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Fatty acid content in epididymal fluid and spermatozoa during sperm maturation in dogs

Journal of Animal Science and Biotechnology 2017年第3期8卷 574-581页

作者： Daniel S.Ramos Angrimani marcilio Nichi Joāo Diego A.Losano cristina F.Lucio Gisele A.Lima Veiga márcia V.m.Junqueira Franco Camila I.Vannucchi Department of Animal Reproduction School of Veterinary Medicine and Animal Science University of Sāo Paulo Rua Prof. Orlando Marques de Paiva 87 Sāo Paulo 05508-270 Brazil Department of Internal medicine Division of Nutrition University of Sāo Paulo Av. Bandeirantes 3900 - 14040-040 Ribeirāo Preto. Brazil

Background： During sperm maturation, there is a reorganization of fatty acids from plasmatic membrane of the spermatozoa, which allows higher membrane integrity and acquisition of sperm motility. However, the fatty acid profile during sperm maturation remains unclear in dogs. Thus, the aim of this study was to identify the fatty acids from the epididymal spermatozoa and plasma during the sperm maturation, and observed changes in the motility and plasmatic membrane parameters. Twenty one adult dogs were used, subsequently to bilateral orchiectomy and epididymal storage, sperm samples were collected from the different segments of the epididymis. Samples were evaluated for conventional microscopy, computer-assisted motility analysis, sperm plasma membrane permeability and the fatty acid analysis（lipids were extracted, transmethylated and analyzed by chromatography）.Results： Caput and corpus sperm showed lower values for the motility variables evaluated and plasmatic membrane integrity, indicating different levels of the fatty acids organization. Saturated, monounsaturated and polyunsaturated fatty acids were in higher concentrations in the spermatozoa from epididymis cauda. Highlighting the presence of caprylic, stearic and docosahexaenoic ***： These findings demonstrate the influence of the fatty acid profile during sperm maturation, assigning physical and chemical changes in sperm cells, essential for fertilization.

关键词： Dogs Epididymis Fatty acids Sperm maturation

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Fine-scale habitat differentiation shapes the composition, structure and aboveground biomass but not species richness of a tropical Atlantic forest

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Journal of Forestry Research 2020年第5期31卷 1599-1611页

作者： Alice cristina Rodrigues Pedro manuel Villa Arshad Ali Walnir Ferreira-Junior Andreza Viana Neri Laboratorio de Ecologia e Evoluc¸ao de Plantas–LEEP Departamento de Biologia VegetalUniversidade Federal de Vic¸osaVic¸osaMinas Gerais CEP 36570-900Brazil Fundacion para la Conservacion de la Biodiversidad Merida 7101MeridaVenezuela College of Forestry Nanjing Forestry UniversityNanjing 210037JiangsuPeople’s Republic of China Setor de Biologia e meio Ambiente Instituto Federal do Sul de Minas Gerais-IFSULDEMINAS-Campus MachadoHighway Machado-Paraguac¸ukm 3MachadoMG CEP 37750000Brazil

Evaluating the influences of fine-scale habitat heterogeneity on the composition,diversity,structure and functioning of forests is critical to understand how tropical forests will respond to climate change and devise forest management strategies that will enhance biodiversity conservation and aboveground biomass ***,we hypothesized that topographic and soil factors determine fine-scale habitat differentiation,which in turn shape community composition,species richness,structure and aboveground biomass at the local scale in tropical *** test this hypothesis,we selected two areas(each 100×100 m)with contrasting fine-scale topographic conditions where all trees,palms and lianas with a diameter at breast height ≥ 10 cm were tagged and identified to *** each selected area,100 subplots of 10×10 m were *** mainly found that higher topographic variability caused higher habitat differentiation with changes in species composition and community structure,but did not change species *** habitat-scale analyses indicated that,in the less heterogeneous area,the distribution of species was more uniform along a fine-scale topographical gradient with no variation in convexity,which induced changes in structure and aboveground biomass,but not in species *** nonsignificant relationship between species richness and aboveground biomass may be attributable to species redundancy or functional *** study suggests that environmental filtering is a fundamental process for shaping community assembly and forest functioning along a local topographical gradient in tropical forests.

关键词： Community–habitat associations Convexity Rarefaction Topographic variability

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Use of Caffeine for the Evaluation of the Anthropic Influence over the Upper and middle Iguaçu River Basins

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Journal of Water Resource and Protection 2022年第3期14卷 273-291页

作者： Bruna Scipioni márcia Cristiane Kravetz Andrade Luis Otávio miranda Peixoto Alinne mizukawa Tais cristina Filippe Júlio César Rodrigues De Azevedo Programa de Pós-Graduaç ã o em Engenharia de Recursos Hídricos e Ambiental Universidade Federal do Paraná Curitiba Brasil Universidade Tecnológica Federal do Paraná Curitiba Brasil

many parameters are usually used as gauges to describe water quality worldwide, such as the concentrations of phosphorus, forms of nitrogen, dissolved oxygen (DO), among others. Though legislative limits for the concentrations of these substances are in place, such is not the case for caffeine. Caffeine is a pharmacologically active alkaloid, from the xanthine group, which can be used as a chemical tracer for anthropic influence over water resources. The objective of this study was to analyze the pollution indicators over the Igua?u River, one of the main rivers in Southern Brazil, through the examination of nutrients, DO and their correlations to caffeine. The water samples were collected from 10 sampling sites along the river course, unevenly spaced to better represent the different environmental scenarios present in its basin, extracted from 2014 to 2017. Caffeine was detected and quantified through high-efficiency liquid state chromatography. Results show that both nutrient and caffeine concentrations increased in intensely urbanized areas, specially from IG2 to IG5 sampling sites. Downstream from IG6 the contaminant concentrations decreased mainly due to higher river flows and lower population density. Caffeine was detected in 82% of the samples, indicating that most of the sampling sites were under anthropic influence.

关键词： Water Resources Water Quality Caffeine Urban Areas

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High-Capacity Quantum Associative memories

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Journal of Applied mathematics and Physics 2016年第11期4卷 2079-2112页

作者： m. cristina Diamantini Carlo A. Trugenberger Nips Laboratory INFN and Dipartimento di Fisica University of Perugia Perugia Italy Swiss Scientific Cologny Switzerland

We review our models of quantum associative memories that represent the “quantization” of fully coupled neural networks like the Hopfield model. The idea is to replace the classical irreversible attractor dynamics driven by an Ising model with pattern-dependent weights by the reversible rotation of an input quantum state onto an output quantum state consisting of a linear superposition with probability amplitudes peaked on the stored pattern closest to the input in Hamming distance, resulting in a high probability of measuring a memory pattern very similar to the input. The unitary operator implementing this transformation can be formulated as a sequence of one-qubit and two-qubit elementary quantum gates and is thus the exponential of an ordered quantum Ising model with sequential operations and with pattern-dependent interactions, exactly as in the classical case. Probabilistic quantum memories, that make use of postselection of the measurement result of control qubits, overcome the famed linear storage limitation of their classical counterparts because they permit to completely eliminate crosstalk and spurious memories. The number of control qubits plays the role of an inverse fictitious temperature. The accuracy of pattern retrieval can be tuned by lowering the fictitious temperature under a critical value for quantum content association while the complexity of the retrieval algorithm remains polynomial for any number of patterns polynomial in the number of qubits. These models thus solve the capacity shortage problem of classical associative memories, providing a polynomial improvement in capacity. The price to pay is the probabilistic nature of information retrieval.

关键词： Quantum Information Associative memory Quantum Pattern Recognition

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Human NK cells: surface receptors, inhibitory checkpoints, and translational applications

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Cellular & molecular Immunology 2019年第5期16卷 430-441页

作者： Simona Sivori Paola Vacca Genny Del Zotto Enrico munari maria cristina mingari Lorenzo moretta Department of Experimental medicine(DImES)and Centre of Excellence for Biomedical Research(CEBR) University of GenoaGenoaItaly Department of Immunology IRCCS Bambino GesuChildren’s HospitalRomeItaly Department of Research and Diagnostics Istituto G.GasliniGenoaItaly Department of Diagnostics and Public Health University of VeronaVeronaItaly Department of Pathology Sacro Cuore Don CalabriaNegrarVRItaly UOC Immunologia IRCCS Ospedale Policlinico San Martino GenovaGenoaItaly

NK cells play important roles in innate defenses against viruses and in the control of tumor growth and *** regulation/induction of NK cell function is mediated by an array of activating or inhibitory surface *** humans,major activating receptors involved in target cell killing are the natural cytotoxicity receptors(NCRs)and *** receptors recognize ligands that are overexpressed or expressed de novo upon cell stress,viral infection,or tumor *** HLA-class I-specific inhibitory receptors,including KIRs recognizing HLA-class I allotypic determinants and CD94/NKG2A recognizing the class-Ib HLA-E,constitute a fail-safe mechanism to avoid unwanted NK-mediated damage to healthy *** receptors such as PD-1,primarily expressed by activated T lymphocytes,are important inhibitory checkpoints of immune responses that ensure T-cell ***-1 also may be expressed by NK cells in cancer *** PD-1 ligand(PD-L1)may be expressed by different tumors,PD-1/PD-L1 interactions inactivate both T and NK ***,the reliable evaluation of PD-L1 expression in tumors has become a major issue to select patients who may benefit from therapy with mAbs disrupting PD-1/PD-L1 ***,NKG2A was revealed to be an important checkpoint controlling both NK and T-cell *** most tumors express HLA-E,mAbs targeting NKG2A has been used alone or in combination with other therapeutic mAbs targeting PD-1 or tumor antigens(e.g.,EGFR),with encouraging *** translational value of NK cells and their receptors is evidenced by the extraordinary therapeutic success of haploidentical HSCT to cure otherwise fatal high-risk leukemias.

关键词： Human NK cells NK receptors Inhibitory checkpoints Immunotherapy

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Arylated analogues of cypronazole: fungicidal effect and activity on human fibroblasts. Docking analysis and molecular dynamics simulations

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Natural Products and Bioprospecting 2022年第1期12卷 107-120页

作者： Natividad Herrera Cano Sebastian A.Andujar cristina Theoduloz Daniel A.Wunderlin Ana N.Santiago Guillermo Schmeda-Hirschmann Ricardo D.Enriz Gabriela E.Feresin Instituto de Biotecnología Facultad de IngenieríaUniversidad Nacional de San JuanCONICET-CCT San JuanAv.Libertador General San Martín1109(O)5400 San JuanArgentina Facultad de Química Bioquímica y Farmacia-IMIBIO-SL(CONICET)Universidad Nacional de San LuisChacabuco 9155700 San LuisArgentina Laboratorio de Cultivo Celular Facultad de Ciencias de la SaludUniversidad de TalcaCasilla 7473460000 TalcaChile ICYTAC CONICET and Universidad Nacional de CórdobaFacultad de Ciencias QuímicasDepartamentoQuímica OrgánicaCiudad UniversitariaBv.Juan Filloy s/n5000 CórdobaArgentina INFIQC CONICET and Universidad Nacional de CórdobaFacultad de Ciencias QuímicasDepartamento Química OrgánicaCiudad UniversitariaHaya de La Torre S/N5000 CórdobaArgentina Laboratorio de Química de Productos Naturales Instituto de Química de Recursos NaturalesUniversidad de TalcaCasilla 7473460000 TalcaChile

Triadimefon(TDm)and cyproconazole(CPZ)are two triazoles widely used as *** azoles were synthe-sised starting from commercial TDm and *** compounds were evaluated against phytopathogenic filamentous fungi,including Aspergillus fumigatus(AF),***(AN),***(AU),***(AJ),***(AT),Fusarium oxyspo-rum and Botrytis cinerea isolated from grapevine in the province of San Juan,*** of the synthesised compounds(1-(Biphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one,1;2-(Biphenyl-4-yl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol,3;3-Cyclopropyl-2-(4’-fluorobiphenyl-4-yl)-1-(1H-1,2,4-triazol1-yl)butan-2-ol,4)presented remarkable in vitro fungicidal properties,with better effects than TDm and CPZ on some of the target *** was assessed using human lung fibroblasts *** 1,with IC50 values of 389.4μm,was less toxic towards mRC-5 human lung fibroblasts than commercial TDm(248.5μm)and CPZ(267.4μm).Docking analysis and molecular dynamics simulations suggest that the compounds present the same interaction in the binding pocket of the CYP51B enzyme and with the same amino acids as *** derivatives investigated could be considered broad-spectrum but with some selectivity towards imperfect fungi.

关键词： Azoles Antifungal cytotoxicity Conformational and electronic analysis

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S-adenosyl-methionine decreases ethanol-induced apoptosis in primary hepatocyte cultures by a c-Jun N-terminal kinase activity-independent mechanism

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World Journal of Gastroenterology 2006年第12期12卷 1895-1904页

作者： maria del Pilar Cabrales-Romero Lucrecia márquez-Rosado Samia FatteI-Fazenda cristina Trejo-Solis Evelia Arce-Popoca Leticia Alemán-Lazarini Saúl Villa-Trevineo Department of Cell Biology Centro de Investigacién y Estudios Avanzados IPN Av. IPN No. 2508 México DF México Department of Neuroimmunology Instituto National de Neurologia y Neurocirugia MVS Insurgentes Sur 3877 Col La Fama DF México

AIm:To determine the role of c-Jun N-terminal kinase(JNK)activity in ethanol-induced apoptosis and themodulation of this signaling cascade by S-Adenosyl-methionine(Adomet).mETHODS:Primary hepatocyte cultures werepretreated with 100 μmol/L SP600125,a selective JNKinhibitor,1 mL/L DmSO or 4 mmol/L Adomet and thenexposed to 100 mmo/L *** apoptosiswas determined by the TUNEL and DNA ladder *** activity and its inhibition by SP600125 and Adometwere determined by Western blot analysis of c-junphosphorylation and Bid ***600125 andAdomet effects on the apoptotic signaling pathway weredetermined by Western blot analysis of cytochrome crelease and pro-caspase 3 *** Adometeffect on glutathione levels was measured by Ellman'smethod and reactive oxygen species(ROS)generationby cell ***:The exposure of hepatocytes to ethanolinduced JNK activation,c-jun phosphorylation,Bidfragmentation,cytochrome c release and pro-caspase 3cleavage;these effects were diminished by SP600125,and caused a significant decrease in ethanol-inducedapoptosis(Pmet exerted an antioxidanteffect maintaining glutathione levels and decreasing ROSgeneration,without a significant effect on JNK activity,and prevented cytochrome c release and pro-caspase 3cleavage. CONCLUSION:The JNK signaling cascade is a keycomponent of the proapoptotic signaling pathwayinduced by *** activation may be independentfrom ROS generation,since Adomet which exertedantioxidant properties did not have a significant effect onJNK *** pathway modulator agents and Adometmay be components of promising therapies for alcoholicliver disease(ALD)treatment.

关键词：蛋氨酸甲硫氨酸乙醇细胞调亡肝细胞酶活性

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Effect of a basic Chinese traditional diet in overweight patients

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Journal of Traditional Chinese medicine 2013年第3期33卷 322-324页

作者： Aldo Liguori Filomena Petti Susanna Rughini Laura Silli Rosa Asprino cristina maglio Frida Leonetti Department of Anatomic Histologic Forensic Medicine and Locomotor System Sciences Sapienza UniversityRome Italy Paracelso Clinical Center Paracelso InstituteRome Italy Department of Clinical Science Sapienza UniversityRome Italy

OBJECTIVE: To evaluate the effect of a basic Chinese traditional diet (BTCD) in overweight patients on body mass index (BmI), lean mass, sense of hunger, and eating behaviour. mETHODS: A total of 694 enrolled subjects (218 male and 476 female) were divided into two groups: group A undergoing a 1200-Kcal BTCD, and group B undergoing a 1200-Kcal standard western diet. RESULTS: From T0 (before treatment) to T1 (6 weeks after treatment), BmI was lowered in group A from (32.33±5.51) to (31.96±5.56) kg/m2 , and in group B from (31.62±6.29) to (31.36±6.47) kg/m2 . After treatment, patients in group A lost more weight (0.37±0.52) kg than group B (0.26±0.79) kg (P=0.0044). From T0 to T1, the mean lean mass of group A decreased from (16.48±5.50) to (16.27± 5.45) kg. In group B, mean lean mass decreased from (16.93±6.49) to (16.44±6.29) kg. The difference was significant (P=0.0078). CONCLUSION: The two diets could lead to lowerBmI, improve lean mass as well as eating behaviour and sense of hunger. However, the BTCD was significantly better than the western standard diet.

关键词：传统饮食患者中国超重质量指数饮食行为饮食习惯 BmI

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What can we learn from β-cell failure biomarker application in diabetes in childhood?A systematic review

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World Journal of Diabetes 2021年第8期12卷 1325-1362页

作者： maría F Calderón-Hernández Nelly F Altamirano-Bustamante cristina Revilla-monsalve maría Belen mosquera-Andrade myriam m Altamirano-Bustamante Unidad de Investigación en Enfermedades metabólicas Centro Médico Nacional Siglo XXIIMSSMexico 06720Mexico Department of Endocrinology Instituto Nacional de PediatríaMexico 04530Mexico

BACKGROUND The prevalence of diabetes as a catastrophic disease in childhood is growing in the *** search for novel biomarkers ofβ-cell failure has been an elusive task because it requires several clinical and biochemical measurements in order to integrate the risk of metabolic *** To determine which biomarkers are currently used to identifyβ-cell failure among children and adolescents with high risk factors for diabetes *** This systematic review was carried out using a modified version of the PICO protocol(Participants/Intervention/Comparison/Outcome).Once our research question was established,terms were individually researched on three different databases(Pubmed,BIREmE and Web of Science).The total articles obtained underwent a selection process from which the 78 most relevant articles were retrieved to undergo further *** were assessed individually according to quality *** First,we made the classification of theβ-cell-failure biomarkers by the target tissue and the evolution of the disease,separating the biomarkers in relation to the types of ***,we demonstrated that most biomarkers currently used as early signs ofβ-cell failure are those that concern local or systemic inflammation processes and oxidative stress as well as those related to endothelial dysfunction ***,we explored the novelties of diabetes as a protein conformational disease and the novel biomarker called real human islet amyloid polypeptide amyloid ***,we ended with a discussion about the best practice of validation and individual control of using different types of biomarkers in type 1 and type 2 diabetes in order to assess the role they play in the progress of diabetes in *** This review makes widely evident that most biomarkers currently used as early signs ofβ-cell failure are those that concern local or systemic inflammation processes and oxidative stress as well as those related to endo

关键词： Biomarker β-cell failure Children Adolescents Diabetes mellitus metabolic syndrome

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Nitrification inhibitor nitrapyrin does not affect yield-scaled nitrous oxide emissions in a tropical grassland

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Pedosphere 2021年第2期31卷 265-278页

作者： Ana Gabriela PÉREZ-CASTILLO cristina CHINCHILLA-SOTO Jorge Alberto ELIZONDO-SALAZAR Ronny BARBOZA Dong-Gill KIm Christoph mÜLLER Alberto SANZ-COBENA Azam BORZOUEI Khadim DAWAR mohammad ZAmAN Environmental Pollution Research Center(CICA) University of Costa RicaMontes de Oca 11501(Costa Rica) Alfredo Volio mata Experimental Station University of Costa RicaOchomogo 30304(Costa Rica) Wondo Genet College of Forestry and Natural Resources Hawassa UniversityP.O.Box 128Shashemene(Ethiopia) Institute of Plant Ecology Justus Liebig University GiessenHeinrich-Buff Ring 26Giessen 35392(Germany) School of Biology and Environmental Science University College DublinBelfieldDublin 4(Ireland) Research Center for the management of Environmental and Agricultural Risks(CEIGRAm) Department of Chemistry and Food Technology(ETSIAAB)Universidad Politécnica de MadridMadrid 28040(Spain) Nuclear Agriculture Research School Nuclear Science and Technology Research Institute(NSTRI)Karaj 31465-1498(Iran) Department of Soil and Environmental Sciences The University of AgriculturePeshawar 25000(Pakistan) Soil and Water management&Crop Nutrition Section Joint Food and Agriculture Organization(FAO)/International Atomic Energy Agency(IAEA)Division of Nuclear Techniques in Food and AgricultureDepartment of Nuclear Sciences and ApplicationsIAEAVienna International CentreP.O.Box 100Vienna 1400(Austria)

Urea is the most common nitrogen(N)fertilizer used in the tropics but it has the risk of high gaseous nitrogen(N)*** of nitrification inhibitor has been suggested as a potential mitigation measure for gaseous N losses in N fertilizer-applied *** a field trial on a tropical Andosol pastureland in Costa Rica,gaseous emissions of ammonia(NH_(3))and nitrous oxide(N_(2)O)and grass yield were quantified from plots treated with urea(U;41.7 kg N ha^(-1)application^(-1))and urea plus the nitrification inhibitor nitrapyrin(U+NI;41.7 kg N ha^(-1)application^(-1)and 350 g of nitrapyrin for each 100 kg of N applied)and control plots(without U and NI)over a six-month period(rainy season).Volatilization of NH_(3)(August to November)in U(7.4%±1.3%of N applied)and U+NI(8.1%±0.9%of N applied)were not significantly different(P>0.05).Emissions of N_(2)O in U and U+NI from June to November were significantly different(Pmission in U+NI was higher than that in *** and crude protein production of grass were significantly higher(Pmission between U(0.31±0.10 g N kg^(-1)dry matter)and U+NI(0.47±0.10 g N kg^(-1)dry matter).The results suggest that nitrapyrin is not a viable mitigation option for gaseous N losses under typical N fertilizer application practices of pasturelands at the study site.

关键词： ammonia volatilization Andosol Costa Rica field trial gaseous N loss greenhouse gas emission urea

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