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Annual and seasonal changes of the air temperature with altitude in the upper dades valley, High Atlas, Morocco

Journal of Mountain Science 2022年第1期19卷 85-102页

作者： ŻMudZKA Elwira dłużewski maciej dĄBSKI maciej LEZIAK Kamil ROJAN Elżbieta department of Climatology Faculty of Geography and Regional StudiesUniversity of WarsawKrakowskie Przedmieście 3000-927 WarsawPoland department of Geomorphology Faculty of Geography and Regional StudiesUniversity of WarsawKrakowskie Przedmieście 3000-927 WarsawPoland

The purpose of this study is to determine the size of air temperature changes with altitude in the mountains of the arid zone, on the example of the upper dades valley(High Atlas, Morocco). The air temperature change with altitude was determined on the basis of 5 years data from three meteorological stations. The analysis was carried out on an annual and seasonal basis. The annual and daily variations of thermal gradients between pairs of stations were also determined. It was found that the average thermal gradient in the upper dades valley was-1.02℃ per 100 m. The highest values of the thermal gradient occur in winter and the lowest in summer. In winter,the thermal gradient was characterized by the greatest variability. Minima of the daily variation of air temperature gradients were observed in early morning hours and maxima around midday. In the lower part of the valley, air temperature inversion frequently developed between 10 AM and 3 PM *** obtained results show high thermal gradients in the mountains of the arid zone, with their annual amplitude increasing in the lower parts of the *** instantaneous values of the gradients were significantly modified by the supply of latent heat and the occurrence of dust storms. It has been shown that the advection factor plays an important role in shaping large gradient values. The study contains novel results of thermal gradient measurements in high mountains of arid zone.

关键词： Air temperature gradient Thermal inversion Annual and seasonal variability Synoptic situation High mountains of arid zone High Atlas Mountains

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

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Gadolinium-modified titanium oxide materials for photoenergy applications:a review

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Journal of Rare Earths 2014年第6期32卷 487-495页

作者： maciej Zalas Faculty of Chemistry Adam Mickiewicz University in Poznań

Gadolinium doped titania materials were explored for application in photoenergy production. Incorporation of gadolinium into titania permitted improvement of photocatalytic or photovoltaic performance of the latter. This review provided a deep analysis of gadolinium applications in photoenergy processes and devices with the main focus on explanation of gadolinium doping effect on physicochemical properties of titania.

关键词： gadolinium doped titania Gd-TiO2 photocatalysis dye-sensitized solar cells photoenergy rare earths

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Statistical variation of characteristics of random packed beds of Raschig rings:The influence of the sample size

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Particuology 2021年第3期19卷 50-61页

作者： PawełNiegodajew maciej Marek Czestochowa university of Technology Department of Thermal Machineryal.Armii Krajowej 2142-200 CzestochowaPoland

Many studies on random packed beds have been dedicated to local porosity(void fraction)or orientation distribution of ***,despite the random nature of the considered packings,very little attention has been devoted to examination whether the number of particles used in experiments/simulations is sufficiently large to get reproducible *** reproducibility of the key packing parameters depends on the size of the population of particles(sample size)and ordering effects induced by the confining *** work investigates quantitatively the influence of the sample size on the statistical variation of the packed bed *** beds of Raschig rings were generated with a sequential algorithm and three column diameters were *** has been found that in the case of the orientation distribution the results depend strongly on the sample size,especially for slender columns,while the porosity profiles are well-reproducible characteristics even for relatively small packings of *** complementary results for full cylinders are also included.

关键词： Random packing Raschig rings Full cylinders Particle orientation Porosity Reproducibility

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Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

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Modeling of Propagation and Transformation of Transient Nonlinear Waves on A Current

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China Ocean Engineering 2013年第5期27卷 579-592页

作者： Wojciech Sulisz maciej Paprota Institute of Hydroengineering Polish Academy of Sciencies

A novel theoretical approach is applied to predict the propagation and transformation of transient nonlinear waves on a current. The problem was solved by applying an eigenfunction expansion method and the derived semi-analytical solution was employed to study the transformation of wave profile and the evolution of wave spectrum arising from the nonlinear interactions of wave components in a wave train which may lead to the formation of very large waves. The results show that the propagation of wave trains is significantly affected by a current. A relatively small current may substantially affect wave train components and the wave train shape. This is observed for both opposing and following current. The results demonstrate that the application of the nonlinear model has a substantial effect on the shape of a wave spectrum. A train of originally linear and very narrow-banded waves changes its one-peak spectrum to a multi-peak one in a fairly short distance from an initial position. The discrepancies between the wave trains predicted by applying the linear and nonlinear models increase with the increasing wavelength and become significant in shallow water even for waves with low steepness. Laboratory experiments were conducted in a wave flume to verify theoretical results. The free-surface elevations recorded by a system of wave gauges are compared with the results provided by the nonlinear model. Additional verification was achieved by applying a Fourier analysis and comparing wave amplitude spectra obtained from theoretical results with experimental data. A reasonable agreement between theoretical results and experimental data is observed for both amplitudes and phases. The model predicts fairly well multi-peak spectra, including wave spectra with significant nonlinear wave components.

关键词： numerical modeling transient waves current boundary conditions initial conditions

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Modelling of wave transmission through a pneumatic breakwater

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Journal of Hydrodynamics 2017年第2期29卷 283-292页

作者： maciej Paprota Wojciech Sulisz Institute of Hydro-Engineering of Polish Academy of Sciences GdafiskPoland

A theoretical approach is derived to study interaction of linear water waves with an air bubble curtain used as a pneumatic breakwater. Modelling of wave transmission through an aerial barrier is a complex task due to a need to cover processes associated with wave-current interaction, effects of two-phase flows, wave damping, etc.. An initial boundary-value problem is solved by applying an efficient eigenfunction expansion method and a time-stepping procedure. The derived semi-analytical solution is used to study the effect of basic parameters of the model on wave dissipative properties of the pneumatic breakwater. Results show that wave damping by the breakwater is mainly affected by an air flow rate. The increased air discharge results in higher velocities of ascending bubbles and increases aerial barrier width. This leads to a substantial reduction of transmitted wave heights, especially for waves of intermediate length and short waves. In order to verify the applicability of the presented theoretical approach, laboratory experiments are conducted in a wave flume for different wave regimes and pneumatic breakwater characteristics. The analysis of a wave trans- mission coefficient calculated numerically and measured in the laboratory confirms that the derived model can be used for a certain range of wave conditions.

关键词： Surface waves wave transmission wave-current interaction pneumatic breakwater numerical modelling

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Possibilities of Increase of Adhesion of the Cubic Boron Nitride Coatings by Applying an Interfacial Layers

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材料热处理学报 2004年第05B期25卷 1191-1194页

作者： maciej Kupczyk Poznan university of Technology Institute of Mechanical Engineering Poznan Poland

In the work the chosen investigations of the adhesion force of thin, superhard coatings to the cutting edges made of cemented carbides are presented. For identification of the adhesion force of coatings to substrate an automatic scratch tester constructed at Poznan university of Technology was applied. The estimation of the adhesion force (value of critical load measured during scratch test) was carried out on the base of the vibration signal. Results of investigations are pointed at the influence of a surface preparation (degreasing, etching, low and high-temperature sputtering) on a critical load values. It was found that the most effective method for surface preparation is low temperature sputtering. The influence of the TiC+Al2O3+TiN interfacial layer on increase of the adhesion force of BN coating to cemented carbides substrate was observed.

关键词：氮化硼界面间层耐磨性脆性

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