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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie d.de Schutter lies de groef lieve Moons Steven Bergmans KU leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

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NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal g-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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Rice spouted bed for manufacturing inclusion complexes of endopleura uchi l extracts in β-cyclodextrin

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Particuology 2019年第1期17卷 208-215页

作者： l.V.d. Freitas A.C.R. Montes e.I.A. Campos e.C. Conceicao l.A. Tacon A.d. lanchote l.A.P.Freitas Faculdade de Ciencias Farmaceuticas de Ribeirao Preto University of Sao PauloVia do Cafe s/n14040-903Ribeirao PretoSPBrazil

Uxi (endopleura uchi) is a plant from the Brazilian Amazon. It has many biological activities that are attributed to its main active component, bergenin (Bg), which has low water solubility. The aim of this work was to obtain β-cyclodextrin (β-Cd) inclusion complexes of uxi using lyophilized cooked rice as the solid substrate. The process was studied using a Box–Behnken design with the solution feed rate, molar ratio of β-Cd to Bg, and rice bed load as factors. These factors greatly affected the product bulk density, angle of repose, water content, and Bg content, loss, and water solubility. The optimum process conditions determined using a desirability functions methodology were an extract feed rate of 1 ml/min, a ratio of β-Cd to Bg of 3:1, and a substrate load of 100 g. The predicted values under the optimum conditions were close to the experimental results of a water content of 5.8%± 0.2%, Bg content of 985.7 ± 15.4 μg/g, Bg water solubility of 2230.2 ± 21.1 μg/ml, and Bg loss of 1.2%± 0.1%. These results confirm that spouted beds are an important tool for rapid, one-step preparation of pharmaceutical β-Cd inclusion complexes in a solid form.

关键词： Bergenin Chromatography Yield Active loss Solubility

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land use impact on clay dispersion/flocculation in irrigated and flooded vertisols from Northern Cameroon

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International Soil and Water Conservation Research 2018年第3期6卷 237-244页

作者： Simon djakba Basga désiréTsozue Jean Pierre Temga Jules Balna Jean Pierre Nguetnkam Institute of Agricultural Research for development(IRAd) P.O.Box33MarouaCameroon department of earth Sciences Faculty of ScienceUniversity of MarouaP.O Box814MarouaCameroon department of earth Sciences Faculty of ScienceUniversity of Yaoundé1P.O Box812YaoundéCameroon department of earth Sciences Faculty of ScienceUniversity of NgaoundéréP.O Box454NgaoundéréCameroon

Clay dispersion by water is important for soil and water conservation as well as for irrigation scheduling. In the present study, clay dispersion/flocculation of irrigated and flooded vertisols in North Cameroon was investigated using clay dispersion/stability indices. Nine vertisols topsoils (0–20 cm) samples were collected on different land use and their clay dispersion indices were assessed. Vertisols were acidic to slightly basic, with smectites as dominant clay mineral. The water dispersible clay (160–340 g kg-1), the dispersion ratio (0.55–0.79) and the clay dispersion ratio (0.48–0.83) were high in the studied vertisols while the clay flocculation index (0.17–0.54) and the clay aggregation (70–230 g kg-1) were low to moderate, indicating their high dispersion. Cropped vertisols displayed the higher amount of water dispersible clay while not cropped recorded the smaller amount. Concerning the cropped soils, irrigated vertisols displayed the highest clay dispersion indices suggesting that agricultural practices (irrigation) enhance clay dispersion. globally, the clay dispersibility trend was: irrigated paddy ? rainy sorghum ? rainfed paddy ? dry-season sorghum ? not cropped. Statistical analyses revealed that amorphous Al, Na+ and electrical conductivity enhance clay dispersion while organic matter, nitrogen and Ca++ promote clay flocculation/aggregation. The overall findings emphasized that practices such as heavy tillage and irrigation induce clay dispersion. Minimum tillage, electrolytes concentration monitoring in irrigation water, irrigation scheduling based on soil moisture control, organic matter inputs and implementation of adapted dams are measures susceptible to limit their degradation through clay dispersion.

关键词： Vertisols Clay dispersion Irrigation land use North Cameroon

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Ultra‑Transparent and Multifunctional IZVO Mesh electrodes for Next‑generation Flexible Optoelectronics

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Nano-Micro letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram d.dongale Atul C.Khot Chenjie Yao Nahyun Kim Tae geun Kim School of electrical engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea Computational electronics and Nanoscience Research laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

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effect of cobalt substitution on structure and magnetic properties of Nd0.4Zr0.6Fe10-xCoxSi2（x =0-3） alloys and their ribbons

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Journal of Rare earths 2019年第10期37卷 1096-1101页

作者： M.gjoka C.Sarafidis g.giannopoulos d.Niarchos g.Hadjipanayis J.A.Tabares g.A.Pérez Alcázar l.e.Zamora Institute of Nanoscience and Nanotechnology NCSR Demokritos15310AthensGreece department of Physics and Astronomy University of DelawareNewarkDEUSA department of Physics Aristotle University of Thessaloniki54124ThessalonikiGreece departamento de Física Universidad del ValleA.A.25360CaliColombia

This study reports the stabilization of the RFe12-type based compounds where part of R and Fe are substituted with Zr and Co and Si, respectively, in order to examine whether these rare-earth-lean materials are suitable for applications as permanent magnets. Structural and magnetic characterization of the family of alloys with the general formula Nd0.4 Zr0.6 Fe10-xCoxSi2(x = 0 -3) and their melt-spun ribbons were carried out using X-ray diffraction and M€ossbauer spectroscopy. The ThMn12-type structure is obtained for all samples as the majority phase with a minority a-Fe(CoSi) phase(less than 5 wt%) as it was estimated by XRd for x = 1 and 2. The Curie temperature increases linearly with Co substitution from 561 K for x = 0 to 712 K for x = 3. The saturation magnetization decreases slightly from 130.5(x =1)to 129.1 A·m2/kg(x=3), while the anisotropy field is following the same trend.

关键词： Permanent magnets X-ray diffraction M€ossbauer spectroscopy Rare-earth-lean magnetic materials Magnetic properties Melt-spun ribbons

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Maternal effects, malaria infections and the badge size of the house sparrow

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Chinese Birds 2015年第4期6卷 215-224页

作者： Philip l.g.Birget Stephen d.larcombe St Peter’s College University of Oxford Institute of evolutionary Biology University of Edinburgh edward grey Institute of Field Ornithology University of Oxford Centre de Recherche de la Tour du Valat Jesus College University of Oxford Institute of Biodiversity Animal Health and Comparative Medicine University of Glasgow

Background: The evolution of sexual signals is not only determined by immediate sexual selection but also by selection arising from the environment and the interaction with developmental *** this study we aimed to investigate how the badge size of male house sparrows(Passer domesticus) is correlated to avian malaria infections as well as to prenatal testosterone exposure,measured as the 2d:4d digit *** rationale behind this study is that the immunosuppressive effect of maternal testosterone deposition combined with the fitness cost imposed by parasites may cause important trade-offs to the development of secondary sexual ***: Assuming that vector abundance is a key variable associated with infection risk by avian malaria,we caught adult male sparrows from eight different populations in the Camargue,France,four of which were located in a vector-controlled area,and the other four in an untreated *** each bird we measured its badge size,digit ratio and took blood to determine its infections *** used PCR to identify the malaria parasite species and strain that caused the ***: Contrary to our expectation,prevalence of disease did not differ across the vector-treatment regions,with around 80 % of birds being infected in both areas,and those infections were caused largely by a single strain,Plasmodium relictum *** infected birds had a badge size not significantly different from uninfected males,there was a condition-dependent association between badge size,infection status and maternal testosterone ***: This study illustrates that the complexity of temporal and ecological dimensions makes the relationships between disease,testosterone-related traits and secondary sexual signals that have been previously reported less general than thought.

关键词： Avian malaria digit ratio Passer domesticus Sexual signals

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Ursodeoxycholic acid improves gastrointestinal motility defects in gallstone patients

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World Journal of gastroenterology 2006年第33期12卷 5336-5343页

作者： A Colecchia g Mazzella l Sandri F Azzaroli M Magliuolo P Simoni Ml Bacchi-Reggiani e Roda d Festi department of Internal Medicine and gastroenterology University of Bologna Bologna Italy department of Pharmaceutical Sciences University of Bologna Bologna Italy department of Cardiovascular diseases University of Bologna Bologna Italy

AIM: To simultaneously evaluate the presence of defects in gallbladder and gastric emptying, as well as in intestinal transit in gallstone patients (gS) and the effect of chronic ursodeoxycholic acid (UdCA) administration on these parameters and on serum bile acids and clinical outcome in gS and controls (CTR). MeTHOdS: After a standard liquid test meal, gallbla-dder and gastric emptying (by ultrasound), oroileal transit time (OITT) (by an immunoenzymatic technique) and serum bile acids (by HPlC) were evaluated before and after 3 mo of UdCA (12 mg/kg bw/d) or placebo administration in 10 symptomatic gS and 10 matched healthy CTR. ReSUlTS: OITT was longer in gS than in CTR (P dCA significantly reduced OITT in gS (P gS had longer gastric half-emptying time (t1/2) than CTR (P eline; after UdCA, t1/2 significantly decreased (P gS but not in CTR. Placebo administration had no effect on gastric emptying and intestinal transit in both gS and CTR. CONClUSION: The gallstone patient has simultaneous multiple impairments of gallbladder and gastric emptying, as well as of intestinal transit. UdCA administration restores these defects in gS, without any effect in CTR. These results confirm the pathogenetic role of gastrointestinal motility in gallstone disease and suggest an additional mechanism of action for UdCA in reducing bile cholesterol supersaturation.

关键词： Bile acids Biliary cholesterol deoxycholic acid gallbladder emptying gastric emptying Intestinaltransit Tauroursodeoxycholic acid

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Bayesian model averaging(BMA)for nuclear data evaluation

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Nuclear Science and Techniques 2024年第11期35卷 193-218页

作者： e.Alhassan d.Rochman g.Schnabel A.J.Koning SCK CeN(Belgian Nuclear Research Centre) Boeretang 2002400 MolBelgium laboratory for Reactor Physics and Thermal‑Hydraulics Paul Scherrer Institute5232 VilligenSwitzerland Nuclear data Section International Atomic Energy Agency(IAEA)ViennaAustria division of Applied Nuclear Physics Department of Physics and AstronomyUppsala UniversityUppsalaSweden

To ensure agreement between theoretical calculations and experimental data,parameters to selected nuclear physics models are perturbed and fine-tuned in nuclear data *** approach assumes that the chosen set of models accurately represents the‘true’distribution of considered ***,the models are chosen globally,indicating their applicability across the entire energy range of ***,this approach overlooks uncertainties inherent in the models *** this work,we propose that instead of selecting globally a winning model set and proceeding with it as if it was the‘true’model set,we,instead,take a weighted average over multiple models within a Bayesian model averaging(BMA)framework,each weighted by its posterior *** method involves executing a set of TAlYS calculations by randomly varying multiple nuclear physics models and their parameters to yield a vector of calculated ***,computed likelihood function values at each incident energy point were then combined with the prior distributions to obtain updated posterior distributions for selected cross sections and the elastic angular *** the cross sections and elastic angular distributions were updated locally on a per-energy-point basis,the approach typically results in discontinuities or“kinks”in the cross section curves,and these were addressed using spline *** proposed BMA method was applied to the evaluation of proton-induced reactions on ^(58)Ni between 1 and 100 *** results demonstrated a favorable comparison with experimental data as well as with the TeNdl-2023 evaluation.

关键词： Bayesian model averaging(BMA) Nuclear data Nuclear reaction models Model parameters TAlYS code system Covariances

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Machine learning empowers efficient design of ternary organic solar cells with PM6 donor

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Journal of energy Chemistry 2025年第1期100卷 337-347页

作者： Kiran A.Nirmal Tukaram d.dongale Santosh S.Sutar Atul C.Khot Tae geun Kim School of electrical engineering Korea University Computational electronics and Nanoscience Research laboratory School of Nanoscience and Biotechnology Shivaji University Yashwantrao Chavan School of Rural development Shivaji University

Organic solar cells(OSCs) hold great potential as a photovoltaic technology for practical ***, the traditional experimental trial-and-error method for designing and engineering OSCs can be complex, expensive, and time-consuming. Machine learning(Ml) techniques enable the proficient extraction of information from datasets, allowing the development of realistic models that are capable of predicting the efficacy of materials with commendable accuracy. The PM6 donor has great potential for high-performance OSCs. However, it is crucial for the rational design of a ternary blend to accurately forecast the power conversion efficiency(PCe) of ternary OSCs(TOSCs) based on a PM6 ***, we collected the device parameters of PM6-based TOSCs and evaluated the feature importance of their molecule descriptors to develop predictive models. In this study, we used five different Ml algorithms for analysis and prediction. For the analysis, the classification and regression tree provided different rules, heuristics, and patterns from the heterogeneous dataset. The random forest algorithm outperforms other prediction Ml algorithms in predicting the output performance of PM6-based TOSCs. Finally, we validated the Ml outcomes by fabricating PM6-based TOSCs. Our study presents a rapid strategy for assessing a high PCe while elucidating the substantial influence of diverse descriptors.

关键词： Random forests

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