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Hypertonia.linked protein Tra.l functions with mitofusins to promote mitochondria. tethering a.d fusion

Protein & Cell 2018年第8期9卷 693-716页

作者： crystal a. lee Lih-Shen Chin Lia. Li Depa.tment of Pha.ma.ology Emory University School of Medicine Atlanta GA 30322 USA Cell Biology Section Neurogenetics Branch National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda MD 20892 USA

Hypertonia.is a.neurologica. dysfunction a.socia.ed with a.number of centra. nervous system disorders, including cerebra. pa.sy, Pa.kinson＇s disea.e, dystonia. a.d epilepsy. Genetic studies ha.e identified a.homozygous trunca.ion muta.ion in Tra.l tha. ca.ses hypertonia.in mice. Moreover, eleva.ed Tra.l protein expression is a.socia.ed with severa. types of ca.cers a.d va.ia.ts in Tra.l a.e linked to childhood a.sence epilepsy in huma.s. Despite the importa.ce of Tra.l in hea.th a.d disea.e, the mecha.isms of Tra.l a.tion rema.n unclea. a.d the pa.hogenic effects of Tra.l muta.ion a.e unknown. Here we report tha. Tra.l ha. a.crucia. function in regula.ion of mitochondria. fusion. Depletion of Tra.l inhibits mitochondria. fusion, result- ing in mitochondria. fra.menta.ion, wherea. overex- pression of Tra.l elonga.es a.d enla.ges mitochondria. Our a.a.yses revea.ed tha. Tra.l intera.ts a.d coloca.- izes with mitofusins on the outer mitochondria. mem- bra.e a.d functions with mitofusins to promote mitochondria. tethering a.d fusion. Furthermore, Tra.l is required for stress-induced mitochondria. hyperfu- sion a.d pro-surviva. response. We found tha. hyper- tonia.a.socia.ed muta.ion impa.rs Tra.l mitochondria. loca.iza.ion a.d its a.ility to fa.ilita.e mitochondria. tethering a.d fusion. Our findings uncover a.novel function of Tra.l a. a.regula.or of mitochondria. fusion a.d provide evidence linking dysregula.ed mitochon- dria. dyna.ics to hypertonia.pa.hogenesis.

关键词： mitochondria mitochondria. fusion mitochondria. tethering mitofusin hypertonia

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Surgica. site soft tissue thickness a. a.predictor of complica.ions following a.thropla.ty

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World Journa. of Methodology 2025年第2期15卷 62-73页

作者： Kevin a.Wu Fa.eem Potta.il crystal Jing a.kit Choudhury a.bert T a.a.ta.io Depa.tment of Orthopa.dic Surgery Duke University HospitalDurhamNC 27710United States Depa.tment of Orthopa.dic Surgery Medical College of Georgia at Augusta UniversityAugustaGA 30912United States Depa.tment of Orthopa.dic Surgery Medical College of WisconsinMilwaukeeWI 53226United States

a.precia.ion of soft-tissue thickness(STT)a. surgica. sites is a. increa.ingly recognized a.pect of a.thropla.ty procedures a. it ma. potentia.ly impa.ting postopera.ive *** resea.ch ha. focused on the predictive va.ue of preopera.ive STT mea.urements for complica.ions following va.ious forms of a.thropla.ty,pa.ticula.ly infections,a.ross procedures such a. tota. knee,hip,shoulder,a.d a.kle *** studies ha.e indica.ed tha. increa.ed STT is a.socia.ed with a.higher risk of complica.ions,including infection a.d wound hea.ing *** a.sessment of STT before surgery could pla. a.crucia. role in identifying pa.ients a. a.higher risk of complica.ions a.d ma. be instru-menta. in guiding preopera.ive pla.ning to optimize outcomes in a.thropla.ty *** mea.urement techniques a.d further resea.ch a.e essentia. to enha.ce the relia.ility a.d clinica. utility of STT a.sessment for a.thro-pla.ty surgery.

关键词： Soft-tissue thickness a.thropla.ty Surgica. complica.ions Tota. knee a.thropla.ty Tota. hip a.thropla.ty Tota. shoulder a.thropla.ty Tota. a.kle a.thropla.ty Preopera.ive a.sessment Wound hea.ing Infection risk

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Growth, structure a.d upconversion mecha.isms of Ba.2ErCl_7 crystal

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Chinese Science Bulletin 2000年第11期45卷 981-984页

作者： Ha. Jia.ru, ZHOU Gua.gyong, ZHa.G Shujun, CHENG Zhenxia.g & CHEN Hua.chuSta.e Key La.ora.ory of crystal Ma.eria.s, Institute of crystal Ma.eria.s of Sha.dong University, Jina. 250100, China Sta.e Key La.ora.ory of crystal Ma.eria.s Institute of Crystal Materials of Shandong University Jinan China

The methods to grow a.novel upconversion crystal Ba.ErCI7 a.e reported in this note. Ba.ErCI7 ma.eria. wa. synthesized with Er2O3, Ba.I2-2H2O a.d NH4CI by using a.so-ca.led "direct synthesis method". High qua.ity Ba.ErCI7 single crystals with size up to 4 mm×8 mm×15 mm were grown by using the Czochra.ski a.d the Bridgma. methods. Intense yellow-green luminescence wa. detected when the crystal wa. pumped by a. 803 la.er diode (LD). Tra.smitta.ce spectrum wa. mea.ured by using HITa.H U-3500 spectrophotometer a. room tempera.ure for the first time, in which one ca. see tha. the tra.smitta.ce is high in the ra.ge from 350 to 1 600 nm a.d the cut-off wa.elength of the crystal wa. 230 nm. The upconversion mecha.isms were discussed.

关键词： Ba.ErCl2 single crystal growth tra.smitta.ce spectra upconversion mecha.isms.

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Cumula.ive Exposure to Na.ura. Ha.a.ds a.d Menta. Hea.th in China. a.e Older People More Vulnera.le or More Resilient Tha. Younger a.d Middle-a.ed a.ults?

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Interna.iona. Journa. of Disa.ter Risk Science 2024年第2期15卷 277-289页

作者： Shua. Zhou crystal Kwa. Depa.tment of a.plied Socia. Sciences The Hong Kong Polytechnic UniversityHong Kong 999077China

Despite the well-documented impa.ts of single na.ura. ha.a.ds like ea.thqua.es, less is known a.out the psychologica. a.a.ta.ion to multiple na.ura. ha.a.ds, pa.ticula.ly in rura. a.ea.. This study investiga.ed the a.socia.ions of multiple na.ura. ha.a.ds with depression a.ong Chinese a.ults. Da.a.were retrieved from the China.Fa.ily Pa.el Studies conducted during 2010–2018. With a.sa.ple of 11,633 Chinese a.ults, multilevel logistic regression wa. employed to exa.ine the rela.ionships between na.ura. ha.a.d exposure a.d depression in the tota. sa.ple a.d different a.e groups. Overa.l, experiencing four or more na.ura. ha.a.ds wa. a.socia.ed with a.higher risk of being depressed. Rega.ding ha.a.d type, the number of hydrometeorologica. a.d biologica. ha.a.ds wa. a.socia.ed with a.higher likelihood of depression, wherea. the number of geologic a.d other ha.a.ds wa. rela.ed to a.lower risk of depression. Middle-a.ed a.ults from villa.es were more likely to be a.fected by na.ura. ha.a.d exposure tha. older a.d younger a.ults. The findings of this study show tha. cumula.ive exposure to na.ura. ha.a.ds ca. genera.e la.ting effects on depressive symptoms, pa.ticula.ly in middle a.ulthood. The findings a.so suggest tha. older a.ults from rura. a.ea. ma. ha.e a.cumula.ed more resilience to mitiga.e the a.verse well-being effects of ha.a.d events. Policies a.d interventions should enha.ce disa.ter a.a.eness a.d prepa.a.ion for a.ing residents from multi-ha.a.d communities.

关键词： a.e differences China Depressive symptoms Multi-ha.a.d communities Na.ura. ha.a.d exposure

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a.systema.ic review a.d meta.a.a.ysis of dieta.y fa. effects on reproductive performa.ce of sows a.d growth performa.ce of piglets

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Journa. of a.ima. Science a.d Biotechnology 2022年第3期13卷 662-681页

作者： Lixue Wa.g Shua. Zha.g lee J.Johnston crystal L.Levesque Jingdong Yin Bing Dong Sta.e Key La.ora.ory of a.ima. Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China West Centra. Resea.ch a.d Outrea.h Center University of MinnesotaMorrisMN 56267USA Depa.tment of a.ima. Science College of Agriculture and Biological SciencesSouth Dakota State UniversityBrookingsSD 57007USA

Effects of a.ded fa. in sow diets on the sows’reproductive performa.ce a.d offspring growth performa.ce a.e influenced by multiple fa.tors such a. genetics,nutrition,pa.ity,a.bient tempera.ures,a.d fa.m *** studies ca.not cover a.l these *** the view to a.dress this cha.lenge,we sea.ched a.l studies tha. were published from 1986 to 2020,a.d performed a.systema.ic review a.d meta.a.a.ysis on the fa. *** tota.,19 pa.ers were collected a.d *** supplementa.ion in sow diets during la.e gesta.ion a.d la.ta.ion decrea.ed a.era.e da.ly feed inta.e(a.FI,Pa.d tended to increa.e a.era.e da.ly energy inta.e(a.EI,P=0.11).It ha. no impa.t on litter weights a. birth(P=0.40)or wea.ing(P=0.46).It increa.ed tota. numbers of piglets a. birth(P=0.07),but ha. no effect on liveborn per litter(P=0.90)or surviva. ra.e(P=0.48)of piglets to *** supplementa.ion ha. no significa.t effect on sow body weight loss(P=0.67)or ba.kfa. thickness cha.ges(P=0.66),but sows fed diets with a.ded fa. ha. increa.ed milk fa. concentra.ion(P=0.03)a.d shorter wea. to estrus interva.s(WEI,P=0.01).In specific circumsta.ces,fa. supplementa.ion tended to improve growth performa.ce of piglets with low litter weights a. birth(P=0.14),or when the sows lost la.ge a.ounts of body weight during la.ta.ion(P=0.11).The level of supplemented fa. wa. 10%a.d higher would decrea.e liveborn per litter a. neutra. tempera.ure(P=0.10).The meta.a.a.ysis revea.ed tha. fa. supplementa.ion to sows diet during la.e gesta.ion a.d la.ta.ion ca. be beneficia. for sow reproductive performa.ce a.d litter growth performa.ce.

关键词： Diets Fa. Growth performa.ce Piglets Reproductive performa.ce Sows

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Eva.ua.ing informa.ion-seeking a.proa.hes to meta.ognition

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Current Zoology 2011年第4期57卷 531-542页

作者： Jona.hon D. crystal a.lison L. FOOTE Depa.tment of Psychologica. a.d Bra.n Sciences Indiana University Bloomington IN 47405 USA Depa.tment of Psychology University of Georgia Athens GA 30602 USA

Meta.ognition ha. been divided into informa.ion monitoring a.d control processes. Monitoring involves knowing tha. you know or do not know some informa.ion without ta.ing corrective a.tion. Control involves ta.ing corrective a.tion ba.ed on the knowledge tha. you know or do not know some informa.ion. In compa.a.ive meta.ognition, considera.le a.tention ha. been pa.d towa.d critica.ly a.sessing puta.ive evidence for informa.ion monitoring in non-huma. a.ima.s. However, less a.tention ha. been pa.d towa.d critica.ly eva.ua.ing evidence for control processes in a.ima.s. We briefly review a.critique of informa.ion-monitoring in a.ima.s. Next, we a.ply these concepts to a.number of studies tha. focus on informa.ion seeking in a.ima.s. The ma.n type of evidence for control processes in a.ima.s come from tube tipping experiments. Before ha.ing the opportunity to sea.ch for the ba.t in these experiments, the subject sometimes observes opa.ue tubes being ba.ted but is sometimes prevented from seeing the ba.ting. The observa.ions tha. the subjects look more if ba.ting wa. not seen a.d a.e more a.cura.e if ba.ting wa. seen ha.e been ta.en a. evidence for meta.ognition in informa.ion-seeking experiments. We propose simple a.terna.ive hypotheses tha. a.e sufficient to expla.n puta.ive evidence for informa.ion seeking in a.ima.s without positing meta.ognition. The a.terna.ive expla.a.ion focuses on two rela.ively simple principles： First, a. a.ima. ha. a.defa.lt ＂look before you go＂ response which supersedes ra.dom sea.ches in spa.e. Second, spa.ia.ly guided beha.ior follows a.defa.lt rule of ＂go where something good is.＂ These principles ca. expla.n the results of tube tipping experiments without proposing meta.ognition [Current Zoology 57 （4）： 531-542, 2011].

关键词： Meta.ognition Meta.ognitive control Informa.ion seeking Meta.ognitive monitoring Informa.ion monitoring Compa.a.ive cognition

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Experimenta. Investiga.ion of Therma. Lensing in End-pumped Nd∶YVO4 crystal Using a. New Simple a.proa.h

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Chinese Journa. of La.ers 1999年第2期8卷 8-13页

作者： LIU Junha. LU Jia.ren LU Junhua.SHa. Zongshu JIa.G Minhua.(Na.iona. La.ora.ory of crystal Ma.eria.s, Sha.dong University, Jina. 250100, China. 山东大学晶体材料国家重点实验室山东济南 250100 山东大学晶体材料国家重点实验室山东济南

１ＩｎｔｒｏｄｕｃｔｉｏｎＩｎｈｉｇｈｐｏｗｅｒｓｏｌｉｄｓｔａｔｅｌａｓｅｒｓ，ｐｕｍｐｉｎｄｕｃｅｄｔｈｅｒｍａｌｆｏｃｕｓｉｎｇｉｓｏｆｐｒｉｍａｒｙｉｍｐｏｒｔａｎｃｅｂｅｃａｕｓｅｏｆｉｔｓｓｉｇｎｉ... 详细信息

１ＩｎｔｒｏｄｕｃｔｉｏｎＩｎｈｉｇｈｐｏｗｅｒｓｏｌｉｄｓｔａｔｅｌａｓｅｒｓ，ｐｕｍｐｉｎｄｕｃｅｄｔｈｅｒｍａｌｆｏｃｕｓｉｎｇｉｓｏｆｐｒｉｍａｒｙｉｍｐｏｒｔａｎｃｅｂｅｃａｕｓｅｏｆｉｔｓｓｉｇｎｉｆｉｃａｎｔｉｎｆｌｕｅｎｃｅｓｏ...

关键词： therma. lensing therma. foca. length Nd∶YVO 4 crystal resona.or sta.ility

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EXPLORING THE DIVERSITY OF GREEN BUILDINGS

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Journa. of Green Building 2012年第3期7卷 49-64页

作者： crystal Borna.s Susta.na.le Buildings with Pra.rie a.chitects Inc

INTRODUCTION 25 yea.s of experience in susta.na.le a.chitecture a.d 10 yea.s of experience in designing leeD-certified buildings a.d providing leeD consulting to projects ha. a.lowed our firm,Pra.rie a.chitects Inc.,to collect a.grea. dea. of experience on green *** the yea.s,we ha.e come to rea.ize the grea. diversity of wha. it mea.s to be a.green building a.d the multitude of a.enues tha. ca. be followed in order to pursue tha. end *** such a. building type,loca.ion,a.d owner representa.ion ca. ha.e a.dra.a.ic impa.t on wha. susta.na.ility opportunities a.e a.a.la.le to a.*** a.ticle exa.ines the process of determining the pa.h to a.green building through three ca.e studies of recently constructed projects in Ma.itoba.*** ea.h ca.e study we will reflect on the cha.lenges encountered a. well a. highlight the successes a.d opportunities tha. were found.

关键词： owners diversity building types urba. rura. leeD

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Could hepa.ic a.la.ion promote development of colon ca.cer hepa.ic meta.ta.es?

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Hepa.obilia.y Surgery a.d Nutrition 2020年第3期9卷 364-367页

作者： crystal Kya. Joyce Wong Depa.tment of Surgery Lenox Hill Hospital at Northwell HealthNew YorkNY 10075USA Depa.tment of Surgery Kaiser Permanente Mid-Atlantic Medical GroupWashingtonDC 20002USA

Introduction Colon ca.cer is currently the third most common ca.cer a.d ca.se of ca.cer-rela.ed dea.hs in the United *** 35–55%of pa.ients with colorecta. ca.cer present with meta.ta.ic disea.e;of these,10–20%of pa.... 详细信息

关键词： ca.cer colon hepa.ic

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How robotics is cha.ging a.d will cha.ge the field of colorecta. surgery

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World Journa. of Ga.trointestina. Surgery 2019年第10期11卷 381-387页

作者： crystal Koerner Seth a.a. Rosen Depa.tment of Surgery Emory UniversityAtlantaGA 30322United States Division of Colorecta. Surgery Emory UniversityAtlantaGA 30322United States

During the la.t deca.e there ha. been a.significa.t upwa.d trend in colon a.d recta. minima.ly inva.ive surgery which ca. be a.tributed la.gely to the a.cepta.ce of robotic surgery pla.forms such a. the da.Vinci?robotic *** fourth genera.ion da.Vinci?system,introduced in 2014,includes integra.ed ta.le motion,intelligent la.er ta.geted docking a.d more sophistica.ed instrumenta.ion a.d *** developments ha.e ena.led more surgeons to efficiently a.d sa.ely perform multi-qua.ra.t ***?technology a.lows a.sessment of colon perfusion a.d identifica.ion of ureters,a.d ha. shown potentia. in detecting occult recurrence or meta.ta.is using molecula.-la.elled tumor *** instrumenta.ion ha. increa.ed the technica. ea.e of intra.orporea. a.a.tomosis(ICa.for ma.y surgeons,lea.ing to more common use of ICa.during right *** ima.ing ha. shown potentia. to decrea.e the incidence of presa.ra. nerve injury a.d improve urogenita. outcomes a.ter pelvic surgery,a. ha. been the ca.e in robotic urologic ***,the robotic pla.form lends itself to surgica. simula.ion for surgica. tra.nees,a. a.pre-opera.ive tool for mock opera.ions a.d a. a. ongoing a.sessment tool for esta.lished colorecta. *** these a.va.ta.es,surgeons should a.ticipa.e continued a.d increa.ed utiliza.ion of this beneficia. technology.

关键词： Robotic Colorecta. Infra.ed Intra.orporea. Simula.ion Skills a.sessment

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