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Antimicrobial and synergistic effects of lemongrass and geranium essential oils against Streptococcus mutans,Staphylococcus aureus,and Candida spp.

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World Journal of Critical Care Medicine 2024年第3期13卷 63-74页

作者： Patrícia Michelle Nagai de Lima Thaís Cristine Pereira Lara Steffany de Carvalho Letícia Ferreira dos Santos Carlos Eduardo Rocha Oliveira Lucas de Paula Ramos Maria cristina Marcucci Amjad Abu Hasna Luciane Dias de Oliveira Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000SPBrazil Anhembi Morumbi University School of MedicineSão Josédos Campos 12230-002SPBrazil Department of Restorative Dentistry Endodontics DivisionInstitute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000São PauloBrazil

BACKGROUND The oral cavity harbors more than 700 species of bacteria,which play crucial roles in the development of various oral diseases including caries,endodontic infection,periodontal infection,and diverse oral *** To investigate the antimicrobial action of Cymbopogon Schoenanthus and Pelargonium graveolens essential oils against Streptococcus mutans,Staphylococcus aureus,Candida albicans,***,and *** Minimum microbicidal concentration was determined following Clinical and Laboratory Standards Institute *** synergistic antimicrobial activity was evaluated using the Broth microdilution checkerboard method,and the antibiofilm activity was evaluated with the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide *** were analyzed by one-way analysis of variance followed by the Tukey post-hoc test(P≤0.05).RESULTS *** and *** essential oils were as effective as 0.12%chlorhexidine against *** and *** monotypic biofilms after 24 *** 24 h *** essential oil at 0.25%was more effective than the nystatin group,and *** essential oil at 0.25%was as effective as the nystatin *** *** and *** essential oils are effective against ***,***,***,***,and *** at different concentrations after 5 min and 24 h.

关键词： Antifungal effect Lemongrass Geranium Candida albicans Candida dubliniensis Candida krusei Staphylococcus aureus Streptococcus mutans

Circulating tumor cells isolation:the "post-EpCAM era"

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Chinese Journal of Cancer Research 2015年第5期27卷 461-470页

作者： cristina Raimondi Chiara Nicolazzo Angela Gradilone Dipartimento Medicina Molecolare Sapienza Universita di RomaRoma Italy

Circulating tumor cells （CTCs） represent a submicroscopic fraction detached from a primary tumor and in transit to a secondary site. The prognostic significance of CTCs in metastatic cancer patients was demonstrated for the first time more than ten years ago. To date, it seems clear enough that CTCs are highly heterogeneous and dynamically change their shape. Thus, the inadequacy of epithelial cell adhesion molecule （EpCAM） as universal marker for CTCs detection seems unquestionable and alternative methods able to recognize a broader spectrum of phenotypes are definitely needed. In this review the pleiotropic functions of EpCAM are discussed in detail and the role of the molecule in the biology of CTCs is critically dissected.

关键词： Epithelial cell adhesion molecule(EpCAM) circulating tumor cells(CTCs) epithelial-mesenchymal transition EpICD

Formation of iodo-trihalomethanes, iodo-haloacetic acids, and haloacetaldehydes during chlorination and chloramination of iodine containing waters in laboratory controlled reactions

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Journal of Environmental Sciences 2017年第8期29卷 127-134页

作者： cristina Postigo Susan D.Richardson Damia Barceló Water and Soil Quality Research Group Department of Environmental Chemistry Institute of Environmental Assessment and Water Research (IDAEA-CSIC) Barcelona Spain Department of Chemistry and Biochemistry University of South Carolina SC 29208 United States Catalan Institute for Water Research(ICRA) Parc Científic i Tecnològic de la Universitat de Girona17003 GironaSpain

Iodine containing disinfection by-products（I-DBPs） and haloacetaldehydes（HALs） are emerging disinfection by-product（DBP） classes of concern. The former due to its increased potential toxicity and the latter because it was found to be the third most relevant DBP class in mass in a U.S. nationwide drinking water study. These DBP classes have been scarcely investigated, and this work was performed to further explore their formation in drinking water under chlorination and chloramination scenarios. In order to do this, iodo-trihalomethanes（I-THMs）,iodo-haloacetic acids（I-HAAs） and selected HALs（mono-HALs and di-HALs species, including iodoacetaldehyde） were investigated in DBP mixtures generated after chlorination and chloramination of different water matrices containing different levels of bromide and iodide in laboratory controlled reactions. Results confirmed the enhancement of I-DBP formation in the presence of monochloramine. While I-THMs and I-HAAs contributed almost equally to total I-DBP concentrations in chlorinated water, I-THMs contributed the most to total I-DBP levels in the case of chloraminated water. The most abundant and common I-THM species generated were bromochloroiodomethane, dichloroiodomethane, and chlorodiiodomethane. Iodoacetic acid and chloroiodoacetic acid contributed the most to the total I-HAA concentrations measured in the investigated disinfected water. As for the studied HALs, dihalogenated species were the compounds that predominantly formed under both investigated treatments.

关键词： Iodinated disinfection by-products Chlorination Chloramination Drinking water Mass spectrometry Iodo-trihalomethanes Iodo-haloacetic acids Haloacetaldehydes

A CFD–DEM study of the behaviour of single-solid and binary mixtures in a pyramidal spouted bed

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Particuology 2019年第1期17卷 79-91页

作者： Filippo Marchelli cristina Moliner Barbara Bosio Elisabetta Arato Faculty of Science and Technology Free University of Bozen-BolzanoPiazza Universita 539100 BolzanoItaly Department of Civil Chemical and Environmental EngineeringUniversity of GenovaVia all'Opera Pia 1516145 GenovaItaly

We simulated a lab-scale cold-flow spouted bed through computational fluid dynamics (CFD), coupled with the discrete element method (DEM) for the solid phase, using a commercial CFD program, ANSYS FLUENT 18.0. To limit the computational expense, we tested both a simplified pseudo-2D geometry and a complete 3D geometry. We found that the Haider and Levenspiel drag model is suitable for the pseudo-2D geometry;however, this model does not correctly predict fluidisation in the 3D geometry. Conversely, the Gidaspow drag model behaves accurately in the 3D geometry but overestimates the motion of particles in the pseudo-2D geometry. We studied several single-solid and binary mixtures to assess the reproducibility of segregation phenomena. The pseudo-2D model was able to predict the onset and minimum spouting flow rates of all mixtures with good accuracy. An analysis of the volume fraction contours of the binary mixtures permitted us to confirm that segregation phenomena were correctly predicted at low gas velocities. We showed that segregation decreased as the inlet gas flow rate was increased. Calculations performed in the complete 3D geometry were preliminarily assessed as more reliable but required almost four times as much computational time as those for the pseudo 2D geometry.

关键词： Spouted beds Computational fluid dynamics Discrete element method Binary mixtures Segregation phenomena

Biomechanical modeling of metal screw loadings on the human vertebra

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Acta Mechanica Sinica 2021年第2期37卷 307-320页

作者： Leonardo Molinari cristina Falcinelli Alessio Gizzi Alberto Di Martino Department of Engineering Campus Bio-Medico University of RomeVia A.del Portillo 21Rome 00128Italy Department of Biomedical and Neuromotor Science DIBINEM University of BolognaBolognaItaly 1st Orthopaedic and Traumatologic Clinic IRCCS Istituto Ortopedico RizzoliBolognaItaly

During spinal fusion surgery,angled screw insertion can provide a more favorable stress distribution reducing failure events(screw breakage and loosening).Finite element(FE)analysis can be employed for identifying the optimal insertion path,preventing stress concentrations,and ensuring a lower failure *** this work,a patient-specific FE model of L4 vertebra,virtually implanted with two pedicle screws,was obtained from diagnostic images and numerically *** elastic,inhomogeneous,and isotropic material properties were assigned to bone based on density distributions reconstructed from the medical *** mechanical response of the screws-vertebra system was analyzed through a progressive damage procedure,considering a stress-based *** screws insertion angles were simulated,as well as physiological loading *** each loading case,screw orientation influences the fracture mechanism(i.e.,brittle or ductile one),as well as the fracture pattern and ***,stresses in trabecular bone and pedicle screws are significantly affected by the screw *** caudomedial trajectory indicates the most safe case,significantly reducing the stress concentrations in both trabecular bone and *** findings aim to furnish a useful indication to surgeons regarding the screws insertion angle,further reducing the failure risk and improving the clinical outcome of the fixation procedure.

关键词： Fracture mechanics Patient-specific FE modeling Vertebra mechanics Screw orientation Stress analysis

Mechanisms of retinal neuroprotection of calcium dobesilate：therapeutic implications

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Neural Regeneration Research 2017年第10期12卷 1620-1622页

作者： Olga Simó-Servat cristina Solà-Adell Patricia Bogdanov cristina Hernández Rafael Simó Diabetes and Metabolism Research Unit Vall d'Hebron Research InstituteCIBERDEM(Instituto de Salud CarlosⅢ)BarcelonaSpain

Current treatments for diabetic retinopathy （DR） are based on laser photocoagulation and intravitreal injections of corti- costeroids or anti-vascular endothelial growth factor （VEGF） agents. These treatments are applicable only at advanced stages of the disease. In addition, they are expensive, require a vitreo- retinal specialist and are associated with significant adverse ef- fects. Therefore, new pharmacological treatments for the early stages of the disease are needed.

关键词： Ca Mechanisms of retinal neuroprotection of calcium dobesilate:therapeutic implications

Boll weevils in dry bolls:is there a performance disadvantage?

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Journal of Cotton Research 2024年第3期7卷 243-252页

作者： COELHO Beatriz S. LEITE Suzany A. SANTOS Mateus P.dos MATES Eloito C.de MORAES Beatriz M.L.de BASTOS cristina S. GUEDES Raul N.C. MOREIRA Aldenise A. CASTELLANI Maria A. Departamento de Fitotecnia e Zootecnia Universidade Estadual do Sudoeste da BahiaVitória da ConquistaBA 45031‑900Brazil Faculdade de Agronomia e Veterinária Universidade de BrasíliaBrasíliaDF 70910‑900Brazil Departamento de Entomologia Universidade Federal de ViçosaViçosaMG 36570‑900Brazil Pós‑GraduaCão em Agronomia(Fitotecnia) Universidade Estadual do Sudoeste da BahiaVitória da ConquistaBA 45031‑900Brazil

Background Anthonomus grandis grandis is the main cotton pest in the Americas,with the potential to become a pest in other *** insect uses the plant's reproductive organs for feeding,oviposition,and survival strategies in the off-season,sheltering in dry *** study aimed to know the reproductive potential,feeding,longevity,and morphometric characteristics of boll weevils from dry bolls,squares,and *** were obtained from infested squares,dry bolls,and traps installed in cotton fields and the Caatinga *** weevil pairs were maintained in the laboratory to assess the oviposition,feeding holes,longevity,and morphometric measurements of the parental and F_(1) *** In the parental generation,boll weevils from traps(the Caatinga area and cotton cultivation)showed greater reproductive *** weevils from squares and the Caatinga area showed greater feeding activity compared with those from cotton *** rostrum length,thorax+abdomen length,and abdomen width were observed in boll weevils from cotton cultivation and dry *** origin of boll weevils parental generation did not affect progeny emergence *** F_(1) generation of boll weevils showed significant differences in average longevity depending on the origin of different ***,differences in rostrum lengths were observed,with the boll weevils coming from traps installed in cotton cultivation,the Caatinga area,and dry bolls being the *** thorax+abdomen length and abdomen width,the highest values were observed in those from the Caatinga area and cotton *** It was proven that dry bolls did not affect the reproductive,feeding,and longevity performance of boll weevils,enabling better insect fitness(reproduction and size)in relation to those coming from *** use of dry bolls as off-season shelter is an important survival strategy for the boll weevil.

关键词： Anthonomus grandis grandis Gossypium hirsutum Off-season Survival

New neuroprotective perspectives in fighting oxidative stress and improving cellular energy metabolism by oleocanthal

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Neural Regeneration Research 2019年第7期14卷 1217-1218页

作者： cristina Angeloni Laura Giusti Silvana Hrelia School of Pharmacy University of Camerino Department of Clinical and Experimental Medicine University of Pisa Department for Life Quality Studies Alma Mater Studiorum-University of Bologna

Neurodegenerative diseases are a heterogeneous group of disorders characterized by a progressive dysfunction and death of neural cells which lead to compromised motor or cognitive ***,the loss of neuron is associated with both gliosis and,frequently,with abnormal accumulation of extracellular and intracellular filamentous deposit in specific cell *** a rapidly increasing aging population,these diseases are becoming a primary health problem(Albers and Beal,2000).

关键词： New neuroprotective fighting oxidative

Erratum to: Born to sing! Song development in a singing primate

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Current Zoology 2024年第2期70卷 276-276页

作者： Chiara De Gregorio Filippo Carugati Vittoria Estienne Daria Valente Teresa Raimondi Valeria Torti Longondraza Miaretsoa Jonah Ratsimbazafy Marco Gamba cristina Giacoma Department of Lifte Sciences and Systems Biology University of Torinovia Accademia Alberina 13Torino 10125Italy Groupe d'Etude et de Recherche sur les Primates de Madagascar(GERP) BP 779-Antananarivo 101Madagascar

The pagination of this article online has been updated to pages 597-608 to match the print *** Publisher sincerely apologizes for introducing this error online.

关键词： introducing sincerely match