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Safety and Efficacy of Cefovecin (Convenia<sup>®</sup>) as an Adjunctive Treatment of Periodontal Disease in Dogs

Open Journal of Veterinary Medicine 2012年第3期2卷 89-97页

作者： Henry Giboin csilla becskei Jacky Civil Michael R. Stegemann Veterinary Medicine Research & Development Pfizer Animal Health Zaventem Belgium

This study was designed to determine the safety and efficacy of cefovecin (Convenia?;Pfizer Animal Health) when compared to clindamycin (Antirobe?;Pfizer Animal Health) as an adjunctive therapy to periodontal scaling or surgery for severe periodontal disease in dogs. A multi-centre, double-masked, randomised study was conducted in 299 dogs with severe periodontal disease. Clindamycin, administered once daily at 11 mg/kg bodyweight orally for 10 days following dental surgery was compared with a single, subcutaneous injection of cefovecin (8 mg/kg bodyweight) administered at the time of dental surgery. The primary efficacy parameter assessed was percentage of tooth-root sites bleeding when probed (an indicator of gingival inflammation) 42 days after surgery. Two-hundred and ninety-one (291) dogs were included in the efficacy assessments. Cefovecin was shown to be non-inferior to clindamycin. The percentage of sites bleeding on probing was reduced from 54.3% to 20.3% for the cefovecin group (53.1% reduced to 17.4% for the clindamycin group). There were no suspected adverse drug experiences attributed to treatment with cefovecin or clindamycin. Cefovecin was shown to be as effective and safe adjunctive treatment for severe periodontal disease in dogs undergoing periodontal scaling and surgery as clindamycin.

关键词： Canine Antibiotics Dentistry Porphyromonas gulae Prevotella intermedia

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Palatability Testing of Oral Chewables in Veterinary Medicine for Dogs

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Open Journal of Veterinary Medicine 2018年第8期8卷 107-118页

作者： Michelle Aleo Stacy Ross csilla becskei Eileen Coscarelli Vickie King Mary Darling Julie Lorenz VMRD Global Therapeutics Zoetis Kalamazoo MI USA VMRD Lab Sciences Zoetis Kalamazoo MI USA VMRD Global Therapeutics Zoetis Zaventem Belgium VMRD Global Development and Operations Zoetis Kalamazoo MI USA

For veterinary medications administered per os, animal health companies strive to develop highly palatable dosage forms that are voluntarily accepted by animals to improve compliance and convenience. Achieving high palatability is often complex and difficult even without the presence of an active ingredient. This work compared acceptance and preference studies, as standardized methods are not established for informing formulation development or for more routine testing. Formulation development was followed by an acceptance study completed with laboratory Beagle dogs. One acceptance study and one preference study were completed in mixed breed dogs, also laboratory-housed, to gain wider representation of dog breed and age. Through these studies, we have evaluated both formulation parameters and palatability study conduct. In general, more complex palatants that have appealing taste, smell, and mouth feel enhance voluntary uptake. However, dosage forms that are too chewy may not be freely consumed even with complex palatants. The addition of aroma can entice dogs to prehend the tablet, as observed in one preference study. Preference studies in the veterinary pharmaceutical field identify the preferred first choice or first prehend, but not which product will be routinely voluntarily and fully consumed. Acceptance studies with cross-over treatment groups are used to quantify the full consumption of a dosage form when a dog is not given two choices at once. Since all dogs in acceptance studies are offered all treatment groups throughout the study, a comparison between degrees of consumption could suggest that one formulation might be preferred over another.

关键词： Palatability Acceptance Preference Dog Veterinary

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