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Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

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Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy g.White Chunyan li department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSds)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSds,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSds,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(eC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular eCs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

grafting affects yield and phenolic prof ile of Solanum melongena l. landraces

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Journal of Integrative Agriculture 2016年第5期15卷 1017-1024页

作者： l Sabatino g Iapichino A Maggio e d’ Anna M Bruno F d’ Anna department of Agricultural and Forest Sciences University of Palermo department of Biological Chemical and Pharmaceutical Sciences and Technologies University of Palermo Regional Centres for Agricultural Technologies (Ce.R.T.A.) University of Foggia

The influence of grafting on agronomical and qualitative characteristics of four Sicilian eggplant landraces was investigated. grafted and ungrafted plants were compared in the open field in the northern coast of Sicily. Solanum torvum seedlings were used as rootstock. Regardless of genotypes tested, grafting significantly increased total fruit production, marketable production, and number of marketable fruits, but did not affect weight of marketable fruits and waste production. landrace 2（Sciacca）, with black epidermal tissue and pyriform fruit shape, when grafted onto S. torvum not only gave a higher yield performance than ungrafted plants, but also showed a higher phenolic antioxidant content. landrace 4（Sicilia）, with black epidermal tissue and small cylindrical fruits also benefited, when grafted onto S. torvum, from a substantial increase in antioxidant fruit content. As consumers＇ demand for fruits and vegetables rich in compounds important for human health is steadily increasing, these landrace/rootstock combinations should deserve more attention by plant nurseries involved in grafted seedling production and interested in the valorization and conservation of eggplant biodiversity.

关键词： eggplant propagation technique yield polyphenols HPlC analysis

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： larissa M.g.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Identification of major sources controlling groundwater geochemistry in Mount Makabaï in the Far-North of Cameroon(the northernmost part of the Pan-African Belt)

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Acta geochimica 2023年第2期42卷 266-289页

作者： Merlin gountiédedzo désiréTsozué Amidou Kpoumié Aubin Nzeugang Nzeukou department of life and earth Sciences Higher Teachers’Training CollegeUniversity of MarouaP.O.Box.55MarouaCameroon department of earth Sciences Faculty of ScienceUniversity of MarouaP.O.Box.814MarouaCameroon

The present work focuses on the volcanic basement rock geochemistry of Mount Makabaï(MarouaCameroon city)in relation to groundwater *** were centered on an approach involving an association of several methods such as geological cartography,hydrogeology,and *** rock samples,four disturbed soil samples,three undisturbed soil samples,and 20 samples of groundwater in 10 wells were collected during fieldwork and prepared for laboratory *** exhibit porphyritic,aphyric,and subaphiric *** phenocryst phases are mainly olivine,clinopyroxene,and *** on whole rock major element chemical compositions,the Makabaï samples,plotted on Na_(2)O+K_(2)O versus SiO_(2)diagram,are mugearite,hawaiite,and *** ratio of(MgO+CaO)/(Na_(2)O+K_(2)O)exceeds unity and shows dominance of alkaline earth metals(MgO:2.99-4.48%;CaO:6.19-9.80%)relatively to alkali metals(Na_(2)O:2.27-4.46%;K_(2)O:2.09-2.51%).exchangeable base contents are high,mostly represented by Ca and Mg,whose contents vary from 14.6 to 35.28 cmol(+)kg^(-1)and from 3.28 to9.48 cmol(+)kg^(-1)*** CeCclayis likewise high,fluctuating between 116.80 and181.38 cmol(+)kg^(-1),values in line with the presence of 2:1 clay minerals represented in the study area by *** the water samples,the Ca2+and Na+contents are generally higher than K^(+)and Mg^(2+),reflecting the relative abundance of Na_(2)O and CaO oxides to K_(2)O and MgO oxides in rocks where different waters were *** waters of Makabaï are acidic to neutral(6.3≤pH≤7.4)and weakly to highly mineralized(110.0≤eC≤1190.0μS/cm).Hydro-geochemical classification by using the Piper diagram revealed two water types:(1)CaMg-HCO_(3)(40%)and(2)CaMg-Cl or CaMg-SO4(60%).The average content of ions in all the analyzed samples was HCO_(3)^(-)>>NO_(3)^(-)>SO_(4)^(2-)>Cl-for anions and Ca^(2+)>>Mg^(2+)>Na^(+)>K^(+)for *** mechanisms governing ionic constituents of groundwater in

关键词： Mount Makabaï-Maroua city Far-North Cameroon Bedrock minerals groundwater-rock-soil interaction Crystalline basement

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling lü Chunchi Zhang dong liang lei Yang Zegao Wang College of Materials Science and engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China electronics Technology group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2d-FeT)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FeT for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang Jie dang Jia guo Hanghang Zhou Xuewei lü College of Materials Science and engineering Chongqing UniversityChongqing 400044China Chongqing Key laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.goldschmidt-Clermont Aisha Khan george Jimsheleishvili Patricia graham Adriana Brooks Risset Silvera Alexander J.P.goldschmidt damien d.Pearse W.dalton dietrich Allan d.levi James d.guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International llC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 ml of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell