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Absorbed Bioactive Compounds Replicate GuanxinⅡ-Induced Endothelium-Associated in/ex vivo Vasodilation

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Chinese Journal of Integrative medicine 2024年第5期30卷 387-397页

作者： XU min LIU Hao SU meng-qing LI Lan YU Ai-ling CHEn Ken HUAnG Yun-ke ZHAO Qiu-long HUAnG Wen-ya HUAnG Xi Institute of Traditional Chinese medicine Related Comorbid Depression Nanjing University of Chinese MedicineNanjing 210029China Department of Gynecology Women's HospitalZhejiang University School of MedicineHangzhou 310053China

Objective:To develop an interference-free and rapid method to elucidate GuanxinⅡ(GXⅡ)'s representative vasodilator absorbed bioactive compounds(ABCs)among enormous ***:The contents of ferulic acid,tanshinol,and hydroxysafflor yellow A(FTA)in GXⅡ/rat serum after the oral administration of GXⅡ(30 g/kg)were detected using ultra-performance liquid chromatography-mass *** 18 rats were randomly assigned to the control group(0.9%normal saline),GXⅡ(30 g/kg)and FTA(5,28 and 77 mg/kg)by random number table *** coronary flow velocity-time integral(VTI),i.e.,coronary flow or coronary flow-mediated dilation(CFmD),and endothelium-intact vascular tension of isolated aortic rings were *** 12 h of exposure to blank medium or 0.5 mmol/L H_(2)O_(2),endothelial cells(ECs)were treated with post-dose GXⅡof supernatant from deproteinized serum(PGSDS,300μL PGSDS per 1 m L of culture medium)or FTA(237,1539,and 1510 mg/m L)for 10 min as control,H_(2)O_(2),PGSDS and FTA *** oxide(nO),vascular endothelial growth factor(VEGF),endothelin-1(ET-1),superoxide dismutase(SOD),malondialdehyde(mDA)and phosphorylated phosphoinositide 3 kinase(p-PI3K),phosphorylated protein kinase B(p-AKT),phosphorylated endothelial nitric oxide synthase(p-e nOS)were *** was developed as a GXⅡproxy of ex vivo herbal crude ***:PGSDS effectively eliminates false responses caused by crude GXⅡ*** doses equaled the contents in GXⅡ/its post-dose serum,FTA accounted for 98.17%of GXⅡ-added CFmD and 92.99%of PGSDS-reduced vascular *** ECs,FTA/PGSDS was found to have significant antioxidant(lower mDA and higher SOD,Pnd endothelial function-protective(lower VEGF,ET-1,Pncreases in aortic relaxation,endothelial nO levels and phosphorylated PI3K/Akt/e nOS protein induced by FTA/PGSDS were markedly abolished by nG-nitro-L-arginine methyl ester(L-nA,e nOS inhibitor)and wortmannin(PI3K/AKT inhibitor

关键词： ultra-performance liquid chromatography-mass spectrometry endothelium-dependent vasodilation herbal extract GuanxinⅡ absorbed bioactive compound

Charge regulation by ferromagnetic metal/LiF spin-polarized interface for high-performance Li metal anodes

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Rare metals 2024年第3期43卷 995-1005页

作者： ming-yang Feng Shuang Zhou Yi-Fang Zhang ya-Ping Wang Chun-yan Fu Jian-Wen Li Yuan-Lang Wan Zhi-Jia Zhang Yong Jiang An-Qiang Pan State Key Laboratory of Powder metallurgy School of Materials Science and EngineeringCentral South UniversityChangsha410083China State Key Laboratory of Separation membranes and membrane Processes Tianjin Key Laboratory of Advanced Fibers and Energy StorageSchool of Material Science and EngineeringTiangong UniversityTianjin300387China School of materials Science and Engineering Hebei University of TechnologyTianjin300130China

The interfacial characteristics of the Li metal anode(LmA)play a crucial role in its overall *** various materials being applied to modify the interface,a comprehensive understanding of their specific mechanisms remains to be ***,we have prepared carbon cloth(CC)frameworks with their surfaces modified using ferromagnetic metal/LiF heterogeneous films(T^(m)-LiF-CC)as the substrate for LmA,which exhibit superior electrochemical *** ferromagnetic Co as a representative example,our study demonstrates that the enhanced performance of Co-LiF-CC,compared to bare CC,is attributed to the spinpolarized interface contributed by the Co/LiF *** and LiF play individual roles in redistributing electrons and Li^(+)to promote homogeneous Li *** nanoparticles play a crucial role in generating strong surface capacitance by storing electrons in spin-split bands,while LiF,with low surface diffusion barriers,ensures fast transportation of Li^(+).The Co-LiF-CC@Li electrodes deliver long lives of 7400 and 3600 h at 1 and 2 mA·cm^(-2)in symmetric cells,respectively;moreover,they enable full batteries with high and durable capacities,particularly when the n/P ratios are low(3.3 or even 1.7).

关键词： Lithium metal anode Interfacial charge Ferromagnetic metal Lithium fluoride Spin polarization

Sulfonated poly(aryl ether ketone sulfone)modified by polyoxometalates LaW_(10) clusters for proton exchange membranes with high proton conduction performance

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Tungsten 2024年第2期6卷 454-464页

作者： meng-Long Liu Xu Han Wen-Wen He Feng-Yu Jiang Fang Ji Wang-Wang Shen Tao Zhou Jing-mei Xu ya-Qian Lan School of Chemistry and Life Science Changchun University of TechnologyChangchun 130012China Advanced Institute of materials Science Changchun University of TechnologyChangchun 130012China School of Chemistry South China Normal UniversityGuangzhou 510006China

Polyoxometalates(POms)are classified as solid superacids which can exhibit notable proton conductivity,making them a promising functional inorganic filler for enhancing the proton conductivity of proton exchange membranes(PEms).In this study,a series of hybrid membranes were obtained by molecular-level hybridization of Weakley-type POm na_(7)H_(2)LaW_(10)O_(36)(LaW_(10))clusters into sulfonated poly(aryl ether ketone sulfone)(SPAEKS).All hybrid membranes exhibited greater proton conductivity than the pristine membrane in the 30–80℃temperature *** the doping amount of LaW 10 reached 7 wt.%,the proton conductivity of m-LaW 10^(-7)achieved 64 mS·cm^(−1)at 80℃.Lanthanide ions'high coordination number property and variable coordination environment can aid to attract more water molecules from the *** 10 and these bound water can construct denser hydrogen bonds with–SO_(3)H of *** intensive hydrogen bonds will facilitate the constitution of more continuous proton transport channels,and improve the proton conductivity of the hybrid *** work off ers a fresh approach to using POms containing rare-earth components in PEms.

关键词： Polyoxometalates Rare-earth elements Sulfonated poly(arylene ether ketone sulfone) Proton exchange membranes

mETTL5 promotes gastric cancer progression via sphingomyelin metabolism

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1925-1946页

作者： ya-Qiong Zhang Jian Li Zhe Qin De-ming Li Fang-Zhou Ye Song-Hua Bei Xiao-Hong Zhang Li Feng Endoscopy Center Minhang Hospital Affiliated to Fudan UniversityShanghai 201100China

BACKGROUnD The treatment of gastric cancer(GC)has caused an enormous social burden *** studies have reported that n6-methyladenosine(m6A)is closely related to tumor ***5 is a m6A methyltransferase that plays a pivotal role in maintaining the metabolic stability of ***,its aberrant regulation in GC has not been fully *** To excavate the role of mETTL5 in the development of *** mETTL5 expression and clinicopathological characteristics were analyzed via The Cancer Genome Atlas dataset and further verified via immunohistochemistry,western blotting and real-time quantitative polymerase chain reaction in tissue microarrays and clinical *** tumor-promoting effect of mETTL5 on HGC-27 and AGS cells was explored in vitro by Cell Counting Kit-8 assays,colony formation assays,scratch healing assays,transwell assays and flow *** tumor-promoting role of mETTL5 in vivo was evaluated in a xenograft tumor *** EpiQuik m6A RnA methylation Quantification Kit was used for m6A ***,liquid chromatography-mass spectrometry was used to evaluate the association between mETTL5 and sphingomyelin metabolism,which was confirmed by Enzyme-linked immunosorbent assay and rescue *** addition,we investigated whether mETTL5 affects the sensitivity of GC cells to cisplatin via colony formation and transwell *** Our research revealed substantial upregulation of mETTL5,which suggested a poor prognosis of GC *** mETTL5 expression indicated distant lymph node metastasis,advanced cancer stage and pathological *** increased level of mETTL5 correlated with a high degree of m6A ***5 markedly promotes the proliferation,migration,and invasion of GC cells in ***5 also promotes the growth of GC in animal ***5 knockdown resulted in significant changes in sphingomyelin metabolism,which implies that mETTL5 may impact the development of GC via sphin

关键词： Gastric cancer mETTL5 Sphingomyelin metabolism Cisplatin

UWLPIPE:Ultra-wide Bandwidth Low-frequency Pulsar Data Processing Pipeline

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Research in Astronomy and Astrophysics 2024年第7期24卷 145-157页

作者： ya-Zhou Zhang Hai-Long Zhang Jie Wang Jian Li Xin-Chen Ye Shuang-Qiang Wang Xu Du Han Wu Ting Zhang Shao-Cong Guo Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China national Astronomical Data Center Beijing 100101China Southeast University Nanjing 211189China

For real-time processing of ultra-wide bandwidth low-frequency pulsar baseband data,we designed and implemented an ultra-wide bandwidth low-frequency pulsar data processing pipeline(UWLPIPE)based on the shared ringbuffer and GPU parallel *** runs on the GPU cluster and can simultaneously receive multiple 128 mHz dual-polarization VDIF data packets preprocessed by the front-end *** aligning the dual-polarization data,multiple 128m subband data are packaged into PSRDADA baseband data or multi-channel coherent dispersion filterbank data,and multiple subband filterbank data can be spliced into wideband data after time *** used the nanshan 26 m radio telescope with the L-band receiver at964~1732 mHz to observe multiple ***,we processed the data using DSPSR software,and the results showed that each subband could correctly fold out the pulse profile,and the wideband pulse profile accumulated by multiple subbands could be correctly aligned.

关键词： (stars)pulsars general-methods data analysis-techniques miscellaneous

Carbon cathode with heteroatom doping and ultrahigh surface area enabling enhanced capacitive behavior for potassium-ion hybrid capacitors

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Rare metals 2024年第5期43卷 2136-2149页

作者： yan Xiong ya-Fei Zhang Chun-Liu Zhu lei yang Huan-Yu Liang Jing Shi Jing-Wei Chen Wei-QianTian Shuai Liu Zhi Li Jing-Yi Wu Huan-lei Wang School of materials Science and Engineering Ocean University of ChinaQingdao 266100China Department of Chemical and materials Engineering University of AlbertaEdmontonAB T6G 2V4Canada

Potassium-ion hybrid capacitors(PIHCs)are widely regarded as highly promising energy storage devices,due to their exceptional energy density,impressive power density,and abundant potassium ***,restricted by the inherent capacitive storage mechanism,the carbon cathodes possess a much lower specific capacity than battery-type ***,designing high-performance carbon cathodes is extremely urgent for the development of ***,n,O codoped porous carbon(nOPC)was fabricated through the naCl hard template method and combined KOH/melamine chemical activation technique,displaying the characteristics of abundant n/O content(4.7 at%/16.9 at%),ultrahigh specific surface area(3092 m^(2)g^(-1))and hierarchical pore *** designed nOPC cathode delivers a high specific capacity(164.4 mAh.g^(-1)at 0.05 A.g^(-1))and superior cyclability(95.1%retention ratio at 2 A·g^(-1)over 2500 cycles).notably,the adjustable ratio of micropores to mesopores facilitates the achievement of the optimal bal-ance between capacity and rate ***,the pseudocapacitance can be further augmented through the incorporation of n/O functional *** expected,the graphite//nOPC based PIHC possesses a high energy density of 113 Wh·kg-at 747 W·kg^(-1)and excellent capacity retention of 84.4% fter 400 cycles at 1.0 A·g^(-1).This work introduces a novel strategy for designing carbon cathodes that enhances the electrochemical performance of PIHCs.

关键词： Template method n/O co-doping High specific surface area Carbon cathode Potassium-ion capacitors

Synthesis of highly stable ni nanoparticles via electrostatic self-assembly for enhanced hydrogen storage of mgH_(2)

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Rare metals 2024年第9期43卷 4356-4366页

作者： Qin-Ke Tang Jiang-Chuan Liu Rui Shi Yun-Feng Zhu Ji-Guang Zhang ya-na Liu Jun Wang yao Zhang Xiao-Hui Hu Zhi-Bin Liu Li-Quan Li College of materials Science and Engineering Jiangsu Collaborative Innovation Centre for Advanced Inorganic Function CompositesNanjing Tech UniversityNanjing 211816China School of materials Science and Engineering Southeast UniversityNanjing 211189China

magnesium-based hydrides have been widely recognized as an appropriate choice for solid-state hydrogen ***,its undesirable thermodynamics and sluggish hydrogenation/dehydrogenation kinetics are major bottlenecks for its ***,a highly stable and highly dispersed ni-based catalyst(ni/Al_(2)O_(3)/Gn)was fabricated to promote the hydrogen storage performance of mgH_(2)via the electrostatic effect of niAl-LDH/Gn precursor with a co-calcination reduction ***_(2)-5wt%ni/Al_(2)O_(3)/Gn exhibits excellent hydrogen storage performance,releasing about 5.7 wt%hydrogen in 3500 s at 250℃,and can reach a saturation hydrogen absorption of about 6.15 wt%in 3000 s at 100℃.Furthermore,it also shows low dehydrogenation apparent activation energy of 89.1 and 118.2 kJ·mol^(-1).Impressively,the catalyst ensures the stability of both the physical phase and structure during ball milling and cycling *** role of each phase in ni/Al_(2)O_(3)/Gn on the hydrogen storage performance of mgH_(2)was also discussed through experiments and theoretical calculation,and the synergistic catalytic mechanism of ni/Al_(2)O_(3)/Gn was clearly *** work provides a unique perspective for the preparation of highly stable and highly dispersible catalysts.

关键词： magnesium hydride ni/Al_(2)O_(3)/Gn Hydrogen storage performance Catalytic mechanism

Epidemiology,therapy and outcome of hepatocellular carcinoma between 2010 and 2019 in Piedmont,Italy

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 761-772页

作者： Christian Bracco marta Gallarate marco Badinella martini Corrado magnino Salvatore D'Agnano Roberta Canta Giulia Racca Remo melchio cristina Serraino Valentina Polla mattiot Giovanni Gollè Luigi Fenoglio Department of Internal medicine Santa Croce e Carle General HospitalCuneo 12100Italy Department of medical Sciences "City of Health and Science"University HospitalTorino 10100Italy

BACKGROUnD Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and the second leading cause of cancer deaths *** is often diagnosed at an advanced stage and therefore its prognosis remains poor with a low 5-year survival *** patients have increasingly complex and constantly changing characteristics,thus up-to-date and comprehensive data are *** To analyze the epidemiology and main clinical characteristics of HCC patients in a referral center hospital in the northwest of Italy between 2010 and *** In this retrospective study,we analyzed the clinical data of all consecutive patients with a new diagnosis of HCC recorded at"Santa Croce e Carle"Hospital in Cuneo(Italy)between 1 January 2010 and 31 December *** highlight possible changes in HCC patterns over the 10-year period,we split the population into two 5-year groups,according to the diagnosis period(2010-2014 and 2015-2019).RESULTS Of the 328 HCC patients who were included(m/F 255/73;mean age 68.9±11.3 years),154 in the first period,and 174 in the *** C virus infection was the most common HCC risk factor(41%,135 patients).The alcoholic etiology rate was 18%,the hepatitis B virus infection etiology was 5%,and the non-viral/non-alcoholic etiology rate was 22%.The Child-Pugh score distribution of the patients was:class A 75%,class B 21%and class C 4%.The average mayo end-stage liver disease score was 10.6±3.7.A total of 55 patients(17%)were affected by portal vein thrombosis and 158(48%)by portal *** average nodule size of the HCC was 4.6±3.1 cm.A total of 204 patients(63%)had more than one nodulend 92%(305 patients)had a non-metastatic stage of the *** Barcelona Clinic Liver Cancer(BCLC)staging distribution of all patients was:4%very early,32%early,23%intermediate,34%advanced,and 7%*** survival rate was 1.6±0.3 *** 20%of the patients underwent ***,presence of ascites,BCLC stage and therapy w

关键词： Hepatocellular carcinoma Hepatitis virus Alcoholic hepatitis non-alcoholic fatty liver disease Diagnosis Etiology Treatment

Curcumin for gastric cancer:mechanism prediction via network pharmacology,docking,and in vitro experiments

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3635-3650页

作者： Peng-Hui yang ya-nan Wei Bi-Juan Xiao Si-Yi Li Xin-Long Li Liang-Jun yang Hua-Feng Pan Geng-Xin Chen The Second School of Clinical medicine Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Department of Traditional Chinese medicine The People's Hospital of LonghuaShenzhen 518109Guangdong ProvinceChina Department of Gastroenterology Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Centre for Translational medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina

BACKGROUnD Curcumin originates from the natural herb turmeric,and its antitumor effects have been known about for a long ***,the mechanism by which curcumin affects gastric cancer(GC)has not been *** To elucidate the potential mechanisms of curcumin in the treatment of *** network pharmacological approaches were used to perform network analysis of *** first analyzed Lipinski’s Rule of Five for the use of *** latent targets were predicted using the Pharmmapper,SwissTargetPrediction and DrugBank network *** disease targets were mined through the GeneCard,OmIm,DrugBank and TTD network ***,GO enrichment,KEGG enrichment,protein-protein interaction(PPI),and overall survival analyses were *** results were further verified through molecular docking,differential expression analysis and cell *** We identified a total of 48 curcumin-related genes with 31 overlapping GC-related *** intersection targets between curcumin and GC have been enriched in 81 GO biological processes and 22 significant *** PPI analysis,6 hub targets were identified,namely,estrogen receptor 1(ESR1),epidermal growth factor receptor(EGFR),cytochrome P450 family 3 subfamily A member 4(CYP3A4),mitogen-activated protein kinase 14(mAPK-14),cytochrome P450 family 1 subfamily A member 2(CYP1A2),and cytochrome p450 family 2 subfamily B member 6(CYP2B6).These factors are correlated with decreased survival rates among patients diagnosed with *** docking analysis further substantiated the strong binding interactions between Curcumin and the hub target *** experimental findings demonstrated that curcumin not only effectively inhibits the growth of BGC-823 cells but also suppresses their *** levels of hub targets CYP3A4,mAPK14,CYP1A2,and CYP2B6 in BGC-823 cells were significantly increased in each dose *** Curcumin can play an anti-GC role through a variety of

关键词： Curcumin Gastric cancer network pharmacology molecular docking Survival analysis