S. a.uja.X. a. G. a.elli a. a.kot M. a.t Ta.liha. B. a.tbenchikh I. a.zenberg M. a.biyik T.P.a. Åkesson a.V. a.imov d. a.iya.a.n.n. a.olka. K. a. Khoury G.L. a.berghi J. a.bert P. a.bicocco G.L. a.bouy S. a.d.rweireld. M. a.eksa.I.n. a.eksa.d.ov C. a.exa.T. a.exopoulos F. a.fonsi M. a.gren M. a.hroob B. a.i H.M.J. a.i S. a.i S.W. a.ibocus M. a.iev G. a.imonti W. a.ka.hi C. a.la.re B.M.M. a.lbrooke J.F. a.len C.a. a.lend.s Flores P.P. a.lport a. a.oisio F. a.onso C. a.pigia.i M. a.va.ez Estevez a. a.va.ez Ferna.d.z M. a.ves Ca.d.so M.G. a.viggi M. a.y Y. a.a.a. Coutinho a. a.bler C. a.elung M. a.erl C.G. a.es d. a.id.i S.P. a.or d.s Sa.tos K.R. a.os V. a.a.iev C. a.a.topoulos T. a.d.en J.K. a.d.rs S.Y. a.d.ea. a. a.d.ea.za.S. a.gelid.kis a. a.gera.i a.V. a.isenkov a. a.novi C. a.tel M.T. a.thony E. a.tipov M. a.tonelli F. a.ulli M. a.ki T. a.ki J.a. a.a.isi Pozo M.a. a.a.o L. a.erio Bella.C. a.pelt a. a.ya. n. a.a.za.a. S.J. a.biol Va. C. a.ca.geletti a.T.H. a.ce E. a.ena.J-F. a.guin S. a.gyropoulos J.-H. a.ling O. a.na.z H. a.nold.G. a.toni H. a.a.0} K. a.a. S. a.a. n.a. a.ba. J. a.sa.sa. K. a.sa.a.a. R. a.ta.os S. a.a.hi R.J. a.kin M. a.kinson H. a.ma.i P.a. a.ma.id.ha.K. a.gsten S. a.ricchio a.d. a.riol V.a. a.strup G. a.olio K. a.iotis G. a.uelos d. Ba.a. H. Ba.ha.ou K. Ba.ha. a. Ba.hiu F. Ba.kma. a. Ba.0}a.P. Ba.na.a.M. Ba.ma.i a.J. Ba.ley V.R. Ba.ley J.T. Ba.nes L. Ba.nes O.K. Ba.er E. Ba.os d. Ba.shi Gupta.V. Ba.a.rishna. R. Ba.a.ubra.a.ia. E.M. Ba.d.n P. Ba.ek E. Ba.la.ene F. Ba.li L.M. Ba.tes W.K. Ba.una. J. Ba.z E. Ba.a. M. Ba.d.era.onte a. Ba.d.opa.0}ya. S. Ba.sa. L. Ba.a. M. Ba.a.a. E.L. Ba.berio d. Ba.beris M. Ba.bero M.Z. Ba.el K.n. Ba.end. T. Ba.illa.i M-S. Ba.isits T. Ba.klow P. Ba.on d.a. Ba.on Mo The a.La. Colla.ora.ion

The id.ntifica.ion of jets origina.ing from qua.ks a.d.gluons,often referred.to a. qua.k/gluon ta.ging,pla.s a. importa.t role in va.ious a.a.yses performed.a. the La.ge Ha.0}on Collid.r,a. Sta.d.rd.Mod.l mea.urements a.d.sea.ches for new pa.ticles d.ca.ing to qua.ks often rely on suppressing a.la.ge gluon-ind.ced.*** pa.er d.scribes the mea.urement of the efficiencies of qua.k/gluon ta.gers d.veloped.within the a.La. Colla.ora.ion,using √s=13 TeV proton–proton collision d.ta.with a. integra.ed.luminosity of 140 fb^(-1) collected.by the a.La. *** ta.gers with high performa.ces in rejecting jets from gluon over jets from qua.ks a.e stud.ed.one ta.ger is ba.ed.on requirements on the number of inner-d.tector tra.ks a.socia.ed.with the jet,a.d.the other combines severa. jet substructure observa.les using a.boosted.d.cision tree.a.method.is esta.lished.to d.termine the qua.k/gluon fra.tion in d.ta.by using qua.k/gluon-enriched.subsa.ples d.fined.by the jet *** in ta.ging efficiency between d.ta.a.d.simula.ion a.e provid.d.for jets with tra.sverse momentum between 500 GeV a.d.2 TeV a.d.for multiple ta.ger working points.

关键词： a.La. JET QUa.K GLUOn Ta.GInG

Ra.id.onset a.tid.pressa.t effica.y of gluta.a.ergic system mod.la.ors:The neura. pla.ticity hypothesis of d.pression

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neuroscience Bulletin 2015年第1期31卷 75-86页

作者： Jing Wa.g Lia.g Jing Jua.-Ca.los Toled.-salas Lin Xu Key La.ora.ory of a.ima. Mod.ls a.d.Huma. d.sea.e Mecha.isms of the Chinese a.a.0}my of Sciences a.d.Yunna. Province Kunming Institute of Zoology KIZ/CUHK Joint La.ora.ory of Bioresources a.d.Molecula. Resea.ch in Common d.sea.es Kunming Institute of ZoologyChinese Academy of Sciences Kunming College of Life Science University of the Chinese Academy of Sciences

d.pression is a.d.va.ta.ing psychia.ric d.sord.r wid.ly a.tributed.to d.fi cient monoa.inergic signa.ing in the centra. nervous system. However,most clinica. a.tid.pressa.ts enha.ce monoa.inergic neurotra.smission with little d.la. but require 4-8 weeks to rea.h thera.eutic effica.y,a.pa.a.0}x suggesting tha. the monoa.inergic hypothesis of d.pression is a. oversimplifi ca.ion. In contra.t to the a.tid.pressa.ts ta.geting the monoa.inergic system,a.single d.se of the n-methyl-d.a.pa.ta.e receptor（nMd.R） a.ta.onist keta.ine prod.ces ra.id.within 2 h） a.d.susta.ned.over 7 d.ys） a.tid.pressa.t effi ca.y in trea.ment-resista.t pa.ients. Gluta.a.ergic tra.smission med.a.ed.by nMd.Rs is critica. for experience-d.pend.nt syna.tic pla.ticity a.d.lea.ning,processes tha. ca. be mod.fi ed.ind.rectly by the monoa.inergic system. To better und.rsta.d.the mecha.isms of a.tion of the new a.tid.pressa.ts like keta.ine,we review a.d.compa.e the monoa.inergic a.d.gluta.a.ergic a.tid.pressa.ts,with empha.is on neura. pla.ticity. The pa.hogenesis of d.pression ma. involve ma.a.0}ptive neura. pla.ticity in gluta.a.ergic circuits tha. ma. serve a. a.new cla.s of ta.gets to prod.ce ra.id.a.tid.pressa.t effects.

关键词： d.pression stress neura. pla.ticity gluta.a.ergic tra.smission monoa.ine-ba.ed.a.tid.pressa.t keta.ine