检索结果-南通市图书馆

Structural effects of reedbed grazing and its cessation on reed-nesting songbird densities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Avian Research 2024年第2期15卷 238-248页

作者： Thomas Pagnon Clemence Pechinot Lea Sgro jeremie Demay Remi jullian Regis Gallais Brigitte Poulin cyril Marmoex Theria Ecologie 6 avenue des martyrs05400VeynesFrance UMR 6249 Chrono-Environnement CNRSUniversite de Franche-Comte16 route de Gray25000BesanconFrance Conservatoire d’Espaces Naturels d’Occitanie 26 alle de Mycenes34000MontpellierFrance Office Français de la Biodiversite 12 cours Lumiere94300VincennesFrance Tour du Valat Research Institute for the Conservation of Mediterranean Wetlands Le Sambuc13200ArlesFrance

Reedbeds are crucial breeding habitats for vulnerable songbird *** of their protection status,these habitats may be threatened by organic matter accumulation,progressively leading to structural homoge-nization and habitat succession towards *** prevent excessive litter build-up with various in-terventions opening-up the reedbeds,such as grazing,which may be detrimental or suitable for some reed bird *** assessed the effects of extensive grazing by horses and its cessation in the medium and long terms on reedbed structure,and the consequences on reed-nesting songbird densities in Estagnol Nature Reserve,a pro-tected wetland near the French Mediterranean *** compared reedbed structural features between grazed,newly ungrazed and old-ungrazed *** nine years,we censused four songbird species in spring and collected water level data in the same survey *** reduced reedbed extent,rejuvenated the vegetation with more short green stems on a thinner litter,and produced higher structural heterogeneity and discontinuity compared to long-lasting non *** ungrazed plot showed intermediate *** surveyed songbird total densities were similar among plots while species numbers and densities *** reedbed was more attractive to Moustached Warblers(Acrocephalus melanopogon)and Great Reed Warblers(Acrocephalus arundi-naceus),likely due to the large edges and the high vegetation structural ***,Moustached Warblers were more negatively affected by higher water level in grazed reedbed,presumably because flooding prevents litter *** newly ungrazed reedbed was not preferred by any *** warbler species were found under low density in the old-ungrazed reedbed,where Reed Buntings(Emberiza schoeniclus)were exclu-sively *** availability related to thick litter layer may explain this *** Reed Warblers(Acrocephalus scirpaceus)were found everywhere in similar

关键词： Bird conservation Edge complexity Fragmentation Habitat management Horse grazing Phragmites australis Reed passerine

肌萎缩侧索硬化蛋白激活小胶质细胞NLRP3炎性体

在线全文

学校读者我要写书评

暂无评论

神经损伤与功能重建 2022年第1期17卷 F0003-F0003页

作者： Vandana Deora john D Lee Eduardo AAlbornoz Luke McAlary cyril j jagaraj Avril A B Robertson julie D Atkin Matthew A Cooper Kate Schroder justin j Yerbury Richard Gordon Trent MWoodruff School of Biomedical Sciences Faculty of MedicineThe University of QueenslandSt.LuciaQueenslandAustralia University of Queensland Centre for Clinical Research Faculty of MedicineThe University of QueenslandHerstonQueenslandAustralia Institute for Molecular Bioscience and Centre for Inflammation and Disease ResearchThe University of QueenslandSt.LuciaQueenslandAustralia School of Chemistry and Molecular Biosciences Faculty of ScienceMedicine and HealthUniversity of WollongongWollongongNew South WalesAustralia Illawarra Health and Medical Institute University of WollongongWollongongNew South WalesAustralia Faculty of Medicine and Health Sciences Department of Biomedical SciencesCentre for MND ResearchMacquarie UniversityNew South WalesAustralia School of Chemistry and Molecular Biosciences The University of QueenslandSt.LuciaQueenslandAustralia

小胶质细胞NLRP3炎症小体激活正在成为神经退行性变期间神经炎症的关键因素。β-淀粉样蛋白和α-突触核蛋白等致病蛋白的聚集体可触发小胶质细胞NLRP3激活,并导致半胱氨酸天冬氨酸酶激活和白介素-1β分泌。半胱氨酸天冬氨酸酶和白介素-... 详细信息

小胶质细胞NLRP3炎症小体激活正在成为神经退行性变期间神经炎症的关键因素。β-淀粉样蛋白和α-突触核蛋白等致病蛋白的聚集体可触发小胶质细胞NLRP3激活,并导致半胱氨酸天冬氨酸酶激活和白介素-1β分泌。半胱氨酸天冬氨酸酶和白介素-1β均促进肌萎缩侧索硬化(ALS)小鼠SOD1G93A模型的疾病进展,这提示小胶质细胞NLRP3在该进程中起作用。然而,先前的研究表明SOD1G93A模型小鼠的小胶质细胞并不表达NLRP3,并且SOD1G93A蛋白在小胶质细胞中产生白介素-1β不依赖于NLRP3。本研究展示了使用Nlrp3-GFP基因敲入小鼠,在SOD1G93A小鼠中小胶质细胞表达NLRP3。结果表明,聚集和可溶性SOD1G93A均以剂量和时间依赖性方式激活小鼠原代小胶质细胞中的炎性体,导致半胱氨酸天冬氨酸酶和白介素-1β裂解、ASC斑点形成和白介素-1β分泌。重要的是,SOD1G93A不能诱导缺乏Nlrp3的小胶质细胞或用特异性NLRP3抑制剂MCC950预处理的小胶质细胞分泌白介素-1β,这证实NLRP3是介导SOD1诱导的小胶质细胞白介素-1β分泌的关键炎性体复合物。在TDP-43Q331K ALS小鼠模型中也观察到小胶质细胞NLRP3上调,并且TDP-43野生型和突变蛋白也能以NLRP3依赖性方式激活小胶质细胞炎症小体。从机制上,本研究确定活性氧簇和ATP的产生是SOD1G93A介导的NLRP3激活所需的关键事件。总之,本研究的数据表明ALS小胶质细胞表达NLRP3,病理性ALS蛋白激活了小胶质细胞NLRP3炎性体。因此,抑制NLRP3可能是阻止小胶质细胞神经炎症和ALS疾病进展的潜在治疗方法。

关键词：白介素-1β 胶质细胞先天免疫运动神经元病

维普期刊数据库博看期刊

肌萎缩性侧索硬化蛋白激活小胶质细胞NLRP3炎性小体

在线全文

学校读者我要写书评

暂无评论

神经损伤与功能重建 2020年第9期15卷 F0003-F0003页

作者： Vandana Deora john D Lee Eduardo AAlbornoz Luke McAlary cyril j jagaraj Avril A B Robertson julie D Atkin Matthew A Cooper Kate Schroder justin j Yerbury Richard Gordon Trent MWoodruff 杜一星(编译) School of Biomedical Sciences Faculty of MedicineThe University of QueenslandSt.LuciaQueenslandAustralia University of Queensland Centre for Clinical Research Faculty of MedicineThe University of QueenslandHerstonQueenslandAustralia Institute for Molecular Bioscience and Centre for Inflammation and Disease ResearchThe University of QueenslandSt.LuciaQueenslandAustralia School of Chemistry and Molecular Biosciences Faculty of ScienceMedicine and HealthUniversity of WollongongWollongongNew SouthWalesAustralia Illawarra Health and Medical Institute University ofWollongongWollongongNew SouthWalesAustralia Faculty of Medicine and Health Sciences Department of Biomedical SciencesCentre for MND ResearchMacquarie UniversityNew SouthWalesAustralia School of Chemistry and Molecular Biosciences The University of QueenslandSt.LuciaQueenslandAustralia 不详

小胶质细胞NLRP3炎性小体激活正在成为神经退行性变过程中神经炎症的关键因素。诸如β-淀粉样蛋白和α-突触核蛋白之类的致病性蛋白质聚集体触发小胶质NLRP3激活,从而导致半胱天冬酶-1激活和IL-1β的分泌。在小鼠肌萎缩性侧索硬化症(ALS... 详细信息

小胶质细胞NLRP3炎性小体激活正在成为神经退行性变过程中神经炎症的关键因素。诸如β-淀粉样蛋白和α-突触核蛋白之类的致病性蛋白质聚集体触发小胶质NLRP3激活,从而导致半胱天冬酶-1激活和IL-1β的分泌。在小鼠肌萎缩性侧索硬化症(ALS)的SOD1G93A模型中,半胱天冬酶-1和IL-1β均促进疾病进展,提示小胶质NLRP3在该进程中发挥作用。然而先前的研究表明,SOD1G93A小鼠小胶质细胞不表达NLRP3,SOD1G93A蛋白在小胶质细胞中产生独立于NLRP3的IL-1β。本研究论证了使用Nlrp3-GFP基因敲入小鼠,在SOD1G93A小鼠中小胶质细胞表达NLRP3。本研究显示聚集和可溶性SOD1G93A均可激活小鼠原代小胶质细胞中的炎性小体,导致半胱天冬酶-1和IL-1β裂解,ASC斑点形成以及呈剂量和时间依赖性的IL-1β分泌。重要的是,SOD1G93A无法从缺乏Nlrp3的小胶质细胞或者用特异性NLRP3抑制剂MCC950预处理的小胶质细胞中诱导IL-1β分泌,从而证实NLRP3是介导SOD1诱导的小胶质细胞IL-1β分泌的关键炎症小体复合物。在TDP-43Q331K ALS小鼠模型中也观察到小胶质NLRP3上调,TDP-43野生型和突变蛋白亦可以NLRP3依赖性的方式激活小胶质炎性小体。从机制上讲,本研究确定了活性氧簇和ATP的生成是SOD1G93A介导的NLRP3激活所需的关键事件。总之,本研究的数据表明ALS小胶质细胞表达NLRP3,而病理ALS蛋白激活小胶质NLRP3炎性小体。因此,NLRP3抑制可能是阻止小胶质细胞神经炎症和ALS疾病进展的潜在治疗方法。

关键词：白介素-1β 胶质细胞先天免疫运动神经元病

Crystallographic Analysis of Martensite in 0.2C-2.0Mn-1.5Si-0.6Cr Steel using EBSD

在线全文

学校读者我要写书评

暂无评论

journal of Materials Science & Technology 2011年第10期27卷 920-930页

作者： Pasi P.Suikkanen cyril Cayron Anthony j.DeArdo L.Pentti Karjalainen Department of Mechanical Engineering University of OuluBox 420090014 University of Oulu CEA LITEN17 rues des Martys38054GrenobleFrance Department of Mechanical Engineering and Materials Science University of Pittsburgh

The crystallography of martensite formed in 0.2C-2.0Mn-1,5Si-0.6Cr steel was studied using the electron backscattered diffraction （EBSD） technique. The results showed that the observed orientation relationship （OR） was closer to that of Nishiyama-Wassermann （N-W） than Kurdjumov-Sachs. The martensite consisted of parallel laths forming morphological packets. Typically, there were three different lath orientations in a morphological packet consisting of three specific N-W OR variants sharing the same {111} austenite plane. A packet of martensite laths with a common {111} austenite plane was termed a crystallographic packet. Generally, the crystallographic packet size corresponded to the morphological packet size, but occasionally the morphological packet was found to consist of two or more crystallographic packets. Therefore, the crystallographic packet size appeared to be finer than the morphological packet size. The relative orientation between the variants in crystallographic packets was found to be near 60°〈110〉, which explains the strong peak observed near 60° in the grain boundary misorientation distribution. Martensite also contained a high fraction of boundaries with a misorientation in the range 2.5-8°. Typically these boundaries were found to be located inside the martensite laths forming sub-laths.

关键词： Martensite Austenite Nishiyama-Wassermann orientation relationship EBSD Crystallography Packet

Crystallographic Analysis of Isothermally Transformed Bainite in 0.2C-2.0Mn-1.5Si-0.6Cr Steel Using EBSD

在线全文

学校读者我要写书评

暂无评论

journal of Materials Science & Technology 2013年第4期29卷 359-366页

作者： Pasi P.Suikkanen cyril Cayron Anthony j.DeArdo L.Pentti Karjalainen Ruukki Metals Oy Rautaruukintie 155P.O.Box 93FI-92101 RaaheFinland Department of Mechanical Engineering University of OuluP.O.Box 420090014 University of OuluFinland Ruukki Metals Oy Rautaruukintie 155P.O.Box 93FI-92101 RaaheFinland. CEA LITEN17 rues des Martys38054 GrenobleFrance Department of Mechanical Engineering and Materials Science University of Pittsburgh848 Benedum HallPittsburghPA 15261-2285USA

The crystallography of bainite, transformed isothermally at 450 ℃ in 0.2C-2.0Mn-1.5Si-0.6Cr steel, was investigated by electron backscatter diffraction （EBSD） analysis. The orientation relationship （OR） was found to be closer to Nishiyama-Wassermann （N-W） than Kurdjumov-Sachs orientation relationship. Bainite microstructure consisted of parallel laths forming a morphological packet structure. Typically, there were three different lath orientations in a morphological packet. These orientations were dictated by a three specific N-W OR variants sharing the same {111} austenite plane. A packet of bainite laths with common {111} austenite plane was termed as crystallographic packet. Generally, the crystallographic packet size corresponded to the morphological packet size. Locally, crystallographic packets with only two dominant orientations were observed. This indicates strong local variant selection during isothermal bainite transformation. The relative orientation between the variants in crystallographic packets was found to be near 60°/〈110〉. This appears to explain the strong peak observed in the grain boundary misorientation distribution near 60°. Bainite also contained pronounced fraction of boundaries with their misorientation in the range of 2.5°-8° with quite widely dispersed rotation angles. Spatially these boundaries were found to locate inside the bainite laths, forming lath-like sub-grains.

关键词： Bainite Austenite Nishiyama-Wassermann orientation relationship Electron backscatter diffraction OEBSD) Crystallography Packet

Feasibility of Using Wood Chips to Regulate Relative Humidity Inside a Building: A Numerical Study

在线全文

学校读者我要写书评

暂无评论

journal of Renewable Materials 2019年第6期7卷 505-516页

作者： Dimitri Bigot cyril Ott Stéphane Guichard Bruno Malet-Damour University of La Réunion-40 avenue de Soweto-Terre Sainte-BP 373-97455 Saint-Pierre CedexLa RéunionFrance

The use of bio-based materials in buildings has become more and more significant last *** most of the cases,their health properties and natural provenance have made them a great solution to face global climate warming and the new policies to reduce building energy *** many thermal problems,biobased materials can allow to optimize the building thermal behavior according to its energy consumption and inside comfort *** it is when they are used as an insulation material in the ***,it is not the case in this *** fact,the bio-based matter is rather used as a desiccant wheel to control air conditioning inside the *** aim of this paper is to numerically verify if it is possible to use a bed of wood chips as a hygroscopic material(or a desiccant matter)in order to modify the relative humidity inside the building in Reunion Island and so improve thermal comfort.A simple model of heat and mass transfer between a bed of wood chips and building inside air has been set up and implemented into a validated building simulation code named *** simulations were set up for the four climate zones of the island regulations and a focus has been made on the low altitude one(with high,solar irradiation,temperature and relative humidity).Simulation results give the thermal behavior of the building particularly the temperature and relative humidity of inside air temperature,and temperature and moisture content of wood *** obtained results lead to determine if the wood chips bed is suitable for the reference building and to verify its technical feasibility(wood species,size of the bed,integration to the building,etc.).The results show that the use of a WCB help to decrease the building inside air temperature and water content up to 10°C less and 11.6 ***-1 *** are the ways to improve inside comfort ***,comfort analysis have shown the possibility to significantly increase building users’thermal comfort

关键词： Wood chips bed building inside comfort bio-based material desiccant relative humidity temperature building thermal modelling

Pure Hydrocarbons:An Efficient Molecular Design Strategy for the Next Generation of Host Materials for Phosphorescent Organic Light-Emitting Diodes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Accounts of Materials Research 2022年第3期3卷 379-390页

作者： cyril Poriel joëlle Rault-Berthelot 不详 UniversitéRennes CNRSISCR-6226F-35000 RennesFrance

CONSPECTUS:Fantastic progresses have been made since the discovery of phosphorescent organic light-emitting diodes(PhOLEDs)in 1998(Nature 1998,395,151).In the emissive layer of a PhOLED,a heavy-metal complex(emitter)is dispersed as a guest in an organic semiconductor(host)in order to harvest both singlet and triplet *** host/guest technique is essential to reach highperformance ***,designing high-efficiency host materials for red,green,and blue phosphors has been the main driving force of the ***,the most efficient PhOLEDs report very high external quantum efficiency(EQE)above 27%for the three *** molecular design of these high-efficiency host materials is based on small functional units,which have a crucial role in the device *** functional units are constructed on the assembly of electron-rich and/or electron-poor molecular fragments(such as carbazole,phenylamine,phosphine oxide,oxadiazole,pyridine,sulfone,etc.),which allows to finely tune the molecular orbitals energy levels(HOMO and LUMO)and the mobility of the charge carriers(hole and electrons).However,these molecular fragments incorporate heteroatoms,which in turn increase the molecular design complexity and production cost of the target materials and also create potential instability in the ***,the fragile C−N,C−P,and C−S bonds of such heteroatom-based hosts are involved,in part,in the OLED *** the instability of OLEDs is one of the most important problem to address at the current stage of development,developing new generations of host materials,without heteroatoms,has appeared as an important challenge in the *** recent years,this new generation of host materials,called Pure HydroCarbons(PHC),only incorporating carbon and hydrogen atoms,has drawn the attention of the scientific *** host materials only contain benzene rings,one of the most robust and inert building unit,which are assemble with suitable linkages to a

关键词： Strategy Host Molecular

Mechanocatalysis of CO to CO_(2)on TiO_(2)surface controlled at atomic scale

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第7期17卷 5826-5834页

作者： Yuuki Adachi Robert Turanský ján Brndiar Kamil Tokár Qiang Zhu Huan Fei Wen Yasuhiro Sugawara IvanŠtich Yan jun Li Department of Applied Physics Osaka University2-1 YamadaokaSuitaOsaka 565-0871Japan Institute of Physics Slovak Academy of SciencesBratislava 84511Slovakia Institute of Informatics Slovak Academy of SciencesBratislava 84507Slovakia Faculty of Natural Sciences University of Ss.Cyril and MethodiusTrnava 91701Slovakia Key Laboratory of Instrumentation Science and Dynamic Measurement School of Instrument and ElectronicsNorth University of ChinaTaiyuan 030051China

The common ways to activate a chemical reaction are by heat,electric current,or ***,mechanochemistry,where the chemical reaction is activated by applied mechanical force,is less common and only poorly understood at the atomic *** we report a tip-induced activation of chemical reaction of carbon monoxide to dioxide on oxidized rutile TiO_(2)(110)*** activation is studied by atomic force microscopy,Kelvin probe force microscopy under ultrahigh-vacuum and liquid nitrogen temperature conditions,and density functional theory(DFT)*** reaction is inferred from hysteretic behavior of frequency shift signal further supported by vector force mapping of vertical and lateral forces needed to trigger the chemical reaction with torque motion of carbon monoxide towards an oxygen *** reaction is found to proceed stochastically at very small tip-sample ***,the local contact potential difference reveals the atomic-scale charge redistribution in the reactants required to unlock the *** results open up new insights into the mechanochemistry on metal oxide surfaces at the atomic scale.

关键词： atomic resolution mechanochemistry atomic force microscopy Kelvin probe force microscopy density functional theory(DFT)simulation CO oxidation catalysis rutile TiO_(2)surface

Animal models of Parkinson’s disease:bridging the gap between disease hallmarks and research questions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2023年第1期12卷 391-415页

作者： Axelle Dovonou cyril Bolduc Victoria Soto Linan Charles Gora Modesto RPeraltaⅢ Martin Lévesque CERVO Brain Research Centre 2601Chemin de la CanardièreQuébecQC G1J 2G3Canada Department of Psychiatry and Neurosciences Faculty of MedicineUniversitéLavalQuébecQCCanada

Parkinson’s disease(PD)is a progressive neurodegenerative disorder characterized by motor and non-motor *** than 200 years after its first clinical description,PD remains a serious affliction that affects a growing proportion of the *** treatments only alleviate symptoms;there is still neither a cure that targets the neurodegenerative processes nor therapies that modify the course of the *** the past decades,several animal models have been developed to study *** no model precisely recapitulates the pathology,they still provide valuable information that contributes to our understanding of the disease and the limitations of our treatment *** review comprehensively summarizes the different animal models available for Parkinson’s research,with a focus on those induced by drugs,neurotoxins,pesticides,genetic alterations,α-synuclein inoculation,and viral vector *** highlight their characteristics and ability to reproduce PD-like *** is essential to realize that the strengths and weaknesses of each model and the induction technique at our disposal are determined by the research question being *** review,therefore,seeks to better aid researchers by ensuring a concrete discernment of classical and novel animal models in PD research.

关键词： Parkinson’s disease Animal model Alpha-synuclein Transgenic model Preformed fibril Mouse