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Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan yin Jiahui Kang Xuan Cheng hui Gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

CaH2-promoted activity of Ni-carbonate interface for CO_(2) methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-cui Mao hui-Lin Jiang Bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002JiangsuChina

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO_(2)hydrogenation reaction,involving surface carbonate hydrogenation and CO_(2)***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic CO_(2)*** work demonstrated that the incorporation of CaH_(2)in Ni/CaCO_(3)enhances the CO_(2)methanation activity of the *** CO_(2)conversion for Ni/CaH_(2)-CaCO_(3)reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO_(3)(31.6%) and Ni/CaH_(2)-CaO (42.4%) ***,the Ni/CaH_(2)-CaCO_(3)catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH_(2)played a crucial role in promoting the activity of the Ni-carbonate interface for CO_(2)***_(2)could modify the electronic structure of Ni and tune the structural properties of CaCO_(3)to generate medium basic sites (OH groups),which are favorable for the activation of H2and CO_(2).In-situ Fourier transform infrared spectroscopy (FTIR) analysis combined with density functional theory calculations demonstrated that CO_(2)activation occurs at the hydroxyl group (OH) on the CaH_(2)-modified Ni-carbonate surface,leading to the formation of CO_(3)H****,our study has confirmed that CO_(2)methanation over the Ni/CaH_(2)-CaCO_(3)catalysts proceeds via the formate pathway.

关键词： CO_(2)methanation Metal hydride Ni catalysts Carbonate Metal-carbonate interface

Effect of lanthanum on microstructure of a nickel-based single crystal superalloy

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China Foundry 2025年第1期22卷 55-64页

作者： Hong Gao Kai Guan Ren-jie cui Jian-chao Qin Zi-han Zhao Zhao-hui Huang Science and Technology on Advanced High Temperature Structural Materials Laboratory Beijing Institute of Aeronautical MaterialsBeijing 100095China

To enhance the high-temperature oxidation resistance and mechanical properties of a secondgeneration nickel-based superalloy,various concentrations of lanthanum(La)ranging from 5.0×10^(-5)wt.%to 3.4×10^(-4)wt.%are added to the *** microstructure of the nickel-based single crystal superalloy with trace of La was examined by means of SEM,EDS and *** show the addition of La decreases the segregation of elements and increases the amount ofγ/γ′eutectics of the as-cast alloy,and in the interdendritic region,the growth of eutectics is accompanied by the growth of strip clusters composed of Ni_(5)La and Ni_(3)*** the La content in the alloy increases,the proportion of Ni_(5)La in the cluster *** heat treatment,incipient melting occurs in the cluster regions,leading to an increase in microporosity compared to the original as-cast ***,the heat treatment alters the shape of the clusters from a strip morphology to an elliptical one,and it changes their composition from Ni_(5)La and Ni_(3)Ta to a combination of Ni_(5)La,Ni_(3)Ta,and MC carbides.

关键词： single crystal superalloy lanthanum microstructure heat-treatment precipitate phase

Atlantoaxial dislocation with vertebral artery anomaly:A case report

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World Journal of Orthopedics 2025年第2期16卷 81-87页

作者： Ruo-hui Tang Jin yin Zhao-Wen Zhou Department of Orthopedic The First People’s Hospital of KunmingKunming 650000Yunnan ProvinceChina

BACKGROUND Surgical intervention is a critical treatment approach for symptomatic atlantoaxial ***,vertebral artery injury remains a significant challenge during such *** present a case of successful treatment of atlantoaxial dislocation with concurrent vertebral artery injury using interlaminar screw technology,and review the relevant *** SUMMARY A 69-year-old female patient,with no history of trauma,was diagnosed with atlantoaxial dislocation based on X-ray,computed tomography(CT),and magnetic resonance *** CT angiography(CTA)revealed vertebral artery developmental anomalies,and she underwent posterior cervical *** follow-up showed improvement in the patient’s clinical symptoms such as unstable walking and dizziness,as well as functional scores compared to *** vertebral artery injury was successfully managed,and postoperative CTA review revealed no complications related to vascular *** Thorough preoperative evaluation,such as CTA imaging,and the surgeon’s expertise in various spinal screw placement techniques are crucial for improving the success rate of atlantoaxial dislocation surgeries.

关键词： Atlantoaxial dislocation Vertebral artery injury Vertebral artery congenital Screw techniques Computed tomography angiography Case report

Contribution of fungal biomass to persistent soil carbon across natural ecosystems

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Science China Earth Sciences 2025年第2期68卷 444-456页

作者： Xiang WANG Guang-hui YU Yakov KUZYAKOV Bo-Hao yin Andreas KAPPLER Cong-Qiang LIU Bohai Coastal Critical Zone National Observation and Research Station Institute of Surface-Earth System ScienceSchool of Earth System ScienceTianjin Key Laboratory of Earth Critical Zone Science and Sustainable Development in Bohai RimTianjin UniversityTianjin 300072China Department of Soil Science of Temperate Ecosystems Department of Agricultural Soil ScienceUniversity of GöttingenGöttingen 37077Germany Agro-Technological Institute Peoples Friendship University of Russia(RUDN University)Moscow 117198Russia Geomicrobiology Center for Applied GeosciencesUniversity of TübingenTübingen 72076Germany Cluster of Excellence EXC 2124 Controlling Microbes to Fight InfectionUniversity of TübingenTübingen 72076Germany

Fungi are known to be crucial in the formation and stabilization of soil organic matter through their exudates and dead residues(necromass).Yet,it remains unclear how fungi contribute to the persistence of carbon in soils over millennial scales across ***,this study fills the knowledge gap by linking fungal carbon stocks with minerals-associated carbon stocks across major biomes.A strong correlation between fungal biomass and reactive mineral-associated carbon stocks in soils across six biomes supports the substantial role of fungi in soil carbon persistence at the global *** spatial resolution nanoscale secondary ion mass spectrometry revealed that fungi may stabilize carbon by forming organo-mineral associations through their close physical connection to reactive minerals and weathered *** propose a conceptual model that emphasizes the dualistic role of hypha-mineral interactions:(i)fungi accelerate organic matter decomposition by producing reactive oxygen species on the hypha-mineral interfaces,and(ii)fungi stabilize their residues on mineral surfaces,leading to millennial scale persistence of soil ***,fungi play a fundamental role in ecosystems that extends beyond the decomposition of persistent *** are crucial in stabilizing carbon on mineral surfaces,thereby facilitating the long-term removal of carbon from rapid biotic cycling.

关键词： Biogeography Fungi Mineral-associated organic matter(MAOM) Reactive minerals Soil carbon stability NanoSIMS

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Micro-macro regulating heterogeneous interface engineering in 3D N-doped carbon fiber/MXene/TiO_(2) nano-aerogel for boosting electromagnetic wave absorption

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Nano Research 2025年第2期18卷 843-857页

作者： ying Li Chunlei Dong Sijia Wang Dongyi Lei Binbin yin Yifei cui Yanru Wang Ran Li School of Civil Engineering Qingdao University of TechnologyQingdao 266033China Cooperative Innovation Center of Engineering Construction and Safety in Shandong Blue Economic Zone Qingdao University of TechnologyQingdao 266033China Department of Architecture and Civil Engineering City University of Hong KongHong Kong 999077China

MXene,as a rising star among two-dimensional(2D)electromagnetic wave materials,faces urgent challenges in addressing its self-stacking issue and regulating its ***,a micro-macro collaborative design strategy was proposed to regulate heterogeneous interface engineering in MXene-based ***-based cotton was introduced as three dimensional(3D)framework for constructing a porous structure,TiO_(2) was in-situ generated and nitrogen atom was doped on Ti_(3)C_(2)T_(x) MXene to regulate its dielectric properties,a 3D N-doped carbon fiber/MXene/TiO_(2)(CMT)nano-aerogel was successful *** synergistic effects of diverse components and structural designs,porous frameworks and TiO_(2) lattice contraction can significantly adjust the density of the conductive network and create abundant heterogeneous interfaces,as well as the lattice defects induced by nitrogen atom doping can enhance polarization loss,ultimately leading to the excellent microwave absorption performance of 3D N-CMT *** optimized N-CMT 30%aerogel exhibited a minimum reflection loss(RLmin)of−72.56 dB and an effective absorption bandwidth(EAB)of 6.92 GHz at 2.23 ***,when the thickness was adjusted from 1 to 5 mm,the EAB of the N-CMT 30%aerogel reached 13.94 GHz,achieving coverage of 98% of the C-band and the entire X and Ku ***,the attenuation capabilities of the N-CMT aerogel were further confirmed through RCS simulations,whose RCS reduction value reaches up to 19.969 dB·m^(2).These results demonstrate that 3D N-CMT nano-aerogel relying on interface engineering design exhibits significant potential in the field of electromagnetic protection,providing an important reference for future efficient absorbers.

关键词： interface engineering electromagnetic wave absorption MXene micro-macro design nano-aerogel

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铁路重载货车车轮新材料的研制

钢铁 2007年第8期42卷 56-59,77页

作者：朱昌逑江波安涛陈刚崔银会马鞍山钢铁股份有限公司技术中心安徽马鞍山243000

针对重载车轮的损伤特点,研制了一种以C、Si为主要强化元素的铁素体-珠光体型车轮新材料,通过C、Si含量的合理配合,使车轮材料具备了高强度并保持了较高的韧性,同时具有合理的相变特性。装车运行试验表明,与目前常用的车轮材料相比,这... 详细信息

针对重载车轮的损伤特点,研制了一种以C、Si为主要强化元素的铁素体-珠光体型车轮新材料,通过C、Si含量的合理配合,使车轮材料具备了高强度并保持了较高的韧性,同时具有合理的相变特性。装车运行试验表明,与目前常用的车轮材料相比,这种车轮材料的抗机械损伤性能和抗热损伤性能得到了较好的协调,更适合重载运输条件。

关键词：重载铁路车轮铁素体-珠光体钢力学性能相变特性

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车轮钢中的白点(一)

钢铁 2007年第4期42卷 61-66页

作者：江波陈刚崔银会任学冲褚武扬马鞍山钢铁股份有限公司技术中心安徽马鞍山243000 北京科技大学材料物理系北京100083

研究了车轮钢中白点形成的机理以及白点对断口形貌的影响。结果表明,氢和空位聚集导致鼓泡形核和长大,随着鼓泡内氢气压力的升高,裂纹从鼓泡核壁形核、扩展导致白点形成。白点的断口为准解理,和氢致滞后开裂断口相同,含白点试样的断口... 详细信息

研究了车轮钢中白点形成的机理以及白点对断口形貌的影响。结果表明,氢和空位聚集导致鼓泡形核和长大,随着鼓泡内氢气压力的升高,裂纹从鼓泡核壁形核、扩展导致白点形成。白点的断口为准解理,和氢致滞后开裂断口相同,含白点试样的断口形貌依赖于断裂方式和试样厚度。钢中的白点除了产生二次裂纹和局部准解理断面外,对各种断口形貌均没有明显的影响。

关键词：车轮钢白点断口形貌氢致滞后开裂

Development of Gravity Theories in the View of TRAPPIST-1e

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Research in Astronomy and Astrophysics 2025年第1期25卷 143-161页

作者： Nan Wang Lu-Yao Lu hui-Gen Liu An-Dong Chen Tiger Lu Ao-Ran cui Jun-Kai Wang Marine Science and Technology College Zhejiang Ocean University Key Laboratory of Modern Astronomy and Astrophysics Ministry of Education Zhoushan Astronomical Society School of Astronomy and Space Science Nanjing University Department of Astronomy Yale University Kuang Yaming Honors School Nanjing University School of Physics Nanjing University

Contrary to the solar system, most exoplanet systems detected hitherto are close-in and compact. One typical system is TRAPPIST-1, which has seven nearly co-planar terrestrial planets all within the orbit of Mercury,including three in the habitable zone. To evaluate the differences in developing sophisticated gravity theories from the solar system, we use N-body integrations to simulate ephemeris and reproduce some important astronomy phenomena observed on the potentially habitable planet TRAPPIST-1e. Retrograde motions of other planets last1–2 orders of magnitude shorter than in the solar system, but occur much more frequently. Transit events of all inner planets can be observed steadily. Except for Kepler's first law, which is hard to notice for low eccentricities of planets, the other two laws can then be precisely verified in 102days, because the areas swept by planets vary by?0.01% and the observed semimajor axes and periods result in constants with theoretical and observation accuracies both ?2%. However, the mean motion correlation implies that the Great Inequality is not always apparent between one pair of planets like Jupiter and Saturn. Furthermore, general relativity can hardly be discovered because it gives rise to perihelion precession of inner planets only ～0.1% of gravity precession, dozens of times smaller than Mercury. Our results support the possibility of developing part of gravity theories by potential exo-civilizations in compact systems like TRAPPIST-1.

关键词： ephemerides extraterrestrial intelligence gravitation planets and satellites: terrestrial planets