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Arsenite provides a selective signal that coordinates arsenate uptake and detoxification through the regulation of PHR1 stability in Arabidopsis

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Molecular Plant 2021年第9期14卷 1489-1507页

作者： cristina navarro Cristian Mateo-Elizalde Thotegowdanapalya C.Mohan Eduardo Sanchez-Bermejo Oscar Urrutia Maria Nieves Fernandez-Muniz Jose M.Garcia-Mina Riansares Munoz Javier Paz-Ares Gabriel Castrillo Antonio Leyva Department of Plant Molecular Genetics Centro Nacional de Biotecnología-Consejo Superior de Investigaciones CientíficasMadrid 28049Spain Department of Environmental Biology Sciences SchoolUniversity of NavarraPamplona 31008Spain Department of Analytical Chemistry School of Chemical SciencesUniversidad Complutense de MadridMadrid 28040Spain Present address:Department of Biotechnology and Bioinformatics Faculty of Life SciencesJSS Academy of Higher Education and ResearchMysuruKarnataka 570015India Present address:S&A Fresh Produce.Brook Farm MardenHereford HR13ETUK Future Food Beacon of Excellence&School of Biosciences University of NottinghamNottingham LE125RDUK

In nature,plants acquire nutrients from soils to sustain growth,and at the same time,they need to avoid the uptake of toxic compounds and/or possess tolerance systems to cope with *** is particularly challenging when the toxic compound and the nutrient are chemically similar,as in the case of phosphate and *** this study,we demonstrated that regulatory elements of the phosphate starvation response(PSR)coordinate the arsenate detoxification machinery in the *** showed that arsenate repression of the phosphate transporter PHT1;1 is associated with the degradation of the PSR master regulator *** arsenic is sequestered into the vacuole,PHR1 stability is restored and PHT1;1 expression is ***,we identified an arsenite responsive SKP1-like protein and a PHR1 interactor F-box(PHIF1)as constituents of the SCF complex responsible for PHR1 *** found that arsenite,the form to which arsenate is reduced for compartmentalization in vacuoles,represses PHT1;1 expression,providing a highly selective signal versus phosphate to control PHT1;1 expression in response to ***,our results provide molecular insights into a sensing mechanism that regulates arsenate/phosphate uptake depending on the plant’s detoxification capacity.

关键词： arsenic signaling F-box protein arsenate uptake arsenic detoxification phosphate starvation phytoremediation

Impact of HIV on the health-related quality of life in youth with perinatally acquired HIV

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World Journal of Pediatrics 2019年第5期15卷 492-498页

作者： Isabel Cuéllar-Flores Talís Saínz Carlos Velo María Isabel González-Tomé cristina García-navarro Caroclina Fernández-Mcphee Sara Guillén JoséTomás Ramos Pilar Miralles Rafae Rubio JoséIgnacio Bernardino Luis Prieto Pablo Rojo Santiago Jiménez de Ory Maria Luisa navarro CoRiSpe(FARO and NeuroCoRISpeS projects,RITIP-Traslational Research Network in Pediatric Infectious Diseases) Pediatric Department Hospital Clínico San CarlosMadridSpain Infectious Diseases Service Paed DepartmentHospital La PazMadridSpain La Paz Research Institute(IdiPAZ) MadridSpain Infectious Diseases Service Paed DepartmentHospital 12 de OctubreMadridSpain Infectious Diseases Service Paed DepartmentH.Gregorio MaranónMadridSpain Paed Department Hospital de GetafeMadridSpain Infectious Diseases Service H.Gregorio MaranónMadridSpain HIV Service Hospital 12 de OctubreMadridSpain Infectious Diseases Service Hospital La PazMadridSpain Instituto de Investigación Sanitaria Hospital Gregorio Maranón(IiSGM) MadridSpain Universidad Complutense de Madrid MadridSpain Translational Research Network in Pediatric Infectious Diseases(RITIP) MadridSpain 不详

Background Studies investigating health-related quality of life(HRQoL)in youth with perinatally acquired HIV(PHIV+)are *** study aimed to compare HRQoL of PHIV+to sociodemographic-matched youth not living with HIV(HIV-),Spanish general youth population,and to explore associations between sociodemographic variables,drug consumption,and *** PHIV+youth were randomly selected from CoRISpe database(Cohort of the Spanish Pediatric HIV Network).HRQoL was evaluated by *** Thirty-nine PHIV+youth(mean age:23.36 years,SD=3.83)and thirty-nine HIV-youth(mean age:22.97 years,SD=3.80)participated in this ***+obtained lower scores in SF-12 physical health subscale(PCS)than HIV-(P=0.001)and Spanish general youth population(P=0.006).PHIV+had lower scores on the mental health subscale(MCS)than the Spanish general youth population(P<0.001).PHIV+who were at school obtained better scores than those were not at ***+youth who had used cocaine and cannabis had lower scores in MCS(P=0.002).Conclusions There is a need for HRQoL management in the associated medical follow-up.

关键词： Drug consumption Health-related quality of life Mental health Perinatally acquired HIV youth

Proposed Occupational Vulnerability Index COVID-19

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Occupational Diseases and Environmental Medicine 2020年第4期8卷 175-187页

作者： Mª Teófila Vicente-Herrero Mª Victoria Ramírez Iñiguez de la Torre Mª Teresa del Campo Balsa Luis Reinoso Barbero Juan Carlos Rueda Garrido cristina Santamaría navarro Asociación Españ ola de Especialistas en Medicina del Trabajo Madrid Spain Occupational Health and Safety Services of SPP Correos Valencia Spain Occupational Health and Safety Services of SPP Correos Albacete Spain Occupational Health and Safety Services of SPA ITEM-Prevención Albacete Spain Department of Occupational and Prevention at University Hospital Fundación Jiménez Díaz Universidad Autónoma de Madrid Madrid Spain Occupational Medicine Service Grupo Banco Santander Madrid Spain Faculty of Health Sciences Universidad Internacional de la Rioja La Rioja Spain Occupational Medicine SABIC Medical Services Cartagena Spain University-PDI. Instituto de Matemática Multidisciplinar. Universitat Politècnica de València Valencia Spain

Introduction: Vulnerable is someone who can be hurt or receive injury, physically or morally. The work environment appears as one of the dimensions in which social vulnerability develops and social and occupational vulnerability is defined. The literature does not include an assessment of quantified occupational vulnerability as it already exists in the case of social vulnerability. The aim of this paper is to identify and quantify the variables included in the Protocol for the Assessment of Vulnerability to COVID-19 in such a way that the result can be quantified and allows for a predictive effect on the degree of vulnerability. Methodology: The starting point is the design of a protocol proposal that includes 29 variables. Data is collected from a sample of 420 workers, quantifying the results according to each variable, the overall scores for each group of aspects assessed and, finally, the total score that estimates the degree of vulnerability according to established ranges. Results: Variables that have the highest coefficient and, therefore, the greatest weight in the probability of reaching a group of high or medium vulnerability are cardiovascular disease, cancer, and coagulation alteration. The weight of the labour aspects due to inadequate working conditions stands out. Conclusions: The results obtained with this protocol allow us to make a quantified assessment of labour vulnerability to COVID-19 by integrating individual variables of the worker, his working conditions and the preventive actions of his company against COVID-19, and can be useful as an Occupational Vulnerability Index (OVI).

关键词： COVID-19 Index Occupational Vulnerability Occupational Health Occupational Medicine

Arsenite provides a selective signal that coordinates arsenate uptake and detoxification through the regulation of PHR1 stability in Arabidopsis

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Molecular Plant 2022年第11期15卷 1826-1826页

作者： cristina navarro Cristian Mateo-Elizalde Thotegowdanapalya CMohan Eduardo Sánchez-Bermejo Oscar Urrutia María Nieves Fernández-Muñiz JoséMGarcía-Mina Riansares Muñoz Javier Paz-Ares Gabriel Castrillo Antonio Leyva 不详

(Molecular Plant 14,1489-1507;September 6,2021)In the“Accession numbers”section in the originally published version of our manuscript,we mistakenly listed At5g44570 as the Arabidopsis Genome Initiative locus identif... 详细信息

关键词： Arabidopsis identifier stability

Sexual behavior and male volatile compounds in wild and mass-reared strains of the Mexican fruit fly Anastrepha ludens （Diptera： Tephritidae） held under different colony management regimes

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Insect Science 2016年第1期23卷 105-116页

作者： Carlos Felipe Bosa Leopoldo Cruz-Lopez cristina Silvia Zepeda-Cisneros Javier Valle-Mora Karina Guillen-navarro Pablo Liedo El Colegio de la Frontera Sur Carretera Antiguo Aeropuerto km 2.5 Chiapas 30700 Mexico Campana Nacional Moscas de laFruta Programa Moscafrut SAGARPA-IICA Metapa de Dominguez Chiapas Mexico

We compared the calling and mating behavior and volatile release of wild males Anastrepha ludens （Loew） with males from 4 mass-reared strains：（i） a stan- dard mass-reared colony （control）, （ii） a genetic sexing strain （Tap-7）, （iii） a colony started from males selected on their survival and mating competitiveness abilities （selected）, and （iv） a hybrid colony started by crossing wild males with control females. Selected and wild males were more competitive, achieving more matings under field cage conditions. Mass-reared strains showed higher percentages of pheromone calling males under field conditions except for Tap-7 males, which showed the highest percentages of pheromone calling males under laboratory cage conditions. For mature males of all strains, field-cage calling behavior increased during the last hour before sunset, with almost a 2 fold increase exhibited by wild males during the last half hour. The highest peak mating activity of the 4 mass-reared strains occurred 30 rain earlier than for wild males. By means of solid phase microextraction （SPME） plus gas chromatography-mass spectrometry （GC- MS）, the composition of volatiles released by males was analyzed and quantified, Wild males emitted significantly less amounts of （E,E）-α-farnesene but emitted significantly more amounts of （E,E）-suspensolide as they aged than mass-reared males. Within the 4 mass-reared strains, Tap-7 released significantly more amounts of （E,E）-α-farnesene and hybrid more of （E,E）-suspensolide. Differences in chemical composition could be ex- plained by the intrinsic characteristics of the strains and the colony management regimes. Characterization of calling behavior and age changes of volatile composition between wild and mass-reared strains could explain the differences in mating competitiveness and may be useful for optimizing the sterile insect technique in A. ludens.

关键词： age-dependent changes fruit fly mating pheromone

Chemotherapy induces cell plasticity;controlling plasticity increases therapeutic response

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3563-3566页

作者： Francisco J.Iborra cristina Martí Virtu Calabuig-navarro Petros Papadopoulos Salvador Meseguer Pedro M.Iborra Francisco García Antonio Martínez-Lorente Fernando Almazán Juana Calabuig Centro de Investigación Príncipe Felípe(Associated Unit to Instituto de Biomedicína de Valencia) ValenciaSpain Pathology and Molecular Therapy Department Instituto de Biomedicína de Valencia(IBV)CSICValenciaSpain Molecular and Cellular Biology Department Centro Nacional de Biotecnología(CNB)CSICMadridSpain Hematology Department Hospital Clínico San CarlosMadridSpain Medical Systems Biology Faculty of MedicineUniversity of HelsinkiHelsinkiFinland IC Biomed AlicanteSpain VinalopóHospitals Elcheand Biotechnology DepartmentUniversidad de AlicanteAlicanteSpain

Dear Editor,One of the most serious issues in modern oncology is the ineffectiveness of treatments in destroying tumours,which leads to tumour recurrence and,ultimately,patient *** phenomenon is caused by conventional therapies’fractional killing of tumour cells,which can also cause resistant cells to spread.1 We analysed chemotherapy-resistant cells and discovered that they are smaller than untreated cells(Fig.1a).The fact that this phenomenon occurs in all tested cell types(Hela,A549,Huh7,and MCF7)and regardless of the chemotherapy regimen(TRAIL,Camptothecin,Doxorubicin)suggests that it is a widespread phenomenon(Fig.1a,Supplementary Fig.S1).

关键词： chemotherapy tumour plasticity

Validation of a Marker Model for Gait Analysis with Wearable Exoskeletons

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Journal of Mechanics Engineering and Automation 2015年第7期5卷 407-410页

作者： Maria Gomez cristina Lopez de Subijana Eloy Urendes Enrique navarro Faculty of Physical Activity and Sport Technical University of Madrid Madrid 28040 Spain Bioengineering Group of the Spanish National Research Council Madrid 28500 Spain

The aim of the present study was to develop and validate a new marker model for optoelectronic systems adapted to wearable devices, in order to have an analysis tool for kinematic gait evaluation of reproduced patterns by exoskeletons. The marker model has a total of 36 retro-reflective markers attached bilaterally to anatomical landmarks during the static measures （without exoskeleton） and 28 markers at the dynamics measures （with exoskeleton）. The main difference between others kinematic models and the described adapted model was the placement of the three markers in the back thigh and the other three in the back calf, what allowed removing the hip, thigh, knee, tibia and ankle markers. The proposed adapted marker model could be an effective tool to validate the joint movement and velocities of those wearable exoskeletons that at present have been developing.

关键词： Optoelectronic system adapted model gait analysis

Ecosystem services potential and soil conservation policies with emphasis on degraded pastures in Brazil

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Geography and Sustainability 2024年第4期5卷 660-672页

作者： Adriana Monteiro da Costa Maise Soares de Moura Isadora Fonseca navarro Victor Cordeiro da Silva Teresa cristina TarléPissarra Carlos Alberto Valera Luís Filipe Sanches Fernandes Fernando Antonio Leal Pacheco Federal University of Minas Gerais(UFMG) Avenida Antônio Carlos6620PampulhaBelo HorizonteMG 31270-901Brazil São Paulo State University(Unesp) School of Agricultural and Veterinarian SciencesJaboticabal.Access Way Prof.Paulo Donato Castellanes/nJaboticabal SP 14884–900Brazil Luiz de Queiroz College of Agriculture University of São Paulo(ESALQ)Avenida Pádua Dias235CEP 13418-900PiracicabaSão Paulo StateBrazil Regional Coordination of Environmental Justice Prosecutors for the Paranaíba and Baixo Rio Grande River Basins Rua Coronel Antônio Rios951UberabaMG 38061-150Brazil CITAB–Center for Agro-environmental and Biological Research and Technologies University of Trás-os-Montes and Alto DouroAp.10135001–801 Vila RealPortugal CQVR–Vila Real Chemistry Center University of Trás-os-Montes and Alto DouroAp.10135001-801 Vila RealPortugal Post-Doctorate researcher University of Trás-os-Montes and Alto DouroAp.10135001-801 Vila RealPortugal POLUS-Land Use Policy Group Paulista State University(UNESP)Access Way Prof.Paulo Donato Castellanes/nJaboticabal SP 14884–900Brazil

Different global agendas have discussed the role of soils in mitigating and reducing global problems related to climate change,food security,biodiversity and erosion,among *** this in mind,the aim was to draw up an overview of the main soil agendas in Europe and Brazil,analysing their impact on the establishment of legal frameworks for soil use and *** Brazil,pastures are seen as an important alternative for converting degraded areas into ecosystem *** this end,a literature review was carried out using databases on the Scopus,Web of Science,Science Direct and Scielo platforms,as well as consulting documents from the European Union Missions in Horizon Europe and Brazilian legislation on the *** a pilot river basin,the Potential for Conservation Use(PCU)method was applied,which is used in Brazil to assess the impacts of different uses on the natural capital of soils,serving as a metric to guide public soil conservation *** was concluded that,on the European scene,discussions on soils have taken place in an integrated and organised way,with actions to mobilise different players in *** Brazil,even though there are important legal frameworks,actions are still restricted and disjointed,pointing to the need for progress in soil *** both scenarios,there is a need for scientifically validated metrics at regional scales that can contribute to a harmonised database capable of subsidising the development of efficient public policies to advance soil conservation at a global level.

关键词： EU mission Soil governance Conservation use potential Soil services PronaSolos

A Modified Shannon Trap for Use in Forensic Entomology

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Advances in Entomology 2014年第2期2卷 69-75页

作者： Maria Luiza Cavallari Fabio navarro Baltazar Erika cristina de Carvalho Daniel Romero Munoz Jose Eduardo Tolezano Centro de Parasitologia e Micologia Instituto Adolfo LutzSao PauloBrasil Laboratorio de Zoologia Medico-Legal Departamento de Medicina LegalEtica MedicaMedicina Social e do Trabalho da Faculdade de Medicina da Universidade de Sao PauloSao PauloBrasil

The objective of this study was to determine the efficacy of a modified Shannon trap to capture adult insects that are involved in cadaveric decomposition processes. The Shannon trap proposed here is composed of a thin fabric tent with a top formed by a transparent bottle containing a compartment filled with alcohol gel on which the captured insects are affixed. The trap was effective both for weather resistance and the quantity, quality and diversity of insects caught.

关键词： Forensic Science Flight Interception Trap Diptera Cadaveric Decomposition