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Optimized nerve block techniques while performing percutaneous hepatic ablation: Literature review and practical use

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Journal of Interventional Medicine 2020年第4期3卷 161-166页

作者： dM Liu A Hadjivassiliou d valenti SG Ho d Klass JB Chung PT Kim LM Boucher Faculty of Medicine University of British ColumbiaCanada Miller School of Medicine University of MiamiUSA department of Radiology-division of Interventional Radiology Vancouver General HospitalCanada department of Radiology Vancouver General HospitalCanada department of Surgery division of Hepatopancraticobiliary Surgery/Liver Transplantation Vancouver General HospitalVancouverCanada Faculty of Medicine McGill UniversityDepartment of RadiologyDivision of Interventional RadiologyMcGill University Health CentreMontrealCanada Faculty of Applied Science University of British ColumbiaCanada

Percutaneous image guided thermal ablation has become a cornerstone of therapy for patients with oligometastatic disease and primary liver *** from percutaneous ethanol injection(PEI),thermal ablation utilizing radiofrequency ablation(RFA)and microwave ablation(MWA)have become the standard approach in the treatment of isolated lesions that fit within the size criteria for curative intent therapy(typically 3-4 cm).With the evolution of more intense thermal ablation,such as MWA,the dramatic increase in both the size of ablation zone and intensity of heat generation have extended the limits of this *** a result of these innovations,intra-procedural and post-procedural pain have also significantly increased,requiring either higher levels of intravenous sedation or,in some institutions,general *** addition to the increase in therapeutic intensity,the use of intravenous sedation during aggressive ablation procedures carries the risk of over-sedation when the noxious insult(*** ablation)is removed,adding further difficulty to post-procedural recovery and ***,high subdiaphragmatic lesions become challenging in this setting due to issues relating to sedation and compliance with breath hold/breathing *** general anesthesia may mitigate these complications,the added resources associated with providing general anesthesia during ablation is not cost effective and may result in substantial delays in *** reduction of Aerosol Generating Medical Procedures(AGMP),such as intubation due to the COVId-19 Pandemic,must also be taken into *** to the potential increased risk of infection transmission,alternatives to general anesthesia should be considered when safe and *** abdominal regional nerve block techniques have been used to manage pain related to trauma,surgery,and cancer;however,blocks of this nature are not well described in the interventional radiology ***

关键词： anesthesia ablation corners

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接受经皮穿刺动脉栓塞术的大型多中心队列研究中自发性软组织血肿死亡率的预测因子

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国际医学放射学杂志 2019年第3期 366-366页

作者：赵永 M.Barral O.Pellerin V.T.Tran B.Gallix L.M.Boucher d.valenti department of Abdominal and Interventional Radiology H?pital CochinAssistance Publique-Hopitaux de ParisAPHP

摘要目的评价经皮动脉栓塞(PTAE)治疗自发性软组织血肿(SSTH)的安全性和有效性,并确定短期预后的预测变量。材料与方法对2011—2017年期间的112例病人的临

关键词：经皮穿刺动脉栓塞血肿体积预测因子死亡率

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肝门神经阻滞治疗肝损伤:肝肿瘤热消融的解剖学、技术和初步临床经验

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国际医学放射学杂志 2021年第6期 738-738页

作者： K.S.He R.Fernando T.Cabrera d.valenti A.Algharras N.Martínez 朱冬勇

成像引导治疗肝脏疾病的过程可能是痛苦的,需要病人大量的镇静。局部区域神经阻滞可改善疼痛控制,减少过度镇静风险,但没有文献证明肝脏特异性神经阻滞。目

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Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Comparison of 2d and 4d Flow MRI Measurements for Hemodynamic Evaluation of the Fontan Palliation

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Congenital Heart disease 2023年第6期18卷 627-638页

作者： Elisa Listo Nicola Martini Stefano Salvadori Elisa valenti Nicola Stagnaro Gianluca Trocchio Chiara Marrone Alberto Clemente Francesca Raimondi Pierluigi Festa Lamia Ait Ali department of Radiology IRCCS Istituto Giannina GasliniGenovaItaly U.O.C.Bioingegneria Gabriele Monasterio CNR-Tuscany FoundationPisaItaly Institute of Clinical Physiology CNR PisaItaly Cardiology Unit IRCCS Istituto Giannina GasliniGenovaItaly Pediatric Cardiology and GUCH Unit Massa Gabriele Monasterio CNR-Tuscany FoundationMassaItaly Gabriele Monasterio CNR-Tuscany Foundation PisaItaly department of Cardiology Azienda Ospedaliero-Universitaria MeyerFlorenceItaly Institute of Clinical Physiology CNR MassaItaly

Background:The assessment of Fontan circuit’sﬂow is traditionally evaluated by multiple through-plane phase-contrast MRI acquisitions(2dﬂow),while recently,a single volumetric 4d-ﬂow MRI acquisition is emerging as a comprehensive tool for the hemodynamic evaluation in congenital heart ***:To compare 2d and 4d-ﬂow MRI measurements in patients after Fontan palliation and to evaluate parameters affecting potential ***:39 patients after Fontan palliation(23 males,age 22±11 years)who underwent cardiac MRI with 2d and 4d-ﬂow MRI acquisition were included in the *** all patients,bloodﬂow quantiﬁcation in the Fontan circuit and aorta by 2dﬂow and by 4dﬂow MRI acquisition blinding to the 2d results was *** agreement between 2d and 4d-ﬂow MRI was calculated as the intraclass correlation coefﬁcient(ICC).The mean absolute differences between 4d and 2dﬂows were analyzed using linear regression ***:4d-ﬂow MRI acquisition time was slightly lower than 2d(7.6±1.8 min vs.9.4±3.3 min,p=0.03).Flow was slightly predominant in the right pulmonary artery(58%of total pulmonaryﬂow).Conduit/tunnel-pul-monary arteriesﬂow accounted for 60%of the Fontan *** between 2d and 4d was overall good-to-excellent from ICC:0.81795%CI:0.637–0.907 to 0.93295%CI:0.866–*** was no signiﬁcant inﬂu-ence of evaluated parameters on the agreement on 4d and 2dﬂ***:4d-ﬂow MRI represents a valid tool in Fontan’sﬂow quantiﬁ*** larger studies are needed to conﬁrm our results and to evaluate the impact of advanced 4d-ﬂow MRI parameters on the prognostic stratiﬁcation in patients after Fontan palliation.

关键词： Fontan palliation fontanﬂows 4dﬂow MRI 2dﬂow MRI cardiac magnetic resonance

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CRISPR/Cas system: An emerging technology in stem cell research

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World Journal of Stem Cells 2019年第11期11卷 937-956页

作者： Maria Teresa valenti Michela Serena Luca dalle Carbonare donato Zipeto department of Medicine Section of Internal Medicine DUniversity of VeronaVerona 37134Italy department of Biochemistry University of OxfordOxford OX13QUUnited Kingdom department of Neurosciences Biomedicine and Movement SciencesLaboratory of Molecular BiologyVerona 37134Italy

The identification of new and even more precise technologies for modifying and manipulating the genome has been a challenge since the discovery of the dNA double *** ability to modify selectively specific genes provides a powerful tool for characterizing gene functions,performing gene therapy,correcting specific genetic mutations,eradicating diseases,engineering cells and organisms to achieve new and different functions and obtaining transgenic animals as models for studying specific *** regularly interspaced short palindromic repeats(CRISPR)/Cas9 technology has recently revolutionized genome *** application of this new technology to stem cell research allows disease models to be developed to explore new therapeutic *** possibility of translating new systems of molecular knowledge to clinical research is particularly appealing for addressing degenerative *** this review,we describe several applications of CRISPR/Cas9 to stem cells related to degenerative *** addition,we address the challenges and future perspectives regarding the use of CRISPR/Cas9 as an important technology in the medical sciences.

关键词： Gene editing CRISPR/Cas9 Stem cells degenerative diseases

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Role of autophagy in bone and muscle biology

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World Journal of Stem Cells 2016年第12期8卷 396-398页

作者： Maria Teresa valenti Luca dalle Carbonare Monica Mottes department of Medicine Section of Internal Medicine D University of Verona department of Neurological Biomedical and Movement Sciences Section of Biology and Genetics University of Verona

Autophagy in eukaryotic cells is a constitutive process and functions as a homeostatic mechanism; it is up-regulated in response to specific stress stimuli such as starvation, hypoxia and as oxidative stress. In addition to playing a crucial role in adaptive responses to different stimuli, autophagy is also required for intracellular quality control. This second aspect is important to prevent the activation of pathological processes. Autophagy also plays a central role in cellular development and differentiation because it is involved in the regulation of energetic balance. This final aspect is critical for maintaining proper bone and muscle function as well as to prevent any pathological changes. Therefore, identifying new molecular targets involved in autophagy is critical to assure a good quality of life.

关键词： Autophagy Bone Muscle

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