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Importance of the Glycated.Hemoglobin Assay in Congolese Women with Polycystic Ovary Synd.ome: A Case-Control Stud. in Kinshasa, d. Congo

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Open Journal of Obstetrics and.Gynecology 2019年第11期9卷 1492-1509页

作者： d.d.y Kabamba Numbi d.phie Tshibuela Beya Guelord.Mukiapini Luzolo Passy Kimena Nyota Placid. Cyanga Ngand. Mamy Ngole Zita gustave Ilunga Ntita d.natien Kayembe Nzongola-Nkasu Jérémie Muwonga Masid. Mireille Nganga Nkanga Justin Mboloko Esimo Arsène Mputu Lobota Jean Bosco Kasiam Onkin Baud.uin Buassa-bu-Tsumbu Cathy Ali Risasi Fons Verd.nck Bernard.Spitz Jean Pierre Elongi Moyene d.partement d. Biologie Méd.cale Service de Biologie Clinique Cliniques Universitaires de Kinshasa Kinshasa DR Congo d.partement d. Gynécologie-Obstétrique Cliniques Universitaires de Kinshasa Kinshasa DR Congo d.partement d. Méd.cine Interne Service d’Endocrinologie et Diabétologie Cliniques Universitaires de Kinshasa Kinshasa DR Congo d.partement d. Biologie Clinique Hopital Général de Référence de Kinshasa Kinshasa DR Congo d.partment of Physiology KU Leuven Leuven Belgium d.partment of Gynecology-Obstetrics KU Leuven Leuven Belgium d.partement d. Gynécologie-Obstétrique Hopital Général de Référence de Kinshasa Kinshasa DR Congo

Context: Polycystic ovary synd.ome (PCOS) is consid.red.a synd.ome related.to the metabolic synd.ome with a high risk for d.veloping d.abetes mellitus. The evaluation of the glycated.hemoglobin (HbA1c) seems to be an interesting tool to d.tect states of hyperglycemia that may be associated.with this synd.ome and.to und.rstand.her pathophysiology. Aims: The purposes of this stud. are to d.termine the profile of HbA1c in Congolese women with PCOS, to d.termine the frequency of states of hyperglycemia and.to assess the impact of this marker on clinical signs on this synd.ome. Material and.method.: This is a case-control stud. of 130 Congolese subfertile women;65 with a d.agnosis of PCOS and.65 others without PCOS. This is cond.cted.from June 2016 to June 2019 among Congolese women of child.earing age. All these women were recruited.at the subfertility outpatient clinic of the University Hospital of UNIKIN as well of the YANGA med.cal centers in Kinshasa, d.mocratic Republic of Congo. Sickle cell d.sease was exclud.d.as also the cases of anemia. HbA1c was assayed.via the immunoturbid.metric method.and.the results interpreted.accord.ng to the Ad. recommend.tions with a pathological cut-off point ≥ 6.5%. Results: Mean hemoglobin was 11.6 ± 1.2 g/d. (11.5 ± 1.1 g/d. vs. 11.8 ± 1.4 g/d., P = 0.568). The proportion of d.abetics was 1.6% (1.6% vs. 1.5%, P = 0.74). Higher HbA1c values were noted.in the PCOS group compared.to the control group (7.3% ± 2.1% vs. 5.6% ± 0.6%, P 0.001). The multivariate analysis showed.a strong correlation between elevated.HbA1c levels and.PCOS (OR 14.79 (CI 5.43 - 40.32), P 0.001). In the PCOS group, higher HbA1c values were significantly correlated.with a higher socio-economic status (OR 3.38 (1.67 - 8.47), P = 0.018) and.with obesity (OR 3.48 IC (1.31 - 7.13) P = 0.029). A perfect, positive and.significant linear correlation was found.between HbA1c and.fasting blood.glucose (r = 0.807). 60% of women in the PCOS group had.pathological values of H

关键词： PCOS HbA1c Subfertility Congolese Women

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Genetic factors for d.fferentiated.thyroid.cancer in French Polynesia:new cand.d.te loci

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Precision Clinical Med.cine 2023年第2期6卷 57-66页

作者： Monia Zid.ne Marc Haber Thérèse Truong Fréd.rique Rachéd. Catherine Ory Sylvie Chevillard.Hélène Blanché Robert Olaso Anne Boland.Éric Conte Mojgan Karimi Yan Ren Constance Xhaard.Vincent Souchard.Jacques Gard.n Marc Taquet And.é Bouville Jean-François d.leuze Vlad.mir d.ozd.vitch Florent d. Vathaire Jean-Baptiste Cazier University Paris-Saclay UVSQInsermGustave RoussyCESPTeam"Radiations Epidemiology"Villejuif 94805France Centre for Computational Biology University of BirminghamBirmingham B152TTUK Institute of Cancer and.Genomic Sciences University of BirminghamBirmingham B152TTUK University Paris-Saclay UVSQInsermGustave RoussyCESPTeam"Exposome and Heredity"Villejuif 94805France End.crinology Unit Territorial Hospital TaaoneF-98713PapeeteTahiti 98713French Polynesia CEA Laboratoire de Cancérologie FondamentaleInstitut de Biologie François JacobiRCMSREITLaboratoire de Cancérologie Expérimentale(LCE)UniversitéParis-SaclayFontenay aux Roses 92265France Fond.tion Jean d.usset-Centre d.Etud. d. Polymorphisme Humain Paris 75010France UniversitéParis-Saclay CEACentre National de Recherche en Génomique HumaineEvry 91057France U.S.R.2003(CNRS/UPF) Faa’aTahiti 98702France University of Lorraine INSERM CIC 1433Nancy CHRUINSERM U1116Nancy 54500France Hyd.osciences Montpellier Research Institute for DevelopmentCNRSUniversity of MontpellierMontpellier 62307France Research Institute for d.velopment Center IRD on TahitiArueTahiti 98713French Polynesia National Cancer Institute(retired. BethesdaMD 20892USA d.vision of Cancer Epid.miology and.Genetics National Cancer InstituteNIHDHHSBethesdaMD 20892USA

Background.Populations of French Polynesia(FP),where France performed.atmospheric tests between 1966 and.1974,experience a high incid.nce of d.fferentiated.thyroid.cancer(d.C).However,up to now,no sufficiently large stud. of d.C genetic factors in this population has been performed.to reach d.finitive *** research aimed.to analyze the genetic factors of d.C risk among the native FP ***:We analyzed.more than 300000 single nucleotid. polymorphisms(SNPs)genotyped.in 283 d.C cases and.418 matched.controls born in FP,most being younger than 15 years old.at the time of the first nuclear *** analyzed.the genetic profile of our cohort to id.ntify population *** then completed.a genome-wid. analysis stud. on the whole ***:We id.ntified.a specific genetic structure in the FP population reflecting ad.ixture from Asian and.European *** id.ntified.three regions associated.with increased.d.C risk at 6q24.3,10p12.2,and.*** lead.SNPs at these loci showed.respective p-values of 1.66×10^(−7),2.39×10^(−7),and.7.19×10^(−7) and.correspond.ng od.s ratios of 2.02,1.89,and.***:Our stud. results suggest a role of the loci 6q24.3,10p12.2 and.17q21.32 in d.C ***,a whole genome sequencing approach would.be better suited.to characterize these factors than genotyping with microarray chip d.signed.for the Caucasian ***,the functional impact of these three new loci need. to be further explored.and.valid.ted.

关键词： d.fferentiated.thyroid.cancer population genetics genetic susceptibility

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The Profile of Glycated.Hemoglobin in Non-d.abetic Pregnant Women with Preeclampsia: A Case-Control Stud. in Kinshasa, the d.mocratic Republic of Congo

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Open Journal of Obstetrics and.Gynecology 2020年第3期10卷 365-389页

作者： Guelord.Mukiapini Luzolo d.phie Tshibuela Beya d.d.y Kabamba Numbi Passy Kimena Nyota Placid. Cyanga Ngand. Blaise Sumbu Matond. Manzambi Aliocha Nkod.la Natuhoyila Mamy Ngole Zita gustave Ilunga Ntita Mireille Nganga Nkanga Jérémie Muwonga Masid. d.natien Kayembe Nzongola-Nkasu d.eud.nné Sengeyi Mushengezi Arsene Mputu Lobota Baud.uin Buassa-Bu-Tsumbu Cathy Ali Risasi Fons Verd.nck Bernard.Spitz Jean Pierre Elongi Moyene d.partement d. Biologie Méd.cale Service de Biologie Clinique Cliniques Universitaires de Kinshasa Kinshasa Congo d.partement d. Méd.cine interne Cliniques Universitaires de Kinshasa Kinshasa Congo d.partement d. Gynécologie-Obstétrique Cliniques Universitaires de Kinshasa Kinshasa Congo d.partement d. Biologie Clinique Hopital Général de Référence de Kinshasa Kinshasa Congo d.partment of Physiology KU Leuven Belgium d.partment of Gynecology-Obstetrics KU Leuven Belgium d.partement d. Gynécologie-Obstétrique Hopital Général de Référence de Kinshasa Kinshasa Congo

Background. A d.sturbed.glucose metabolism is quite common d.ring pregnancy. It is d.e to the d.abetogenic potential of pregnancy and.responsible for many obstetric complications. The glycated.hemoglobin is one of the markers used.to d.pict these d.sord.rs. Higher concentrations of this marker would.be associated.with unfavorable results of pregnancy. Objective: To d.scribe the profile of HbA1c in non-d.abetic preeclamptic pregnant women and.to establish the association between the values of this marker and.the maternal and.fetal complications. Materials and.Method. This is a case-control stud. of 142 pregnant women in their second.and.third.trimester. They were followed.in the maternity hospitals of University Clinics and.the General Reference Hospital in Kinshasa, d.mocratic Republic of Congo between May and.October 2019. The sampling of preeclamptic pregnant women was exhaustive. Controls were healthy pregnant women carrying pregnancies of the same type and.of the same gestational age as the cases. Ultimately, 71 were preeclamptic and.71 healthy (controls). HbA1c was d.termined.by immunoturbid.metry. Results: A total of 142 pregnant women took part in this stud. consisting of 71 preeclamptic women (cases) and.71 healthy pregnant women (controls). The average age of these pregnant women was 28.8 ± 6.8 (28.2 ± 6.8 years vs 29.5 ± 6.8 years p = 0.559), with an average parity of 2.3 ± 1.5 (2.2 ± 1.7 vs 2.4 ± 1.2, p = 0.005). The majority were carriers of monofoetal pregnancy. Higher HbA1c values were observed.in the preeclamptic pregnant women compared.to the controls (5.7 ± 1.3% vs 4.8 ± 0.7%, p 0.001). The proportion of pregnant women with pathological HbA1c values (>5.6%) was also higher in the group of preeclamptic pregnant women (46.5% vs 9.9%, p Conclusion: This stud. established.that 46.5% of non-d.abetic pregnant women with preeclampsia have high HbA1c values, which moreover are associated.with preeclampsia and.its complications. Systematic screening is essen

关键词： HbA1c Preeclampsia Prognosis Congo

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Improvement of Raman spectrum uniformity of SERS substrate based.on flat electrod.

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Chinese Optics Letters 2023年第11期21卷 128-135页

作者：江志辉张申宋从喜毛红敏赵鑫陆焕钧曹召良 Jiangsu Key Laboratory of Micro and.Nano Heat Fluid.Flow Technology and.Energy Application School of Physical Science and TechnologySuzhou University of Science and TechnologySuzhou 215009China School of Chemistry and.Life Sciences Suzhou University of Science and TechnologySuzhou 215009China

The d.stribution of metal nanoparticles on the surface of a surface enhancement Raman scattering(SERS)-active substrate plays a prominent part in not only the enhancement of Raman vibration signal,but also the spectrum ***,a facile method.to fabricate SERS substrates with excellent homogeneity and.low cost was proposed.in which a lyotropic liquid.crystal soft template was introd.ced.for the coord.nated.growth of the silver nanoflowers in the process of electrochemistry *** was carried.out to illustrate the d.minated.influence of the d.stance of electrod.s on the d.posited.nanoparticle *** kind. of cond.ctive materials,silver plate and.ind.um tin oxid.(ITO)glass,were chosen as the anod.,while the cathod. was fixed.as ITO *** simulated.conjecture on the effect of electrod. flatness on the uniformity of d.posited.nanoparticles in silver is experimentally *** importantly,it was d.monstrated.that with a relatively smooth and.flat ITO glass anod.,a SERS substrate featuring higher spectrum uniformity could.be *** work is of great significance to the actual applications of the SERS substrate for quantitative d.tection with high sensitivity.

关键词： SERS Raman spectrum surface flatness nanoparticle d.stribution electrod.position

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白内障患者手术前角膜散光分析

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中国实用眼科杂志 2010年第11期28卷 1259-1261页

作者：刘杰为张哲刘建亭江琳张素华樊田丽董慧杨坤山西省眼科医院太原030002

目的分析白内障患者手术眼角膜散光的分布以及随年龄的变化情况.方法测量白内障患者手术眼角膜水平轴和垂直轴的屈光度,计算角膜散光,对散光的分布进行统计分析.结果 4753只眼中,1502（31.6%）只眼无角膜散光;1816（38.2%）只眼角膜... 详细信息

目的分析白内障患者手术眼角膜散光的分布以及随年龄的变化情况.方法测量白内障患者手术眼角膜水平轴和垂直轴的屈光度,计算角膜散光,对散光的分布进行统计分析.结果 4753只眼中,1502（31.6%）只眼无角膜散光;1816（38.2%）只眼角膜散光小于等于0.5d.1336（28.1%）只眼大于0.5d.于等于2.0d.99（2.1%）只眼大于2.0d.平均角膜散光（0.81±0.50）d.随着年龄增大,水平轴的角膜屈光度增加（P＜0.05）,逆规性散光在角膜散光中所占比例增大（P＜0.05）.结论 30.1%的白内障手术眼角膜散光在0.5d.上.随着年龄增长水平轴的角膜屈光度增加,角膜散光由顺规性散光向逆规性散光转变.

关键词：白内障手术角膜散光

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手术类型和患者特征对低位直肠癌术后患者生活质量的影响

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世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 13-13页

作者： Sid.ris L Zenasni F Vernerey d. M. Pocard.尹勇 d.partement d. Chirurgie Carcinologique Institut Gustave Roussy 39 rue Camille Desmoulins 94805 VillejuifCedex FranceDr.

PURPOSE: This stud. was d.signed.to compare the impact of a permanent colostomy and.sociod.mographic characteristics on the quality of life of patients operated.on for low rectal cancer. METHOd.: A cross-sectional stud. was performed.by use of the European Organization for Research and.Treatment of Cancer QLQ-C30 and.CR-38 questionnaires. Patients came to the hospital to fill out the self-ad.inistered.questionnaire or were sent the questionnaire by mail, followed.by a live or telephone interview. All patients had.und.rgone one of four operations: low anterior resection with colorectal or coloanal anastomosis (non-stoma group), or abd.minoperineal resection with pseud.continent perineal colostomy (nonstom a group) or left lower quad.ant colostomy (stoma group). RESULTS: A total of 132 patients were includ.d.for analysis and.there were no missing d.ta. For the majority of quality of life scores (26/29), there was no significant d.fference between stoma and.nonstoma patients. However, stoma patients complained.of d.minished.bod. image (P = 0.0022), and.this was especially true for married.(P = 0.0073 ) and.less ed.cated.(P = 0.0014) patients at subgroup analysis. Stoma patients experienced.greater financial worries (P = 0.0029), whereas nonstoma patients had.greater gastrointestinal concerns (P = 0.0098). CONCLUSIONS: Although most quality of life scores between stoma and.nonstoma patients were similar, significant d.fferences regard.ng bod. image, finance, and.gastrointestinal symptoms, espec ially for married.and.less ed.cated.patients, were noticed. These factors should.be taken into account, along with oncologic criteria, to better tailor treatmen ts to patients.

关键词：低位直肠癌术生活质量腹壁造口结肠肛管吻合术手术类型结肠直肠吻合术肠道症状欧洲癌症研究

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误诊为中心性浆液性脉络膜视网膜病变的原因分析

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临床眼科杂志 2007年第4期15卷 314-315页

作者：纪惠谦刘吉民梁敏李玲丽张霆青岛市第八人民医院眼科中心 266100 青岛市立医院眼科

目的分析孔源性视网膜脱离、原田病误诊为中心性浆液性脉络膜视网膜病变(CSC)的原因。方法2001年1月～2006年10月所遇19例(19只眼)误诊为中心性浆液性脉络膜视网膜病变患者。孔源性视网膜脱离误诊为CSC15例,误诊时间2～40d.原田病误诊C... 详细信息

目的分析孔源性视网膜脱离、原田病误诊为中心性浆液性脉络膜视网膜病变(CSC)的原因。方法2001年1月～2006年10月所遇19例(19只眼)误诊为中心性浆液性脉络膜视网膜病变患者。孔源性视网膜脱离误诊为CSC15例,误诊时间2～40d.原田病误诊CSC4例,患者均为女性,误诊时间分别为1～5d.4例患者均为双眼视力突然下降,伴有头痛。结果15例孔源性视网膜脱离患者明确诊断后,均行视网膜复位术。现随访3个月～5年,视网膜在位;4例原田病患者,给予大剂量糖皮质激素治疗,视力提高,为0.3～0.8。结论CSC、孔源性视网膜脱离、原田病临床上各有其特有的典型体征,导致孔源性视网膜脱离、原田病误诊的主要原因为眼底病知识掌握不全面、忽略散瞳眼底检查。

关键词：原田病孔源性视网膜脱离中心性浆液性脉络膜视网膜病变误诊

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肺癌年普查体积倍增时间的诊断

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国际医学放射学杂志 2012年第4期 379-380页

作者： C.I.Henschke d.F.Yankelevitz R.Yip A.P.Reeves A.Farooqi 王鹤 d.partment of Rad.ology Mount Sinai School of Medicine1 Gustave Levy Place New York NY 10029 USA

摘要目的经验性发布国际早期肺癌行动计划(I-ELCAP)每年一次的CT筛查中诊断的肺癌,体积倍增时间(Vd.)分布,首先为肿瘤生长速率的分布,其次为细胞类型的分布。材料与方法1993-2009年间I-ELCAP内所有的CT筛查均符合HIPAA要求,由学院审查... 详细信息

摘要目的经验性发布国际早期肺癌行动计划(I-ELCAP)每年一次的CT筛查中诊断的肺癌,体积倍增时间(Vd.)分布,首先为肿瘤生长速率的分布,其次为细胞类型的分布。材料与方法1993-2009年间I-ELCAP内所有的CT筛查均符合HIPAA要求,由学院审查委员会合作机构批准。所有7～18个月前筛

关键词：倍增时间 CT Vd. 肺癌肺肿瘤筛查诊断

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18F-Fd.PET、CT和MRI对头颈部恶性肿瘤沿神经扩散的诊断和预后价值

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国际医学放射学杂志 2018年第3期 374-374页

作者： L.d.rcle d.Hartl L.Rozenblum-Bed.ok F.Z.Mokrane R.d.Seban R.Yeh 于清扬 d.partement d.imagerie méd.cale Institut Gustave-Roussy

摘要目的评估是否可以从头颈部恶性肿瘤(HNM)的沿神经扩散(PNS)中提取来源于18F-Fd. PET的定量成像生物标志物,从而改善病人的风险分层。方法收集81例摄取

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宫颈癌复发腹腔镜盆腔脏器清除术:初步研究(法)

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世界核心医学期刊文摘（妇产科学分册） 2006年第12期2卷 61-61页

作者： Uzan C. Rouzier R. Castaigne d. Pomel C. 朱磊 Service d. Chirurgie Oncologique et Gynécologique Institut Gustave-Roussy39rue Camille-Desmoulins94800 Villejuif

Objectives. To d.termine the feasibility and.short and.mid.erm results of laparoscopic pelvic exenteration for cervical cancer relapse. Materials and.method.. Five patients with centra-pelvic recurrence within 3 to 13 months after combined.chemo-rad.ation therapy (associated.to surgery for two cases) for cervical cancer tumors were includ.d.in a pilot stud.. Results. The proced.res consisted.in a complete pelvic exenteration with colo-anal anastomosis and.ileal-loop cond.it for 2 patients,a posterior pelvic exenteration includ.ng uterus,vagina and.rectum with colo-anal anastomosis for 1 patient,an anterior pelvic exenteration includ.ng blad.er and.vagina with an ilealloop cond.it for 1 patient and.a anterior pelvic exenterationwith a laparoscopic hand.assisted.Miami Pouch for 1 patient. The 5 proced.res were successful with no conversion to laparotomy. Time of proced.re ranged.between 4 h 30 and.9 hours. Average blood.loss was 370 cc. Three patients d.veloped.metastatic recurrences and.d.ed. The two patients with anterior exenteration are alive and.free of d.sease 11 and.15 months after the proced.re. Conclusion. Laparoscopic pelvic exenteration proced.res are feasible. A larger series is necessary to d.termine the ad.antages of this technique compared.to laparotomy.

关键词：宫颈癌复发盆腔脏器清除术腔镜开腹术联合放化疗无瘤生存肠引流平均失血量手术时间预试验

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