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Journal of Pharmaceutical Analysis 2019年第5期9卷 324-331页

作者： cristina Panella Rosella Ferretti Adriano Casulli Roberto Cirilli Centro Nazionale peril Controllo e la Valutazione dei Farmaci Istituto Superiore di Sanita Viale Regina Elena 299 00161 Rome Italy European Union Reference Laboratory for the Parasites Istituto Superiore di Sanita Viale Regina Elena 299 00161 Rome Italy World Health Organization Collaborating Centre for the Epidemiology Detection and Control of Cystic and Alveolar Echinococcosis (in Animals and Humans) Istituto Superiore di Sanita Viale Regina Elena 299 00161 Rome Italy

Carvedilol is a chiral drug with potent antihypertensive and antianginal activities. Although it is clinically used as a racemic mixture, its enantiomers show different pharmacokinetic and pharmacodynamic profiles. Here, the direct chiral separation of racemic drug by high performance liquid chromatography using two immobilized-type amylose-based chiral stationary phases is presented. Some chromatographic parameters, such as retention and selectivity, were determined under multimodal eluent conditions and different temperatures. A temperature-dependent inversion of the elution order of enantiomers was observed in the operative temperature range of chiral chromatographic support. Finally, an effective direct enantioselective method was successfully applied to the separation of the enantiomers of carvedilol on a semipreparative scale.

关键词： Chiralpak^(■) IG-3 Enantioselective HPLC Carvedilol Column temperature Isoenantioselective temperature Semipreparative enantioseparation

The inflammasomes in health and disease:from genetics to molecular mechanisms of autoinflammation and beyond

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Cellular & Molecular Immunology 2011年第2期8卷 135-145页

作者： cristina Conforti-Andreoni Paola Ricciardi-Castagnoli Alessandra Mortellaro Singapore Immunology Network(SIgN) Agency for ScienceTechnology and Research(A*STAR)ImmunosSingapore

Nucleotide-binding oligomerization domain(NOD)-containing protein-like receptors(NLRs)are a recently discovered class of innate immune receptors that play a crucial role in initiating the inflammatory response following pathogen *** NLRs form the framework for cytosolic platforms called inflammasomes,which orchestrate the early inflammatory process via IL-1b *** and polymorphisms in NLR-coding genes or in genetic loci encoding inflammasome-related proteins correlate with a variety of autoinflammatory ***,the activity of certain inflammasomes is associated with susceptibility to infections as well as autoimmunity and *** this review,we will discuss how identifying the genetic characteristics of inflammasomes is assisting our understanding of both autoinflammatory diseases as well as other immune system-driven disorders.

关键词： autoinflammatory diseases polymorphisms NLRs NLRP3

Evolutionary consequences of deception： Complexity and informational content of colony signature are favored by social parasitism

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Current Zoology 2014年第1期60卷 137-148页

作者： Maria cristina LORENZI Laura AZZANI Anne-Genevieve BAGNRRES Department of Life Sciences and Systems Biology University of Turin via Accademia Albertina 13 10123 Torino Italy I.R.B.I. - UMR CNRS 7261 - Universit6 de Tours Facult6 des Sciences Parc Grandmont 37200 Tours France

Nestmate recognition codes show remarkable chemical complexity, involving multiple biochemical pathways. This complexity provides the opportunity to evaluate the ecological and social conditions that favor the evolution of complex signaling. We investigated how the chemical signatures of three populations of the social paper wasp Polistes biglumis differed in terms of concentration of hydrocarbons, proportions of branched hydrocarbons and overall variation. We tested whether the variation in chemical signatures among populations could be explained by the prevalence of social parasites or whether this was just an effect of local abiotic conditions which influenced the composition of the hydrocarbon cuticular layer. We studied the chemical signa- ture in three populations in which obligate social parasites differed in the selection pressures they imposed on host populations. Within each population, we restricted our analyses to non-parasitized hosts, to avoid potential short-term effects of parasite pres- ence on the host chemical signatures. We found that host colonies in parasitized populations had more diverse profiles than the parasite-free population. Moreover, the overall concentration of hydrocarbons and the relative proportion of branched hydrocar- bons were larger in the parasitized populations, relative to the non-parasitized one. This is to our knowledge the first evidence in favour of the hypothesis that different traits in the host chemical signatures as a whole undergo evolutionary changes resulting from directional or balancing selection imposed by social parasites. We conclude that obligate social parasites act as ＇engines of diversity＇ on host chemical signatures and operate in favor of a geographic mosaic of diverging communication codes

关键词： Polistes Brood parasitism Cipher Nestmate recognition Hydrocarbons Geographic mosaic Crozier's paradox

Three-dimensional trees for virtual globes

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International Journal of Digital Earth 2014年第10期7卷 789-810页

作者： cristina Rebollo Inmaculada Remolar Jesus Gumbau Miguel Chover Institute of New Imaging Technologies Universitat Jaume ICastellonSpain

One of the problems in virtual globes technologies is the real-time representation of vegetal *** forest or garden representations,the low detailed plants produce a lack of *** techniques are required to achieve accurate interactive visualisation due to the great number of polygons the vegetal species *** article presents a multi-resolution model based on a geometric representation of vegetal species that allows the application to perform the progressive transmission of the model,that is,the transmission of a simple representation followed by successive refinements of *** has a hardware-oriented design in order to obtain interactive frame *** geometric data of the objects are stored in the graphics processing unit and,moreover,the change from one approximation to another is obtained by performing mathematical calcula-tions in this graphics *** multi-resolution model presented here enables instancing:as many vegetal species as desired can be rendered with different levels of detail,while all of them are accessing the same geometric *** model has been used to build a real-time representation of a not imaginary scenario.

关键词： virtual globes real-time rendering vegetal species level of detail graphics hardware progressive transmission

A Comparative Study of the Ghost Literary Motif in Snow in Midsummer by Guan Hanqing and Hamlet by Shakespeare

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Journal of Foreign Languages and Cultures 2021年第1期5卷 125-134,155页

作者： cristina-Madalina Dinu University of Bucharest

In classical Chinese literature,employing the literary motif of the ghost represents both the writers'desire to escape the pattern of didactic literature promoted by Confucianism and their attempt to revolt against the rigidity of the Confucian dogma that is far too entrenched in reality and inhibits their *** during the Yuan Dynasty(1279-1368)by Guan Hanqing(1225-1302),Snow in Midsummer presents the injustice of Dou'E who dies for a crime she did not commit,with the girl returning to the world of the living in the form of a ghost to obtain her *** motif of the vengeful ghost also appears in Shakespeare's(1564-1616)play,*** this essay,I will investigate comparatively the dramatic aesthetics through which the spirits are outlined in the two plays,the comedy used by Guan Hanqing and Shakespeare,respectively,in the scenes of the appearance of spirits,and last but not least,the religious substratum contained in the symbolism of these *** a contrastive analysis of the dramaturgical and aesthetic construction of the two spirits in these plays,I argue that,despite their belonging to two different cultural spaces,both authors question through the supernatural the moral values of the societies in which they lived.

关键词： Snow in Midsummer Hamlet ghost Guan Hanqing Shakespeare Shakespearean theater zaju theater

Sorbents with high efficiency for CO2 capture based on amines-supported carbon for biogas upgrading

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Journal of Environmental Sciences 2016年第10期28卷 138-150页

作者： Lidia Pino cristina Italiano Antonio Vita Concetto Fabiano Vincenzo Recupero CNR Institute of Aduanced Technology for Energy "Nicola Giordano" Via S. Lucia 5 98126 Messina Italy

Sorbents for CO2 capture have been prepared by wet impregnation of a commercial active carbon （Ketjen-black, Akzo Nobel） with two CO2-philic compounds, polyethylenimine （PEI） and tetraethylenepentamine （TEPA）, respectively. The effects of amine amount （from 10 to 70 wt.%）, CO2 concentration in the feed, sorption temperature and gas hourly space velocity on the CO2 capture performance have been investigated. The sorption capacity has been evaluated using the breakthrough method, with a fixed bed reactor equipped with on line gas chromatograph. The samples have been characterized by N2 adsorption-desorption, scanning electron microscopy and energy dispersive X-ray （SEM/EDX）. A promising CO2 sorption capacity of 6.90 mmo1/gsorbent has been obtained with 70 wt.% of supported TEPA at 70℃ under a stream containing 80 vol% of CO2. Sorption tests, carried out with simulated biogas compositions （CH4/CO2 mixtures）, have revealed an appreciable CO2 separation selectivity; stable performance was maintained for 20 adsorption-desorption cycles.

关键词： CO2 capturePEI-TEPA based sorbentsAmine efficiencyBiogasSeparation selectivity

Insights on ZEB1-AS1:emerging role from cancer to neurodegeneration

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Neural Regeneration Research 2024年第6期19卷 1187-1188页

作者： Stephana Carelli Federica Rey Erika Maghraby cristina Cereda Pediatric Research Center“Romeo ed Enrica Invernizzi” Department of Biomedical and Clinical SciencesUniversity of MilanMilanItaly Center of Functional Genomics and Rare Diseases Department of PediatricsBuzzi Children’s HospitalMilanItaly Department of Biology and Biotechnology“L.Spallanzani” University of PaviaPaviaItaly

Implications for lncRNAs in the central nervous system:Transcriptional dysregulation is a key contributor to the pathogenesis of a wide range of diseases and long non-coding RNAs(lncRNAs)are highly expressed in the nervous ***,amongst the over 50,000 lncRNAs expressed in the human genome,more than 40%are specifically expressed in the brain where their roles in brain development,neuron functions,maintenance.

关键词： ZEB1 diseases pathogenesis

Extracts from Marine Macroalgae and Opuntia ficus-indica Cladodes Enhance Halotolerance and Enzymatic Potential of Diazotrophic Rhizobacteria and Their Impact on Wheat Germination Under Salt Stress

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Pedosphere 2018年第2期28卷 241-254页

作者： Abdelwahab RAI Ameur CHERIF cristina CRUZ Elhafid NABTI Département de Microbiologie Faculté des Sciences de la Nature et de la Vie Université Ferhat Abbas Sdtif-1 19000 (Algdrie) Universitg de Béjaia FSNV Laboratoire de Maitrise des Energies Renouvelables (LMER) Equipe de Biomasse et Environnement Targa Ouzemmour Béaia 06000 (Algérie) LR Biotechnology and Bio-Geo Resources Valorization Higher Institute for Biotechnology University of Manouba Sidi Thabet Biotechpole 2020 Sidi Thabet Ariana 2080 (Tunisia) cE3c-Centre for Ecology Evolution and Environmental Changes Campo Grande Bloco C-2 Piso 5 Sala 03 Lisboa 1749-016 CPor- tugal)

Soil salinity, which affects more than 6% of the earth’s land surface and more than 20% of its irrigated areas, is a major threat to agriculture. Diazotrophic bacteria are among the functional groups of soil microbiota that are threatened by this abiotic stress, as their activity is mostly inhibited by salt stress. Seventy bacterial strains with distinct characteristics were isolated from soils by using N-free Jensen’s selective medium. Based on their ability to produce metabolites of agricultural interest, four strains were selected and identified as Flavobacterium johnsoniae, Pseudomonas putida, Achromobacter xylosoxidans, and Azotobacter chroococcum. The selected strains were grown at different NaCl concentrations (0–600 mmol L^(-1) in N-free broth and 0–2 000 mmol L^(-1) in Luria-Bertani medium) in the presence and absence of glycine betaine (GB), aqueous and hydro-alcoholic extracts from marine macroalgae, Ulva lactuca and Enteromorpha intestinalis, and Opuntia ficus-indica cladodes. The selected bacterial strains, GB, and the aforementioned extracts were tested for their ability to promote the germination of wheat (Triticum durum) seeds at 0–300 mmol L^(-1) NaCl. Compared with the results obtained with the synthetic osmoprotectant GB, the extracts from O. ficus-indica, U. lactuca, and E. intestinalis significantly promoted bacterial growth and seed germination under salt stress.

关键词： glycine betaine Ulva lactuca Enteromorpha intestinalis plant growth-promoting rhizobacteria (PGPR) seed germi-nation Triticum durum

The effect of rippling on the mechanical properties of graphene

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Nano Materials Science 2022年第1期4卷 18-26页

作者： Guillermo Lopez-Polin cristina Gomez-Navarro Julio Gomez-Herrero Instituto de Ciencia de Materiales de Madrid CSICMadrid E 28049Spain Departamento de Física de La Materia Condensada Universidad Autónoma de MadridMadridE-28049Spain IFIMAC Condensed Matter Physics Center(IFIMAC).Universidad Autónoma de Madrid MadridE-28049Spain

Graphene is the stiffest material known so far but, due to its one-atom thickness, it is also very ***, free-standing graphene exhibit ripples that has major effects on its elastic properties. Here we will summarize three experiments where the influence of rippling is essential to address the results. Firstly, we observed that atomic vacancies lessen the negative thermal expansion coefficient(TEC) of free-standing *** also observed an increase of the Young's modulus with global applied strain and with the introduction of small density defects that we attributed to the decrease of rippling. Here, we will focus on a surprising feature observed in the data: the experiments consistently indicate that only the rippling with wavelengths between 5 and 10 nm influences the mechanics of graphene. The rippling responsible of the negative TEC and anomalous elasticity is thought to be dynamic, i.e. flexural phonons. However, flexural phonons with these wavelengths should have minor effects on the mechanics of graphene, therefore other mechanisms must be considered to address our observations. We propose static ripples as one of the key elements to correctly understand the thermomechanics of graphene and suggest that rippling arises naturally due to a competition of symmetry breaking and anharmonic fluctuations.

关键词： Graphene Mechanical properties Atomic force microscopy Defects Ripples Stmain

Determination of future land use changes using remote sensing imagery and artificial neural network algorithm:A case study of Davao City,Philippines

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Artificial Intelligence in Geosciences 2023年第1期4卷 111-118页

作者： cristina E.Dumdumaya Jonathan Salar Cabrera College of Information and Computing University of Southeastern PhilippinesBrgy.ObreroDavao CityPhilippines Faculty of Computing Data SciencesEngineering and TechnologyDavao Oriental State UniversityMati CityDavao Oriental8200Philippines

Land use and land cover(LULC)changes refer to alterations in land use or physical *** changes can be caused by human activities,such as urbanization,agriculture,and resource extraction,as well as natural phenomena,for example,erosion and climate *** changes significantly impact ecosystem services,biodiversity,and human *** this study,LULC changes in Davao City,Philippines,were simulated,predicted,and projected using a multilayer perception artificial neural network(MLP-ANN)*** MLP-ANN model was employed to analyze the impact of elevation and proximity to road networks(i.e.,exploratory maps)on changes in LULC from 2017 to *** predicted 2021 LULC map shows a high correlation to the actual LULC map of 2021,with a kappa index of 0.91 and a 96.68%*** MLP-ANN model was applied to project LULC changes in the future(i.e.,2030 and 2050).The results suggest that in 2030,the built-up area and trees are increasing by 4.50%and 2.31%,***,water will decrease by up to 0.34%,and crops is about to decrease by approximately 3.25%.In the year 2050,the built-up area will continue to increase to 6.89%,while water and crops will decrease by 0.53%and 3.32%,***,the results show that anthropogenic activities influence the land’s ***,the study illustrates how machine learning models can generate a reliable future scenario of land usage changes.

关键词： LULC Artificial neural network Remote sensing Land use land cover prediction Multilayer perception Philippines