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Efficient Mimics for Elucidating Zaxinone Biology and Promoting Agricultural Applications

Molecular Plant 2020年第11期13卷 1654-1661页

作者： Jian You Wang Muhammad Jamil Pei-Yu Lin Tsuyoshi Ota Valentina Fiorilli Mara Novero Randa A.Zarban Boubacar AKountche Ikuo Takahashi Claudio Martinez Luisa Lanfranco Paola Bonfante Angel R.de lera Tadao Asami Salim Al-Babili King Abdullah University of Science and Technology Division of Biological and Environmental Science and Engineeringthe BioActives LabThuwal 23955-6900Saudi Arabia Graduate School of Agricultural and Life Sciences The University of TokyoTokyoJapan Department of Life Sciences and Systems Biology University of TorinoTorinoItaly Universidade de Vigo Facultade de Quimica and CINBIOVigoSpain

Zaxinone is an apocarotenoid regulatory metabolite required for normal rice growth and *** addition,zaxinone has a large application potential in agriculture,due to its growth-promoting activity and capability to alleviate infestation by the root parasitic plant Striga through decreasing strigolactone(SL)***,zaxinone is poorly accessible to the scientific community because of its laborious organic synthesis that impedes its further investigation and *** this study,we developed easy-to-synthesize and highly efficient mimics of zaxinone(MiZax).We performed a structure-activity relationship study using a series of apocarotenoids distinguished from zaxinone by different structural *** the obtained results,we designed several phenyl-based compounds synthesized with a high-yield through a simple *** tests showed that MiZax3 and MiZax5 exert zaxinone activity in rescuing root growth of a zaxinone-deficient rice mutant,promoting growth,and reducing SL content in roots and root exudates of wild-type ***,these compounds were at least as efficient as zaxinone in suppressing transcript level of SL biosynthesis genes and in alleviating Striga infestation under greenhouse conditions,and did not negatively impact *** together,MiZax are a promising tool for elucidating zaxinone biology and investigating rice development,and suitable candidates for combating Striga and increasing crop growth.

关键词： apocarotenoids zaxinone zaxinone mimics strigolactone Striga root parasitic plants

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Evaluation of a Nutrition Intervention through a School-Based Food Garden to Improve Dietary Consumption, Habits and Practices in Children from the Third to Fifth Grade in Chile

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Food and Nutrition Sciences 2016年第10期7卷 884-894页

作者： Diego Vinueza Lydia lera Judith Salinas Carmen Gloria Gonzá lez Lorena Barrios Fernando Vio Institute of Nutrition and Food Technology (INTA) University of Chile Santiago Chile

Objective: Use a school-based food garden as an instrument to improve healthy dietary consumption, habits, and practices among children from the third to fifth grade in public schools in Chile. Design: Quasi-experimental, six-month intervention with an evaluation of dietary consumption, habits, and practices and use of the school-based food garden among the 3rd to 5th grade students. Setting: Two municipal schools in a low-middle income district in Santiago de Chile;one with a school garden intervention and a control school without a garden. Subjects: 155 third to fifth grade children, 63 in the intervention school and 92 in the control school (average age 10 years old, 58% boys). Results: In the intervened school, there was a significant improvement in the children’s dietary habits, such as peeling and slicing fruit (p < 0.05), making sandwiches (p < 0.05), and increased motivation to cook (p < 0.05). Fruit purchases at the school rose from 4% to 37% (p < 0.05) by the end of the intervention. Interest in growing vegetables or fruits at home increased from 48% to 70% (p < 0.05). The school children at the intervention school significantly increased their knowledge about 16 of 21 garden crops (p < 0.05), expanding the spectrum of the vegetables they can consume. There were no significant changes in the control school. Conclusions: The school-based food garden was effective in achieving change in dietary habits and practices among the third to fifth grade children. The project should be carried out for a longer period of time, so that the changes will be reflected in the students’ food consumption and nutritional status.

关键词： Nutritional Education School-Based Food Gardens Elementary Education Healthy Eating

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Continuous Gas Outflow Is More Effective Than Carbon Filters to Evacuate Smoke in Laparoscopic Colorectal Resections: A Comparative Study

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Surgical Science 2017年第2期8卷 86-93页

作者： Enrique M. Balén Javier Suárez Begoñ a Oronoz José M. lera Dept of Surgery Complejo Hospitalario de Navarra Pamplona Spain

Background: Carbon filters and expensive evacuation machines are available to evacuate surgical smoke in long-lasting laparoscopic operations and achieve good visibility and patient’s safety. Methods: This study was aimed to determine which of two methods for laparoscopic smoke evacuation is most effective getting the best visibility. 20 patients submitted to elective laparoscopic colorectal resections were allocated to be operated using, either a carbon filter (Group A) or a home-made tubing with a continuous suction (Group B) connected through one of the ports to the hospital vacuum system: both methods were regulated with a roller clamp to increase smoke evacuation in order to obtain good visibility. A mono-polar hook and the LigasureV 5-mm vessel-sealing device were used. Groups were comparable for demographic characteristics, surgical techniques, and malignancy. Mann-Whitney and Fisher’s exact test were used for statistics. Results: Morbidity was 10%. There was no mortality, and there was no difference between Group A and B according to complications (p = 1.00), hospital stay (p = 0.23), duration of the operation (p = 0.79) and total consumption of CO2 (p = 0.36). However, the number of times that the clamp had to be released (Group A: 3.4 + 1 vs Group B: 1.5 + 1) (p = 0.006) and that a port had to be opened freely to quickly evacuate dense smoke (Group A: 0.9 + 0.7 vs Group B: 0) (p = 0.002) was very significantly increased in Group A as compared to Group B. Mean follow-up was 60 months and no port site metastases that could be a consequence of “chimney effect” or wound recurrence have been detected. Conclusions: The surgeon’s subjective impression that carbon filters are less effective for smoke evacuation than continuous outflow of gas through a port connected to the hospital vacuum source was confirmed. This simple method is advised for long-lasting laparoscopic procedures to improve visibility throughout the procedure.

关键词： Advanced Laparoscopy Surgical Smoke Evacuation Visibility Advanced Laparoscopy Visibility

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唯一值得奋斗的东西

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疯狂英语（初中天地） 2015年第11期 4-5页

作者： lera Lynn 鱼又

2014年HBO侦探剧《真探》（True Detective）甫一推出就吸引了大批拥趸。不紧不慢的叙事方式、精妙的剧情架构、严密冷静的推理和演技精湛的主角使其成为少有的良心侦探剧。然而《真探》的独特之处在于其哥特式的电影风格和高贵冷艳的... 详细信息

2014年HBO侦探剧《真探》（True Detective）甫一推出就吸引了大批拥趸。不紧不慢的叙事方式、精妙的剧情架构、严密冷静的推理和演技精湛的主角使其成为少有的良心侦探剧。然而《真探》的独特之处在于其哥特式的电影风格和高贵冷艳的文艺气质，每当音乐响起，这种气质就被展现得淋漓尽致。

关键词：奋斗叙事方式电影风格哥特式侦探气质良心冷静

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Role of pancreatography in the endoscopic management of encapsulated pancreatic collections-review and new proposed classification

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World Journal of Gastroenterology 2020年第45期26卷 7104-7117页

作者： Igor Mendonca Proença Marcos Eduardo lera dos Santos Diogo Turiani Hourneaux de Moura Igor Braga Ribeiro Sergio Eiji Matuguma Spencer Cheng Thomas R McCarty Epifanio Silvino do Monte Junior Paulo Sakai Eduardo Guimaraes Hourneaux de Moura Gastrointestinal Endoscopy Unit Department of GastroenterologyHospital das ClinicasUniversity of Sao PauloSao Paulo 05403000Brazil Division of Gastroenterology Hepatology and EndoscopyBrigham and Women’s Hospital-Harvard Medical SchoolBostonMA 02115United States

Pancreatic fluids collections are local complications related to acute or chronic pancreatitis and may require intervention when symptomatic and/or *** the last decade,endoscopic management of these collections via endoscopic ultrasound-guided transmural drainage has become the gold standard treatment for encapsulated pancreatic collections with high clinical success and lower morbidity compared to traditional surgery and percutaneous *** understanding of anatomic landmarks,including assessment of the main pancreatic duct and any associated lesions–such as disruptions and strictures-are key to achieving clinical success,reducing the need for reintervention or recurrence,especially in cases with suspected disconnected pancreatic duct ***,proper review of imaging and anatomic landmarks,including collection location,are pivotal to determine type and size of pancreatic stenting as well as approach using long-term transmural indwelling plastic *** to adequately assess the main pancreatic duct may be performed by two methods:Either non-invasively using magnetic resonance cholangiopancreatography or endoscopically via retrograde *** the critical need to understand anatomy via pancrea tography and assess the main pancreatic duct,a standardized approach or uniform assessment strategy has not been described in the ***,the aim of this review was to clarify the role of pancreatography in the endoscopic management of encapsulated pancreatic collections and to propose a new classification system to aid in proper assessment and endoscopic treatment.

关键词： Endoscopic retrograde cholangiopancreatography Endoscopy Endoscopic ultrasound Pseudocyst Endosonography Pancreatic ducts

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控制和预防产蛋母鸡的脱肛

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国外畜牧学（猪与禽） 2023年第2期43卷 54-58页

作者： Rafael lera 蔡霞(译) 李红(校) 不详

目前蛋鸡的生产状况得到了明显改善,但脱肛会对鸡群的福利和生产状况产生负面影响,依然是家禽生产者关注的问题。本文概述了脱肛、导致脱肛发生的因素以及降低脱肛发生率的预防策略,为家禽生产者提供解决蛋鸡脱肛问题的建议。

关键词：蛋鸡脱肛啄癖控制和预防

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Pancreatitis after endoscopic retrograde cholangiopancreatography:A narrative review

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World Journal of Gastroenterology 2021年第20期27卷 2495-2506页

作者： Igor Braga Ribeiro Epifanio Silvino do Monte Junior Antonio Afonso Miranda Neto Igor Mendonça Proença Diogo Turiani Hourneaux de Moura Mauricio Kazuyoshi Minata Edson Ide Marcos Eduardo lera dos Santos Gustavo de Oliveira Luz Sergio Eiji Matuguma Spencer Cheng Renato Baracat Eduardo Guimarães Hourneaux de Moura Department of Gastrointestinal Endoscopy Unit University of São Paulo School of MedicineSão Paulo 05403-010Brazil

Acute post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP)is a feared and potentially fatal complication that can be as high as up to 30%in high-risk ***-examination measures,during the examination and after the examination are the key to technical and clinical success with a decrease in adverse *** studies have debated on the subject,however,numerous topics remain controversial,such as the effectiveness of prophylactic medications and the amylase dosage *** review was designed to provide an update on the current scientific evidence regarding PEP available in the literature.

关键词： Endoscopic retrograde cholangiopancreatography Pan-creatitis Postendoscopic retrograde cholangiopancreatography pancreatitis Adverse events Pancreatitis Prevention

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营养和代谢在预防蛋鸡脂肪肝中的作用

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国外畜牧学（猪与禽） 2019年第4期39卷 43-45页

作者：孟霞(译) 周宗清管方(校) 何闪(制图表) Rafael lera 不详 Hendrix Genetics Layers 公司

随着鸡蛋产业面临诸如人口大幅增长,食品、饲料、燃料冲突以及对动物福利的承诺增加等挑战,延长生产周期对确保鸡蛋生产有利可图和可持续发展至关重要。

关键词：蛋鸡脂肪肝脏生产周期

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设计蛋鸡免疫程序面临的挑战

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国外畜牧学（猪与禽） 2017年第6期37卷 72-73页

作者：章薇(译) 王晶晶(校) 邵建忠(审) rafael lera 不详安徽省农业科学院畜牧兽医研究所

较长的产蛋周期在世界范围内已经成为现实,且势不可挡。对产蛋持久性的选育在获得较高的生产性能方面无疑发挥了重大的作用,但是除了遗传因素,我们不该忽视确保产蛋成功的其他关键因素,如科学的管理方法、更合理的营养、理想的生物安全... 详细信息

较长的产蛋周期在世界范围内已经成为现实,且势不可挡。对产蛋持久性的选育在获得较高的生产性能方面无疑发挥了重大的作用,但是除了遗传因素,我们不该忽视确保产蛋成功的其他关键因素,如科学的管理方法、更合理的营养、理想的生物安全标准以及有针对性的“特制”免疫程序。在蛋行业,免疫程序的主要目的是尽量降低疾病对蛋鸡健康、福利和生产性能的不利影响,同时通过增强蛋鸡对人畜共患病（如肠炎沙门氏菌）的抵抗力来减少公共卫生风险。

关键词：免疫程序人畜共患病肠炎沙门氏菌产蛋周期生产性能生物安全载体疫苗传染性支气管炎马立克氏病公共卫生

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MRI Signal Abnormalities of the Optic Tracts, a Marker of Meningoencephalitis Caused by Trypanosoma Gambiense (TG)—A Delayed Patho-Radlological Correlation

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Open Journal of Radiology 2022年第1期12卷 1-7页

作者： Cherif Mohamadou Aidara Caroline Magne Nfally Badji lera Geraud Akpo Gaelle Ebinda Mipinda Hamidou Deme Philomène Kouna Abdoulaye Dione Diop Abdoulaye Ndoye Diop Sokhna Ba Elhadj Niang Radiology Office of “De la Paix University Hospital” Ziguinchor Senegal Internal Medicine Office of Polyclinique El Rapha Libreville Gabon Radiology Office of Aristide Le Dantec University Hospital Dakar Senegal Radiology Office of Polyclinique El Rapha Libreville Gabon Radiology Office of Fann University Hospital Dakar Senegal

Parasitic meningoencephalitis presents several etiologies which sometimes depend on their geographical location. They require thorough blood and cerebrospinal fluid check-up for directing an efficient treatment. Clinicians and radiologists are constantly looking for specific signs that could point to a particular etiology. The meningoencephalitis caused by Human African Trypanosomiasis (HAT) due to Trypanosoma brucei gambiense (TG) is a rare disease characterized by a slow progression, over years sometimes. Its non-specific presentation either clinically or in imaging can lead to misdiagnosis and thus, delay the treatment. However, involvement of the optic tracts seems to be characteristic of this condition, on old data from animal experimentation and recent high-field MRI data. MRI is the best current technique to explore the brain, cranial nerves, and visual pathways. In this article, we are going to present two observations of meningoencephalitis caused by HAT and then discuss some specific aspects of this neglected and re-emerging disease.

关键词： Human African Trypanosomiasis Trypanosoma Brucei Gambiense Diffuse Meningo-Encephalitis Optic Tract Evolvement

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