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Resilience in action: The bottom up! architecture festival in Turin (Italy)

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Journal of Safety Science and Resilience 2023年第2期4卷 174-187页

作者： cristina Coscia Angioletta Voghera Department of Architecture and Design(DAD) Politecnico di Torinoviale Mattioli39Torino 10125Italy Responsble Riskresilience InteruniverstyDepartmentof Rgional and Urban Studies and Planing(DIST) Politecnico diTorinoviale Mattioli39Torino12 Italy

This article describes the practice of co-evolutionary and transformative resilience through a case study con-ducted in Turin(Italy).According to a broad definition,resilience includes performing actions of urban design and planning,innovating community-based project procedures,and creating positive financial outcomes that are assessable because of the monitoring process of short-and long-term outcomes and *** the Turin-based case of the Bottom Up!Architecture Festival,this article observes processes in which resilience is in action in metropolitan areas,feeding urban projects and practices of self-organization of the social and financial actors *** applying the definition of community projects,the festival manages to take territorial problems and crises(the pandemic,inequality,etc.)and view them as an opportunity to change the system,recommending in-tegrated action on the natural,cultural,financial,and social capital,innovating practices and holding society and institutions more *** transformation of spaces relies on collaborations between social and institu-tional actors,operating spatially concentrated transformations in the city of Turin,and using flexible governance tools based on co-planning and crowdfunding for project design and financing.

关键词： Resilience Bottom-up Co-evolution Crowdfunding AdaptiveGovernance Turin(Italy)

Blood extracellular vesicles (EVs) of central nervous system origin: a window into the brain

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Neural Regeneration Research 2020年第1期15卷 55-56页

作者： cristina Agliardi Mario Clerici IRCCS Fondazione Don Carlo Gnocchi MilanoItaly(Agliardi CClerici M) Department of Pathophisiology and Transplantation University of MilanMilanoItaly(Clerici M)

Extracellular vesicles(EVs)are heterogeneous nano-sized vesicles of endocytic origin shed into blood and other body fluids such as urine,saliva,seminal fluid,ascites,amniotic liquid,synovial fluid,breast milk and cerebrospinal fluid(CSF)by quite all cell *** actively contribute to intercellular communication as they carry bioactive molecules that are selectively incorporated by the originating cell and are delivered to recipient cells over long and short distances(Simons and Raposo,2009).EVs can be divided into three main groups according to their size and cellular origin:1)exosomes(40–120 nm),that have an endocytic origin and are formed by inward budding of the limiting membrane of multivescicular bodies,which fuse with the plasma membrane and release exosomes into the extracellular space;2)microvesicles(50–1000 nm),budding directly off the plasma membrane;3)apoptotic bodies(>1000 nm),which are released during *** originating via distinct processes,different subtypes of EVs carry different proteins within their membrane and luminal compartments that reflect the phenotype of the tissue of origin.

关键词： Blood urine origin

Vee-tail conceptual design criteria for commercial transport aeroplanes

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Chinese Journal of Aeronautics 2019年第3期32卷 595-610页

作者： Alejandro SANCHEZ-CARMONA cristina CUERNO-REJADO Faculty of Aerospace Engineering Department of Aircraft and Spacecraft Technical University of Madrid (Universidad Poltécnica de Madrid)

Vee-tail configuration is an unconventional tail configuration for commercial transport aviation, the use of which could suppose reductions on CO2 emissions. The conceptual design criteria have been selected inspired on the certification requirements established by the aviation regulation in force. They are static stability in cruise, control after Critical Engine Failure(CEF),control in crosswind landing, and trim in these three conditions. The study is carried out through a combination of semi-empirical techniques and Vortex-Lattice Methods(VLM) and thus this analyses the consequences of applying these criteria to a reference aeroplane substituting its conventional tail by a parametrised Vee-tail configuration. The Vee-tail is defined by four parameters:span, root chord, taper ratio and dihedral angle. The results of the study establish a relation between the parameters in order to accomplish the proposed conceptual design criteria. To sum up, minimum and maximum limits are obtained for dihedral angle depending on the combination of the rest of parameters. In addition, a design restriction to the yawing trailing-edge tail control is reached when the results are analysed, demonstrating that its minimum size must be between 60%and 80% of the half-span of the tail, depending on the Vee-tail geometry.

关键词： Commercial transport aeroplane Conceptual aircraft design Tail design requirements Unconventional tail design Vee-tail

Can dietary flavonoids be useful in the personalized treatment of colorectal cancer?

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World Journal of Gastrointestinal Oncology 2022年第6期14卷 1115-1123页

作者： cristina Pereira-Wilson Department of Biology Centre of Biological EngineeringLABBELS Associate LaboratoryUniversity of MinhoBraga 4710-057Portugal

Activating mutations in the oncogenes KRAS,BRAF and PI3K define molecular colorectal cancer(CRC)subtypes because they play key roles in promoting CRC development and in determining the efficacy of chemotherapeutic agents such as 5-fluorouracil and anti-epidermal growth factor receptor monoclonal *** of patients with cancers displaying these molecular profiles is *** the limited efficacy of therapeutic strategies for CRC presenting mutational activations in mitogen-activated protein kinase and/or PI3K pathways,developing combination therapies with natural flavonoids or other phytochemicals with demonstrated effects on these pathways(and little or no toxic effects)may constitute a valuable path *** has been published on the anticancer effects of dietary ***,even an exhaustive characterization of potential beneficial effects produced by in vitro studies cannot be extrapolated to effects in *** far,the available data constitute a good starting *** results show quercetin and curcumin as possibly the best candidates to be further explored in the context of adjuvant CRC therapy either as part of dietary prescriptions or as purified compounds in combination regimens with the drugs currently used in CRC *** trial data is still largely missing and is urgently needed to verify relevant effects and for the development of more personalized treatment approaches.

关键词： Colorectal cancer Personalized treatment Quercetin Curcumin KRAS BRAF

Targeting neuronal nitric oxide synthase as a valuable strategy for the therapy of neurological disorders

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Neural Regeneration Research 2016年第11期11卷 1731-1734页

作者： cristina Maccallini Rosa Amoroso Department of Pharmacy University "G.d'Annunzio" of Chieti-Pescara

The management of neurological disorders have huge and increasing human and economic costs. Despite this, there is a scarcity of effective therapeutics, and there is an extreme urgency for new and real treatments. In this short review we analyze some promising advancements in the search of new bioactive molecules targeting neuronal nitric oxide synthase （nNOS）, an enzyme deputed to the biosynthesis of nitric oxide （NO）. In different conditions of neuronal damages, this molecule is overproduced, contributing to the pathogenesis and progression of neuronal diseases. Two main approaches to modulate nNOS are discussed： a first one consisting in the direct inhibition of the enzyme by means of small organic molecules, which can be also active against other different targets involved in such diseases. A second section is dedicated to molecules able to prevent the formation of the ternary complex N-methyl-D-aspartate （NMDA）type glutamate receptors, postsynaptic density-95 （PSD95） protein-nNOS, which is necessary to activate the latter for the biosynthesis of NO.

关键词： amidines carbonic anhydrase inhibitors neurological diseases neuronal nitric oxide synthase NMDAR PSD95

Statistical Structures on Metric Path Spaces

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Chinese Annals of Mathematics,Series B 2012年第6期33卷 889-902页

作者： Mircea CRASMAREANU cristina-Elena HRET CANU Faculty of Mathematics Alexandru Ioan Cuza University Faculty of Food Engineering Stefan Cel Mare University

The authors extend the notion of statistical structure from Riemannian geometry to the general framework of path spaces endowed with a nonlinear connection and a generalized *** particular cases of statistical data are *** existence and uniqueness of a nonlinear connection corresponding to these classes is *** Koszul tensors are introduced in accordance with the Riemannian *** applications,the authors treat the Finslerian (α,β)-metrics and the Beil metrics used in relativity and field theories while the support Riemannian metric is the Fisher-Rao metric of a statistical model.

关键词： Semispray Nonlinear connection Metric path space Statistical struc-ture Skewness Koszul tensors (~ ~)-metric Beil metric Rayleigh sta-tistical structure Fisher-Rao metric Statistical model

Overview of dyslipidemia and metabolic syndrome in myeloproliferative neoplasms

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World Journal of Clinical Oncology 2024年第6期15卷 717-729页

作者： Mihnea-Alexandru Găman Bahadar Singh Srichawla Yong-Feng Chen Poulami Roy Arkadeep Dhali Ahmed Nahian Muhammad Romail Manan Vincent Kipkorir Richard Christian Suteja Lakshmi Venkata Simhachalam Kutikuppala Amelia Maria Găman Camelia cristina Diaconu Faculty of Medicine “Carol Davila”University of Medicine and PharmacyBucharest 050474Romania Department of Hematology Center of Hematolog Department of Cellular and Molecular Pathology Stefan S Nicolau Institute of VirologyRomanian AcademyBucharest 030304Romania Department of Neurology University of Massachusetts Chan Medical SchoolWorcesterMA 01655United States Department of Basic Medical Sciences School of Medicine of Taizhou UniversityTaizhou UniversityTaizhou 318000Zhejiang ProvinceChina Department of Medicine North Bengal Medical College and HospitalWest Bengal 734012India Academic Department of Gastroenterology Sheffield Teaching Hospitals NHS Foundation TrustSheffield S57AUUnited Kingdom Lecom at Seton Hill GreensburgPA 15601United States Faculty of Medicine Services HospitalLahore 54000Pakistan Department of Human Anatomy and Physiology University of NairobiNairobi 00100Kenya Faculty of Medicine Udayana UniversityDenpasarBali 80361Indonesia Department of General Surgery Dr.NTR University of Health SciencesVijayawada 520008Andhra PradeshIndia Department of Pathophysiology University of Medicine and Pharmacy of CraiovaCraiova 200349Romania Clinic of Hematology Filantropia City HospitalCraiova 200143Romania Department of Internal Medicine Faculty of Medicine“Carol Davila”University of Medicine and PharmacyBucharest 050474Romania Internal Medicine Clinic Clinical Emergency Hospital of BucharestBucharest 105402Romania

Myeloproliferative neoplasms(MPNs)occur due to the abnormal proliferation of one or more terminal myeloid cell lines in peripheral *** suffering from MPNs display a high burden of cardiovascular risk factors,and thrombotic events are often the cause of death in this population of ***,we provide a brief overview of dyslipidemia and metabolic syndrome and their epidemiology in MPNs and examine the common molecular mechanisms between dyslipidemia,metabolic syndrome,and MPNs,with a special focus on cardio-vascular risk,atherosclerosis,and thrombotic ***,we investigate the impact of dyslipidemia and metabolic syndrome on the occurrence and survival of thrombosis in MPN patients,as well as the management of dyslipidemia in MPNs,and the impact of MPN treatment on serum lipid concentrations,particularly as side/adverse effects reported in the context of clinical trials.

关键词： Polycythemia vera Essential thrombocythemia Myelofibrosis Cardiovascular disease Hypercholesterolemia Hypertriglyceridemia Obesity Diabetes Inflammation Oxidative stress

The Finite-dimensional Decomposition Property in Non-Archimedean Banach Spaces

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Acta Mathematica Sinica,English Series 2014年第11期30卷 1833-1845页

作者： Albert KUBZDELA cristina PEREZ-GARCIA Institute of Civil Engineering Poznań University of TechnologyUl.Piotrowo 561-138 PoznańPoland Department of Mathematics Facultad de CienciasUniversidad de CantabriaAvda.de los Castros s/n39071SantanderSpain

A non-Archimedean Banach space has the orthogonal finite-dimensional decomposition property（OFDDP） if it is the orthogonal direct sum of a sequence of finite-dimensional *** property has an influence in the non-Archimedean Grothendieck＇s approximation theory,where an open problem is the following： Let E be a non-Archimedean Banach space of countable type with the OFDDP and let D be a closed subspace of *** D have the OFDDP？ In this paper we give a negative answer to this question; we construct a Banach space of countable type with the OFDDP having a one-codimensional subspace without the *** we prove that,however,for certain classes of Banach spaces of countable type,the OFDDP is preserved by taking finite-codimensional subspaces.

关键词： Non-Archimedean Banach spaces finite-dimensional decomposition property orthogonal base

α-Synuclein oligomers and fibrils:partners in crime in synucleinopathies

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Neural Regeneration Research 2023年第11期18卷 2332-2342页

作者： Alessandra Bigi Roberta Cascella cristina Cecchi Department of Experimental and Clinical Biomedical Sciences Section of BiochemistryUniversity of FlorenceFlorenceItaly

The misfolding and aggregation of a-synuclein is the general hallmark of a group of devastating neurodegenerative pathologies referred to as synucleinopathies,such as Parkinson’s disease,dementia with Lewy bodies,and multiple system *** such conditions,a range of different misfolded aggregates,including oligomers,protofibrils,and fibrils,are present both in neurons and glial *** expe rimental evidence supports the proposition that solu ble oligomeric assemblies,formed during the early phases of the aggregation process,are the major culprits of neuronal toxicity;at the same time,fibrillar confo rmers appear to be the most efficient at propagating among interconnected neurons,thus contributing to the spreading ofα-synuclein ***,α-synuclein fibrils have been recently repo rted to release soluble and highly toxic oligomeric species,responsible for an immediate dysfunction in the recipient *** this review,we discuss the current knowledge about the plethora of mechanisms of cellular dysfunction caused byα-synuclein oligome rs and fibrils,both contributing to neurodegeneration in synucleinopathies.

关键词： amyloid aggregation neurodegeneration Parkinson’s disease protein aggregation protein misfolding