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Epidemiology of carbapenem-resistant Acinetobacter baumannii colonization in neonatal intensive care units:A systematic review and meta-analysis

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World Journal of Meta-Analysis 2024年第1期12卷 1-10页

作者： Donatien Serge Mbaga Sebastien Kenmoe Seraphine Nkie Esemu Arnol Bowo-Ngandji Nene Kaah Keneh Jane-Francis Tatah Kihla Akoachere Hortense Kamga Gonsu Roland ndip ndip Jean Thierry Ebogo-Belobo cyprien kengne-ndé Nicholas Tendongfor Jean Paul Assam Assam Lucy Mande ndip Jacky Njiki Bikoï Sara Honorine Riwom Essama Department of Microbiology The University of Yaounde IYaounde 00237Cameroon Department of Microbiology and Parasitology University of BueaBuea 00237Cameroon Faculty of Medicine and Biomedical Sciences The University of Yaounde IYaounde 00237Cameroon Center for Research in Health and Priority Pathologies Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Epidemiological Surveillance Evaluation and Research UnitNational AIDS Control CommitteeDouala 00237Cameroon

BACKGROUnd The rising prevalence of carbapenem-resistant Acinetobacter baumannii(CRAB)in neonatal intensive care units(NICUs)represents an escalating challenge in healthcare settings,particularly in managing hospital-acquired infections(HAIs).Studies across various World Health Organization regions have documented a significant incidence of CRAB-related HAIs,with rates as high as 41.7 cases per 1000 patients in ICUs,accounting for 13.6%of all *** infections pose a doubled mortality risk compared to infections with carbapenem-susceptible Acinetobacter baumannii.A particularly concerning aspect of CRAB colonization is its asymptomatic nature,enabling its transmission through healthcare workers(HCWs)or the NICU environment to vulnerable neonates with developing immune *** To explore the prevalence of CRAB colonization in NICUs,focusing on neonates,healthcare workers,and the environmental samples,to enhance epidemiological understanding and inform targeted *** We conducted according to PRISMA 2020 checklist guidelines,a comprehensive literature search across multiple databases including MEDLINE(Ovid),EMBASE(Ovid),Global Health(Ovid),Web of Science,and Global Index *** were selected based on predetermined criteria,primarily involving neonates,HCWs,and environmental swabs,using culture or molecular methods to detect CRAB *** excluded studies that did not specifically focus on NICUs,were duplicates,or lacked necessary *** study selection and quality assessment were conducted independently by two *** extraction involved collecting comprehensive details about each *** statistical analysis used a random-effects model to calculate the pooled prevalence and confidence intervals,stratifying results by regional *** assessed study heterogeneity using Cochran's Q statistic and I²statistic,with regression tests employed to evaluate potential publication *** We analyzed 737 records from f

关键词： Colonization Carbapenem-resistant Acinetobacter baumannii Neonatal intensive-care unit

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Association between early viral lower respiratory tract infections and subsequent asthma development

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World Journal of Critical Care Medicine 2022年第4期11卷 298-310页

作者： Sebastien Kenmoe Etienne Atenguena Okobalemba Guy Roussel Takuissu Jean Thierry Ebogo-Belobo Martin Gael Oyono Jeannette Nina Magoudjou-Pekam Ginette Irma Kame-Ngasse Jean Bosco Taya-Fokou Chris Andre Mbongue Mikangue Raoul Kenfack-Momo Donatien Serge Mbaga Arnol Bowo-Ngandji cyprien kengne-ndé Seraphine Nkie Esemu Richard Njouom Lucy ndip Department of Microbiology and Parasitology University of BueaBuea 00237Cameroon Department of Virology Centre Pasteur of CameroonYaounde 00237Cameroon Faculty of Medicine and Biomedical Science The University of Yaounde IYaounde 00237Cameroon Centre of Research in Food Food Security and NutritionInstitute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Medical Research Centre Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Laboratory of Parasitology and Ecology The University of Yaounde IYaounde 00237Cameroon Department of Biochemistry The University of Yaounde IYaounde 00237Cameroon Department of Microbiology The University of Yaounde IYaounde 00237Cameroon Epidemiological Surveillance Evaluation and Research UnitNational Aids Control CommitteeDouala 00237Cameroon

BACKGROUnd The association between hospitalization for human respiratory syncytial virus(HRSV)bronchiolitis in early childhood and subsequent asthma is well *** long-term prognosis for non-bronchiolitis lower respiratory tract infections(LRTI)caused by viruses different from HRSV and rhinovirus,on the other hand,has received less *** To investigate the relationship between infant LRTI and later asthma and examine the influence of confounding *** The PubMed and Global Index Medicus bibliographic databases were used to search for articles published up to October 2021 for this systematic *** included cohort studies comparing the incidence of asthma between patients with and without LRTI at≤2 years regardless of the virus *** meta-analysis was performed using the random effects *** of heterogeneity were assessed by stratified *** This review included 15 articles(18 unique studies)that met the inclusion *** at≤2 years were associated with an increased risk of subsequent asthma up to 20 years[odds ratio(OR)=5.0,95%CI:3.3-7.5],with doctor-diagnosed asthma(OR=5.3,95%CI:3.3-8.6),current asthma(OR=5.4,95%CI:2.7-10.6),and current medication for asthma(OR=1.2,95%CI:0.7-3.9).Our overall estimates were not affected by publication bias(P=0.671),but there was significant heterogeneity[I 2=58.8%(30.6-75.5)].Compared to studies with hospitalized controls without LRTI,those with ambulatory controls had a significantly higher strength of association between LRTIs and subsequent *** strength of the association between LRTIs and later asthma varied significantly by country and age at the time of the *** sensitivity analyses including only studies with similar proportions of confounding factors(gender,age at LRTI development,age at interview,gestational age,birth weight,weight,height,smoking exposure,crowding,family history of atopy,and family history of asthma)between cases and controls

关键词： Asthma Lower respiratory tract infections Respiratory viruses Long term sequelae Children

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Systematic review and meta-analysis of seroprevalence of human immunodeficiency virus serological markers among pregnant women in Africa, 1984-2020

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World Journal of Critical Care Medicine 2023年第5期12卷 264-285页

作者： Jean Thierry Ebogo-Belobo Sebastien Kenmoe Chris Andre Mbongue Mikangue Serges Tchatchouang Lontuo-Fogang Robertine Guy Roussel Takuissu Juliette Laure ndzie Ondigui Arnol Bowo-Ngandji Raoul Kenfack-Momo cyprien kengne-ndé Donatien Serge Mbaga Elisabeth Zeuko'o Menkem Ginette Irma Kame-Ngasse Jeannette Nina Magoudjou-Pekam Josiane Kenfack-Zanguim Seraphine Nkie Esemu Paul Alain Tagnouokam-Ngoupo Lucy ndip Richard Njouom Center for Research in Health and Priority Pathologies Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Department of Microbiology and Parasitology University of BueaBuea 00237Cameroon Department of Microbiology The University of Yaounde IYaounde 00237Cameroon Scientific Direction Centre Pasteur du CamerounYaounde 00237Cameroon Department of Animal Biology University of DschangDschang 00237Cameroon Centre for Food Food Security and Nutrition ResearchInstitute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Department of Biochemistry The University of Yaounde IYaounde 00237Cameroon Epidemiological Surveillance Evaluation and Research UnitNational AIDS Control CommitteeDouala 00237Cameroon Department of Biomedical Sciences University of BueaBuea 00237Cameroon Department of Virology Centre Pasteur du CamerounYaounde 00237Cameroon

BACKGROUnd Human immunodeficiency virus(HIV)is a major public health concern,particularly in Africa where HIV rates remain *** women are at an increased risk of acquiring HIV,which has a significant impact on both maternal and child *** To review summarizes HIV seroprevalence among pregnant women in *** also identifies regional and clinical characteristics that contribute to study-specific estimates *** The study included pregnant women from any African country or region,irrespective of their symptoms,and any study design conducted in any *** electronic literature searches,articles published until February 2023 were *** quality of the included studies was *** DerSimonian and Laird random-effects model was applied to determine HIV pooled seroprevalence among pregnant women in *** and sensitivity analyses were conducted to identify potential sources of *** was assessed with Cochran's Q test and I2 statistics,and publication bias was assessed with Egger's *** A total of 248 studies conducted between 1984 and 2020 were included in the quantitative synthesis(meta-analysis).Out of the total studies,146(58.9%)had a low risk of bias and 102(41.1%)had a moderate risk of *** HIV-positive pregnant women died in the included *** overall HIV seroprevalence in pregnant women was estimated to be 9.3%[95%confidence interval(CI):8.3-10.3].The subgroup analysis showed statistically significant heterogeneity across subgroups(Pnd the lowest seroprevalence observed in Northern Africa(0.7%,95%CI:0.3-1.3).CONCLUSION The review found that HIV seroprevalence among pregnant women in African countries remains significant,particularly in Southern African *** review can inform the development of targeted public health interventions to address high HIV seroprevalence

关键词： Human immunodeficiency virus Pregnant women Africa Prevalence Review Meta-analysis

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Global prevalence of occult hepatitis C virus: A systematic review and meta-analysis

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World Journal of Methodology 2022年第3期12卷 179-190页

作者： Donatien Serge Mbaga Sebastien Kenmoe Jacky Njiki Bikoï Guy Roussel Takuissu Marie Amougou-Atsama Etienne Atenguena Okobalemba Jean Thierry Ebogo-Belobo Arnol Bowo-Ngandji Martin Gael Oyono Jeannette Nina Magoudjou-Pekam Ginette Irma Kame-Ngasse Alex Durand Nka Alfloditte Flore Feudjio Cromwel Zemnou-Tepap Elie Adamou Velhima Juliette Laure ndzie Ondigui Rachel Audrey Nayang-Mundo Sabine Aimee Touangnou-Chamda Yrene Kamtchueng Takeu Jean Bosco Taya-Fokou Chris Andre Mbongue Mikangue Raoul Kenfack-Momo cyprien kengne-ndé Carole Stephanie Sake Seraphine Nkie Esemu Richard Njouom Lucy ndip Sara Honorine Riwom Essama Department of Microbiology The University of Yaounde IYaounde 00237Cameroon Department of Microbiology and Parasitology University of BueaBuea 00237Cameroon Department of Virology Centre Pasteur of CameroonYaounde 00237Cameroon Centre of Research in Food Food Security and NutritionInstitute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Centre de Recherche sur les Maladies Emergentes et Re-Emergentes Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Faculty of Medicine and Biomedical Science The University of Yaounde IYaounde 00237Cameroon Medical Research Centre Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Laboratory of Parasitology and Ecology The University of Yaounde IYaounde 00237Cameroon Department of Biochemistry The University of Yaounde IYaounde 00237Cameroon Virology Laboratory Chantal Biya International Reference Center for Research on HIV/AIDS Prevention and ManagementYaounde 00237Cameroon

BACKGROUnd Occult hepatitis C infection(OCI)is characterized by the presence of hepatitis C virus(HCV)RNA in the liver,peripheral blood mononuclear cells(PBMC)and/or ultracentrifuged serum in the absence of detectable HCV-RNA in *** has been described in several categories of populations including hemodialysis patients,patients with a sustained virological response,immunocompromised individuals,patients with abnormal hepatic function,and apparently healthy *** To highlight the global prevalence of *** We performed a systematic and comprehensive literature search in the following 4 electronic databases PubMed,EMBASE,Global Index Medicus,and Web of Science up to 6th May 2021 to retrieve relevant studies published in the *** studies were unrestricted population categories with known RNA status in serum,PBMC,liver tissue and/or ultracentrifuged *** were extracted independently by each author and the Hoy et al tool was used to assess the quality of the included *** used the random-effect meta-analysis model to estimate the proportions of OCI and their 95%confidence intervals(95%CI).The Cochran's Q-test and the I2 test statistics were used to assess heterogeneity between *** plot and Egger test were used to examine publication bias.R software version 4.1.0 was used for all *** The electronic search resulted in 3950 *** obtained 102 prevalence data from 85 included *** pooled prevalence of seronegative OCI was estimated to be 9.61%(95%CI:6.84-12.73)with substantial heterogeneity[I^(2)=94.7%(95%CI:93.8%-95.4%),Pnd in Southern Europe and Northern Africa,and in patients with abnormal liver function,hematological disorders,and kidney *** seropositive OCI prevalence was found in Southern Europe,Northern

关键词： Occult hepatitis C virus infection Prevalence Worldwide Peripheral blood mononuclear cells Hepatitis C virus

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Contribution of SAR Radar Imagery in the Detection of Suspicious Vessels in the Ivorian EEZ

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World Journal of Engineering and Technology 2024年第1期12卷 200-212页

作者： Koffi cyprien Yoboue Jean-Baptiste Kassi Eric Valère Djagoua Tiemelé Jacque-André Laboratory of Remote Sensing and GIS University Center for Research and Application in Remote Sensing (CURAT) Félix Houphouet-Boigny University of Abidjan Cocody Ivory Coast

The present work proposed a method for match SAR and AIS data to detect vessels carrying out suspicious activity in the Ivorian EEZ. Two superposition methods, detected AIS and SAR data, based on point-to-point association on the one hand and point-to-line on the other hand, were used to detect suspicious vessels in Ivorian marine waters. The results showed that most vessels detected in the Ivorian EEZ do not declare their positions to avoid being spotted. These funds are likely to practice illegal, undeclared and unregulated fishing (INN fishing). This clandestine activity is very recurrent in Ivorian waters. This is illustrated by the number of suspicious vessels detected by SAR radar imagery which is greater compared to declared or authorized vessels.

关键词： INN Fishing CFAR Algorithm AIS Sentinel-1A Ivory Coast

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Blood pressure-related white matter microstructural disintegrity and associated cognitive function impairment in asymptomatic adults

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Stroke & Vascular Neurology 2023年第5期8卷 358-367页

作者： Julián N Acosta Stefan P Haider cyprien Rivier Audrey C Leasure Kevin N Sheth Guido J Falcone Seyedmehdi Payabvash Department of Neurology Yale School of MedicineNew HavenConnecticutUSA Department of Radiology and Biomedical Imaging Yale School of MedicineNew HavenConnecticutUSA Department of Otorhinolaryngology Ludwig Maximilians University MunichMunchenGermany

Background and objectives We aimed to investigate the white matter(WM)microstructural/cytostructural disintegrity patterns related to higher systolic blood pressure(SBP),and whether they mediate SBP effects on cognitive performance in middle-aged *** Using the UK Biobank study of community-dwelling volunteers aged 40-69 years,we included participants without a history of stroke,dementia,demyelinating disease or traumatic brain *** investigated the association of SBP with MRI diffusion metrics:fractional anisotropy(FA),mean diffusivity(MD),intracellular volume fraction(a measure of neurite density),isotropic(free)water volume fraction(ISOVF)and orientation dispersion across WM ***,we determined whether WM diffusion metrics mediated the effects of SBP on cognitive *** We analysed 31363 participants-mean age of 63.8 years(SD:7.7),and 16523(53%)*** SBP was associated with lower FA and neurite density,but higher MD and *** different WM tracts,diffusion metrics of the internal capsule anterior limb,external capsule,superior and posterior corona radiata were most affected by higher *** seven cognitive metrics,SBP levels were only associated with‘fluid intelligence’(adjusted pnd superior cerebellar peduncle mediated 13%,9%and 13%of SBP effects on fluid intelligence,while the averaged MD of external capsule,internal capsule anterior and posterior limbs,and superior corona radiata mediated 5%,7%,7%and 6%of SBP effects on fluid intelligence,*** Among asymptomatic adults,higher SBP is associated with pervasive WM microstructure disintegrity,partially due to reduced neuronal count,which appears to mediate SBP adverse effects on fluid *** metrics of select WM tracts,which are most reflective of SBP-related parenchymal damage and cognitive impairment,may serve as imaging biomarkers to

关键词： capsule Blood impairment

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Planting position and shade enhance native seedling performance in forest restoration for an endangered malagasy plant

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Plant Diversity 2019年第2期41卷 118-123页

作者： cyprien Miandrimanana J.Leighton Reid Tahiry Rivoharison Chris Birkinshaw Missouri Botanical Garden Madagascar Research and Conservation Program Center for Conservation and Sustainable Development Missouri Botanical Garden

The critically endangered tree Schizolaena tampoketsana is confined to a few diminished and degraded forest fragments on the Malagasy highlands. This habitat is vulnerable to loss due to frequent fires in the surrounding grassland that threaten to spread into the forest. One of these fragments is the focus a conservation project and here the managers aim to conserve S. tampoketsana by restoring its forest habitat to its former extent as evidenced by remnant woody plants. To inform this activity the survival and early-stage growth of seedlings of four locally native tree species were compared under contrasting conditions of proximity to the remaining forest and shade. After 12 months, seedlings of three species(Baronia taratana, Eugenia pluricymosa, Uapaca densifolia) survived better and experienced improved growth in height in grassland close to the existing forest rather than distant from it, and two survived better with shade rather than unshaded. A number of mechanisms could explain these results including reduced exposure to desiccating sunlight and winds and better soil and greater water availability close to the forest. The seedlings of one species(Nuxia capitata) survived well under all conditions. This study suggests that reforestation in these dry highlands is most feasible adjacent to remnant forest fragments and in microhabitats that minimize water loss, though young plants of some tree species may be capable of surviving in harsher conditions.

关键词： Grassland Fire Forest restoration Local environment Schizolaena tampoketsana

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Olecranon Fractures in Children: About 21 Cases Treated at the Owendo University Hospital Center at Libreville (Gabon)

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Open Journal of Orthopedics 2022年第3期12卷 113-121页

作者： cyprien Mba Mba Natacha Boumas Christelle Mezene Mendome Scarlette Mengue Mba Meyo Magdalie Nancy Mamfoumbi Arthur Matsanga Francois Ondo N’dong Centre Hospitalier Universitaire d’Owendo Orthopedic and Trauma Surgery Department Libreville Gabon Pediatric Surgery Department of Centre Hospitalier Universitaire Mère Enfant Fondation Jeanne Ebori Libreville Gabon Centre Hospitalier Universitaire d’Owendo Anesthesia and Resuscitation Department Libreville Gabon Department of Surgery University of Health Sciences Libreville Gabon

Background: The olecranon fractures in children are relatively rare articular fractures. The aim of this work is to study the epidemiological, clinical and therapeutic particularities of this fracture in children at Owendo University Teaching Hospital. Patients and Methods: This was a retrospective analytical, monocentric study over 2 years from January 1, 2018 to January 1, 2020 at the Owendo University Hospital in Libreville and relating to the medical files of patients treated for a fracture of the olecranon in children in the service and regularly followed in outpatient consultation. Results: We collected 21 patients with an average age of 8.7 years. Falls dominated the etiologies. The Bracq classification was the one used in our series with the predominance of type D. The treatment was orthopedic in 33.3% of cases and surgical in 66.7% of cases. With an average follow-up of 12 months, the results were good in 71.5%, average in 19.0% and poor in 9.5%. Conclusion: The analysis of our results compared to those of the authors of the literature according to the precise parameters seems satisfactory.

关键词： Fracture Olecranon Child Prognosis Libreville

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Prognostication algorithm for non-cirrhotic non-B non-C hepatocellular carcinoma-a multicenter study under the aegis of the French Association of Hepato-Biliary Surgery and liver Transplantation

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 192-204,I0002-I0004页

作者： Charlotte Maulat Stéphanie Truant Christian Hobeika Louise Barbier Astrid Herrero Alexandre Doussot Johan Gagnière Édouard Girard Hadrien Tranchart Jean-Marc Regimbeau David Fuks François Cauchy Mathieu Prodeau Antoine Notte cyprien Toubert Ephrem Salamé Mehdi El Amrani Sandrine Andrieu Fabrice Muscari Jason Shourick Bertrand Suc Department of Digestive Surgery Hepatobiliary and Pancreatic Surgery and Liver Transplantation UnitToulouse University HospitalToulouseFrance Department of Digestive Surgery and Transplantation Claude-HuriezHospitalCHRU LilleLilleFrance CANTHER laboratory“Cancer Heterogeneity Plasticity and Resistance to Therapies”Inserm UMR-S1277 Teams“MucinsCancer and Drug Resistance”LilleFrance Department of Hepato-bilio-pancreatic Surgery and Liver Transplantation Beaujon HospitalAPHPClichyFrance Department of Digestive Surgery and Liver Transplantation Trousseau HospitalTours University HospitalToursFrance Department of Digestive Surgery and Liver Transplantation Saint Eloi HospitalMontpellier University HospitalMontpellierFrance Department of Digestive Surgery and Liver Transplantation Besançon University HospitalBesançonFrance Department of Digestive and Hepatobiliary Surgery University Hospital of Clermont-FerrandClermont-FerrandFrance U1071 Inserm/UniversitéClermont-Auvergne Clermont-FerrandFrance Department of Digestive Surgery and Emergency CHU Grenoble-AlpesGrenobleFrance Department of Mini-invasive Surgery Antoine Béclère HospitalAPHPClamartFrance Department of Digestive Surgery Amiens Picardie University Hospital and Picardie Jules Verne UniversityAmiensFrance Department of Digestive Surgery Institut Mutualiste MontsourisParisFrance Department of Epidemiology Toulouse University HospitalToulouseFrance

Background:Liver resection and local ablation are the only curative treatment for non-cirrhotic hepatocellular carcinoma(HCC).Few data exist concerning the prognosis of patients resected for non-cirrhotic *** objectives of this study were to determine the prognostic factors of recurrence-free survival(RFS)and overall survival(OS)and to develop a prognostication algorithm for non-cirrhotic ***:French multicenter retrospective study including HCC patients with non-cirrhotic liver without underlying viral hepatitis:F0,F1 or F2 ***:A total of 467 patients were included in 11 centers from 2010 to ***-cirrhotic liver had a fibrosis score of F0(n=237,50.7%),F1(n=127,27.2%)or F2(n=103,22.1%).OS and RFS at 5 years were 59.2%and 34.5%,*** multivariate analysis,microvascular invasion and HCC differentiation were prognostic factors of OS and RFS and the number and size were prognostic factors of RFS(Pnd number(P10 cm(n=176,Group 2);>2 HCC regardless of size Conclusions:We developed a prognostication algorithm based on the number(≤or>2)and size(≤or>10 cm),which could be used as a treatment decision support concerning the need for perioperative *** case of bifocal HCC,surgery should not be a contraindication.

关键词： Hepatocellular carcinoma(HCC) non-cirrhotic liver prognostic factors recurrence-free survival(RFS) prognostication algorithm

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The Global Stability Analysis of a Mathematical Cellular Model of Hepatitis C Virus Infection with Non-Cytolytic Process

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Journal of Applied Mathematics and Physics 2019年第7期7卷 1531-1546页

作者： Alexis Nangue cyprien Fokoue Raoue Poumeni Department of Mathematics Higher Teachers’ Training College University of Maroua Maroua Cameroon Department of Mathematics and Computer Science Faculty of Science University of Maroua Maroua Cameroon

The aim of this work is to analyse the global dynamics of an extended mathematical model of Hepatitis C virus (HCV) infection in vivo with cellular proliferation, spontaneous cure and hepatocyte homeostasis. We firstly prove the existence of local and global solutions of the model and establish some properties of this solution as positivity and asymptotic behaviour. Secondly we show, by the construction of appropriate Lyapunov functions, that the uninfected equilibrium and the unique infected equilibrium of the mathematical model of HCV are globally asymptotically stable respectively when the threshold number and when .

关键词： HCV Model Global Solutions Non-Cytolytic Process Invariant Set Lyapunov Functions Basic Reproduction Number Equilibrium Points

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