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Evaluating the Compatibility Mechanism of Shengxian Decoction Based on an Excretion Study of 18 Bioactive Constituents in Rat Biosamples

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 40-52页

作者： Tao Pang Nan Weng Yong Chen cui-yun huang Mei Sun Feng Zhang Wan-Sheng Chen Department of Pharmacy Changzheng HospitalNaval Medical University(Second Military Medical University)ShanghaiChina Department of Pharmacognosy Shenyang Pharmaceutical University ShenyangLiaoning ProvinceChina Traditional Chinese Medicine Resource and Technology Center Shanghai University of Traditional Chinese MedicineShanghaiChina

Introduction:The Shengxian decoction(SXT),a Chinese herbal medication used to treat heart failure,is composed of Astragali Radix,Anemarrhenae Rhizoma,Bupleuri Radix,Cimicifuage Rhizoma,and Platycodonis *** of the excretion of the active compounds in this herbal medication is vital for investigating the underlying mechanisms behind its ***,this remains ***:Liquid chromatography coupled with mass spectrometry was performed in both positive and negative modes to assay 18 constituents of SXT from rat urinary,fecal,and biliary ***:The methodology was validated and showed good linearity(r≥0.9),precision,stability,repeatability,and *** relative standard deviations and relative errors for the precision and accuracy did not exceed 15%.The recoveries of all the compounds ranged from 77.37%to 114.82%,and the matrix effect was between 82.53%and 105.71%.The results suggested that,when combined with Platycodonis Radix,the levels of 14 constituents from the four herbs were reduced in the urine,while the levels of six constituents were reduced in the ***:The comparative excretion results indicated that Platycodonis Radix reduced the excretion of compounds in SXT,demonstrating the compatibility mechanism and holistic properties of these compounds,favoring the pharmacological effects of SXT.

关键词： Compatibility excretion liquid chromatography coupled with mass spectrometry Platycodonis Radix Shengxian decoction

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Gria:an efficient deterministic concurrency control protocol

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Frontiers of Computer Science 2024年第4期18卷 25-37页

作者： Xinyuan WANG yun PENG Hejiao huang School of Computer Science and Technology Harbin Institute of TechnologyShenzhen 518055China Institute of Artificial Intelligence and Blockchain Guangzhou UniversityGuangzhou 510006China

Deterministic databases are able to reduce coordination costs in a *** property has fostered a significant interest in the design of efficient deterministic concurrency control ***,the state-of-the-art deterministic concurrency control protocol Aria has three ***,it is impractical to configure a suitable batch size when the read-write set is ***,Aria running in low-concurrency scenarios,e.g.,a single-thread scenario,suffers from the same conflicts as running in high-concurrency ***,the single-version schema brings write-after-write *** address these issues,we propose Gria,an efficient deterministic concurrency control *** has the following ***,the batch size of Gria is ***,Gria’s conflict probability in low-concurrency scenarios is lower than that in high-concurrency ***,Gria has no write-after-write conflicts by adopting a multi-version *** further reduce conflicts,we propose two optimizations:a reordering mechanism as well as a rechecking *** evaluation result on two popular benchmarks shows that Gria outperforms Aria by 13x.

关键词： deterministic concurrency control transaction processing

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Synthesis and anti-HIV activities of phorbol derivatives

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Chinese Journal of Natural Medicines 2024年第2期22卷 146-160页

作者： huang Xiaolei TANG Chengrun huang Xusheng YANG yun LI Qirun MA Mengdi ZHAO Lei YANG Liumeng cui Yadong ZHANG Zhenqing ZHENG Yongtang ZHANG Jian College of Pharmaceutical Science Soochow UniversitySuzhou 215123China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China

In this study,37 derivatives of phorbol esters were synthesized and their anti-HIV-1 activities evaluated,building upon our previous synthesis of 51 phorbol derivatives.12-Para-electron-acceptor-trans-cinnamoyl-13-decanoyl phorbol derivatives stood out,demonstrating remarkable anti-HIV-1 activities and inhibitory effects on syncytia *** derivatives exhibited a higher safety index compared with the positive control *** them,12-(trans-4-fluorocinnamoyl)-13-decanoyl phorbol,designated as compound 3c,exhibited the most potent anti-HIV-1 activity(EC_(50)2.9 nmol·L^(−1),CC50/EC_(50)11117.24)and significantly inhibited the formation of syncytium(EC_(50)7.0 nmol·L^(−1),CC50/EC_(50)4891.43).Moreover,compound 3c is hypothesized to act both as an HIV-1 entry inhibitor and as an HIV-1 reverse transcriptase *** titration calorimetry and molecular docking studies indicated that compound 3c may also function as a natural activator of protein kinase C(PKC).Therefore,compound 3c emerges as a potential candidate for developing new anti-HIV drugs.

关键词： Phorbol esters Anti-HIV-1 activity Syncytia formation 12-(Trans-4-fluorocinnamoyl)-13-decanoyl phorbol Safety index HIV-1 entry inhibitor HIV-1 reverse transcriptase inhibitor PKC activator

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Effect of the vortical structures on the hydrodynamic performance of a pitching hydrofoil

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Journal of Hydrodynamics 2024年第2期36卷 406-420页

作者： Rui Yuan Hui-yun Hao Qin Wu yun-qing Liu Biao huang School of Mechanical Engineering Beijing Institute of TechnologyBeijing100081China

The objective is to study the vortical structural behaviors of a transient pitching hydrofoil and their effects on the hydrodynamic performance. The pitching motion of the hydrofoil is set to pitch up with an almost constant rate from 5° to 15° and then back to 5°, with the Reynolds number 4.4×10^(5) and the frequency 2 Hz. The results show that the main coherent structures around the pitching hydrofoil include small-scale laminar separation bubble (LSB), large-scale second vortex (SV) and trailing edge vortex (TEV) which are all vortical. The relationship between the vortical structure and the lift is investigated with the finite-domain impulse theory. It indicates that the major part of the lift is contributed by the LSB, whereas the shedding and the formation of the SV and TEV cause the fluctuation of the lift. The proper orthogonal decomposition (POD) method is applied to capture the most energetic modes, revealing that the LSB mode occupies a large amount of energy in the flow field. The dynamic mode decomposition (DMD) method accurately extracts the dominant frequency and modal characteristics, with the first mode corresponding to the mean flow, the second mode corresponding to the LSB structure and the third and fourth modes corresponding to the vortex shedding.

关键词： Hydrodynamics vortical structures finite-domain impulse theory proper orthogonal decomposition(POD) dynamic mode decomposition(DMD) Pitching hydrofoil

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Non-equilibrium kinetic separation of thulium,yttrium and erbium on the surface of freely rising oil droplets

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Journal of Rare Earths 2024年第1期42卷 200-209,I0007页

作者： Na Sui Shukai Miao Kaihui cui Fancheng Meng Kun huang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Green Recovery and Extraction of Rare and Precious Metals University of Science and Technology BeijingBeijing100083China Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China

It is difficult to achieve selective separation and enrichment of different rare earths from high abundance yttrium ores efficiently only dependent on their discrepancy in thermodynamic *** present work suggests a new strategy based on non-equilibrium kinetic separation of Er and Tm on the surface of freely rising oil droplets to control the separation order of *** is revealed that the mutual separation of Er/Tm is significantly promoted with the separation coefficient of 2.89 during the non-equilibrium extraction with the addition of diethylenetriaminepentaacetic acid(DTPA).The extraction sequence of Tm,Er and Y can be controlled as Tm>Y>Er,thus Y can be selectively enriched during the process of separation of Er and Tm,Such a sequence is subject to the controllable dissociation rates of RE(Ⅲ)-DTPA complexes and extraction abilities of P507 with the three RE(Ⅲ)*** dissociation rate is dependent on the stabilities of RE(Ⅲ)-DTPA complexes and follows the sequence ofY(Ⅲ)—DTPA Er>Y to Tm>Y>Er.

关键词： DTPA Interface interaction Non-equilibrium kinetic separation Rare earths P507

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Dynamic Characteristics of Functionally Graded Timoshenko Beams by Improved Differential Quadrature Method

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1647-1668页

作者： Xiaojun huang Liaojun Zhang Hanbo cui Gaoxing Hu School of Architecture and Civil Engineering Anhui Polytechnic UniversityWuhu241000China College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing210098China

This study proposes an effective method to enhance the accuracy of the Differential Quadrature Method(DQM)for calculating the dynamic characteristics of functionally graded beams by improving the form of discrete node ***,based on the first-order shear deformation theory,the governing equation of free vibration of a functionally graded beam is transformed into the eigenvalue problem of ordinary differential equations with respect to beam axial displacement,transverse displacement,and cross-sectional rotation angle by considering the effects of shear deformation and rotational inertia of the beam ***,ignoring the shear deformation of the beam section and only considering the effect of the rotational inertia of the section,the governing equation of the beam is transformed into the eigenvalue problem of ordinary differential equations with respect to beam transverse *** on the differential quadrature method theory,the eigenvalue problem of ordinary differential equations is transformed into the eigenvalue problem of standard generalized algebraic ***,the first several natural frequencies of the beam can be *** feasibility and accuracy of the improved DQM are verified using the finite element method(FEM)and combined with the results of relevant literature.

关键词： Timoshenko beams functionally graded materials dynamic characteristics natural frequency improved differential quadrature method

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Geometric Programming for Nonlinear Satellite Buffer Networks With Time Delays under L_(1)-Gain Performance

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 554-556页

作者： Yukang cui Yihui huang Michael V.Basin Zongze Wu College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060China Shenzhen University Shenzhen 518060China Peng Cheng Laboratory Shenzhen 518060China Robotics Institute Ningbo University of TechnologyNingbo 315211China Autonomous University of Nuevo Leon Nuevo Leon 66455Mexico

Dear Editor,This letter concerns the parameter tuning problem for nonlinear satellite buffer networks with communication delays, aiming to optimize their stability properties under L_(1)-gain. We first model the satellite buffer networks by a nonlinear time-delay positive system and propose a novel characterization under which the nonlinear system is asymptotically stable with a prescribed L_(1)-induced performance.

关键词： nonlinear system prescribed

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Effect of drying-wetting cycles on pore characteristics and mechanical properties of enzyme-induced carbonate precipitation-reinforced sea sand

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 291-302页

作者： Ming huang Kai Xu Zijian Liu Chaoshui Xu Mingjuan cui College of Civil Engineering Fuzhou UniversityFuzhou350108China Xiamen Rail Transit Construction and Development Group Co. Ltd.Xiamen361000China School of Civil Environment and Mining EngineeringThe University of AdelaideAdelaide5005Australia

Enzyme-induced carbonate precipitation(EICP)is an emanating,eco-friendly and potentially sound technique that has presented promise in various geotechnical ***,the durability and microscopic characteristics of EICP-treated specimens against the impact of drying-wetting(D-W)cycles is under-explored *** study investigates the evolution of mechanical behavior and pore charac-teristics of EICP-treated sea sand subjected to D-W *** uniaxial compressive strength(UCS)tests,synchrotron radiation micro-computed tomography(micro-CT),and three-dimensional(3D)recon-struction of CT images were performed to study the multiscale evolution characteristics of EICP-reinforced sea sand under the effect of D-W *** potential correlations between microstructure characteristics and macro-mechanical property deterioration were investigated using gray relational analysis(GRA).Results showed that the UCS of EICP-treated specimens decreases by 63.7% after 15 D-W *** proportion of mesopores gradually decreases whereas the proportion of macropores in-creases due to the exfoliated calcium carbonate with increasing number of D-W *** micro-structure in EICP-reinforced sea sand was gradually disintegrated,resulting in increasing pore size and development of pore shape from ellipsoidal to columnar and *** gray relational degree suggested that the weight loss rate and UCS deterioration were attributed to the development of branched pores with a size of 100-1000 m m under the action of D-W ***,the results in this study provide a useful guidancee for the long-term stability and evolution characteristics of EICP-reinforced sea sand under D-W weathering conditions.

关键词： Enzyme-induced carbonate precipitation(EICP) Plant-based urease Drying-wetting(D-W)cycles Microstructure

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A Comprehensive Study on the Consequences of Gap-Graded Sands Considering the Loss of Fine Particles

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Journal of Earth Science 2024年第2期35卷 597-612页

作者： Weiping Liu Yu Gan yunwei cui Faming huang Lina Hu School of Civil Engineering and Architecture Nanchang UniversityNanchang330031China

Water and sand leakage disasters are likely to occur during construction in water-rich sand layer areas,resulting in ground *** stress-strain action characteristics of discontinuous graded sand under different internal erosion degrees,and the evolution mechanism of water and sand leakage disasters caused by the internal erosion need to be further ***,this paper takes the discontinuous graded sand in a water rich sand layer area in Nanchang City of China as the research *** the influence of different fine particle losses(0,10%,20%and 30%)under the internal erosion of sand,the salt solution method is used to realize the specified loss of fine particles in the internal *** stress-strain behavior after the loss of fine particles due to internal erosion is studied by triaxial shear ***,the physical model test and PFC-CFD method are both used to study the evolution rules of water and sand leakage disaster considered the influence of internal erosion *** show that:(1)under the same confining pressure,the peak failure strength of sand samples decreases along with the increase of fine particle loss.(2)In the water and sand leakage test of saturated sand,a natural filter channel is formed above the observed soil *** greater the loss of fine particles,the steeper and wider the collapse settlement area.(3)The relationship between the cumulative amount of water and sand leakage and time is *** total mass loss of sand increases along with the increase of internal erosion degree.(4)After the soil arch is formed around the damaged opening,the sand continues to converge above the soil arch under the action of water flow,resulting in the dense convergence of contact force chains.

关键词： sandy soil internal erosion stress and strain water and sand leakage PFC3D engineering geology

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Visible light-driven oxidation of non-native substrate by laccase attached on Ru-based metal-organic frameworks

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Journal of Environmental Sciences 2024年第3期137卷 741-753页

作者： Wenguang huang Wentao Zhang Guantongyi Chen yun Chen Jun Ma Dawei huang Qinzheng Zhaoc Bingdang Wu State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment South China Institute of Environmental SciencesMinistry of Ecology and Environment of PRCGuangzhou 510655China Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China School of Environmental Science and Engineering Suzhou University of Science and TechnologySuzhou 215002China Key Laboratory of Suzhou Sponge City Technology Suzhou 215002China

Light-induced electron transfer can broaden the substrate range of ***,the efficiency of photo-enzyme coupling is limited by the poor combination of photosensitizer or photocatalyst with ***,we prepared the nano-photocatalyst MIL-125-NH_(2)@Ru(bpy)by in site embedding ruthenium pyridine-diimine complex[Ru(bpy)_(3)^(2+)into metal organic frameworks MIL-125-NH_(2)and associated it with multicopper oxidase(MCO)*** to[Ru(bpy)_(3)]^(2+),the coupling efficiency of MIL-125-NH_(2)@Ru(bpy)_(3)for enzymatic oxygen reduction increased by 35.7%.A series of characterizations confirmed that the amino group of laccase formed chemical bonds with the surface defects or hydrophobic groups of MIL-125-NH_(2)@Ru(bpy)_(3).Consequently,the tight binding accelerated the quenching process and electron transfer between laccase and the immobilized ruthenium pyridine-diimine *** work would open an avenue for the synthesis of MOFs photocatalyst towards photo-enzyme coupling.

关键词： Laccase Light-driven biocatalysis Ruthenium photocatalyst Metal-organic frameworks Enzyme immobilization

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