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Evidence for particle acceleration approaching PeV energies in the W51 complex

Science Bulletin 2024年第18期69卷 2833-2841页

作者： Cao, Zhen Aharonian, F. Axikegu Bai, y.X. Bao, y.W. Bastieri, d. Bi, X.J. Bi, y.J. Bian, W. Bukevich, A.V. Cao, Q. Cao, W.y. Cao, Zhe Chang, J. Chang, J.F. Chen, A.M. Chen, E.S. Chen, H.X. Chen, Liang Chen, Lin Chen, Long Chen, M.J. Chen, M.L. Chen, Q.H. Chen, S. Chen, S.H. Chen, S.Z. Chen, T.L. Chen, y. Cheng, N. Cheng, y.d. cui, M.y. cui, S.W. cui, X.H. cui, y.d. dai, B.Z. dai, H.L. dai, Z.G. danzengluobu dong, X.Q. duan, K.K. Fan, J.H. Fan, y.Z. Fang, J. Fang, J.H. Fang, K. Feng, C.F. Feng, H. Feng, L. Feng, S.H. Feng, X.T. Feng, y. Feng, y.L. Gabici, S. Gao, B. Gao, C.d. Gao, Q. Gao, W. Gao, W.K. Ge, M.M. Geng, L.S. Giacinti, G. Gong, G.H. Gou, Q.B. Gu, M.H. Guo, F.L. Guo, X.L. Guo, y.Q. Guo, y.y. Han, y.A. Hasan, M. He, H.H. He, H.N. He, J.y. He, y. Hor, y.K. Hou, B.W. Hou, C. Hou, X. Hu, H.B. Hu, Q. Hu, S.C. Huang, d.H. Huang, T.Q. Huang, W.J. Huang, X.T. Huang, X.y. Huang, y. Ji, X.L. Jia, H.y. Jia, K. Jiang, K. Jiang, X.W. Jiang, Z.J. Jin, M. Kang, M.M. Karpikov, I. Kuleshov, d. Kurinov, K. Li, B.B. Li, C.M. Li, Cheng Li, Cong Li, d. Li, F. Li, H.B. Li, H.C. Li, Jian Li, Jie Li, K. Li, S.d. Li, W.L. Li, X.R. Li, Xin Li, y.Z. Li, Zhe Li, Zhuo Liang, E.W. Liang, y.F. Lin, S.J. Liu, B. Liu, C. Liu, d. Liu, d.B. Liu, H. Liu, H.d. Liu, J. Liu, J.L. Liu, M.y. Liu, R.y. Liu, S.M. Liu, W. Liu, y. Liu, y.N. Luo, Q. Luo, y. Lv, H.K. Ma, B.Q. Ma, L.L. Ma, X.H. Mao, J.R. Min, Z. Mitthumsiri, W. Mu, H.J. Nan, y.C. Neronov, A. Ou, L.J. Pattarakijwanich, P. Pei, Z.y. Qi, J.C. Qi, M.y. Qiao, B.Q. Qin, J.J. Raza, A. Ruffolo, d. Sáiz, A. Saeed, M. Semikoz, d. Shao, L. Shchegolev, O. Sheng, X.d. Shu, F.W. Song, H.C. Stenkin, yu.V. Stepanov, V. Su, y. Sun, d.X. Sun, Q.N. Sun, X.N. Sun, Z.B. Takata, J. Tam, P.H.T. Key Laboratory of Particle Astrophysics & Experimental Physics division & Computing Center Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China University of Chinese Academy of Sciences Beijing 100049 China TIANFU Cosmic Ray Research Center Chengdu China dublin Institute for Advanced Studies 31 Fitzwilliam Place 2 Dublin Ireland Max-Planck-Institut for Nuclear Physics P.O. Box 103980 Heidelberg 69029 Germany School of Physical Science and Technology & School of Information Science and Technology Southwest Jiaotong University Chengdu 610031 China School of Astronomy and Space Science Nanjing University Nanjing 210023 China Center for Astrophysics Guangzhou University Guangzhou 510006 China Tsung-dao Lee Institute & School of Physics and Astronomy Shanghai Jiao Tong University Shanghai 200240 China Institute for Nuclear Research of Russian Academy of Sciences Moscow 117312 Russia Hebei Normal University Shijiazhuang 050024 China University of Science and Technology of China Hefei 230026 China State Key Laboratory of Particle detection and Electronics China Key Laboratory of dark Matter and Space Astronomy & Key Laboratory of Radio Astronomy Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210023 China Research Center for Astronomical Computing Zhejiang Laboratory Hangzhou 311121 China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China School of Physics and Astronomy Yunnan University Kunming 650091 China Key Laboratory of Cosmic Rays (Tibet University) Ministry of Education Lhasa 850000 China National Astronomical Observatories Chinese Academy of Sciences Beijing 100101 China School of Physics and Astronomy (Zhuhai) & School of Physics (Guangzhou) & Sino-French Institute of Nuclear Engineering and Technology (Zhuhai) Sun Yat-sen University Zhuhai 519000 & Guangzhou 510275 Guangdong China Institute of Frontier and

The γ-ray emission from the W51 complex is widely acknowledged to be attributed to the interaction between the cosmic rays (CRs) accelerated by the shock of supernova remnant (SNR) W51C and the dense molecular clouds in the adjacent star-forming region, W51B. However, the maximum acceleration capability of W51C for CRs remains elusive. Based on observations conducted with the Large High Altitude Air Shower Observatory (LHAASO), we report a significant detection of γ rays emanating from the W51 complex, with energies from 2 to 200 TeV. The LHAASO measurements, for the first time, extend the γ-ray emission from the W51 complex beyond 100 TeV and reveal a significant spectrum bending at tens of TeV. By combining the "π0-decay bump" featured data from Fermi-LAT, the broadband γ-ray spectrum of the W51 region can be well-characterized by a simple pp-collision model. The observed spectral bending feature suggests an exponential cutoff at ∼400 TeV or a power-law break at ∼200 TeV in the CR proton spectrum, most likely providing the first evidence of SNRs serving as CR accelerators approaching the PeV regime. Additionally, two young star clusters within W51B could also be theoretically viable to produce the most energetic γ rays observed by LHAASO. Our findings strongly support the presence of extreme CR accelerators within the W51 complex and provide new insights into the origin of Galactic CRs. © 2024 Science China Press

关键词： Cosmic rays

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Metal-to-insulator transitions in 3d-band correlated oxides containing Fe compositions

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 48-59页

作者： yiping yu yuchen cui Jiangang He Wei Mao Jikun Chen Key Laboratory of Advanced Materials and devices for Post-Moore Chips Ministry of EducationUniversity of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Institute of Industrial Science The University of Tokyo4-6-1 KomabaMeguro-kuTokyo 153-8505Japan

Metal-to-insulator transitions (MITs),which are achieved in 3d-band correlated transitional metal oxides,trigger abrupt variations in electrical,optical,and/or magnetic properties beyond those of conventional *** such material families,iron(Fe:3d^(6)4s^(2))-containing oxides pique interest owing to their widely tunable MIT properties,which are associated with the various valence states of *** potential electronic applications also show promise,given the large abundance of Fe on *** MIT properties triggered by critical temperature (TMIT) were reported for ReFe_(2)O_(4)(Fe^(2.5+)),ReBaFe_(2)O_(5)(Fe^(2.5+)),Fe_(3)O_(4)(Fe^(2.67+)),Re_(1/3)Sr_(2/3)FeO_(3)(Fe^(3.67+)),Re Cu_(3)Fe_(4)O_(12)(Fe^(3.75+)),and Ca_(1-x)Sr_(x)FeO_(3)(Fe^(4+))(where Re represents rare-earth elements).The common feature of MITs of these Fe-containing oxides is that they are usually accompanied by charge ordering transitions or disproportionation associated with the valence states of ***,we review the material family of Fe-containing MIT oxides,their MIT functionalities,and their respective *** the perspective of potentially correlated electronic applications,the tunability of the TMITand its resultant resistive change in Fe-containing oxides are summarized and further compared with those of other materials exhibiting MIT *** particular,we highlight the abrupt MIT and wide tunability of TMITof Fe-containing quadruple perovskites,such as Re ***,their effective material synthesis still needs to be further explored to cater to potential applications.

关键词： metal-to-insulator transitions Fe-containing oxides charge ordering charge disproportionation

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Possible Habitats for NH_(3),NH_(2)d,H^(13)CN,HC^(15)N,SO,and C^(18)O in the Initial Conditions of High-mass Star Formation

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Research in Astronomy and Astrophysics 2024年第4期24卷 237-252页

作者： Quan-Ling cui Chuan-Peng Zhang Jun-Jie Wang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China College of Science Qiqihar UniversityQiqihar 161006China Guizhou Radio Astronomical Observatory Guizhou UniversityGuiyang 550000China

The initial condition of high-mass star formation is a complex area of study because of the high densities(n_(H_(2))>106cm^(-3))and low temperatures(T_(dust)<18 K)*** such conditions,many molecules become depleted fro... 详细信息

The initial condition of high-mass star formation is a complex area of study because of the high densities(n_(H_(2))>106cm^(-3))and low temperatures(T_(dust)ditions,many molecules become depleted from the gas phase by freezing out onto dust ***,the N-bearing and deuterated species could remain gaseous under these extreme conditions,suggesting that they may serve as ideal *** this paper,using the Plateau de Bure Interferometer and Very Large Array observations at 1.3 mm,3.5 mm,and 1.3 cm,we investigate the possible habitats for NH_(3),NH_(2)d,H^(13)CN,HC^(15)N,SO,and C^(18)O in eight massive precluster and protocluster clumps G18.17,G18.21,G23.97N,G23.98,G23.44,G23.97S,G25.38,and *** found that the NH3cores are in good agreement with the 3.5 mm peak emission,but the NH_(3)is much more extended than the 3.5 mm emission *** SO distributions agree well with the 3.5 mm peaks for the evolved star formation stage,but we did not detect any SO emission in the four earliest star formation sources.C^(18)O is a poor tracer in conditions of the cold(■18 K)and dense(■10^(4)cm^(-3))cores,e.g.,the prestellar *** also found that the NH_(2)d cores are mainly located in the temperature range of 13.0-20.0 K,and the NH_(2)d lines may be strongly.d.pleted above 20 K.

关键词： galaxies:star formation techniques:interferometric methods:observational

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Synthesis,Style Editing,and Animation of 3d Cartoon Face

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Tsinghua Science and Technology 2024年第2期29卷 506-516页

作者： Ming Guo Feng Xu Shunfei Wang Zhibo Wang Ming Lu Xiufen cui Xiao Ling School of Software and BNRist Tsinghua UniversityBeijing 100084China department of Multimedia and Smart Guangdong OPPO Mobile Telecommunications Corp.Ltd.Dongguan 523860China Intel Labs IntelBeijing 100089China

As a popular kind of stylized face,cartoon faces have rich application *** is challenging to create personalized 3d cartoon faces directly from 2d real ***,in order to adapt to more application scenarios,automatic style editing,and animation of cartoon faces is also a crucial problem that is urgently needed to be solved in the industry,but has not yet had a perfect *** solve this problem,we first propose“3d face cartoonizer”,which can generate high-quality 3d cartoon faces with texture when fed into 2d facial *** contribute the first 3d cartoon face hybrid dataset and a new training strategy which first pretrains our network with low-quality triplets in a reconstruction-then-generation manner,and then finetunes it with high-quality triplets in an adversarial manner to fully leverage the hybrid ***,we implement style editing for 3d cartoon faces based on k-means,which can be easily achieved without retrain the neural *** addition,we propose a new cartoon faces'blendshape generation method,and based on this,realize the expression animation of 3d cartoon faces,enabling more practical *** dataset and code will be released for future research.

关键词： cartoon 3d face animation computer graphics

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Femtosecond laser fabrication of 3d vertically aligned micro-pore network on thick-film Li_(4)Ti_(5)O_(12)electrode for high-performance lithium storage

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Journal of Energy Chemistry 2024年第8期95卷 250-262,I0006页

作者： Quansheng Li Xiaofei Sun Xuesong Mei Lingzhi Wang Minxing yang Jianlei cui Wenjun Wang State Key Laboratory for Manufacturing System Engineering Xi'an Jiaotong UniversityXi'an 710049ShaanxiChina Shaanxi Key Laboratory of Intelligent Robots Xi'an Jiaotong UniversityXi'an 710049ShaanxiChina School of Mechanical Engineering Xi'an Jiaotong UniversityXi'an 710049ShaanxiChina

The development of energy storage devices with high energy.d.nsity relies heavily on thick film electrodes,but it is challenging due to the limited ion transport kinetics inherent in thick ***,we report on the preparation of a directional vertical array of micro-porous transport networks on LTO electrodes using a femtosecond laser processing strategy,enabling directional ion rapid transport and achieving good electrochemical performance in thick film *** three-dimensional(3d)vertically aligned micro-pore networks are innovatively.d.signed,and the structure,kinetics characteristics,and electrochemical performance of the prepared ion transport channels are analyzed and discussed by multiple characterization and testing ***,the rational mechanisms of electrode performance improvement are studied experimentally and simulated from two aspects of structural mechanics and transmission *** ion diffusion coefficient,rate performance at 60 C,and electrode interface area of the laser-optimized 60-15%micro-porous transport network electrodes increase by 25.2 times,2.2 times,and 2.15 times,respectively than those of untreated ***,the preparation of 3d micro-porous transport networks by femtosecond laser on ultra-thick electrodes is a feasible way to develop high-energy *** addition,the unique micro-porous transport network structure can be widely extended to design and explore other high-performance energy materials.

关键词： Femtosecond laser Micro-porous transport networks Laser processing Thick film electrodes Ion transport kinetics

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High-resolution remote thermometry based on Bi^(3+)-doped 0d zinc halide hybrids

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Science China Chemistry 2024年第8期67卷 2599-2605页

作者： cui-Mi Shi Shu-Hua Xue Jin-yun Wang Liang-Jin Xu Zhong-Ning Chen State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian Science Technology Innovation Laboratory for Optoelectronic Information of ChinaFuzhou 350108China University of Chinese Academy of Sciences Beijing 100049China

developing highly sensitive optical thermometers is of great significance due to their capability to enable remote and non-contact temperature measurements, rendering them highly applicable in diverse and harsh environments. Herein we report a temperature-dependent phosphor of 0d metal halide hybrid by incorporating Bi^(3+)into the(MePPh_(3))_(2)ZnCl_(4) matrix. Through Bi^(3+)doping,the initially non-luminescent(MePPh_(3))_(2) ZnCl_(4) matrix exhibits a deep-blue emission centered at 453 nm, with a photoluminescence quantum yield(PLQy) of 5.71% and a Stokes shift of 75 nm at room temperature. Experimental characterization demonstrates that exciton-like luminescence of Bi^(3+)is mainly responsible for the blue emission. Single crystals of Bi^(3+)-doped(MePPh_(3))_(2)ZnCl_(4) show an unusual correlation between photoluminescence(PL) lifetime and temperature. Particularly, the dependence of luminescence lifetime on temperature is most remarkable in the temperature range of 80 to 100 K with an exceptional sensitivity up to 0.09 K^(-1), representing one of the best levels for thermometry based on PL decay lifetime. Our work not only provides a viable strategy for designing a novel, environmentally friendly, and stable blue emitter, but also paves the way for precise thermometric application at low temperature.

关键词： lead-free hybrids Bi^(3+)doping blue emission temperature sensing

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Hernandezine promotes cancer cell apoptosis and disrupts the lysosomal acidic environment and cathepsin d maturation

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Chinese Journal of Natural Medicines 2024年第5期22卷 387-401页

作者： FENG Qianwen SUN Lu Muhammad Jibran Sualeh ZHAO Qingli ZHAO Songji cui Zhengguo INAdERA Hidekuni department of Public Health Graduate School of Medicine and Pharmaceutical SciencesUniversity of ToyamaToyama 930-8501Japan department of Pediatric Cardiology Heart CenterGuangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510000China department of Basic Medical Sciences College of MedicineUniversity of SharjahSharjah 57545United Arab Emirates department of Radiology Graduate School of Medicine and Pharmaceutical SciencesUniversity of ToyamaToyama 930-8501Japan Advanced Clinical Research Center Fukushima Global Medical Science CenterFukushima Medical UniversityFukushima CityFukushima 960-8074Japan department of Environmental Health School of Medical SciencesUniversity of FukuiFukui 910-8580Japan

Hernandezine(Her),a bisbenzylisoquinoline alkaloid extracted from Thalictrum flavum,is recognized for its range of biological activities inherent to this herbal *** its notable properties,the anti-cancer effects of Her have remained largely *** this study,we elucidated that Her significantly induced cytotoxicity in cancer cells through the activation of apoptosis and necroptosis ***,Her triggered autophagosome formation by activating the AMPK and ATG5 conjugation systems,leading to LC3 *** findings revealed that Her caused damage to the mitochondrial membrane,with the damaged mitochondria undergoing mitophagy,as evidenced by the elevated expression of mitophagy ***,Her disrupted autophagic flux,demonstrated by the upregulation of p62 and accumulation of autolysosomes,as observed in the RFP-GFP-LC3 reporter ***,we determined that Her did not prevent the fusion of autophagosomes and ***,it inhibited the maturation of cathepsin d and increased lysosomal pH,indicating an impairment of lysosomal *** use of the early-stage autophagy inhibitor,3-methyladenine(3-MA),did not suppress LC3II,suggesting that Her also induces noncanonical autophagy in autophagosome *** application of Bafilomycin A1,an inhibitor of noncanonical autophagy.d.minished the recruitment of ATG16L1 and the accumulation of LC3II by Her,thereby augmenting Her-induced cell *** observations imply that while autophagy initially plays a protective role,the disruption of the autophagic process by Her promotes programmed cell *** study provides the first evidence of Her’s dual role in inducing apoptosis and necroptosis while also initiating and subsequently impairing autophagy to promote apoptotic cell *** insights contribute to a deeper understanding of the mechanisms underlying programmed cell death,offering potential avenues for enhancing cancer prevention and therapeutic st

关键词： Hernandezine Apoptosis Mitophagy Autophagic flux Lysosome Noncanonical autophagy

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Ultrafast micro/nano-manufacturing of metastable materials for energy

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National Science Review 2024年第4期11卷 283-298页

作者： Xiaoya cui yanchang Liu yanan Chen School of Materials Science and Engineering Key Laboratory of Advanced Ceramics and Machining Technology(Ministry of Education) and Tianjin Key Laboratory of Composite and Functional MaterialsTianjin University Ministry of Education Key Laboratory of Protein Sciences School of Life SciencesTsinghua University

The structural engineering of metastable nanomaterials with abundant defects has attracted much attention in energy-related fields. The high-temperature shock(HTS) technique, as a rapidly.d.veloping and advanced synthesis strategy, offers significant potential for the rational design and fabrication of high-quality nanocatalysts in an ultrafast, scalable, controllable and eco-friendly way. In this review, we provide an overview of various metastable micro-and nanomaterials synthesized via HTS, including single metallic and bimetallic nanostructures, high entropy alloys, metal compounds(e.g. metal oxides) and carbon nanomaterials. Note that HTS provides a new research dimension for nanostructures, i.e. kinetic modulation. Furthermore, we summarize the application of HTS—as supporting films for transmission electron microscopy grids—in the structural engineering of 2d materials, which is vital for the direct imaging of metastable materials. Finally, we discuss the potential future applications of high-throughput and liquid-phase HTS strategies for non-equilibrium micro/nano-manufacturing beyond energy-related *** is believed that this emerging research field will bring new opportunities to the development of nanoscience and nanotechnology in both fundamental and practical aspects.

关键词： high-temperature shock technique defect engineering metastable phase kinetic modulation non-equilibrium micro/nano-manufacturing

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Numerical analysis of high‑speed railway slab tracks using calibrated and validated 3d time‑domain modelling

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Railway Engineering Science 2024年第1期32卷 36-58页

作者： A.F.Esen O.Laghrouche P.K.Woodward d.Medina‑Pineda Q.Corbisez J.y.Shih d.P.Connolly Institute for High‑Speed Rail and System Integration University of LeedsLeeds LS29JTUK Institute for Infrastructure and Environment Heriot-Watt UniversityEdinburgh EH144ASUK Alstom Transport Saint‑OuenFrance Birmingham Centre for Railway Research and Education University of BirminghamBirmingham B152TTUK

Concrete slabs are widely used in modern railways to increase the inherent resilient quality of the tracks,provide safe and smooth rides,and reduce the maintenance *** this paper,the elastic performance of a novel slab trackform for high-speed railways is investigated using three-dimensional finite element modelling in *** is then compared to the performance of a ballasted ***,slab and ballasted track models are developed to replicate the full-scale testing of track *** the models are calibrated with the experimental results,the novel slab model is developed and compared against the calibrated slab track *** slab and ballasted track models are then extended to create linear dynamic models,considering the track geodynamics,and simulating train passages at various speeds,for which the Ledsgard documented case was used to validate the *** travelling at low and high speeds are analysed to investigate the track deflections and the wave propagation in the soil,considering the issues associated with critical *** train loading methods are discussed,and the most practical approach is retained and ***,correlations are made between the geotechnical parameters of modern high-speed rail and conventional *** is found that considering the same ground condition,the slab track deflections are considerably smaller than those of the ballasted track at high speeds,while they show similar behaviour at low speeds.

关键词： High-speed railways Slab track New ballastless track Ballasted track Critical speeds Finite element modelling Calibration of numerical models

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Eco-friendly high-throughput screening of cephalosporins impurities: Utilizing 2d-carbon microfiber fractionation system combined with quadrupole time of flight high-resolution mass spectrometer

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Journal of Pharmaceutical Analysis 2024年第5期14卷 772-774页

作者： Lei yang yan Wang Zhao Wang Meiyu cui Ruolan Jin Hai-Bo Shang donghao Li College of Pharmacy Yanbian UniversityYanjiJilin133002China department of Chemistry Interdisciplinary Program of Biological Functional MoleculesCollege of Integration ScienceYanbian UniversityYanjiJilin133002China

Owing to its high sensitivity,selectivity,and accuracy,liquid chromatography coupled with mass spectrometry(LC-MS)is commonly employ.d.to screen,confirm,and quantify impurities in drugs[1].However,LC-MS has certain drawbacks such as complicated pretreatment steps,long analysis time,large consumption of organic solvents,high maintenance costs,and,most notably,the need for high-pressure pumps and compatible hardware because of the high column backpressure[2].In this study,a two-dimensional(2d)microscale carbon fiber(CF)/active carbon fiber(ACF)system combined with a quadrupole time-of-flight high-resolution mass spectrometry(2dmCFs-QTOF-HRMS)system was developed to rapid screening impurities in the typical three generations of oral cephalosporins,i.e.,cephalexin tablets(CPXTs),cefuroxime axetil tablets(CFATs),and cefixime tablets(CFXTs)(Fig.S1).The“fuzzy chromatographic separation”sample pretreatment method separates complex samples into high-,medium-,and weak-polar fractions for successive detection of MS,achieving effective reduction of the ion suppression effect in electrospray ionization(ESI)-MS and improving the MS detection *** to high performance liquid chromatography(HPLC)-MS,this method has distinct advantages such as less organic solvent consumption(1.5 mL),shorter separation and analysis times(5 min),more information on impurities,and high reproducibility.

关键词： system carbon tablets

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