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Assessing the Effectiveness of Strategies in US Birth Cohort Screening for Hepatitis C Infection

journal of Clinical and Translational Hepatology 2020年第1期8卷 25-41页

作者： cynthia j.tsay joseph K.Lim Department of Internal Medicine Yale University School of MedicineNew HavenCTUSA Yale Liver Center Section of Digestive DiseasesYale University School of MedicineNew HavenCTUSA

Chronic hepatitis C infection in the USA is a highly morbid condition and current guidelines recommend one-time screening among the birth cohort(1945-1965).Understand-ing strategies to optimize screening can help inform future hepatitis C virus(HCV)screening guidelines.A focused literature search was performed using PubMed and manual abstract review from major hepatology conferences over the past 2 *** search strategy involved using Medical Subject Headings terms for hepatitis C,screening,birth cohort,baby boomers,and *** review was limited to data from the USA.A total of 327 articles were identified and 36 abstracts were included,with studies published between *** including clinician education,electronic medical record alerts,reflex HCV RNA testing,point-of-care testing,multisite(outpatient,inpatient,emergency department,endoscopy suite)initiatives,direct patient solicitation,and utilization of non-physician providers have increased HCV screening ***,broad imple-mentation remains less than *** include lack of patient acceptance to screening and engagement in the HCV care *** Veterans Affairs Healthcare System has achieved higher birth cohort screening rates through an integrated approach requiring high-level engagement by leadership and institutional *** strategies for increasing birth cohort screening have been successful,but overall rates of HCV screening remain *** strat-egies can inform public health efforts to implement emerging national recommendations for expansion of HCV screening to all *** age 18 or older.

关键词： Hepatitis C Epidemiology HCV antibody Screening Birth cohort Baby boomers Care cascade Electronic medical records

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Clinical and socioeconomic determinants of survival in biliary tract adenocarcinomas

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World journal of Gastrointestinal Oncology 2024年第4期16卷 1374-1383页

作者： Laura Sahyoun Kay Chen cynthia tsay George Chen Petr Protiva Department of Gastroenterology and Hepatology Weill Cornell MedicineNew YorkNY 10065United States Gastroenterology Section Jennifer Moreno VA San Diego Healthcare SystemSan DiegoCA 92161United States Division of Gastroenterology Department of MedicineUniversity of California San DiegoLa JollaCA 92093United States Department of Gastroenterology and Hepatology John Hopkins HospitalBaltimoreMD 21287United States Department of Digestive Diseases Yale New Haven HospitalNew HavenCT 06520United States Department of Gastroenterology VA Connecticut Health Care SystemWest HavenCT 06516United States

BACKGROUND Despite advances in detection and treatments,biliary tract cancers continue to have poor survival ***,there is limited data investigating the significance of socioeconomic status,race/ethnicity,and environmental factors in biliary tract cancer *** from the Surveillance,Epidemiology,and End Results database for biliary and gallbladder adenocarcinomas were extracted from 1975 to ***-conomic data included smoking,poverty level,education,adjusted household income,and percentage of foreign-born persons and urban *** was calculated with Cox proportional hazards models for death in the 5-year period following *** Our study included 15883 gallbladder,11466 intrahepatic biliary,12869 extrahepatic biliary and 7268 ampulla of Vater adenocarcinoma *** analyzing county-specific demographics,patients from counties with higher incomes were associated with higher survival rates[hazard ratio(HR)=0.97,P<0.05].Similarly,counties with a higher percentage of patients with a college level education and counties with a higher urban population had higher 5-year survival rates(HR=0.96,P=0.002 and HR=0.97,P=0.004,respectively).CONCLUSION Worse survival outcomes were observed in lower income counties while higher income and education level were associated with higher 5-year overall survival among gallbladder and biliary malignancies.

关键词： Biliary tract cancers Survival Outcomes research Socioeconomic factors Healthcare disparities

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Rationale of a Cross Sectional Analytic Study on Determinants of Recurrent Preeclampsia at University Clinics of Kinshasa (Democratic Republic of Congo) and at Victor Dupouy Hospital Center (France)

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Open journal of Obstetrics and Gynecology 2024年第5期14卷 824-831页

作者： Mushengezi Amani Dieudonné Sengeyi Muela Andy Mbangama Mokambanda cynthia Awena Goy Sambwa Christian Kelele Nkongolo Freddy Muamba Banza jésual Lotoy Otem Christian Ndesanzim Department of Obstetrics and Gynecology University Clinics of Kinshasa Kinshasa Democratic Republic of Congo

Research Background: Pre-eclampsia is one of main causes of materno-foetal mortality and morbidity worldwide, with a prevalence of 3% - 7%. Although considered a primiparous condition, it can nevertheless recur. Several factors appear to be associated with risk of recurrence of pre-eclampsia, such as the term of delivery of previous pregnancy, severity of disease, the existence of co-morbidities and the inter-genital space. Purpose: The aim of our study will be to analyse and identify in a population of pregnant women with a history of preeclampsia risk factors associated with occurrence of recurrent preeclampsia at University clinics of Kinshasa (Democratic Republic of Congo) and at Victor Dupouy Hospital Center (France). Methods: In this study, pregnant women with an history of preeclampsia who will give birth between November 2018 and October 2024 at University Clinics of Kinshasa (UCK) and Victor Dupouy Hospital Center (VDHC) will be included. This will be a cross-sectional analytical study, data from previous and subsequent pregnancies will be studied. Expected Result: The prevalence of recurrent preeclampsia in the study population will be determined. And we will highlight the factors that will determine the recurrence of preeclampsia by analysing the risk factors. Conclusion: Knowledge of the factors associated with recurrent preeclampsia could be an excellent tool for predicting and preventing the disease.

关键词： Recurrent Pre-Eclampsia Risk Factor Determinants

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Hybridization despite elaborate courtship behavior and female choice in Neotropical tree frogs

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Integrative Zoology 2023年第2期18卷 208-224页

作者： Renato C.NALI Kelly R.ZAMUDIO cynthia P.A.PRADO Programa de Pós-Graduação em Ecologia Evolução e BiodiversidadeInstituto de BiociênciasUniversidade Estadual PaulistaRio ClaroSão PauloBrazil Department of Ecology and Evolutionary Biology Cornell UniversityIthacaNew YorkUSA Department of Integrative Biology University of TexasAustinTexasUSA Departamento de Morfologia e Fisiologia Animal Faculdade de Ciências Agrárias e VeterináriasUniversidade Estadual Paulista“Júlio de Mesquita Filho”JaboticabalSão PauloBrazil

The mechanisms of hybridization can be elucidated by analyzing genotypes as well as phenotypes that could act as premating barriers,as the reproductive interactions among heterospeciﬁcs can alter the evolutionary history of *** frogs,hybrids typically occur among species that reproduce explosively(in dense aggregations)with few opportunities for mate selection but are rare in species with elaborate courtship behaviors that may prevent erroneous *** 21 microsatellite markers,we examined hybridization in the prolonged-breeding tree frogs Bokermannohyla ibitiguara and *** sampled within a contact zone in the Brazilian savanna(72 tadpoles;74 adults).We also compared acoustic and morphological *** conﬁrmed both parental species genetically;STRUCTURE results conﬁrmed 14 hybrids,11 of which were second-generation according to NEWHYBRIDS,all with intermediate values of genetic dissimilarities compared to the *** and acoustic analyses revealed that hybrids showed variable but not necessarily intermediate ***,2 hybrids exhibited call types different from *** reproduction of *** involves territorial and aggressive males,elaborate courtships with acoustic and tactile stimuli,choosy females,and opportunistic *** study uncovers a rare case of viable hybridization among closely related frogs with such a combination of complex courtship behaviors and mate *** discuss the likely directionality and mechanisms behind this phenomenon,and highlight the importance of investigating hybridization even in species that show elaborate reproduction and female choice to advance our understanding of animal diversiﬁcation.

关键词： heterospeciﬁc mating hybrid zone Hylidae microsatellites prolonged-breeding

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Mass transport in a highly immiscible alloy on extended shear deformation

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journal of Materials Science & Technology 2023年第3期134卷 197-208页

作者： Miao Song jia Liu Xiaolong Ma Qin Pang Matthew j.Olszta joshua Silverstein Madhusudhan R.Pallaka Peter V.Sushko Suveen N.Mathaudhu cynthia Powell Arun Devaraj Bharat Gwalani Physical and Computational Sciences Directorate Pacific Northwest National Laboratory902 Battelle BoulevardRichlandWA 99354USA Energy and Environmental Directorate Pacific Northwest National Laboratory902 Battelle BoulevardRichlandWA 99354USA Material Science and Engineering Program University of CaliforniaRiversideCA92521USA Colorado School of Mines 1500 Illinois St.GoldenCO 8040USA Department of Materials Science and Engineering North Carolina State UniversityRaleighNC27695-7907USA State Key Laboratory of Powder Metallurgy Central South Uni-versityChangsha 410083China

Forced mixing to a single-phase or supersaturated solid solution(SSS)and its prerequisite microstructure evolution in immiscible systems has been a focus of research for fundamental science and practical *** the formation of SSS by shear deformation could enable a material design beyond conventional equilibrium microstructure in immiscible ***,a highly immiscible Cu-50 at.%Cr binary alloy(mixing enthalpy of∼20 kj mol^(−1))was employed to investigate the microstructure evolution and localized tendencies of SSS during severe shear *** results demonstrate the dislocation mediated microstructural refinement process in each phase of the binary alloy and the mechanisms associated with localized solute supersaturation as a function of shear *** grain refinement in the softer Cu phase occurs owing to the strain localization driving the preferential dynamic *** grain refinement of the Cr phase,however,is enabled by the progressive evolution of grain lamination,splitting,and fragmentation as a function of shear *** solute supersaturation is found to be strongly dependent on the local environments that affect the dislocation activity,including the level of microstructure refinement,the interfacial orientation relationship,the mechanical incompatibility,and the localized preferential phase *** initio simulations confirm that it is more favorable to oxidize Cr than Cu at incoherent Cu/Cr interfaces,limiting the mass transport on an incoherent *** results unveil the mechanism underpinning the non-equilibrium mass transport in immiscible systems upon severe deformation that can be applied to produce immiscible alloys with superior mechanical properties.

关键词： Tribology Immiscible alloys Nanostructures Shear deformation Forced mixing Atom probe

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Effects of temperature and hydric environment on survival of the Panamanian Golden Frog infected with a pathogenic chytrid fungus

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Integrative Zoology 2010年第2期5卷 143-153页

作者： Heidi M.BUSTAMANTE Lauren j.LIVO cynthia CAREY Department of Integrative Physiology University of ColoradoBoulderColoradoUSA

Considerable controversy exists concerning whether or not climate changes(particularly global warming)are causing outbreaks of a lethal amphibian pathogen,the chytrid fungus Batrachochytrium dendrobatidis(Longcore,Pessier&*** 1999).In the present study,groups of Panamanian golden frogs(Atelopus zeteki Dunn,1993),a critically endangered amphibian thought to be nearly extinct in Panama,were exposed to varying dosages of zoospores of Batrachochytrium dendrobatidis,temperatures and hydric environments in order to learn whether this species is susceptible to this pathogen and,if so,how environmental factors affect *** pathogen proved to be highly lethal for *** exposed to a dosage of 100 Bd zoospores survived significantly(P<0.0001)longer than those that had been exposed to 104 or 106 *** frogs housed at 23℃survived significantly(P<0.0001)longer than those that were housed at 17℃.Exposed frogs held in dry conditions survived significantly longer than those in wet conditions(P<0.0001).As a laboratory study,these results do not directly test hypotheses about the relation between climate change and the decline of these frogs in the field,but they inform the discussion about how environmental conditions can have an impact on the interaction between a susceptible amphibian and this *** data do not support the contention that rising global temperatures are necessary to cause the death of amphibians infected with this pathogen because the pathogen was equally lethal at 17 as at 23℃,and frogs at the warmer temperature lived significantly longer than those at the cooler one.

关键词： amphibian declines Atelopus zeteki Batrachochytrium dendrobatidis chytridiomycosis climatelinked-epidemic hypothesis

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NETosis,complement,and coagulation:a triangular relationship

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Cellular & Molecular Immunology 2019年第1期16卷 19-27页

作者： cynthia M.de Bont Wilbert C.Boelens Ger j.M.Pruijn Department of Biomolecular Chemistry Institute for Molecules and Materials(IMM)Radboud UniversityNijmegenThe Netherlands

NETosis is a regulated form of neutrophil cell death that contributes to the host defense against pathogens and was linked to various diseases soon after its first description in *** NETosis,neutrophils release neutrophil extracellular traps(NETs),which can capture and kill bacteria and other pathogens to prevent them from *** substantial progress has been made in our understanding of NETosis,the precise mechanism underlying NETosis is still a matter of *** continues to elucidate the molecular pathways involved in *** recent years,interactions with the complement and coagulation systems have become increasingly *** complement proteins can stimulate NET formation,and NETs,in turn,can serve as a platform for complement *** addition,NETs can act as a scaffold for thrombus formation during *** crosstalk between the coagulation and complement systems has been previously described,NETosis appears to be a third important player in this consortium to protect the host against *** review summarizes our current knowledge on the mutual interactions between NETosis,the complement system and the coagulation system,with an emerging description of their complex triangular relationship.

关键词： coagulation complement NETosis neutrophils thrombosis

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Uranium Series Disequilibrium and Precision Measurement of Radionuclides Activity in Sediment Sample Using Low Background Gamma Spectrometry

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journal of Geoscience and Environment Protection 2023年第10期11卷 119-140页

作者： Abdul j. Khan Umme-Farzana Syed Amy L. Roselan cynthia A. Costello Laboratory of Inorganic and Nuclear Chemistry Division of Environmental Health Sciences Wadsworth Center New York State Department of Health Empire State Plaza Albany NY USA Bureau of Environmental Radiation Protection New York State Department of Health Empire State Plaza Albany NY USA

Low background gamma spectrometry was used to measure the radionuclides activity of 238U, 232Th, and 235U series as well as 40K and 137Cs in a sediment sample. The goal of the study was to measure the 238U (63.3 keV peak of 234Th;1001 keV peak of 234mPa) and 235U (143.76 keV, 163.33 keV, and 205.31 keV peaks) activity by low background gamma spectrometry in sediment sample. 235U activity in environmental samples is difficult to accurately measure by gamma spectrometry due to its low abundance in nature and low gamma line intensities at 143.76 keV, 163.33 keV, and 205.31 keV. We have shown that by using low background gamma spectrometry, it is possible to accurately measure the 235U activity in sediment samples. The 235U activity was measured without using the major peak of 185.7 keV (Iγ = 57.2%) which requires interference correction from 186.21 keV of 226Ra. 226Ra activity was determined by measuring 222Rn daughters (214Pb and 214Bi). The precision and accuracy of the gamma activity measurement in the sediment sample were verified by using the HPGe detectors with Certified Reference Material (CRM) Irish Sea Sediment (IAEA-385). The results obtained for the 63.33 keV energy line of 234Th are compared with the 1001 keV energy line of 234mPa. The values of 238U and 235U activities, as well as 40K, 137Cs, and 226Ra, agreed with the certificate values of CRM. The results show that the 238U is in equilibrium with its daughters (234Th, 234mPa, and 210Pb). 232Th is also in equilibrium with its daughters (228Ra, 212Pb, 212Bi and 208Tl). 235U/238U activity ratio of 0.046 ± 0.007 in the

关键词： Low Background Gamma Spectrometry HPGe Detector Sediment 238U 235U Secular Equilibrium

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Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-α-induced inflammatory activation of synovial fibroblasts

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Cellular & Molecular Immunology 2022年第10期19卷 1185-1195页

作者： Ruby j.Siegel Anil K.Singh Paul M.Panipinto Farheen S.Shaikh judy Vinh Sang U.Han H.Mark Kenney Edward M.Schwarz cynthia S.Crowson Sadik A.Khuder Basil S.Khuder David A.Fox Salahuddin Ahmed Department of Pharmaceutical Sciences Washington State University College of Pharmacy and Pharmaceutical SciencesSpokaneWAUSA Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA Center for Musculoskeletal Research University of Rochester Medical CenterRochesterNYUSA Department of Quantitative Health Sciences and Division of Rheumatology Mayo ClinicRochesterMNUSA Department of Medicine and Public Health University of ToledoToledoOHUSA Department of Pathology and Laboratory Medicine Phoenix Children’s HospitalPhoenixAZUSA Department of Medicine Division of Rheumatology and Clinical Autoimmunity Center of ExcellenceUniversity of Michigan Medical SystemAnn ArborMIUSA Division of Rheumatology University of Washington School of MedicineSeattleWAUSA

Extracellular sulfatase-2(Sulf-2)influences receptor-ligand binding and subsequent signaling by chemokines and growth factors,yet Sulf-2 remains unexplored in inflammatory cytokine signaling in the context of rheumatoid arthritis(RA).In the present study,we characterized Sulf-2 expression in RA and investigated its potential role in TNF-α-induced synovial inflammation using primary human RA synovial fibroblasts(RASFs).Sulf-2 expression was significantly higher in serum and synovial tissues from patients with RA and in synovium and serum from hTNFtg *** sequencing analysis of TNF-α-stimulated RASFs showed that Sulf-2 siRNA modulated~2500 genes compared to scrambled *** Pathway Analysis of RNA sequencing data identified Sulf-2 as a primary target in fibroblasts and macrophages in *** blot,ELISA,and qRT‒PCR analyses confirmed that Sulf-2 knockdown reduced the TNF-α-induced expression of ICAM1,VCAM1,CAD11,PDPN,CCL5,CX3CL1,CXCL10,and *** studies identified the protein kinase C-delta(PKCδ)and c-jun N-terminal kinase(jNK)pathways as key in the TNF-α-mediated induction of proteins related to cellular adhesion and *** of Sulf-2 abrogated TNF-α-induced RASF ***-2 knockdown with siRNA and inhibition by OKN-007 suppressed the TNF-α-induced phosphorylation of PKCδand jNK,thereby suppressing the nuclear translocation and DNA binding activity of the transcription factors AP-1 and NF-κBp65 in human ***,Sulf-2 expression positively correlated with the expression of TNF receptor 1,and coimmunoprecipitation assays demonstrated the binding of these two proteins,suggesting they exhibit crosstalk in TNF-α*** study identified a novel role of Sulf-2 in TNF-αsignaling and the activation of RA synoviocytes,providing the rationale for evaluating the therapeutic targeting of Sulf-2 in preclinical models of RA.

关键词： Sulfatase-2 TNF-α Rheumatoid arthritis Synovial fibroblasts Signal transduction

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Role of stem cell therapies in treating chronic wounds:A systematic review

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World journal of Stem Cells 2020年第7期12卷 659-675页

作者： Anjali C Raghuram Roy P Yu Andrea Y Lo cynthia j Sung Melissa Bircan Holly j Thompson Alex K Wong Division of Plastic and Reconstructive Surgery Keck School of Medicine of USCLos AngelesCA 90033United States Wilson Dental Library Herman Ostrow School of Dentistry of USCLos AngelesCA 90089United States

BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial *** modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound ***,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine *** To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing *** PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year *** lists from the articles were reviewed to identify additional pertinent *** manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy *** were extracted from the articles using a standardized collection *** A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this *** stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiolo

关键词： Mesenchymal stem cells Adult stem cells Embryonic stem cells Erythroid precursor cells Stem cell therapies Chronic wounds

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