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Physio-chemical modeling of the NO_(x)-O_(3) photochemical cycle and the air pollutants’ reactive dispersion around an isolated building

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Building Simulation 2023年第9期16卷 1735-1758页

作者： yunfei Fu Xisheng lin Xing Zheng liangzhu Wang Chun-Ho liu Xuelin Zhang cruz y.li K.T.Tse Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Future Cities Lab Global Singapore-ETH CentreSingapore 138602 Department of Building Civil and Environmental Engineering at Concordia UniversityMontrealQuebecCanada Department of Mechanical Engineering The University of Hong KongPok-fu-lam RoadHong KongChina Department of Civil Engineering Chongqing UniversityChongqingChina School of Atmospheric Sciences Sun Yat-sen UniversityZhuhaiChina

A numerical physio-chemical model of the NO_(x)-O_(3) photochemical cycle in the near-wake region of an isolated residential/office building has been presented in this *** investigation delves into the dispersion of reactive air pollutants through the lens of fluid phenomenology and its impact on chemical reactivity,formation,transport,deposition,and *** fluid dynamics(CFD)simulations were conducted for the ground-point-source(GES)and roof-pointsource(RES)*** show that the Damköhler number(Da),which quantifies pollutants’physio-chemical timescales,displays a strong inverse proportionality with the magnitude and spread of NO–increasing Da reduces human exposure to the toxic NO and NO_(2) *** different wind directions were considered,the dispersion range of NO exhibited varying shrinking directions as Da ***,as Da increases,the concentration ratio KNO_(2)/KNO_(x),which quantifies the production of NO_(2) resulting from NO depletion,forms sharp high-low gradients near emission *** GES,the dispersion pattern is governed by the fluid’s phenomenological *** RES,the intoxicated area emanates from the building’s leading-edge,with the lack of shielding inhibiting pollutant interactions in the near-wake,resulting in scant physio-chemical *** NO_(2)/NO_(x) distribution follows a self-similar,stratified pattern,exhibiting consistent layering gradients and attributing to the natural deposition of the already-reacted pollutants rather than in-situ *** the end,building design guidelines have been proposed to reduce pedestrian and resident exposure to NO_(x)-O_(3).

关键词： reactive pollutant dispersion NO_(x)-O_(3)cycle air pollution isolated building physio-chemical modelling

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TiN Paper for Ultrafast-Charging Supercapacitors

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Nano-Micro Letters 2020年第1期12卷 27-39页

作者： Bin yao Mingyang li Jing Zhang Lei Zhang yu Song Wang Xiao Andrea cruz yexiang Tong yat li Department of Chemistry and Biochemistry University of CaliforniaSanta CruzSanta CruzCA 95064USA KLGHEI of Environment and Energy Chemistry MOE of the Key Laboratory of Bioinorganic and Synthetic ChemistrySchool of Chemistry and Chemical EngineeringSun Yat-Sen UniversityGuangzhou 510275People’s Republic of China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China

Ultrafast-charging energy storage devices are attractive for powering personal electronics and electric *** ultrafast-charging devices are made of carbonaceous materials such as chemically converted graphene and carbon ***,their relatively low electrical conductivity may restrict their performance at ultrahigh charging ***,we report the fabrication of a porous titanium nitride(TiN)paper as an alternative electrode material for ultrafast-charging *** TiN paper shows an excellent conductivity of 3.67×104 S m−1,which is considerably higher than most carbon-based *** paper-like structure also contains a combination of large pores between interconnected nanobelts and mesopores within the *** unique electrode enables fast charging by simultaneously providing efficient ion diffusion and electron *** supercapacitors(SCs)made of TiN paper enable charging/discharging at an ultrahigh scan rate of 100 V s−1 in a wide voltage window of 1.5 V in Na2SO4 neutral *** has an outstanding response time with a characteristic time constant of 4 ***,the TiN paper-based SCs also show zero capacitance loss after 200,000 cycles,which is much better than the stability performance reported for other metal nitride ***,the device shows great promise in *** filtration method enables good control of the thickness and mass loading of TiN electrodes and devices.

关键词： Ultrafast charging Wide voltage window TiN Paper-like electrode Supercapacitors

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Pillararene-based supramolecular systems for theranostics and bioapplications

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Science China Chemistry 2021年第5期64卷 688-700页

作者： Huangtianzhi Zhu Qi li Laila E.Khalil-cruz Niveen M.Khashab Guocan yu Feihe Huang State Key Laboratory of Chemical Engineering Key Laboratory of Excited-State Materials of Zhejiang ProvinceDepartment of ChemistryZhejiang UniversityHangzhou 310027China Smart Hybrid Materials Laboratory(SHMs) Advanced Membranes and Porous Materials CenterKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China

As an emerging type of important macrocycles for supramolecular chemistry,pillararenes and their derivatives have been widely studied and applied in numerous fields,which intensively promotes the development of chemistry,materials science and ***-based theranostic systems are of special interest in the biological and medical areas as they have shown very promising *** to easy preparation,reliable guest affinity,good biocompatibility and stability,pillararenes are frequently used to construct functional *** one hand,pillararenes can either be used individually or form diversiform self-assemblies such as micelles,nanoparticles and vesicles to increase water solubility and biocompatibility of *** the other hand,it is promising to modify solid materials like framework materials,silica nanoparticles and graphene oxides with pillararene derivatives to enhance their functions and *** this review,we summarize recent endeavors of pillararene-based supramolecular systems with theranostics and other biological applications comprising drug delivery/chemotherapy,photodynamic/photothermal therapy,antimicrobials,bioimaging,*** introducing several typical examples,the design principles,preparation strategies,identifications and bio-applications of these pillararene-based supramolecular systems are *** challenges and directions of this field are also outlined.

关键词： pillararenes self-assembly theranostics drug delivery supra-amphiphiles

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Surface effects of monolayer-protected gold nanoparticles on the redox reactions between ferricyanide and thiosulfate

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Science China Chemistry 2005年第5期48卷 424-430页

作者： li Di1, SUN Chunyan1, HUANG yunjie1, li Jinghong1,2 & CHEN Shaowei3 1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China 2. Department of Chemistry, Tsinghua University, Beijing 100084, China 3. Department of Chemistry, University of California, Santa cruz, Santa cruz, CA 95064, USA 1. State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences 130022 Changchun China 2. Department of Chemistry Tsinghua University 100084 Beijing China 3. Department of Chemistry University of California 95064 Santa Cruz Santa Cruz CA USA

Electron transfer through the self-assembled monolayers (SAMs) on gold nanopar-ticles is investigated by using the monolayer protected gold nanoclusters (MPCs) as elec-tron-transfer mediators. 3-Mercaptopropionic acid (MPA) and 11-meraptoundecanoic acid (MUA) MPCs were employed to catalyze the redox reaction between potassium ferricyanide and sodium thiosulfate. The catalytic mechanism was proposed that the MPCs act as diffusing elec-tron-mediators and electron transfers to and from the MPCs surface. Therefore the electron transfer rate through the capping layers would be proportional to the MPCs catalyzed reaction rate, which was monitored by the UV absorbance of ferricyanide. The calculated apparent rate constant was orders of magnitude smaller than that of the maximum of tunneling current, which was attributed to the splited energy level of the nanoscale particles.

关键词： electron transfer, three-dimensional self-assembled monolayers, redox reaction, electron transfer mediator, surface effect.

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A controlled random gene perturbation method identifies ARPC1B gene as a key regulator of cancer metastasis

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Genes & Diseases 2023年第3期10卷 687-689页

作者： De Chang Hongzhen Du Xiaowei Chen Xiaocui Bian Wenjia Tian Jing Shen yiju Wei yunpeng Jiang Charles Dela cruz lixin Xie Lokesh Sharma Kailong li College of Pulmonary and Critical Care Medicine Chinese PLA General HospitalBeijing 100083China Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Section of Pulmonary and Critical Care and Sleep Medicine Department of MedicineYale University School of MedicineNew HavenCT 06520USA Department of Biochemistry and Biophysics Peking University Health Science CenterBeijing 100191China

The discovery of clinically useful targets to treat specific pathological conditions can provide novel therapeutic *** unbiasedly identify key genes related to tumor metastasis,we developed a random gene perturbation method using a piggyBac transposon system under the control of a doxycy.line regulated *** this random gene perturbation method and utilizing a mouse model of metastatic pancreatic cancer,we identified genes dysregulated in metastasized cells from a random mutagenesis library after multiple rounds of in vivo *** of these metastasized clones revealed the downregulation of ARPC1B *** further mechanistic studies revealed that ARPC1B gene and its closely related gene ARPC1A worked in a regulatory loop to control tumor *** findings validate that piggyBac transposon mediated random gene perturbation is a powerful tool to investigate the functional relevance of novel genes and the ARPC1A/B axis is a potential key regulator of tumor metastasis.

关键词： metastasis cancer random

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A review of recent research progress on the effect of external influences on tropical cyclone intensity change

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Tropical Cyclone Research and Review 2023年第3期12卷 200-215页

作者： Joshua B.Wadler Johna E.Rudzin Benjamin Jaimes de la cruz Jie Chen Michael Fischer Guanghua Chen Nannan Qin Brian Tang Qingqing li Embry-Riddle Aeronautical University Department of Applied Aviation SciencesDaytona BeachFLUSA Mississippi State University Department of GeosciencesStarkvilleMSUSA University of Miami Department of Ocean SciencesMiamiFLUSA Princeton University Atmospheric and Oceanic Sciences ProgramPrincetonNJUSA University of Miami Cooperative Institute for Marine and Atmospheric Studies and NOAAAtlantic Oceanographic and Meteorological LaboratoryHurricane Research DivisionMiamiFLUSA Institute of Atmospheric Physics of the Chinese Academy of Sciences BeijingChina Key Laboratory of Transportation Meteorology of China Meteorological Administration Nanjing Joint Institute for Atmospheric SciencesNanjingChina University at Albany State University of New YorkDepartment of Atmospheric and Environmental SciencesAlbanyNYUSA Nanjing University of Information and Science Technology NanjingChina

Over the past four years,signiﬁcant research has advanced our understanding of how external factors inﬂuence tropical cyclone(TC)intensity *** on air-sea interactions shows that increasing the moisture disequilibrium is a very effective way to increase surface heatﬂuxes and that ocean salinity-stratiﬁcation plays a non-negligible part in TC intensity *** wind shear from the environment induces vortex misalignment,which controls the onset of signiﬁcant TC intensiﬁ*** due to upper-level outﬂow from TCs can reduce the magnitude of vertical wind shear,making for TC intensiﬁ*** TC-trough interactions are vital for rapid intensiﬁcation in some TC cases because of strengthened warm air advection,but upper-level troughs are found to limit TC intensiﬁcation in other cases due to dry midlevel air intrusions and increased *** effects on TCs can be divided into direct effects involving aerosol-radiation interactions and indirect effects involving aerosol-cloud *** radiation absorption by the aerosols can change the temperature proﬁle and affect outer rainbands through changes in stability and *** spray and sea salt aerosols are more important in the inner region,where the aerosols increase precipitation and latent heating,promoting more intensiﬁ*** landfalling TCs,the intensity decay is initially more sensitive to surface roughness than soil moisture,and the subsequent decay is mainly due to the rapid reduction in surface moistureﬂ*** new insights further sharpen our understanding of the mechanisms by which external factors inﬂuence TC intensity changes.

关键词： Tropical cyclone External inﬂuence Intensity change Review

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Confocal endomicroscopy and cyst fluid molecular analysis: Comprehensive evaluation of pancreatic cysts

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World Journal of Gastrointestinal Endoscopy 2018年第1期10卷 1-9页

作者： Feng li Ahmad Malli Zobeida cruz-Monserrate Darwin L Conwell Somashekar G Krishna Division of Gastroenterology Hepatology and Nutrition Ohio State University Wexner Medical Center

Increases in the quality as well as utilization of cross-sectional imaging have led to rising diagnoses of pancreatic cystic lesions(PCL). Accurate presurgical diagnosis enables appropriate triage of PCLs. Unfortunately, current diagnostic approaches have suboptimal accuracy and may lead to unnecessary surgical resections or missed diagnoses of advanced neoplasia. Additionally, early detection represents an opportunity for intervention to prevent the progression to pancreatic adenocarcinoma. Our aim for this review is to systematically review the current literature on confocal endomicroscopy and molecular biomarkers in the evaluation of PCLs. Confocal laser endomicroscopy is a novel technology that allows for real-time in vivo microscopic imaging with multiple clinical trials identifying characteristic endomicroscopy findings of various pancreatic cystic lesions. DNA-based molecular markers have also emerged as another diagnostic modality as the pattern of genetic alternations present in cyst fluid can provide both diagnostic and prognostic data. We propose that both techniques can be utilized to improve patient outcomes.

关键词： Pancreas Pancreatic cyst Pancreatic adenocarcinoma Confocal endomicroscopy Next generation sequencing Molecular marker

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真皮、皮下组织和腱黄瘤:特异性脂蛋白病的诊断标志

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国外医学（皮肤性病学分册） 1990年第1期16卷 25-27页

作者： cruz PD 李琮辉

很多脂蛋白异常的病人发生早发性动脉粥样硬化和一些全身性疾病的危险性增高, 其中一些病人也可发生黄瘤,并成为脂蛋白病的皮肤标志。本文结合以前对脂蛋白病的概念对黄瘤提出新的鉴别诊断方法,并集中讨论脂蛋白代谢、含量或结构异常与... 详细信息

很多脂蛋白异常的病人发生早发性动脉粥样硬化和一些全身性疾病的危险性增高, 其中一些病人也可发生黄瘤,并成为脂蛋白病的皮肤标志。本文结合以前对脂蛋白病的概念对黄瘤提出新的鉴别诊断方法,并集中讨论脂蛋白代谢、含量或结构异常与发生特殊黄瘤之间的关系。黄瘤黄瘤病分两型:高脂血症性黄瘤病和正常血脂性黄瘤病。表现为黄色或橙色的斑疹、丘疹、皮下斑块或腱结节。

关键词：脂蛋白病黄瘤诊断特异性

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Occupational physical activity, all-cause, cardiovascular disease, and cancer mortality in 349,248 adults: Prospective and longitudinal analyses of the MJ Cohort

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Journal of Sport and Health Science 2024年第4期13卷 579-589页

作者： Emmanuel Stamatakis Matthew N.Ahmadi Tiana-Lee Elphick Bo-Huei Huang Susan Paudel Armando Teixeira-Pinto li-Jung Chen Borja del Pozo cruz yun-Ju Lai Andreas Holtermann Po-Wen Ku Sydney School of Health Sciences Faculty of Medicine and HealthCharles Perkins CentreUniversity of SydneySydneyNSW 2006Australia Sydney School of Public Health Faculty of Medicine and HealthUniversity of SydneySydneyNSW 2006Australia Department of Exercise Health Science “National”Taiwan University of SportTaichung 40404China Department of Sports Science and Clinical Biomechanics University of Southern DenmarkOdense 5230Denmark Division of Endocrinology and Metabolism Department of Internal MedicinePuli Branch of Taichung Veterans General HospitalNantou 54552China National Research Centre for the Working Environment Copenhagen 2100Denmark Graduate Institute of Sports and Health Management “National”Chung Hsing UniversityTaichung 40227China

Background:Evidence on the health benefits of occupational physical activity(OPA)is *** examined the associations of baseline OPA and OPA changes with all-cause,cardiovascular disease(CVD),and cancer mortality and survival ***:This study included prospective and longitudinal data from the MJ Cohort,comprising adults over 18 years recruited in 1998-2016,349,248 adults(177,314 women)with baseline OPA,of whom 105,715(52,503 women)had 2 OPA measures at 6.3±4.2 years(mean±SD)*** were baseline OPA,OPA changes,and baseline leisure-time physical ***:Over a mean mortality follow-up of 16.2±5.5 years for men and 16.4±5.4 years for women,11,696 deaths(2033 of CVD and 4631 of cancer causes)in men and 8980 deaths(1475 of CVD and 3689 of cancer causes)in women *** moderately heavy/heavy baseline OPA was beneficially associated with all-cause mortality in men(multivariable-adjusted hazard ratio(HR)=0.93,95%confidence interval(95%CI):0.89-0.98 compared to light OPA)and women(HR=0.86,95%CI:0.79-0.93).Over a mean mortality follow-up of 12.5±4.6 years for men and 12.6±4.6 years for women,OPA decreases in men were detrimentally associated(HR=1.16,95%CI:1.01-1.33)with all-cause mortality,while OPA increases in women were beneficially(HR=0.83,95%CI:0.70-0.97)associated with the same *** or changes in OPA showed no associations with CVD or cancer ***:Higher baseline OPA was beneficially associated with all-cause mortality risk in both men and *** longitudinal OPA analyses partly confirmed the prospective findings,with some discordance between sex groups.

关键词： Cancer Cardiovascular disease Epidemiology Mortality

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Influence of hypoxia-inducible factor 1-alpha on neuronal apoptosis in a rat model of hypoxia-or hypoxia-ischemia-induced brain injury

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Neural Regeneration Research 2009年第12期4卷 1019-1023页

作者： lihua li yi Qu li Zhang Xihong li Jinhui li Meng Mao Xiudong Jin Dezhi Mu Department of Pediatrics West China Second Hospital Sichuan University Chengdu 610041 Sichuan Province China Departrnent of Pediatrics Bayi Children's Hospital Military General Hospital of Beijing PLA Beijing 100700 China Mudanjiang Medical College Mudanjiang 157011 Heilongjiang Province China

BACKGROUND： In addition to neuroprotective genes, the targeted genes of hypoxia-inducible factor 1α （HIF-1α） include pro-apoptotic genes. However, the influence of HIF-1α on neuronal apoptosis in hypoxia-ischemia remains poorly understood. OBJECTIVE： To investigate the relationship between HIF-1α expression and neuronal apoptosis in hypoxia or hypoxia-ischemia brain injury and to determine the role of HIF-1α in regulating neuronal apoptosis. DESIGN, TIME AND SETTING： A randomized, controlled animal experiment was performed at the Laboratory of Children Neurology of Sichuan University between May 2006 and May 2007. MATERIALS： In situ cell death detected kit was provided by Roche, USA; rabbit anti-mouse HIF-1α polyclonal antibody was purchased from Santa cruz Biotechnologies, USA; rabbit anti-mouse cleaved caspase-3 polyclonal antibody was purchased from Chemicon, USA. METHODS： A total of 36 Sprague Dawley rats aged 10 days were randomly assigned to 3 groups： sham-surgery, hypoxia, and hypoxia-ischemia, with 12 rats per group. The rats were treated at 3 time points： 4, 8, and 24 hours, with 4 rats per time point. In the hypoxia-ischemia group, the right common carotid artery was exposed and permanently.ligated through a midline cervical incision. A 2.5-hour exposure to hypoxia （8% O2/92% N2） was used to induce hypoxia-ischemia injury. In the hypoxia group, rats were exposed to hypoxia without ligation of the common carotid artery. In the sham-surgery group, the common carotid artery was exposed without ligation or hypoxia. MAIN OUTCOME MEASURES： Histopathological changes, HIF-1α and activated caspase-3 protein expression, integrated optical density of positive cells, and apoptosis-positive cells. RESULTS： Hematoxylin and eosin staining showed that neuronal degeneration and edema was most prominent at 24 hours after hypoxia-ischemia. HIF-1α protein expression was significantly upregulated at 4 hours, peaked at 8 hours, and decreased at 24 hours after hypoxia or hypoxia

关键词： HIF-1α apoptosis hypoxia ischemia brain damage

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