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Construction of the Chinese Veteran Clinical Research （CVCR） Platform for the assessment of non-communicable diseases

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Chinese Medical Journal 2014年第3期127卷 448-456页

作者： Tan Jiping Li Nan Gao Jing Guo yuhe Hu Wei yang Jinsheng yu Baocheng yu Jianmin du Wei Zhang Wenjun cui Lianqi Wang Qingsong Xia Xiangnan Li Jianjun Zhou Peiyi Zhang Baohe Liu Zhiying Zhang Shaogang Sun Lanying Liu Nan deng Ruixiang dai Wenguang yi Fang Chen Wenjun Zhang yongqing Xue Shenwu cui Bo Zhao yiming Wang Luning department of Geriatric Neurology Chinese Peoples Liberation Army General Hospital Beijing 100853 China Research Center of Clinical Epidemiology Peking University Third Hospital Beijing 100191 China department of Neurology Peking Union Medical College Hospital Beijing 100730 China Health Bureau of the Ministry of Health of the General Logistics department of PLA Beijing 100038 China department of Neurology General Hospital of Lanzhou Military Command Lanzhou Gansu 730050 China department of Gerontology Bethune International Peace Hospital Shijiazhuang Hebei 050082 China department of Neurology Chinese People's Liberation Army 107 Hospital Yantai Shandong 264002 China department of Neurology Chinese People's Liberation Army 201 Hospital Dalian Liaoning 116021 China department of Gerontology Changhai Hospital Shanghai 200433 China department of Neurology Chinese People's Liberation Army 401 Hospital Qingdao Shandong 266071 China department of Neurology General Hospital of Chengdu Military Command Chengdu Sichuan 610083 China First Cadre department Fuzhou General Hospital of Nanjing Military Command Fuzhou Fujian 350025 China department of Neurology Chinese People's Liberation Army 323 Hospital Xi'an Shaanxi 710054 China Forth Cadre department General Hospital of Guangzhou Military Command Guangzhou Guangdong 510010 China Cadre department Navy General Hospital Beijing 10048 China department of Neurology Chinese People's Liberation Army 264 Hospital Taiyuan Shanxi 030001 China Third Cadre department Chinese People's Liberation Army 254 Hospital Tianjin 300142 China Third Internal Medicine department Chinese People's Liberation Army 44 Hospital Guiyang Guizhou 550009 China department of Neurology Chinese People's Liberation Army 451 Hospital Xi'an Shaanxi 710054 China Cadre department Chinese People's Liberation Army 252 Hospital Baoding Hebei 071000 China department of Neurology Chinese People's Liberation Army 253 Hospital Huhhot Inner Mongol

Background Based on the excellent medical care and management system for Chinese veterans,as well as the detailed medical documentation available,we aim to construct a Chinese Veteran Clinical Research （CVCR） platform on noncommunicable diseases （NCds） and carry out studies of the primary.d.sabling *** The Geriatric Neurology.d.partment of Chinese People＇s Liberation Army General Hospital and veterans＇ hospitals serve as the leading and participating units in the platform *** fundamental constituents of the platform are veteran *** typical cluster sampling is adopted to recruit veteran communities.A cross-sectional study of mental,neurological,and substance use （MNS） disorders are performed in two stages using screening scale such as the Mini-Mental State Examination and Montreal cognitive assessment,followed by systematic neuropsychological assessments to make clinical diagnoses,evaluated disease awareness and care *** A total of 9 676 among 277 veteran communities from 18 cities are recruited into this platform,yielding a response rate of 83.86％.8 812 subjects complete the MNS subproject screening and total response rate is 91.70％.The average participant age is （82.01±4.61） years,69.47％ of veterans are 80 years or *** participants are male （94.01％）,83.36％ of subjects have at least a junior high school *** overall health status of veterans is good and *** most common NCd are cardiovascular disorders （86.44％）,urinary and genital diseases （73.14％）,eye and ear problems （66.25％）,endocrine （56.56％） and neuro-psychiatric disturbances （50.78％）.Conclusion We first construct a veterans＇ comprehensive clinical research platform for the study of NCds that is primarily composed of highly educated Chinese males of advanced age and utilize this platform to complete a cross-sectional national investigation of MNS disorders among *** good and stable health condition of the veterans could facilitat

关键词： non-communicable disease mental, neurological, and substance use disorders clinical research construction of platform veteran oldest old China

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浅析BFC6120L1d6客车底盘悬架结构及安装工艺流程

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客车技术 2019年第3期 15-18页

作者：崔健北京北方华德尼奥普兰客车股份有限公司

介绍了客车底盘前后悬架的结构及特点,从骨架落合与调平、A型臂总成及后桥总成的调正与固定、前桥模块总成的调正与固定、前后悬架气囊/减振器/横向推力杆座的调正与固定四个方面阐述了底盘悬架安装工艺流程。

关键词：客车悬架 A型臂总成装配工艺

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Nanostructured Polymer Composite Electrolytes with Self-Assembled Polyoxometalate Networks for Proton Conduction

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CCS Chemistry 2022年第1期4卷 151-161页

作者： Gang Wang Jialin Li Lichao Shang Haibo He Tingting cui Shengchao Chai Chengji Zhao Lixin Wu Haolong Li State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012 Key Laboratory of High Performance Plastics Ministry of EducationCollege of ChemistryJilin UniversityChangchun 130012

The key challenge for the use of polymer electrolytes is to realize a high ionic conductivity without scarifying their mechanical ***,we report a facile strategy to prepare a nanostructured polymer electrolyte with both high proton conductivity and high modulus,based on the electrostatic self-assembly of polyoxometalate cluster H_(3)PW_(12)O_(40)(PW)and comb copolymer poly(ether-etherketone)-grafted-poly(vinyl pyrrolidone)(PEEK-gPVP).The incorporation of protonic acid PW can enable the PEEK-g-PVP to be highly proton conductive and create flexible composite electrolyte ***,nanoscale phase separation between PEEK domains and PVP/PW domains spontaneously occurs in these membranes,forming a bicontinuous structure with three-dimensional(3d)-connected PW *** to the dual role of PW networks as both proton transport pathways and mechanical enhancers,these membranes exhibit proton conductivities higher than 30 mS cm^(−1) and modulus over 4 ***,the direct methanol fuel cells equipped with these membranes show good cell *** the wide tunability of comb copolymers and polyoxometalates,this system can be extended to develop a variety of functional electrolyte materials,for example,the lithium-ion conductive electrolytes by using polyoxometalatebased lithium salts,which provides a promising platform to explore versatile electrolyte materials for energy and electronic applications.

关键词： self-assembly polyoxometalates polymer electrolytes nanocomposites proton conduction

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Application of Ce-V/sol-gel composite coating for corrosion protection of AM60B magnesium alloy

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Transactions of Nonferrous Metals Society of China 2017年第2期27卷 352-362页

作者： S.NEZAMdOUST d.SEIFZAdEH Physical Chemistry Research Laboratory Applied Chemistry DepartmentFaculty of Basic ScienceUniversity of Mohaghegh ArdabiliArdabil ***Iran

Application of a composite coating on AM60B magnesium alloy consisting of cerium-vanadium conversion coating and a hybrid sol-gel layer was investigated. Scanning electron microscopy and energy.d.spersive X-ray spectroscopy analyses revealed a cracked nodular structure for the cerium-vanadium conversion coating which was mainly composed of O, Ce, V, and Mg atoms. All the cracks in the conversion coating were completely sealed by a thin, compact and defect-free hybrid sol？gel film. Potentiodynamic polarization and electrochemical impedance spectroscopy experiments in Harrison’s solution showed that the cerium-vanadium conversion coating provides minimal protection against corrosion while the composite coating significantly increases the corrosion resistance of the magnesium alloy. Sol-gel film provides protection against corrosion by sealing cracks in the cerium-vanadium conversion coating and acting as a barrier. Scanning electron microscopy analyses after polarization tests confirmed the results obtained by the electrochemical tests.

关键词： magnesium alloy corrosion conversion coating sol-gel

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白鲜开花特性与繁育系统

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东北林业大学学报 2024年第1期52卷 14-20页

作者：白鹭孙宝莹孙淑英崔红梅石雅琴内蒙古大学呼和浩特010020 呼和浩特市植物园

为了解白鲜(dictamnus dasycarpus Turcz.)的开花特性与繁育类型,对内蒙古赤峰市白鲜开花动态及花器官特征、花粉活力、柱头可授性、花粉胚珠数量比(P/O)、杂交指数(OCI)和结实率等指标进行了观测与研究。结果表明:白鲜的花期从5月中旬... 详细信息

为了解白鲜(dictamnus dasycarpus Turcz.)的开花特性与繁育类型,对内蒙古赤峰市白鲜开花动态及花器官特征、花粉活力、柱头可授性、花粉胚珠数量比(P/O)、杂交指数(OCI)和结实率等指标进行了观测与研究。结果表明:白鲜的花期从5月中旬开始,6月下旬结束,持续时间为35~40 d;单株花期平均为19.1 d,单花花期平均为4.1 d。开花过程中,雄蕊具有级联运动及早熟特性,雌蕊能够伸长卷曲,同时存在雌雄异位和雌雄异熟现象;开花2 d时,花粉活力最高,最高时为73.88%,开花3~4 d时,柱头可授性较强;白鲜的杂交指数为5,花粉胚珠数量比为885.95,存在部分自交亲和,繁育系统为兼性异交。白鲜的访花昆虫主要有中华蜜蜂、熊蜂、黄胸木蜂等,其中中华蜜蜂为主要传粉者。

关键词：白鲜开花特性繁育系统级联运动

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基于d-二聚体及血栓图参数构建老年骨科大手术患者早期栓塞风险列线图模型的研究

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现代实用医学 2023年第12期35卷 1586-1589页

作者：崔俊长兴县中医院浙江省长兴313100

目的构建基于d-二聚体(d-d)及血栓图参数的老年骨科大手术患者早期栓塞风险列线图模型,并对其进行验证。方法选取浙江省长兴县中医院2020年1月至2022年1月收治的56例老年骨科大手术患者,对患者进行3个月的随访根据患者术后是否发生栓... 详细信息

目的构建基于d-二聚体(d-d)及血栓图参数的老年骨科大手术患者早期栓塞风险列线图模型,并对其进行验证。方法选取浙江省长兴县中医院2020年1月至2022年1月收治的56例老年骨科大手术患者,对患者进行3个月的随访根据患者术后是否发生栓塞分为未发生栓塞组(41例)和发生栓塞组(15例)。采用Logistic多因素回归分析影响早期栓塞的危险因素。使用R3.5.3软件绘制预测老年骨科大手术患者发生早期栓塞的列线图模型应用受试者工作曲线(ROC)下面积(AUC)对列线图模型预测效能进行检验并利用Bootstrap法检验模型的准确性。选取2022年6月至2023年6月收治的20例老年骨科大手术患者对模型预测效能进行验证。结果栓塞组与未栓塞组术后1、7dd-d及凝血反应时间(R)、血块生成率(α)、血块形成时间(K)及最大血栓幅度(MA)差异均有统计学意义(均P d-d、α、K及MA为影响老年骨科大手术患者术后发生早期栓塞的危险因素(均P dex指数为0.779(95%CI:0.714~0.865)。AUC、灵敏度、特异度分别为0.781、78.9%、82.8%。选取的20例验证患者中,风险预警模型预测发生早期栓塞5例,实际发生4例,AUC、灵敏度、特异度分别为0.821、77.42%、80.94%。结论 d-d及血栓图参数是老年骨科大手术患者发生早期栓塞的危险因素,基于以上因素构建的风险列线图模型对患者早期栓塞的发生具有较好的预测效能。

关键词： d-二聚体血栓图参数早期栓塞风险列线图模型

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Cornel iridoid glycoside induces autophagy to protect against tau oligomer neurotoxicity induced by activation of glycogen synthase kinase-3β

Cornel iridoid glycoside induces autophagy to protect agains...

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2019全国老年痴呆与认知障碍相关疾病学术大会

作者： yANG cui-cui LI Xue-lian ZHANG Li LI ya-li LI Lin ZHANG Lan department of Pharmacy Xuanwu Hospital of Capital Medical UniversityBeijing Institute for Brain DisordersBeijing Engineering Research Center for Nerve System DrugsKey Laboratory for Neurodegenerative Diseases of Ministry of Education Key Laboratory for Basic Pharmacology of Ministry of Education Zunyi Medical College

Tau oligomers are the etiologic molecules of Alzheimer disease(Ad),and correlate strongly with neuronal loss and exhibit *** evidence indicates that small tau oligomers are the most relevant toxic aggregate *** aim of the present study was to investigate the mechanisms of cornel iridoid glycoside(CIG) on tau oligomers and cognitive *** injected wortmannin and GF-109203 X(WM/GFX,200 μmol·L each) into the lateral ventricles to induce tau oligomer and memory impairment in *** orally administered with CIG at 60 and 120 mg·kg-1 per day for 14 d,CIG decreased the escape latency in Morris water maze *** also found that CIG restored the expression of presynaptic p-synapsin,synaptophysin,and postsynaptic density-95(PSd-95) decreased by WM/GFX in rat *** reduced the accumulation of tau oligomers in the brain of WM/GFX rats and in cells transfected with wild type glycogen synthase kinase-3β(wtGSK-3β).In addition,CIG up-regulated the levels of ATG7,ATG12,Beclin-1,and LC3 II in vivo and in vitro,suggesting the restoration of autophagy *** results suggest that CIG could ameliorate memory.d.ficits and regulate memory-associated synaptic proteins through the clearance of tau oligomers ***,CIG clears tau oligomers by restoring autophagy function.

关键词： cornel iridoid glycoside autophagy tau oligomer glycogen synthase kinase-3β

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Low-temperature thermocatalytic particulate carbon decomposition via urea solution-combustion derived CeO2 nanostructures

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Journal of Rare Earths 2021年第1期39卷 67-74,I0003页

作者： S.P.Ratnayake M.M.M.G.P.G.Mantilaka C.Sandaruwan d.dahanayake y.Pivini Gunasekara S.Jeyasakthy N.M.Gurusinghe U.K.Wanninayake K.M.Nalin de Silva Sri Lanka Institute of Nanotechnology Nanotechnology and Science ParkHomagamaSri Lanka School of Science Royal Melbourne Institute of Technology University(RMIT)Victoria3000Australia Postgraduate Institute of Science University of PeradeniyaPeradeniyaSri Lanka Centre for Advanced Materials and devices(CAMd) Department of ChemistryUniversity of ColomboColombo 00300Sri Lanka

A facile,one-pot,urea solution combustion route was utilized to synthesize highly catalytic CeO2 ***2 prepared under varying thermal conditions was characterized by electron microscopy,energy.d.spersive X-ray spectroscopy,X-ray.d.ffraction,X-ray photoelectron spectroscopy,infrared and Raman *** the synthesis temperature is raised from 400 to 1000℃,the crystallite size and dspacing of nanoparticles are observed to reduce while cell parameters remain in the same *** size exhibits an accession from~20 to~50 nm along the *** CeO2 nanoparticles are detected as a composite structure of CeO2 and graphitic carbon nitride(g-C3 N4)produced by the pyrolysis of *** the solid carbon particulate oxidation capacity,an outstanding performance is exhibited by CeO2 synthesized at 800℃where the oxidation onset temperature is reduced by 27%compared with the *** superior performance is attributed to the carbon nitride-generated unique CeO2 nanomorphology consolidating ample reactive sites and facilitated oxygen delivery for a highly efficient thermocatalytic *** atmospheric pollution mitigation,synthesis of these CeO2 nanostructures represents a cost effective and convenient abatement technique for carbon particulates in comparison to cost-intensive,environmentally.d.trimental and noble-metal based techniques.

关键词： Ceria Nanoparticles Soot Solution combustion Graphitic carbon nitride Rare earths

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An efficient SPH methodology for modelling mechanical characteristics of particulate composites

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defence Technology（防务技术） 2021年第1期17卷 135-146页

作者： Z.J.Zheng S.Kulasegaram P.Chen y.Q.Chen department of Mechanics College of Mechanical EngineeringChongqing University of TechnologyChongqing400054China Institute of Applied and Computational Mechanics Cardiff School of EngineeringCardiff UniversityQueen’s BuildingsThe ParadeCardiffCF243AAWalesUK department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing100871China

Particulate composites are one of the widely used materials in producing numerous state-of-the-art components in biomedical,automobile,aerospace including defence *** of modelling techniques have been adopted in the past to model mechanical behaviour of particulate *** to their favourable properties,particle-based methods provide a convenient platform to model failure or fracture of these *** particle hydrodynamics(SPH)is one of such methods which demonstrate excellent potential for modelling failure or fracture of particulate composites in a Lagrangian *** of the major challenges in using SPH method for modelling composite materials depends on accurate and efficient way to treat interface and boundary *** this paper,a masterslave method based multi-freedom constraints is proposed to impose essential boundary conditions and interfacial displacement constraints in modelling mechanical behaviour of composite materials using SPH *** proposed methodology enforces the above constraints more accurately and requires only smaller condition number for system stiffness matrix than the procedures based on typical penalty function approach.A minimum cut-off value-based error criteria is employ.d.to improve the computational efficiency of the proposed *** addition,the proposed method is further enhanced by adopting a modified numerical interpolation scheme along the boundary to increase the accuracy and computational *** numerical examples demonstrate that the proposed master-slave approach yields better accuracy in enforcing displacement constraints and requires approximately the same computational time as that of penalty method.

关键词： Particulate composites SPH Essential boundary condition Multi-point constraints Master-slave method

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基于血清代谢组学探讨养筋解毒汤对糖尿病周围神经病变大鼠的作用机制

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世界中西医结合杂志 2024年第5期19卷 907-914,926页

作者：莫世安邱晓堂杨文奎吴英萍符杨浠吴小翠海南省中医院内分泌科海南海口570203

目的基于血清代谢组学研究养筋解毒汤治疗糖尿病周围神经病变(diabetic peripheral neuropathy.d.N)大鼠的作用机制。方法将24只SPF级雄性Sd大鼠按随机数字表法分为对照组、模型组、养筋解毒汤组,每组各8只,除对照组外,其余各组给予... 详细信息

目的基于血清代谢组学研究养筋解毒汤治疗糖尿病周围神经病变(diabetic peripheral neuropathy.d.N)大鼠的作用机制。方法将24只SPF级雄性Sd大鼠按随机数字表法分为对照组、模型组、养筋解毒汤组,每组各8只,除对照组外,其余各组给予大鼠高脂高糖饲料饲喂8周,之后腹腔注射链脲佐菌制备dPN模型,采用体质量、体长、BMI指数和空腹GLU水平验证模型,模型成功后继续高脂高糖饲料饲喂8周后给予相应药物灌胃给药,2次/d,连续8周。采用空腹GLU水平评价疗效,采集大鼠血液分离血清利用非靶向代谢组学技术,通过主成分分析(PCA)、正交偏最小二乘法判别分析(OPLS-dA),结合t检验、变量重要性投影及差异倍数值筛选差异代谢物及可能的代谢通路。结果经养筋解毒汤干预后与模型组比较,dPN大鼠血糖水平明显降低(Pyr)等148种代谢物水平发生变化,同时对类固醇激素生物合成、精氨酸和脯氨酸代谢、甘氨酸、丝氨酸和苏氨酸代谢等代谢通路产生影响。结论养筋解毒汤对dPN大鼠具有一定的治疗疗效,其机制可能与调节氨基酸及皮质激素代谢等有关。

关键词：糖尿病周围神经病变养筋解毒汤代谢组学代谢通路

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