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Deep Learning-Based Model for Detection of Brinjal Weed in the Era of Precision Agriculture

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Computers, Materials & Continua 2023年第10期77卷 1281-1301页

作者： Jigna Patel Anand Ruparelia Sudeep Tanwar Fayez Alqahtani Amr Tolba Ravi Sharma Maria Simona Raboaca Bogdan Constantin neagu Department of Computer Science and Engineering Institute of TechnologyNirma UniversityAhmedabad382481India Software Engineering Department College of Computer and Information SciencesKing Saud UniversityRiyadh12372Saudi Arabia Computer Science Department Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia Centre for Inter-Disciplinary Research and Innovation University of Petroleum and Energy StudiesDehradun248001India Doctoral School University Politehnica of BucharestBucharest060042Romania National Research and Development Institute for Cryogenic and Isotopic Technologies-ICSI Rm ValceaRamnicu Valcea240050Romania Power Engineering Department Gheorghe Asachi Technical University of IasiIasi700050Romania

The overgrowth of weeds growing along with the primary crop in the fields reduces crop *** solutions like hand weeding are labor-intensive,costly,and time-consuming;farmers have used *** application of herbicide is effective but causes environmental and health ***,Precision Agriculture(PA)suggests the variable spraying of herbicides so that herbicide chemicals do not affect the primary *** by the gap above,we proposed a Deep Learning(DL)based model for detecting Eggplant(Brinjal)weed in this *** key objective of this study is to detect plant and non-plant(weed)parts from crop *** the help of object detection,the precise location of weeds from images can be *** dataset is collected manually from a private farm in Gandhinagar,Gujarat,*** combined approach of classification and object detection is applied in the proposed *** Convolutional Neural Network(CNN)model is used to classify weed and non-weed images;further DL models are applied for object *** have compared DL models based on accuracy,memory usage,and Intersection over Union(IoU).ResNet-18,YOLOv3,CenterNet,and Faster RCNN are used in the proposed *** outperforms all other models in terms of accuracy,i.e.,88%.Compared to other models,YOLOv3 is the least memory-intensive,utilizing 4.78 GB to evaluate the data.

关键词： Precision Agriculture Deep Learning brinjal weed detection ResNet-18 YOLOv3 CenterNet Faster RCNN

Gastrointestinal cancer stem cells as targets for innovative immunotherapy

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World Journal of Gastroenterology 2020年第14期26卷 1580-1593页

作者： Mihaela Chivu-Economescu Laura G Necula Lilia Matei Denisa Laura Dragu Ana I neagu Irina Alexiu Coralia Bleotu Carmen Cristina Diaconu Department of Cellular and Molecular Pathology Stefan S.Nicolau Institute of VirologyBucharest 030304Romania Nicolae Cajal Institute Titu Maiorescu UniversityBucharest 040441Romania

The role of cancer stem cells in gastrointestinal cancer-associated death has been widely *** cancer stem cells(GCSCs)are considered to be responsible for tumor initiation,growth,resistance to cytotoxic therapies,recurrence and metastasis due to their unique *** properties make the current therapeutic trials against GCSCs ***,recent studies have shown that targeting stem cell surface markers or stemness associated pathways might have an additional off-target effect on the immune *** advances in oncology and precision medicine have opened alternative therapeutic strategies in the form of cancer *** approach differs from classical anti-cancer therapy through its mechanism of action involving the activation and use of a functional immune system against tumor cells,instead of aiming physically destruction of cancer cells through radio-or *** immunological approaches for GCSCs targeting involve the use of different immune cells and various immune mechanisms like targeting specific surface antigens,using innate immune cells like the natural killer and T cells,T-cell chimeric antigen receptor technology,dendritic cell vaccine,or immune checkpoint *** this respect,better understandings of immune regulatory mechanisms that govern anti-tumor response bring new hope in obtaining long-term remission for cancer therapy.

关键词： Immunotherapy Gastrointestinal cancer Cancer stem cells CAR-T Dendritic cells vaccines Immune checkpoints inhibitors

Recent advances in gastric cancer early diagnosis

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World Journal of Gastroenterology 2019年第17期25卷 2029-2044页

作者： Laura Necula Lilia Matei Denisa Dragu Ana I neagu Cristina Mambet Saviana Nedeianu Coralia Bleotu Carmen C Diaconu Mihaela Chivu-Economescu Department of Cellular and Molecular Pathology Stefan S.Nicolau Institute of Virology Faculty of Medicine Titu Maiorescu University

Gastric cancer(GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the treatment options are limited. Unfortunately, the existing circulating biomarkers for GC diagnosis and prognosis display low sensitivity and specificity and the GC diagnosis is based only on the invasive procedures such as upper digestive endoscopy. There is a huge need for less invasive or non-invasive tests but also highly specific biomarkers in case of GC. Body fluids such as peripheral blood, urine or saliva,stomach wash/gastric juice could be a source of specific biomarkers, providing important data for screening and diagnosis in GC. This review summarized the recently discovered circulating molecules such as microRNAs, long non-coding RNAs, circular RNAs, which hold the promise to develop new strategies for early diagnosis of GC.

关键词： Biomarkers Gastric cancer Early diagnosis Genetic and epigenetic alterations Circulating molecules

High plasma levels of COL10A1 are associated with advanced tumor stage in gastric cancer patients

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World Journal of Gastroenterology 2020年第22期26卷 3024-3033页

作者： Laura Necula Lilia Matei Denisa Dragu Ioana Pitica Ana Iulia neagu Coralia Bleotu Simona Dima Irinel Popescu Carmen C Diaconu Mihaela Chivu-Economescu Department of Cellular and Molecular Pathology Stefan S.Nicolau Institute of VirologyBucharest 030304Romania Titu Maiorescu University Faculty of MedicineBucharest 040441Romania Fundeni Clinical Institute Bucharest 022328Romania

BACKGROUND Gastric cancer(GC)remains an aggressive malignancy with a high rate of mortality,being the third leading cause of cancer-related *** than one million newly diagnosed cases and 782685 deaths due to GC were reported in *** is characterized by limited effective treatment options and the lack of consistent biomarkers for the diagnosis and prognosis of these *** discovery of new biomarkers useful in the early diagnosis of GC is *** To evaluate the potential of COL10A1 as a circulating biomarker for the diagnosis and prognosis of gastric adenocarcinoma *** Plasma and tissue obtained from 49 patients with gastric adenocarcinoma have been used in exploring the expression of ***-time PCR and western blot techniques were used to evaluate COL10A1 level in gastric tumor tissue compared to normal adjacent *** circulating level of COL10A1 was also evaluated by ELISA in plasma of gastric adenocarcinoma *** analysis was made in order to evaluate the potential of COL10A1 as a biomarker for the diagnosis and prognosis of gastric adenocarcinoma *** Our results showed a significant increase in COL10A1 gene expression and protein levels in gastric tumor tissue compared to adjacent normal tissue(P<0.05).COL10A1 seems to show an elevated expression from the beginning of carcinogenesis,in the early stages,and its increased level remains elevated during cancer progression.A significant increase of COL10A1 plasma level in gastric adenocarcinoma patients was also ***,increased COL10A1 plasma level was associated with poor survival of the *** COL10A1 performed a diagnostic value in GC with area under the receiver operating characteristic curve(AUC)of 0.9171(P=0.0002),sensitivity of 87.76%,and specificity of 100.0%.Furthermore,this study demonstrated the potential role of plasma COL10A1 in the early detection of GC,as in the early stage,we obtained an AUC of 0.8789(P=0.00

关键词： Gastric cancer COL10A1 Circulating biomarkers Early diagnosis Poor prognosis Tumor stage

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反应溅射沉积技术制备燃料电池催化层的模拟

工程热物理学报 2014年第1期35卷 95-99页

作者：胡桂林 neagu R Wang Qianpu 李国能张治国郑友取浙江科技学院轻工学院浙江杭州310023 Institute for Fuel Cell Innovation National Research CouncilBCCanadaV6T1W5

反应溅射沉积技术(RSDT)可以生成纳米大小的颗粒并有效溅射形成性能稳定的催化层,是一项崭新的催化层制备技术。为从理论上研究RSDT过程的复杂物理化学过程,本文提出了RSDT过程的三维综合数学模型,模型描述了流体流动、热/质传递,并与... 详细信息

反应溅射沉积技术(RSDT)可以生成纳米大小的颗粒并有效溅射形成性能稳定的催化层,是一项崭新的催化层制备技术。为从理论上研究RSDT过程的复杂物理化学过程,本文提出了RSDT过程的三维综合数学模型,模型描述了流体流动、热/质传递,并与燃料气的化学反应和液滴的燃烧相耦合。RNGκ-ε模型用于描述湍动燃烧气流,液滴的跟踪和分析在拉格朗日框架下进行,并利用Monte Carlo方法生成了催化层的表面结构。计算结果可以为该技术的优化提供一定的参考。

关键词：反应溅射沉积技术数值模拟 RNG k—ε模型蒙特卡洛法多组分反应

Further Studies of BURSTS and Spallation in High-Energy Heavy Ion Reactions

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World Journal of Nuclear Science and Technology 2017年第1期7卷 35-57页

作者： Reza Hashemi-Nezhad Reinhard Brandt Valery Ditlov Maria Haiduc Elena Firu Alina Tania neagu Eberhard Ganssauge Wolfram Westmeier School of Physics University of Sydney Sydney Australia Kernchemie FB Chemie Philipps Universit&#228 t Marburg Marburg Germany Institute of Theoretical and Experimental Physics Moscow Russia Bucharest Institute of Space Science Bucharest Romania FB Physik Philipps Universit&#228 t Marburg Marburg Germany Dr. Westmeier GmbH Ebsdorfergrund Germany

Aspects of BURSTS and Spallation reactions induced by high-energy heavy ions in thick targets (>10 cm thick) will be investigated: BURSTS are reviewed from a historical and phenomenological point-of-view. Details of interactions in nuclear emulsions will be compared for irradiations of 72 GeV 22Ne-ions from Dubna with irradiations of 72 GeV 40Ar-ions from Berkeley. Measured correlations in individual interactions between multiplicities of “minimum ionizing particles”, ns, and “black prongs”, nb, will be shown as “ns-vs.-nb” per event for BURSTS and separately for Spallation in interactions of 72 GeV 22Ne-ions. Monte Carlo calculations, based on the MCNPX 2.7 code, have been carried out for 72 GeV 22Ne interacting in nuclear emulsions: The correlation between ns and nb in Spallation reactions could be understood. However, “ns-vs.-nb” correlations from BURST-interactions could not be reproduced with this model for events with small numbers of heavy prongs nh ≤ 10. For large numbers of heavy prongs with nh > 10 one could find some agreement between experiments and calculations, however, not in all details. Further experimental and theoretical studies are necessary before one has a complete understanding of BURST interactions in high-energy heavy ion reactions.

关键词： High-Energy HI Reaction BURST Spallation MCNPX

Two Ways of High-Energy Heavy Ion Interactions: Spallation and Burst

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World Journal of Nuclear Science and Technology 2015年第2期5卷 73-87页

作者： Reinhard Brandt Valery Ditlov Maria Haiduc Elena Firu Alina Tania neagu Eberhard Ganssauge Reza Hashemi-Nezhad Wolfram Westmeier Kernchemie FB Chemie Philipps-Universitat Marburg Marburg Germany Alikhanov Institute of Theoretical and Experimental Physics Moscow Russia Bucharest Institute of Space Sciences Bucharest Romania Fachbereich Physik Philipps-Universitat Marburg Marburg Germany School of Physics University of Sydney Sydney Australia Dr. Westmeier GmbH Ebsdorfergrund Germany

A new approach to solving the observation of enhanced neutron production in high-energy heavy ion induced reactions in thick targets is presented. Two different reaction mechanisms in these interactions are considered: 1) Limited fragmentation of the projectile, called SPALLATION;2) Complete nuclear fragmentation of the projectile fragment into individual relativistic hadrons only, referred to as “BURST”. The abundance of this second path increases with the charge and energy of the projectile and may be responsible for enhanced neutron production observed with radiochemical methods in 44 GeV 12C and 72 GeV 40Ar irradiations. Interactions of 72 GeV 22Ne in nuclear emulsions show that SPALLATION and BURST have strongly different interaction signatures, and also that the rate of BURSTS increases from (26 ± 3)% of all interactions in the 1st generation to (78 ± 6)% in the 2nd generation. Further experimental signatures of BURSTS will be described;however, no model based on physics concepts can be presented. This effect may have practical consequences for neutron safety considerations in the construction of advanced heavy ion accelerators.

关键词： Thick Target High Energy Projectile Unresolved Problems BURST

Comment on the Recent Start of a New “IUPAC-Project”

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World Journal of Nuclear Science and Technology 2018年第3期8卷 121-127页

作者： Reinhard Brandt Valery Ditlov Elena Firu Eberhard Ganssauge Maria Haiduc Reza Hashemi-Nezhad Alina Tania neagu Wolfram Westmeier Kernchemie FB Chemie Philipps-Universit&auml t Marburg Marburg Germany Institute of Theoretical and Experimental Physics Moscow Russia Bucharest Institute of Space Science Bucharest Romania FB Physik Philipps-Universit&auml t Marburg Marburg Germany School of Physics The University of Sydney Sydney Australia Dr. Westmeier GmbH Ebsdorfergrund Germany

The opening of a new IUPAC-project is highly appreciated. In the year 2009, the IUPAC had published an article “Discovery of the element with atomic number 112 (IUPAC Technical Report)” [1]* which contains a section on the work of the Marinov collaboration. It appears that this section is not always in agreement with conventional standards for scientific publications. This present comment focuses on these formal questions.

关键词： IUPAC Project 2017-014-2-200 eka-Hg Unresolved Problems

High-energy hybrid femtosecond laser system demonstrating 2×10 PW capability

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High Power Laser Science and Engineering 2020年第4期8卷 104-118页

作者： François Lureau Guillaume Matras Olivier Chalus Christophe Derycke Thomas Morbieu Christophe Radier Olivier Casagrande Sébastien Laux Sandrine Ricaud Gilles Rey Alain Pellegrina Caroline Richard Laurent Boudjemaa Christophe Simon-Boisson Andrei Baleanu Romeo Banici Andrei Gradinariu Constantin Caldararu Bertrand De Boisdeffre Petru Ghenuche Andrei Naziru Georgios Kolliopoulos Liviu neagu Razvan Dabu Ioan Dancus Daniel Ursescu Thales LAS France 78990 ElancourtFrance Thales Systems Romania 060071 BucurestiRomania Extreme Light Infrastructure-Nuclear Physics ‘Horia Hulubei’National Institute for Physics and Nuclear Engineering077125 Bucharest MagureleRomania University of Bucharest Faculty of Physics077125 Bucharest MagureleRomania

We report on a two-arm hybrid high-power laser system(HPLS)able to deliver 2×10 PW femtosecond pulses,developed at the Bucharest-Magurele Extreme Light Infrastructure Nuclear Physics(ELI-NP)Facility.A hybrid frontend(FE)based on a Ti:sapphire chirped pulse amplifier and a picosecond optical parametric chirped pulse amplifier based on beta barium borate(BBO)crystals,with a cross-polarized wave(XPW)filter in between,has been *** delivers 10 mJ laser pulses,at 10 Hz repetition rate,with more than 70 nm spectral bandwidth and high-intensity contrast,in the range of 1013:*** high-energy Ti:sapphire amplifier stages of both arms were seeded from this common *** final high-energy amplifier,equipped with a 200 mm diameter Ti:sapphire crystal,has been pumped by six 100 J nanosecond frequency doubled Nd:glass lasers,at 1 pulse/min repetition *** than 300 J output pulse energy has been obtained by pumping with only 80%of the whole 600 J available pump *** compressor has a transmission efficiency of 74%and an output pulse duration of 22.7 fs was measured,thus demonstrating that the dual-arm HPLS has the capacity to generate 10 PW peak power femtosecond *** reported results represent the cornerstone of the ELI-NP 2×10 PW femtosecond laser facility,devoted to fundamental and applied nuclear physics research.

关键词： lasers high-power laser pulses ultra-short laser pulses