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Self-rectifying magnetoelectric device for remote neural regeneration and function restoration

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Biomaterials Translational 2024年第2期5卷 197-199页

作者： Yuanhao Tong Yuanming Ouyang cunyi fan Yun Qian Department of Orthopedics National Center for OrthopedicsShanghai Sixth People’s Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration ShanghaiChina

Recently,Joshua ***,Gauri Bhave,and Jacob *** from Rice University reported a magnetoelectric nonlinear metamaterial(MNM)for neural signal transmission and nerve function restoration.1 Nonlinear charge transport between the semiconductor layers enabled this magnetoelectric(ME)metamaterial to have a nonlinear ME coupling coefficient,which allowed for self-rectification(Figure 1).

关键词： function magneto nonlinear

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机器人导航技术辅助定位肘关节屈伸轴

中华手外科杂志 2024年第4期40卷 289-291页

作者：屈诚范存义上海交通大学医学院附属第六人民医院骨科上海200233

肘关节对于上肢的功能十分重要,一旦出现肘关节疾病,将严重影响日常生活和工作,创伤后肘关节僵硬的发生率高达12%[1-3]。临床上肘关节切开松解术是保守疗法无效后肘关节僵硬患者的主要治疗方法。而在肘关节切开松解术的过程中,部分关节... 详细信息

肘关节对于上肢的功能十分重要,一旦出现肘关节疾病,将严重影响日常生活和工作,创伤后肘关节僵硬的发生率高达12%[1-3]。临床上肘关节切开松解术是保守疗法无效后肘关节僵硬患者的主要治疗方法。而在肘关节切开松解术的过程中,部分关节韧带可能会遭到破坏,造成肘关节不稳定及脱位,手术医生常选择韧带修补或重建联合铰链式外固定支架来解决上述问题[4-8]。铰链式外固定支架可在维持肘关节稳定的同时,辅助患者进行早期康复锻炼,有利于术后恢复。而应用肘关节铰链式外固定支架最关键的步骤是精准定位肘关节屈伸轴的位置[9]。近年来,随着计算机辅助技术和机器人导航技术的发展,医生开始探索如何利用这些技术来提高肘关节手术的准确性和临床效果。为了更好地探讨计算机辅助技术和机器人导航技术在肘关节疾病诊疗领域中的应用,受《中华手外科杂志》编辑部委托撰写此述评。

关键词：肘关节屈伸计算机辅助技术关节韧带铰链式外固定支架肘关节僵硬早期康复锻炼机器人导航辅助定位

β-磷酸三钙的骨诱导性和组织工程应用研究进展

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中华骨科杂志 2024年第13期44卷 906-914页

作者：杜锦洲钱运范存义上海交通大学医学院附属第六人民医院(国家骨科医学中心)骨科上海200233

目前,在临床中仅应用自体骨已不能满足骨缺损治疗的需求。β-磷酸三钙(beta-tricalcium phosphate,β-TCP)类骨移植替代物因具有良好的修复效果和一定的骨诱导能力而受到广泛关注。可降解β-TCP植入人体后可有效调控炎症,促进血管再生,... 详细信息

目前,在临床中仅应用自体骨已不能满足骨缺损治疗的需求。β-磷酸三钙(beta-tricalcium phosphate,β-TCP)类骨移植替代物因具有良好的修复效果和一定的骨诱导能力而受到广泛关注。可降解β-TCP植入人体后可有效调控炎症,促进血管再生,并以膜内成骨的方式形成新骨,实现骨缺损的愈合。对β-TCP诱导间质干细胞分化为成骨细胞机制的探索也从未停止,最初将骨诱导性归功于被释放钙磷离子和被吸附蛋白的功能,最近的研究热点是材料表面结构对细胞的影响(即整合素与细胞骨架被改变),以及调节信号通路的传导,包括丝裂原活化蛋白激酶/细胞外信号调节激酶(mitogen-activated protein kinase,MAPK/extracellular regulated protein kinases,ERK)通路、WNT家族分泌蛋白通路、Hippo-Yes相关蛋白/转录共激活因子(Yes-associated protein,YAP/transcriptional coactivator with PDZ-binding motif,TAZ)通路等。目前,β-TCP产品的基础结构日趋成熟,宏观与微观设计也被不断创新,相关骨移植替代物广泛用于临床,经临床研究证实具有长期的安全性和有效性。

关键词：磷酸钙类组织工程骨缺损

热处理条件对IrSn纳米颗粒结构及丙烷脱氢性能影响

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山西化工 2024年第6期44卷 1-2,7页

作者：范存毅马瑞梁永襄阳市公共检验检测中心湖北襄阳441058 化学与精细化工广东省实验室广东汕头515041

丙烷脱氢是低碳烯烃生产和页岩气高附加值应用的重要途径之一。通常负载型Pt-Sn双金属催化剂用于该过程面临催化剂失活快、再生流程繁琐的问题。Ir作为配位金属在均相脱氢反应中被证明具有很高的C-H键活化能力,但应用于多相催化的烷烃... 详细信息

丙烷脱氢是低碳烯烃生产和页岩气高附加值应用的重要途径之一。通常负载型Pt-Sn双金属催化剂用于该过程面临催化剂失活快、再生流程繁琐的问题。Ir作为配位金属在均相脱氢反应中被证明具有很高的C-H键活化能力,但应用于多相催化的烷烃脱氢反应未见报道。本文通过改变IrSn双金属催化剂的合成条件,探讨焙烧对Ir-Sn双金属纳米颗粒结构及催化丙烷脱氢性能影响。结果表明,焙烧不仅导致催化剂纳米颗粒严重烧结,而且降低双金属纳米颗粒合金化程度,极大影响催化性能。

关键词：焙烧合金结构元素分布丙烷脱氢

基于科技成果转化的概念验证中心研究综述与展望

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杭州科技 2024年第2期55卷 46-51页

作者：许彬彬周超范存义上海交通大学医学院附属第六人民医院上海200233

科技成果转化是建设科技强国的着力点,概念验证中心是科技成果转化的重要环节,得到学术界的高度关注和研究。概念验证中心的定义分为三类:新型组织模式、可行性验证平台和成果转化平台。通过对国内外研究的梳理,本文提出概念验证中心的... 详细信息

科技成果转化是建设科技强国的着力点,概念验证中心是科技成果转化的重要环节,得到学术界的高度关注和研究。概念验证中心的定义分为三类:新型组织模式、可行性验证平台和成果转化平台。通过对国内外研究的梳理,本文提出概念验证中心的功能,即技术评估、创新指导、融资助力和教育培训。概念验证中心发挥了加速科学创新到技术创新、助推科技成果转化和夯实科技创新基础的作用。概念验证中心对成果转化方案的技术、生产、投融资和商业可行性进行全面分析,并提供所需的资源和服务,促进方案的优化、迭代和转化。最后,提出进一步发展概念验证中心的建议,希望在政府引领、完善流程、人才培养和组织管理体系创新方面进行强化和突破。

关键词：概念验证中心评估评价科技创新科技成果转化创业指导

In vitro antibacterial and osteogenic properties of plasma sprayed silver-containing hydroxyapatite coating

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Chinese Science Bulletin 2009年第23期54卷 4438-4445页

作者： RUAN HongJiang fan cunyi ZHENG XueBin ZHANG Yan CHEN YiKai Department of Orthopaedics Shanghai 6th People's Hospital Shanghai Jiaotong University Shanghai 200233 China Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China

The objective of the present investigation was to characterize the antibacterial and osteogenic properties of plasma sprayed silver-containing hydroxyapatite (HA/Ag) coating in vitro. HA/Ag coating was deposited via vacuum plasma spraying. The concentration of silver ions released from HA/Ag coating, the efficacy of the HA/Ag coating against bacterial biofilm development, the effect of the HA/Ag coating on early adhesion and ossification of osteoblast cells in vitro was measured. The silver ion concentration released from the HA/Ag coating was between the minimum inhibitory concentration to bacteria and the cytotoxic concentration. Bacterial biofilm inhibition studies indicated an antibacterial activity on the HA/Ag coating surface when compared with hydroxyapatite (HA) coating alone. Moreover, it was demonstrated that osteoblast cell adhesion and mineralization occurred on the HA/Ag coating surface during the testing period. We conclude that the vacuum plasma sprayed HA/Ag coating possesses good antibacterial capability and osteogenic properties in vitro and represents a promising candidate for coating orthopedic implants.

关键词：羟基磷灰石涂层真空等离子喷涂体外抗菌成骨细胞涂层性能含银细菌生物膜离子浓度

Reactive oxygen species-scavenging nanoparticles coated with chondroitin sulfate protect cartilage against osteoarthritis in vivo

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Nano Research 2023年第2期16卷 2786-2797页

作者： Zhaoyi Wang Hao Xiong Zihe Zhai Yuejun Yao Tong Zhou Haolan Zhang cunyi fan Changyou Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for X PolymersDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Department of Orthopedics Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China Center for Healthcare Materials Shaoxing InstituteZhejiang UniversityShaoxing 312035China Department of Orthopedics The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration Building 3Langu Science and Technology ParkLane 70Haiji 6th RoadShanghai 201306China

Osteoarthritis(OA)is a prevalent chronic inflammatory disease in *** interventions confront systemic toxicity and insufficient *** unbalanced microenvironment of OA joints mainly fosters over-expressed reactive oxygen species(ROS),extracellular matrix disintegration,and apoptosis of *** this study,a kind of ROS-scavenging,biodegradable and drug-free nanoparticles(PP NPs)were constructed by the crosslinking of poly(propylene fumarate)(PPF)and ROS-scavenging poly(thioketal)(PTK).The high content of PTK and high crosslinking density of PPF and PTK innovatively endowed the NPs with slow degradation and prolonged ROS-elimination *** NPs were further surface-modified with chondroitin sulfate(CS),one of the dietary supplements for *** intrinsic properties of resultant PP-CS NPs were excavated in vitro and in *** PP-CS NPs could desirably consume 1,10-diphenyl-2-picrylhydrazyl(DPPH)radicals without toxicity to RAW264.7 cells in *** an average diameter of~300 nm,the PP-CS NPs could be intra-articular administrated in OA rats and showed prolonged joint retention time,allowing only one injection per ***,the PP-CS NPs possessed a prolonged ROS depletion and M2 macrophage induction effect,down-regulated inflammatory cytokines,and reduced glycosaminoglycans ***,the PP-CS NPs protected articular surface erosion,inhibited uneven cartilage matrix,and attenuated OA progression.

关键词： reactive oxygen species polythioketal osteoarthritis nanoparticles chondroitin sulfate

Functional reconstruction following brachial plexus root avulsion

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Neural Regeneration Research 2007年第1期2卷 54-57页

作者： Guixin Sun cunyi fan Yudong Gu Department of Trauma Medicine Shanghai East Hospital Affiliated to Shanghai Tongji University Shanghai 200120 China Department of Orthopaedics Sixth Hospital Shanghai Jiao Tong University Shanghai 200233 China Department of Hand Surgery Huashan Hospital Affiliated to Fudan University Shanghai 200040 China

OBJECTIVE： To sum up the treatment of brachial plexus root avulsion and the progress in functional reconstruction and rehabilitation following brachial plexus root avulsion. DATA SOURCES： A search of Medline was performed to select functional reconstruction and rehabilitation following brachial plexus injury-related English articles published between January 1990 and July 2006, with key words of ＂brachial plexus injury, reconstruction and rehabilitation＂. Meanwhile, a computer-based search of CBM was carried out to select the similar Chinese articles published between January 1998 and July 2006, with key words of ＂brachial plexus injury, reconstruction and rehabilitation＂. STUDY SELECTION： The materials were checked primarily, and the literatures of functional reconstruction and rehabilitation of brachial plexus injury were selected and the full texts were retrieved. Inclusive criteria： ①Functional reconstruction following brachial plexus injury. ②Rehabilitation method of brachial plexus injury. Exclusive criteria： Reviews, repetitive study, and Meta analytical papers. DATA EXTRACTION： Forty-six literatures about functional reconstruction following brachial plexus injury were collected, and 36 of them met the inclusive criteria. DATA SYNTHESIS： Brachial plexus injury causes the complete or incomplete palsy of muscle of upper extremity. The treatment of brachial plexus is to displace not very important nerves to the distal end of very important nerve, called nerve transfer, which is an important method to treat brachial plexus injury. Postoperative rehabilitations consist of sensory training and motor functional training. It is very important to keep the initiativeness of exercise. Besides recovering peripheral nerve continuity by operation, combined treatment and accelerating neural regeneration, active motors of cerebral cortex is also the important factor to reconstruct peripheral nerve function. CONCLUSION： Consciously and actively strengthening functional exerci

关键词： brachial plexus root avulsion functional reconstruction review literature

玛纳斯县土地制度改革对农用地流转的影响研究

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中国资源综合利用 2024年第2期42卷 36-38页

作者：马子凡王保力陈雪茹余晨蕾刘冰范存义新疆农业大学新生学院新疆农业大学公共管理学院乌鲁木齐830000

中国是个农业大国,土地是中国农村最重要的资源,土地问题解决的关键是对现有的土地制度和土地流转制度进行改革创新,构建与时俱进、因地制宜的土地流转模式和支撑体系。本文通过问卷调查法与深度访谈法对玛纳斯县土地制度改革对农用地... 详细信息

中国是个农业大国,土地是中国农村最重要的资源,土地问题解决的关键是对现有的土地制度和土地流转制度进行改革创新,构建与时俱进、因地制宜的土地流转模式和支撑体系。本文通过问卷调查法与深度访谈法对玛纳斯县土地制度改革对农用地流转的影响现状进行调查,然后采用描述性统计法和归纳分析法对玛纳斯县土地制度改革及土地流转情况进行分析,发现问题,提出对策建议。在土地流转过程中,玛纳斯县存在部分突出问题,即流转程序不规范,缺乏有效监督,土地流转信息时效差,缺乏流转交易平台,土地碎片化严重,整合困难。因此,要规范土地流转程序,实施有效监督,加强土地流转政策宣传,建立土地流转平台,优化空间布局,实现土地规模经营。

关键词：土地制度改革土地流转农用地影响因素玛纳斯县

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