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Early diagnosis of pancreatic cancer: Shedding light on an unresolved challenge

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World Journal of Clinical Cases 2024年第14期12卷 2463-2465页

作者： cristian Lindner Department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile

Diagnosing early-stage pancreatic cancer(PC)remains a clinical ***,studying novel imaging aspects that could enhance the diagnostic accuracy of malignant pancreatic precursor lesions is *** article aims to un-derscore the promising role of emerging imaging aspects that may facilitate the earlier diagnosis of PC,thereby improving its management and prognosis.

关键词： Pancreatic cancer Pancreatic intraepithelial neoplasm High-grade pancreatic intraepithelial neoplasm Pancreatic ducts Cancer Early diagnosis

Imaging features of malignant vs stone-induced biliary obstruction:Aspects to consider

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World Journal of Clinical Cases 2024年第15期12卷 2678-2681页

作者： cristian Lindner Department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile

Radiological studies play a crucial role in the evaluation of patients with biliary duct obstruction,allowing for the guidance of clinical diagnosis towards a malignant or stone-induced etiology through the recognition of relevant imaging features,which must be continuously revisited given their prognostic *** article aims to emphasize the importance of recognizing crucial imaging aspects of malignant and stone-induced biliary obstruction.

关键词： Malignant biliary obstruction Choledocholithiasis Dilated bile ducts Magnetic resonance Multidetector computed tomography

Adaptive immune response during hepatitis C virus infection

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World Journal of Gastroenterology 2014年第13期20卷 3418-3430页

作者： Juan Ramon Larrubia Elia Moreno-Cubero Megha Uttam Lokhande Silvia Garcia-Garzon Alicia Lazaro Joaquin Miquel cristian perna Eduardo Sanz-de-Villalobos Translational Hepatology Unit Guadalajara University HospitalUniversity of AlcalaE-19002 GuadalajaraSpain Department of Medicine and Medical Specialities School of MedicineUniversity of AlcalaE-28801 Alcala de HenaresSpain

Hepatitis C virus(HCV)infection affects about 170 million people worldwide and it is a major cause of liver cirrhosis and hepatocellular *** is a hepatotropic non-cytopathic virus able to persist in a great percentage of infected hosts due to its ability to escape from the immune *** damage and disease progression during HCV infection are driven by both viral and host ***,adaptive immune response carries out an essential task in controllingnon-cytopathic viruses because of its ability to recognize infected cells and to destroy them by cytopathic mechanisms and to eliminate the virus by non-cytolytic *** is able to impair this response by several means such as developing escape mutations in neutralizing antibodies and in T cell receptor viral epitope recognition sites and inducing HCV-specific cytotoxic T cell anergy and *** impair HCV-specific T cell reactivity,HCV affects effector T cell regulation by modulating T helper and Treg response and by impairing the balance between positive and negative co-stimulatory molecules and between pro-and antiapoptotic *** this review,the role of adaptive immune response in controlling HCV infection and the HCV mechanisms to evade this response are reviewed.

关键词： Hepatitis C, Adaptive immune response, Hepatitis C virus-specific cytotoxic T cells, Hepatitis C virus-specific T helper cells, T regs, Hepatitis C virus escape mutations, Anergy, Apoptosis, Chemotaxis

Quality assessment of surgery for colorectal cancer:Where do we stand?

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 982-987页

作者： Stefan Morarasu cristian Livadaru Gabriel-Mihail Dimofte The Second Department of Surgical Oncology Regional Institute of OncologyIasi 707483Romania

Quality assurance in surgery has been one of the most important topics of debate among colorectal surgeons in the past *** has produced new surgical standards that led in part to the impressive oncological outcomes we see in many units *** mesorectal excision,complete mesocolic excision(CME),and the Japanese D3 lymphadenectomy are now benchmark techniques embraced by many surgeons and widely recommended by surgical ***,there are still ongoing discrepancies in outcomes largely based on surgeon *** is one of the main reasons why many countries have shifted colorectal cancer surgery only to high volume *** markers of surgical quality is thus a perquisite to ensure that standards and oncological outcomes are met at an institutional *** the evolution of CME surgery,various quality markers have been described,mostly based on measurements on the surgical specimen and lymph node yield,while others have proposed radiological markers(*** stumps)measured on postoperative scans as part of the routine cancer *** is no ideal marker;however,taken together and assembled into a new score or set of criteria may become a future point of reference for reporting outcomes of colorectal cancer surgery in research studies and defining subspecialization requirements both at an individual and hospital level.

关键词： Colorectal cancer Colon surgery Arterial stump Complete mesocolic excision Surgical quality

Hyperparameter optimization of YOLOv8 for smoke and wildfire detection:Implications for agricultural and environmental safety

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Artificial Intelligence in Agriculture 2024年第2期12卷 109-126页

作者： Leo Ramos Edmundo Casas Eduardo Bendek cristian Romero Francklin Rivas-Echeverría Kauel Inc. Menlo Park(Silicon Valley)CA 94025USA Computer Vision Center Universitat Autònoma de BarcelonaBellaterra 08193Spain Faculty of Engineering University of DeustoBilbao 48007Spain Jet Propulsion Laboratory NASAPasadenaCA 91109USA

In this study,we extensively evaluated the viability of the state-of-the-art YOLOv8 architecture for object detec-tion tasks,specifically tailored for smoke and wildfire identification with a focus on agricultural and environmen-tal *** available versions of YOLOv8 were initially fine-tuned on a domain-specific dataset that included a variety of scenarios,crucial for comprehensive agricultural ***‘large’version(YOLOv8l)was se-lected for further hyperparameter tuning based on its performance *** model underwent a detailed hyperparameter optimization using the One Factor At a Time(OFAT)methodology,concentrating on key param-eters such as learning rate,batch size,weight decay,epochs,and *** from the OFAT study were used to define search spaces for a subsequent Random Search(RS).The final model derived from RS demon-strated significant improvements over the initial fine-tuned model,increasing overall precision by 1.39%,recall by 1.48%,F1-score by 1.44%,mAP@0.50 by 0.70%,and mAP@0.50:0.95 by 5.09%.We validated the enhanced model's efficacy on a diverse set of real-world images,reflecting various agricultural settings,to confirm its ro-bustness in detecting smoke and *** results underscore the model's reliability and effectiveness in scenar-ios critical to agricultural safety and environmental *** work,representing a significant advancement in the field of fire and smoke detection through machine learning,lays a strong foundation for fu-ture research and solutions aimed at safeguarding agricultural areas and natural environments.

关键词： Agricultural safety Wildfire detection Smoke detection Object detection Computer vision YOL

Plant triterpenoid saponins function as susceptibility factors to promote the pathogenicity of Botrytis cinerea

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Molecular Plant 2024年第7期17卷 1073-1089页

作者： Francisco J.Escaray Amelia Felipo-Benavent cristian J.Antonelli Begona Balaguer Maria Pilar Lopez-Gresa Pablo Vera Instituto de Biologia Molecular y Celular de Plantas Universidad Politecnica de Valencia-C.S.l.CCiudad Politecnica de la InnovacionEdificio 8Eacceso GIngeniero Fausto Elios/n46022ValenciaSpain

The gray mold fungus Botrytis cinerea is a necrotrophic pathogen that causes diseases in hundreds of plant species,including high-value *** polyxenous nature and pathogenic success are due to its ability to perceive host signals in its *** this study,we found that laticifer cells of Euphorbia lathyris are a source of susceptibility factors required by *** to cause ***,poor-in-latex(pil)mutants,which lack laticifer cells,show full resistance to this pathogen,whereas lot-of-latex mutants,which produce more laticifer cells,are *** S factors are triterpenoid saponins,which are widely distributed natural products of vast structural *** downregulation of laticifer-specific oxydosqualene cyclase genes,which encode the first committed step enzymes for triterpene and,therefore,saponin biosynthesis,conferred disease resistance to ***,the Medicago truncatula Iha-1 mutant,compromised in triterpenoid saponin biosynthesis,showed enhanced ***,the application of different purified triterpenoid saponins pharmacologically complemented the diseaseresistant phenotype ofpil and hla-1 mutants and enhanced disease susceptibility in different plant *** found that triterpenoid saponins function as plant cues that signal transcriptional reprogramming in ***,leading to a change in its growth habit and infection strategy,culminating in the abundant formation of infection cushions,the multicellular appressoria apparatus dedicated to plant penetration and biomass destruction in *** together,these results provide an explanation for how plant triterpenoid saponins function as disease susceptibility factors to promote *** pathogenicity.

关键词： Euphorbia lathyris laticifer cell latex appressorium infection cushion necrotrophic fungi

Contributing to the prediction of prognosis for treated hepatocellular carcinoma: Imaging aspects that sculpt the future

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3377-3380页

作者： cristian Lindner Department of Radiology Faculty of MedicineUniversity of ConcepcionConcepcion 4030000BiobíoChile Department of Radiology Hospital Regional Guillermo Grant BenaventeConcepcion 4030000BiobíoChile

A novel nomogram model to predict the prognosis of hepatocellular carcinoma(HCC)treated with radiofrequency ablation and transarterial chemoembolization was recently published in the World Journal of Gastrointestinal *** model includes clinical and laboratory factors,but emerging imaging aspects,partic-ularly from magnetic resonance imaging(MRI)and radiomics,could enhance the predictive accuracy *** MRI and deep learning radiomics models significantly improve prognostic predictions for the treatment of ***-corporating advanced imaging features,such as peritumoral hypointensity and radiomics scores,alongside clinical factors,can refine prognostic models,aiding in personalized treatment and better predicting *** letter underscores the importance of integrating novel imaging techniques into prognostic tools to better manage and treat HCC.

关键词： Hepatocellular carcinoma Radiofrequency ablation Transcatheter arterial chemoembolization Prognosis Magnetic resonance imaging Radiomics Artificial intelligence

Emerging and multifaceted potential contributions of polyphenols in the management of type 2 diabetes mellitus

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World Journal of Diabetes 2024年第2期15卷 154-169页

作者： Ileana González cristian Lindner Ivan Schneider Erik Diaz Miguel Angel Morales Armando Rojas Biomedical Research Laboratories Faculty of MedicineCatholic University of MauleTalca 34600000Chile Department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile Centre of Primary Attention South Metropolitan Health ServiceSantiago 3830000Chile Faculty of Medicine Catholic University of MauleTalca 3460000Chile Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Type 2 diabetes mellitus(T2DM)is recognized as a serious public health concern with a considerable impact on human life,long-term health expenditures,and substantial health *** this context,the use of dietary polyphenols to prevent and manage T2DM is widely *** dietary compounds exert their beneficial effects through several actions,including the protection of pancreatic islet β-cell,the antioxidant capacities of these molecules,their effects on insulin secretion and actions,the regulation of intestinal microbiota,and their contribution to ameliorate diabetic complications,particularly those of vascular *** the present review,we intend to highlight these multifaceted actions and the molecular mechanisms by which these plant-derived secondary metabolites exert their beneficial effects on type 2 diabetes patients.

关键词： Polyphenols Antioxidants Oxidative stress Type 2 diabetes mellitus Health benefits

Discovering genetic biomarkers for targeted cancer therapeutics with eXplainable Artificial Intelligence

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Cancer Communications 2024年第5期44卷 584-588页

作者： Debaditya Chakraborty Elizabeth Gutierrez-Chakraborty cristian Rodriguez-Aguayo Hakan Başağaoğlu Gabriel Lopez-Berestein Paola Amero School of Civil and Environmental Engineering and Construction Management The University of Texas at San AntonioSan AntonioTexasUSA Department of Cell Systems and Anatomy University of Texas Health Science CenterSan AntonioTexasUSA Department of Experimental Therapeutics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Edwards Aquifer Authority San AntonioTexasUSA

High-Grade Serous Ovarian Cancer(HGSC)is the most prevalent and lethal form of gynecologic malignancies[1],accounting for 70%-80%of ovarian cancer *** decades of research,the overall survival rate for HGSC has remained largely unchanged[2],and patients with advanced stages of the disease have only a 41%chance of surviving beyond five years[3].

关键词： cancer Cancer targeted