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γ氨基丁酸转运体1在大脑皮质小胶质细胞中的表达

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神经损伤与功能重建 2020年第12期15卷 F0003-F0003页

作者： Giorgia Fattorini Myriam Catalano Marcello Melone Carmela Serpe Silvia Bassi cristina Limatola Fiorenzo Conti 杜一星(编译) Department of Experimental and Clinical Medicine Section of Neuroscience and Cell BiologyUniversitàPolitecnica delle MarcheAnconaItaly Center for Neurobiology of Aging IRCCS INRCAAnconaItaly Department of Physiology and Pharmacology Sapienza University of RomeLaboratory Affiliated to Istituto Pasteur ItaliaRomeItaly IRCCS Neuromed Via AtinensePozzilliItaly 不详

小胶质细胞是脑的免疫细胞。通过感知微环境,小胶质细胞可以使大脑正常发育和发挥功能。它们与其他神经胶质细胞和神经元通讯,释放能对周围细胞产生影响的许多分子,并且能对这些分子做出反应。其中,神经递质,尤其是γ-氨基丁酸(GABA)最... 详细信息

小胶质细胞是脑的免疫细胞。通过感知微环境,小胶质细胞可以使大脑正常发育和发挥功能。它们与其他神经胶质细胞和神经元通讯,释放能对周围细胞产生影响的许多分子,并且能对这些分子做出反应。其中,神经递质,尤其是γ-氨基丁酸(GABA)最近引起了研究者对这一过程的兴趣。我们证明了GABA转运体1(GAT-1)在小胶质细胞的胞体和突起均有表达。我们发现,用强效的和选择性的GAT-1抑制剂NNC-711处理小胶质细胞,可显着降低其钠离子依赖性GABA的摄取。另一方面,用GAT-2/3抑制剂SNAP-5114处理细胞能显著增加其对GABA的摄取。该作用可被肉毒杆菌毒素Bo NT/C1完全阻断,该毒素特异性切割和灭活突触融合蛋白1A(STX1A)。总而言之,这些发现表明小胶质细胞表达GAT-1,且STX1A在小胶质细胞中GAT-1依赖的GABA摄取调控中起着重要作用。

关键词： γ氨基丁酸 γ氨基丁酸转运体1 小胶质细胞

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《读经》

山东工艺美术学院学报 2018年第6期 37-37页

作者：克里斯蒂娜·加兰

Correction to:Proposed nomenclature for Pseudallescheria,Scedosporium and related genera

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Fungal Diversity 2022年第2期113卷 193-194页

作者： Michaela Lackner G.Sybren de Hoog Liyue Yang Leandro Ferreira Moreno Sarah A.Ahmed Fritz Andreas Josef Kaltseis Markus Nagl Cornelia Lass-Florl Brigitte Risslegger Gunter Rambach Cornelia Speth Vincent Robert Walter Buzina Sharon Chen Jean-Philippe Bouchara Jose F.Cano-Lira Josep Guarro Josepa Gene Fabiola Fernandez Silva Rosa Haido Gerhard Haase Vladimir Havlicek Dea Garcia-Hermoso Jacques F.Meis Ferry Hagen Martin Kirchmair Johannes Rainer Katharina Schwabenbauer Mirjam Zoderer Wieland Meyer Felix Gilgado Vania A.Vicente Elena Pieckova Monika Regenermel Peter-Michael Rath Joerg Steinmann Xisto Wellington de Alencar Françoise Symoens Kathrin Tintelnot Krzysztof Ulfig Aristea Velegraki Anna Maria Tortorano Sandrine Giraud Sara Mina Kinga Rigler-Hohenwarter Fernando L.Hernando Andoni Ramirez-Garcia Aize Pellon Jashanpreet Kaur Eliana Barreto Bergter Jardel Vieira de Meirelles Ingrid Dutra da Silva Laurence Delhaes Ana Alastruey-Izquierdo Ruo-yu Li Qiaoyun Lu Tarek Moussa Omar Almaghrabi Hassan Al-Zahrani Gen Okada Shuwen Deng Wangqing Liao Jingsi Zeng Jouni Issakainen Livia cristina Liporagi Lopes Division of Hygiene and Medical Microbiology Innsbruck Medical UniversityInnsbruckAustria CBS Fungal Biodiversity Centre UtrechtThe Netherlands Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands Sun Yat-Sen Memorial Hospital Sun Yat-Sen UniversityGuangzhouChina Medical University of Graz GrazAustria Centre for Infectious Diseases and Microbiology Westmead HospitalWestmeadAustralia Laboratoire de Parasitologie-Mycologie Centre Hospitalier UniversitaireAngersFrance Unitats de Microbiologia i d’Anatomia Patologica Facultat de Medicina i Ciencies de la Salut IISPVUniversitat Rovira i VirgiliReusSpain Universidade Federal do Estado do Rio de Janeiro Rio de JaneiroBrazil Institute of Medical Microbiology University Hospital RWTHAachenGermany Institute of Microbiology Academy of SciencesPragueCzech Republic Institut Pasteur Unite de Mycologie MoleculaireCentre National de Reference Mycoses Invasives et AntifongiquesParisFrance Department of Medical Microbiology and Infectious Diseases Canisius-Wilhelmina HospitalNijmegenThe Netherlands Department of Medical Microbiology RadboudumcNijmegenThe Netherlands Institute of Microbiology eopold-Franzens-University InnsbruckInnsbruckAustria Molecular Mycology Research Laboratory Centre for Infectious Diseases and MicrobiologySydneyMedical School—Westmead HospitalMarie Bashir Institute for Infectious Diseases and BiosecurityThe University of SydneyWestmead Millennium InstituteWestmeadNSWAustralia Basic Pathology Department Federal University of Parana StateCuritibaParanaBrazil Fellowship from Conselho Nacional de Desenvolvimento Cientifico e Tecnologico(CNPq) BrasiliaBrazil Institute of Preventive and Clinical Medicine BratislavaSlovakia Institut für Hygiene und Mikrobiologie Landesklinikum St.Pölten St.PoltenAustria Institute of Medical Microbiology University Hospital EssenEssenGermany Nursing School of Unigranrio Rio de JaneiroBrazil Scientific Institute of Public Health Culture Collect

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欧洲文化统计

中国文化产业评论 2019年第1期27卷 127-152页

作者：文森特·科利-塞拉诺克里斯蒂娜·帕尔多-加西亚玛利亚·卡瓦列尔-塔拉索纳王莹(译) 西班牙瓦伦西亚大学云南大学

文化作为价值和认同的源泉,是欧洲独特性的重要特征和主要优势之一。随着文化在欧洲国内生产总值(GDP)中的比重日益增长,以证据为基础的文化测量活动具有重要意义。因此,文化数据库的可靠性和可获得性对政策制定者和社会科学研究者显得... 详细信息

文化作为价值和认同的源泉,是欧洲独特性的重要特征和主要优势之一。随着文化在欧洲国内生产总值(GDP)中的比重日益增长,以证据为基础的文化测量活动具有重要意义。因此,文化数据库的可靠性和可获得性对政策制定者和社会科学研究者显得尤其重要。在此背景下,本文汇编了国际机构在文化统计和测量方面的最新努力,为文化经理人的工作提供便利。具体而言,本文总结了欧洲国家和欧盟层面现有的文化统计资源,其中包括一组欧洲文化观测台的汇总表。

关键词：文化文化统计欧洲统计局国家统计局

分子标记和尾孢菌素分析方法研究阿根廷大豆紫斑病菌遗传多样性

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大豆科技 2015年第1期 36-36页

作者：李雪光 Maria cristina Lura Maria Gabriela Latorre Rapela Maria Celia Vaccari Roxana Maumary Anabel Soldano Monica Mattio Ana Maria Gonzalez Catedra de Microbiologla General Facultad de Bioqmmica y Ciencias Biologicas Universidad Nacional delLitoral Santa Fe Argentina Catedra de Fitopatologia Pacultad de Ciencias Agrarias Universidad National delLitoral Esperanza Argentina

在阿根廷由大豆紫斑病菌Cercospora kikuchii引起的叶斑和种子变紫是大豆上非常重要的病害。该研究主要进行了以下工作：1、采用内部简单序列重复（ISSR）标记和内转录间隔区r DNA序列信息方法,鉴定在圣达菲省不同大豆产区采集的大豆紫... 详细信息

在阿根廷由大豆紫斑病菌Cercospora kikuchii引起的叶斑和种子变紫是大豆上非常重要的病害。该研究主要进行了以下工作：1、采用内部简单序列重复（ISSR）标记和内转录间隔区r DNA序列信息方法,鉴定在圣达菲省不同大豆产区采集的大豆紫斑病菌不同菌株间的遗传变异;2、分析不同地区大豆紫斑病菌的尾孢菌素产品,以评价该地区菌株间分子分布和毒素产品是否有关系。

关键词：分子标记阿根廷尾孢菌遗传多样性大豆病菌内转录间隔区简单序列重复

复合型遗产的管理——预防性和计划性保护在意大利蒙扎皇家别墅和公园项目中的运用

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中国文化遗产 2020年第2期 47-58页

作者：罗塞拉·莫伊欧利克里斯提娜·伯尼欧迪安卓拉·康斯塔亚历桑德拉皮里吴丽君(译) 意大利米兰理工大学建筑、建成环境和建造工程学院意大利米兰

关于预防性和计划性保护在蒙扎皇家别墅和公园中运用的案例,是基于蒙扎和布里安扎文化区(MonzaandBrianzaCultural District)总体框架下的一个试点项目。蒙扎皇家别墅和公园项目是近年来由公共机构和私人团体共同推进下的计划性保护和... 详细信息

关于预防性和计划性保护在蒙扎皇家别墅和公园中运用的案例,是基于蒙扎和布里安扎文化区(MonzaandBrianzaCultural District)总体框架下的一个试点项目。蒙扎皇家别墅和公园项目是近年来由公共机构和私人团体共同推进下的计划性保护和适度利用⑥活动中的典型代表。该试点项目在蒙扎皇家别墅和公园保护活动所开展的案例分析基础上,对前期相关数据和信息进行收集,通过建立建成文化遗产保护的信息系统,对保护计划的各个组成部分(包括技术手册、保护方案、经济预算以及用户手册)进行设计和后期有效管理。同时也对蒙扎皇家别墅和公园的建成环境进行了分析,尤其关注位于蒙扎公园的每栋特定历史建筑。该项目实施的评估工作是在"上游投资"⑦理论框架内进行的。该研究强调了整合方法的重要性、为建立以事实为基础的政策而对所收集数据实施共享的必要性以及提升相关专业人士和决策者技能的必要性。该研究项目的价值体现在保护方法的进步、将保护和适度利用理解为预防性活动、私有经济模式下维护工作的有效性、优秀案例的宣传以及当地利益相关者间关系网的创建等方面。

关键词：文化遗产管理当地发展政府和社会资本合作模式(PPP模式) 复合型遗产预防性和计划性保护

Pulmonary vein stenosis:Etiology,diagnosis and management

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World Journal of Cardiology 2016年第1期8卷 81-88页

作者： Pablo Pazos-López cristina García-Rodríguez Alba Guitián-González Emilio Paredes-Galán María ángel De La Guarda álvarez-Moure Marta Rodríguez-álvarez José Antonio Baz-Alonso Elvis Teijeira-Fernández Francisco Eugenio Calvo-Iglesias Andrés íniguez-Romo Department of Cardiology Complexo Hospitalario Universitario de Vigo Hospital álvaro Cunqueiro Department of Radiology Complexo Hospitalario Universitario de Vigo Hospital álvaro Cunqueiro Diagnostic Imaging Unit Galaria Empresa Pública de Servicios Sanitarios Hospital do Meixoeiro

Pulmonary vein stenosis(PVS) is rare condition characterized by a challenging diagnosis and unfavorable prognosis at advance stages. At present, injury from radiofrequency ablation for atrial fibrillation has become the main cause of the disease. PVS is characterized by a progressive lumen size reduction of one or more pulmonary veins that, when hemodynamically significant, may raise lobar capillary pressure leading to signs and symptoms such as shortness of breath, cough, and hemoptysis. Image techniques(transesophageal echocardiography, computed tomography, magnetic resonance and perfusion imaging) are essential to reach a final diagnosis and decide an appropriate therapy. In this regard, series from referral centers have shown that surgical and transcatheter interventions may improve prognosis. The purpose of this article is to review the etiology, assessment and management of PVS.

关键词： Pulmonary vein stenosis Pulmonary vein stenosis etiology Pulmonary vein stenosis causes Pulmonary vein stenosis diagnosis Pulmonary vein stenosis management Pulmonary vein stenosis treatment

Accretion in strong field gravity with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 45-73页

作者： Alessandra De Rosa Phil Uttley LiJun Gou Yuan Liu Cosimo Bambi Didier Barret Tomaso Belloni Emanuele Berti Stefano Bianchi Ilaria Caiazzo Piergiorgio Casella Marco Feroci Valeria Ferrari Leonardo Gualtieri Jeremy Heyl Adam Ingram Vladimir Karas FangJun Lu Bin Luo Giorgio Matt Sara Motta Joseph Neilsen Paolo Pani Andrea Santangelo XinWen Shu JunFeng Wang Jian-Min Wang YongQuan Xue YuPeng Xu WeiMin Yuan YeFei Yuan Shuang-Nan Zhang Shu Zhang Ivan Agudo Lorenzo Amati Nils Andersson cristina Baglio Pavel Bakala Altan Baykal Sudip Bhattacharyya Ignazio Bombaci NiccolóBucciantini Fiamma Capitanio Riccardo Ciolfi Wei K.Cui Filippo D'Ammando Thomas Dauser Melania Del Santo Barbara De Marco Tiziana Di Salvo Chris Done Michal Dovciak Andrew C.Fabian Maurizio Falanga Angelo Francesco Gambino Bruce Gendre Victoria Grinberg Alexander Heger Jeroen Homan Rosario Iaria JiaChen Jiang ChiChuan Jin Elmar Koerding Manu Linares Zhu Liu Thomas J.Maccarone Julien Malzac Antonios Manousakis Frédéric Marin Andea Marinucci Missagh Mehdipour Mariano Méndez Simone Migliari Cole Miller Giovanni Miniutti Emanuele Nardini Paul T.O'Brien Julian P.Osborne Pierre Olivier Petrucci Andrea Possenti Alessandro Riggio Jerome Rodriguez Andrea Sanna LiJing Shao Malgosia Sobolewska Eva Sramkova Abigail L.Stevens Holger Stiele Giulia Stratta Zdenek Stuchlik Jiri Svoboda Fabrizio Tamburini Thomas M.Tauris Francesco Tombesi Gabriel Torok Martin Urbanec Frederic Vincent QingWen Wu Feng Yuan Jean J.M.in't Zand Andrzej A.Zdziarski XinLin Zhou INAF-Istituto di Astrofisica e Planetologie Spaziali Via Fosso del Cavaliere Anton Pannekoek Institute for Astronomy University of Amsterdam National Astronomical Observatories Chinese Academy of Science Institute of High Energy Physics Chinese Academy of Science Center for Field Theory and Particle Physics and Department of Physics Fudan University IRAP Universitéde ToulouseCNRSUPSCNES INAF-Osservatorio Astronomico di Brera Department of Physics and Astronomy The University of MississippiUniversity Dipartimento di Matematica e Fisica Universitàdegli studi Roma Tre University of British Columbia INAF-Osservatorio Astronomico di Roma INFN-Roma 2 c/o Dipartimento di Fisica II Universit?di Roma"Tor Vergata" Dipartimento di Fisica Universitàdegli Studi di Roma"La Sapienza"&Sezione INFN Roma1 Department of Physics University of OxfordClarendon Laboratory Astronomical Institute Academy of Sciences School of Astronomy and Space Science Nanjing University MIT Kavli Institute for Astrophysics and Space Research Institut für Astronomie und Astrophysik Eberhard Karls Universität Department of Physics Anhui Normal University Department of Astronomy and Institute of Theoretical Physics and Astrophysics Xiamen University CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of China Instituto de Astrofísica de Andalucia(CSIC) Glorieta de la Astronomía s/n INAF-Istituto di Astrofisica Spaziale e Fisica cosmica di Bologna Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Institute of Physics and Research Centre for Computational Physics and Data Processing Faculty of Philosophy&ScienceSilesian University in OpavaíBezru?ovo nám. Department of Physics Middle East Technical University Department of Astronomy and Astrophysics Tata Institute of Fundamental Research Dipartimento di Fisica Universit?di Pisa&INFN INAF-Osservatorio Astrofisico di Arcetri INAF-Osservatorio Astronomico di Padova INFN-TIFPA Trento Ins

In this paper we describe the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive black-holes. eXTP has the unique capability of using advanced "spectral-timing-polarimetry" techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the material within them and the powerful outflows which are driven by the accretion process.

关键词： X-ray black holes physics accretion

免疫疗法联合立体定向放疗治疗非小细胞肺癌脑转移:一项AIRO多中心回顾性研究

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中国肺癌杂志 2022年第4期25卷 I0007-I0022页

作者： Silvia SCOCCIANTI Emanuela OLMETTO Valentina PINZI Mattia Falchetto OSTI Rossella Di FRANCO Saverio CAINI Paola ANSELMO Paolo MATTEUCCI Davide FRANCESCHINI cristina MANTOVANI Giancarlo BELTRAMO Francesco PASQUALETTI Alessio BRUNI Paolo TINI Emilia GIUDICE Patrizia CIAMMELLA Anna MERLOTTI Sara PEDRETTI Marianna TRIGNANI Marco KRENGLI NiccolòGIAJ-LEVRA Isacco DESIDERI Guido PECCHIOLI Paolo MUTO Ernesto MARANZANO Laura FARISELLI Pierina NAVARRIA Umberto RICARDI Vieri SCOTTI Lorenzo LIVI 王绿化(翻译/校对) Radiation Oncology Unit Ospedale Santa Maria AnnunziataDepartment of OncologyBagno a RipoliFlorenceItaly Radiation Oncology Unit Azienda Ospedaliero Universitaria CareggiDepartment of Experimental and Clinical Biomedical Sciences"Mario Serio"FlorenceItaly U.O Radioterapia Fondazione IRCCS Istituto Neurologico Carlo BestaDepartment of NeurosurgeryMilanItaly U.O.C Radioterapia A.O.U Sant'Andrea Facolta Medicina e Psicologia Universita SapienzaDepartment of MedicineSurgery and Translational MedicineRomeItaly Istituto Nazionale Tumori IRCCS Fondazione G.PascaleDepartment of RadiotherapyNaplesItaly Institute for Cancer Research Prevention and Clinical Network(ISPRO)Cancer Risk Factors and Life-Style Epidemiology UnitFlorenceItaly Radiotherapy Oncology Center S.Maria HospitalDepartment of OncologyTerniItaly Humanitas Research Hospital Radiotherapy and Radiosurgery DepartmentRozzanoItaly Radiotherapy Unit Department of OncologyTurinItaly Cyberknife Centro Diagnostico Italiano Department of RadiologyMilanItaly Radiation Oncology Azienda Ospedaliero Universitaria PisanaDepartment of Translational MedicinePisaItaly Radiotherapy Unit University Hospital of ModenaDepartment of Oncology and HematologyModenaItaly Radiotherapy Unit University of SienaDepartment of Radiotherapy and OncologySienaItaly UOC di Radioterapia Policlinico Universitario Tor VergataDepartment of Onco-HaematologyRomeItaly Radioterapia Oncologica"G.Prodi "AO-IRCCS Arcispedale S.Maria NuovaDepartment of Oncology and Advanced TechnologyReggio EmiliaItaly Radiation Oncology A.S.O.S.Croce e Carle Department of Radiation OncologyCuneoItaly U.O.Radioterapia Oncologica Department of Radiation OncologyASST Spedali Civili di Brescia e Universita degli studi di BresciaBresciaItaly U.O.C.Radioterapia Oncologica Ospedale Clinicizzato SS Annunziata-Universita Chieti G.D'AnnunzioDepartment of Radiation OncologyChietiItaly Radiation Oncology University Hospital Maggiore della CaritdDepartment of Translational Medicine

背景与目的通过意大利放射治疗和临床肿瘤学学会(Italian Association of Radiotherapy and Clinical Oncology, AIRO)的一项多中心回顾性研究,明确免疫疗法(immunotherapy, IT)和立体定向放疗(stereotactic radiotherapy,SRT)包括放射外科治疗(radiosurgery, RS)或大分割立体定向放疗(hypofractionated stereotactic radiotherapy, HFSRT)治疗非小细胞肺癌(non-small cell lung cancer, NSCLC)脑转移的疗效和毒性。方法对来自19个意大利中心接受SRT+IT的NSCLC伴脑转移患者进行分析,并与单独接受SRT的对照组患者进行比较。结果共纳入SRT+IT组100例和单独SRT组50例。接受SRT+IT的患者有更长的颅内局部无进展生存期(intracranial local progression-free survival, i LPFS)(经倾向性评分调整后,P=0.007)。在诊断为脑转移时接受IT合并有颅外进展的患者中(n=24),接受SRT后再进行IT与较好的总生存期(overall survival, OS)相关(P=0.037)。多因素分析显示组织学类型为非腺癌、卡氏体能状态(Karnofsky performance status,KPS)评分=70分以及接受HFSRT与显著减少的生存期相关(P值分别为0.019、0.017和0.007)。与SRT和IT治疗间隔>7天(n=10)相比,治疗间隔≤7天(n=90)与更长的OS相关(经倾向性评分调整后,P=0.008)。联合治疗耐受性良好。在放射性坏死方面,接受SRT+IT的患者与单独SRT的患者无显著差异。SRT和IT的治疗间隔对毒性发生率无影响。结论 SRT+IT是一种安全的联合治疗方法,与单独SRT相比,具有更长的i LPFS。

关键词：立体定向放疗回顾性研究脑转移倾向性评分临床肿瘤学免疫疗法放射治疗