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Emerging role of the gut microbiome in post-infectious irritable bowel syndrome:A literature review

World Journal of Gastroenterology 2023年第21期29卷 3241-3256页

作者： Vasile Valeriu Lupu cristina Mihaela Ghiciuc Gabriela Stefanescu cristina maria mihai Alina Popp maria Oana Sasaran Laura Bozomitu Iuliana Magdalena Starcea Anca Adam Raileanu Ancuta Lupu Faculty of General Medicine “Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania Faculty of General Medicine Ovidius UniversityConstanta 900470Romania Faculty of General Medicine “Carol Davila”University of Medicine and PharmacyBucharest 020021Romania Faculty of General Medicine “George Emil Palade”University of MedicinePharmacyScience and TechnologyTargu Mures 540142Romania

Post-infectious irritable bowel syndrome(PI-IBS)is a particular type of IBS,with symptom onset after an acute episode of infectious *** infectious disease resolution and clearance of the inciting pathogen agent,10%of patients will develop *** susceptible individuals,the exposure to pathogenic organisms leads to a marked shift in the gut microbiota with prolonged changes in host-microbiota *** changes can affect the gut-brain axis and the visceral sensitivity,disrupting the intestinal barrier,altering neuromuscular function,triggering persistent low inflammation,and sustaining the onset of IBS *** is no specific treatment strategy for *** drug classes can be used to treat PI-IBS similar to patients with IBS in general,guided by their clinical *** review summarizes the current evidence for microbial dysbiosis in PI-IBS and analyzes the available data regarding the role of the microbiome in mediating the central and peripheral dysfunctions that lead to IBS *** also discusses the current state of evidence on therapies targeting the microbiome in the management of *** results of microbial modulation strategies used in relieving IBS symptomatology are *** studies on PI-IBS animal models reported promising ***,published data that describe the efficacy and safety of microbial targeted therapy in PI-IBS patients are *** research is required.

关键词： Gut microbiome Infectious gastroenteritis Irritable bowel syndrome Post infection syndrome Pathophysiology Inflammation

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Esterification of Aspen Wood with Maleic Anhydride

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南京林业大学学报(自然科学版) 1997年第3期21卷 105-111页

作者： maria cristina TIMAR and maria Daniela mihai (“Transilvania” University of Brasov, Department of Wood Technology, ROMANIA) 罗马尼亚布拉索夫大学木材工业系

ＥｓｔｅｒｉｆｉｃａｔｉｏｎｏｆＡｓｐｅｎＷｏｏｄｗｉｔｈＭａｌｅｉｃＡｎｈｙｄｒｉｄｅＭａｒｉａＣｒｉｓｔｉｎａＴＩＭＡＲａｎｄＭａｒｉａＤａｎｉｅｌａＭＩＨＡＩ（“Ｔｒａｎｓｉｌｖａｎｉａ”Ｕｎｉｖｅｒｓｉｔ... 详细信息

ＥｓｔｅｒｉｆｉｃａｔｉｏｎｏｆＡｓｐｅｎＷｏｏｄｗｉｔｈＭａｌｅｉｃＡｎｈｙｄｒｉｄｅＭａｒｉａＣｒｉｓｔｉｎａＴＩＭＡＲａｎｄＭａｒｉａＤａｎｉｅｌａＭＩＨＡＩ（“Ｔｒａｎｓｉｌｖａｎｉａ”ＵｎｉｖｅｒｓｉｔｙｏｆＢｒａｓｏｖ，Ｄｅｐａｒｔｍ...

关键词： Aspen wood Maleic anhydride Esterification

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Serum 25-hydroxyvitamin D concentration and inflammatory bowel disease characteristics in Romania

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World Journal of Gastroenterology 2014年第9期20卷 2392-2396页

作者： Gabriela Dumitrescu Catalina mihai Mihaela Dranga cristina Cijevschi Prelipcean Department of Medical Sciences Grigore T. Popa University of Medicine and Pharmacy Iasi 700115 Romania

AIM: To describe the relationship between vitamin D levels and inflammatory bowel disease (IBD) characteristics in northeastern Romanian patients.

关键词： Inflammatory bowel disease, Vitamin D level, Northeastern Romania, Crohn’ s disease activity, Seasonality

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Extrapancreatic necrosis volume:A new tool in acute pancreatitis severity assessment?

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World Journal of Clinical Cases 2021年第31期9卷 9395-9405页

作者： Bogdan Cucuteanu DragoşNegru Otilia Gavrilescu Iolanda Valentina Popa mariana Floria Cătălina mihai cristina Cijevschi Prelipcean Mihaela Dranga Department of Radiology “Grigore T.Popa”University of Medicine and Pharmacy“Saint Spiridon”HospitalIaşi City 700115Romania Department of Gastroenterology “Grigore T.Popa”University of Medicine and Pharmacy“Saint Spiridon”HospitalIaşi City 700115Romania Department of Gastroenterology “Grigore T.Popa”University of Medicine and PharmacyIaşi City 700115Romania Department of Internal Medicine “Grigore T.Popa”University of Medicine and PharmacyIaşi City 700115Romania

BACKGROUND Many scores have been suggested to assess the severity of acute pancreatitis upon *** extrapancreatic necrosis volume is a novel,promising score that appears to be superior to other scores investigated so *** To evaluate the discriminatory power of extrapancreatic necrosis volume to identify severe cases of acute *** A total of 123 patients diagnosed with acute pancreatitis at Institute of Gastroenterology and Hepatology,St Spiridon Hospital between January 1,2017 and December 31,2019 were analyzed *** was classified according to the revised Atlanta classification(rAC)as mild,moderate,or *** was also evaluated by computed tomography and classified according to the computed tomography severity index(CTSI)and the modified CTSI(mCTSI).The results were compared with the extrapancreatic volume necrosis to establish the sensitivity and specificity of each *** The CTSI and mCTSI imaging scores and the extrapancreatic necrosis volume were highly correlated with the severity of pancreatitis estimated by the rAC(r=0.926,P<0.001 and r=0.950,P<0.001;r=0.784,P<0.001,respectively).The correlation of C-reactive protein with severity was positive but not as strong,and was not significant(r=0.133,P=0.154).The best predictor for the assessment of severe pancreatitis was the extrapancreatic necrosis volume[area under the curve(AUC)=0.993;95%confidence interval(CI):0.981-1.005],with a 99.5%sensitivity and 99.0%specificity at a cutoff value of 167 mL,followed by the mCTSI 2007 score(AUC=0.972;95%CI:0.946-0.999),with a 98.0%sensitivity and 96.5%specificity,and the CTSI 1990 score(AUC=0.969;95%CI:0.941-0.998),with a 97.0%sensitivity and 95.0%*** Radiological severity scores correlate strongly and positively with disease *** necrosis volume shows the best diagnostic accuracy for severe cases.

关键词： Acute pancreatitis Extrapancreatic necrosis volume Computed tomography index Modified computed tomography index C-reactive protein Severity score

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Metabolic syndrome and risk of subsequent colorectal cancer

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World Journal of Gastroenterology 2009年第41期15卷 5141-5148页

作者： Raluca Pais Horatiu Silaghi Alina cristina Silaghi mihai Lucian Rusu Dan Lucian Dumitrascu 2nd Department of Internal Medicine University of Medicine and Pharmacy (Iuliu Hatieganu) 2nd Department of Surgery University of Medicine and Pharmacy (Iuliu Hatieganu) Department of Endocrinology University of Medicine and Pharmacy (Iuliu Hatieganu)

The metabolic syndrome and visceral obesity have anincreasing prevalence and incidence in the generalpopulation. The actual prevalence of the metabolicsyndrome is 24% in US population and between24.6% and 30.9% in Europe. As demonstrated by many clinical trials (NAHANES , INTERHART) the metabolic syndrome is associated with an increased risk of both diabetes and cardiovascular disease. In addition to cardiovascular disease, individual components of the metabolic syndrome have been linked to the development of cancer, particularly to colorectal cancer. Colorectal cancer is an important public health problem; in the year 2000 there was an estimated total of 944 717 incident cases of colorectal cancer diagnosed world-wide. This association is sustained by many epidemiological studies. Recent reports suggest that individuals with metabolic syndrome have a higher risk of colon or rectal cancer. Moreover, the clusters of metabolic syndrome components increase the risk of associated cancer. The physiopathological mechanism that links metabolic syndrome and colorectal cancer is mostly related to abdominal obesity and insulin resistance. Population and experimental studies demonstrated that hyperinsulinemia, elevated C-peptide, elevated body mass index, high levels of insulin growth factor-1, low levels of insulin growth factor binding protein-3, high leptin levels and low adiponectin levels are all involved in carcinogenesis. Understanding the pathological mechanism that links metabolic syndrome and its components to carcinogenesis has a major clinical signifi cance and may have profound health benefi ts on a number of diseases including cancer, which represents a major cause of mortality and morbidity in our societies.

关键词： Metabolic syndrome Colorectal cancer Insulin resistance Obesity Adipokines Inflammatory cytokines

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