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The brain as a source and a target of prolactin in mammals

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Neural Regeneration Research 2022年第8期17卷 1695-1702页

作者： Ana R.costa.Brito Isabel Gonçalves cecília R.A.Santos cIcS-UBI-Health Sciences Research centre Universidade da Beira InteriorCovilhãPortugal c4-UBI-cloud computing competence centre Universidade da Beira InteriorCovilhãPortugal

Prolactin is a polypeptide hormone associated with an extensive variety of biological *** the roles of prolactin in vertebrates,some were preserved throughout *** is the case of its function in the brain,where prolactin receptors,are expressed in different structures of the central nervous *** the brain,prolactin actions are principally associated with reproduction and parental behavior,and involves the modulation of adult neurogenesis,neuroprotection,and neuroplasticity,especially during pregnancy,thereby preparing the brain to *** is mainly produced by specialized cells in the anterior pituitary ***,during vertebrate evolution many other extrapituitary tissues do also produce prolactin,like the immune system,endothelial cells,reproductive structures and in several regions of the *** review summarizes the relevance of prolactin for brain function,the sources of prolactin in the central nervous system,as well as its local production and secretion.A highlight on the impact of prolactin in human neurological diseases is also provided.

关键词： brain brain disease choroid plexus neurogenesis neuroplasticity neuroprotection prolactin prolactin receptor

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Population structure of Araucaria angustifolia under distinct forest protection status:implications for management and conservation

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林业研究:英文版 2023年第5期34卷 1437-1446页

作者： Vinicius costa.cysneiros Allan Libanio Pelissari Sylvio Pellico Netto Sebastiao do Amaral Machado Afonso Figueiredo Filho Departamento de Agricultura Biodiversidade e FlorestasUniversidade Federal de Santa Catarina-UFSCRodovia Ulysses GaboardiKm 03CuritibanosSC 89520-000Brazil Departamento de ciencias Florestais Universidade Federal do Paraná-UFPRAv.Prof.Lothario Meissner632CuritibaPR 80210-170Brazil Departamento de Engenharia Florestal Universidade Estadual do Centro-Oeste-UNICENTROPR-153Km 7IratiPR 84500-000Brazil

Araucaria angustifolia is the dominant coniferous species in Brazil,a long-lived pioneer species and a supplier of valuable timber and non-timber products,which gives it key-species *** study examines how *** population structure affects the stand structure,and whether these relationships differ between protected and unprotected *** study was carried out on two protection status forests(national forest and urban forest)in a region of Atlantic mixed forest in ParanáState,southern *** coefficient and the Weibull shape parameter described the population structure and its effects on species diversity and biomass *** diameter distribution differed significantly between forests,with unbalanced structure in both,although regeneration was more abundant in the protected *** positively affected aboveground biomass whereas shape negatively affected it and species *** relationships differed between protected and unprotected *** effect of *** populations on stand structure was conditioned on protection ***-growth populations may have lower diversity and biomass stock even supporting large ***,old-growth forests,can lead to wood loss through mortality,senescence,and declining populations,representing the waste of a valuable timber *** findings provide useful knowledge for forest management,species conservation,and the carbon market.

关键词： Key species Diameter distribution Weibull shape parameter Aboveground biomass

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Research on Activation Method of Recycled Brick Powder

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Research on Activation Method of Recycled Brick Powder

作者： Nidia Alves da costa 北京交通大学

学位级别：硕士

在过去的十年中,随着环境挑战的提出,固体废弃物的再生利用成为一个极具环保效益与经济效益的研究热点。近年来,人们对利用建筑垃圾与工业废物协同制备辅助胶凝材料(ScM)进行了大量的研究,以帮助减少建筑垃圾对环境的影响。最近的研究表... 详细信息

在过去的十年中,随着环境挑战的提出,固体废弃物的再生利用成为一个极具环保效益与经济效益的研究热点。近年来,人们对利用建筑垃圾与工业废物协同制备辅助胶凝材料(ScM)进行了大量的研究,以帮助减少建筑垃圾对环境的影响。最近的研究表明,建筑垃圾的再生产品——再生微粉具有一定的活性,可尝试制备胶凝材料,但相关学者发现,无论再生粉的粒度和来源如何,再生微粉掺入到普通硅酸盐水泥中的最佳掺量限制在0-30%。水泥掺量大于30%的混合料的抗压强度和抗折强度明显降低。为了提高再生粉替代传统水泥的采用,学者们使用活化方法来激发混合料中再生微粉的活性。通过研磨再生微粉的机械活化、使用分级助剂和混合再生微粉的化学活化以及纳米ca cO3料浆活化是再生微粉最常用的活化方法。因为赤泥中含有强碱矿物,本研究研究了以赤泥为可持续建筑材料替代水泥的再生微粉的活化方法,通过对再生微粉机械活化方法进行不同配合比、不同材料替代率下试件力学特性的室内试验。实验1结果表明,赤泥本身不会活化再生微粉,因此实验2使用水泥含量低激活再生微粉的混合物。这个实验的结果表明,添加水泥混合设计增加了整体抗压强度,在使用30%的水泥和35%至50%再生微粉时胶凝材料获得最佳效果。本实验的第一部分使用赤泥作为再生粉的活化剂,制备砂浆试件。第二部分提出水泥作为赤泥和再生微粉的活化剂,利用水泥水化产生的氢氧化钙ca(OH)2活化赤泥和再生微粉中的硅、铝矿物。通过7天和28天的抗压和抗折强度试验确定了水泥活化赤泥再生微粉的力学性能,确定了最佳配合比设计。

关键词：再生微粉赤泥活化法建筑垃圾硅酸盐水泥

Antiglycation and antioxidant activities of the crude extract and saponin fraction of Tribulus terrestris before and after microcapsule release

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Journal of Integrative Medicine 2022年第2期20卷 153-162页

作者： célia cristina Malaguti Figueiredo Amanda da costa.Gomes Filipe Oliveira Granero Joao Luiz Bronzel Junior Luciana Pereira Silva Valdecir Farias Ximenes Regildo Márcio Goncalves da Silva Institute of chemistry São Paulo State UniversityAraraquaraSão Paulo 14800-060Brazil Educational Foundation of the city of Assis AssisSão Paulo 19807-130Brazil Department of chemistry School of SciencesSão Paulo State UniversityBauruSão Paulo 17033-360Brazil Department of Biotechnology School of SciencesHumanities and LanguagesSão Paulo State UniversityAssisSão Paulo 19806-900Brazil

Objective:The present study investigated antiglycation and antioxidant activities of crude dry extract and saponin fraction of Tribulus *** also developed a method of microencapsulation and evaluated antiglycation and antioxidant activities of crude dry extract and saponin fraction before and after microcapsule ***:Antiglycation activity was determined by relative electrophoretic mobility(REM),free amino groups and inhibition of advanced glycation end-product(AGE)*** activity was determined by 2,2-diphenyl-1-picrylhydrazyl(DPPH),ferric ion-reducing antioxidant power(FRAP),nitric oxide(NO)and thiobarbituric acid reactive species(TBARS)*** were prepared using maltodextrin as wall material and freeze-drying as encapsulation *** characterization of microcapsules was evaluated by scanning electron microscopy,and encapsulation efficiency and microcapsule release were determined by total saponins *** and antioxidant assays were performed using crude dry extract and saponin fraction of *** before and after ***:Saponin fraction showed an increase of 32.8%total ***-performance liquid chromatography-mass spectrometry analysis showed the presence of saponins in the obtained *** evaluation by REM demonstrated that samples before and after release presented antiglycation activity similar to bovine serum albumin treated with ***,samples inhibited AGE formation,highlighting treatment with saponin fraction after release(89.89%).Antioxidant tests demonstrated antioxidant activity of the *** dry extract before encapsulation presented the highest activities in DPPH(92.00%)and TBARS(32.49%)*** fraction before encapsulation in FRAP test(499μmol Trolox equivalent per gram of dry sample)and NO test(15.13μmol nitrite formed per gram of extract)presented the highest ***:This study presen

关键词： Glycation Microencapsulation Oxidative stress Saponins Tribulus terrestris

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EurBeST——商业养蜂条件下的抗螨蜂种选育

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中国蜂业 2024年第2期75卷 22-23页

作者： R.Buechler A.Uzunov c.costa.M.Meixner Y Le conte F.Mondet M.Kovacic S.Andonov N.L.carreck L.Dimitrov B.Basso M.Bienkowska R.Dall’Olio F.Hatjina U.Wirtz 陈超(文\图) 单金琼(文\图) 不详

上期我们讲了抗螨蜜蜂的选育以及取得的成效,本期我们继续讨论选育抗螨蜜蜂过程中遇到的问题及建议。一、种蜂王的用户调查对目前蜂王市场的调查显示,客户的期望值很高,但满意度一般。欧洲养蜂人希望买到高品质的蜂王,其中最重要的是抗... 详细信息

上期我们讲了抗螨蜜蜂的选育以及取得的成效,本期我们继续讨论选育抗螨蜜蜂过程中遇到的问题及建议。一、种蜂王的用户调查对目前蜂王市场的调查显示,客户的期望值很高,但满意度一般。欧洲养蜂人希望买到高品质的蜂王,其中最重要的是抗病和高产。但是,他们对抗病性的满意度最低(图1)。近50%的用户认为选择育种是实现免用药养蜂的重要甚至唯一的手段。具有悠久育种传统的国家的用户对选择育种的认可率更高。

关键词：选择育种用户调查蜂王问题及建议抗螨养蜂人蜜蜂商业养蜂

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Hole-doping induced ferromagnetism in 2D materials

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npj computational Materials 2022年第1期8卷 2180-2189页

作者： Ruishen Meng Lino da costa.Pereira Jean-Pierre Locquet Valeri Afanas’ev Geoffrey Pourtois Michel Houssa Department of Physics and Astronomy KU LeuvenCelestijnenlaan 200DLeuvenB-3001Belgium imec Kapeldreef 75B-3001LeuvenBelgium

Two-dimensional(2D)ferromagnetic materials are considered as promising candidates for the future generations of spintronic ***,2D materials with intrinsic ferromagnetism are ***,high-throughput first-principles simulations are performed to screen 2D materials that present a non-magnetic to a ferromagnetic transition upon hole doping.A global evolutionary search is subsequently performed to identify alternative possible atomic structures of the eligible candidates,and 122 materials exhibiting a hole-doping induced ferromagnetism are *** energetic and dynamic stability,as well as magnetic properties under hole doping are investigated *** of these 2D materials are metal halides,followed by chalcogenides,oxides,and nitrides,some of them having predicted curie temperatures above 300 *** exchange interactions responsible for the ferromagnetic order are also *** work not only provides theoretical insights into hole-doped 2D ferromagnetic materials,but also enriches the family of 2D magnetic materials for possible spintronic applications.

关键词： ferromagnetic doping materials

P2X7 receptor blockade decreases inflammation,apoptosis,and enteric neuron loss during clostridioides difficile toxin A-induced ileitis in mice

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World Journal of Gastroenterology 2022年第30期28卷 4075-4088页

作者： Ana A Q A Santos Deiziane V S costa.Danielle A Foschetti Antoniella S G Duarte conceicao S Martins Pedro M G Soares Patricia castelucci Gerly A c Brito Department of Morphology School of MedicineFederal University of CearaFortaleza 60430-170CearaBrazil Department of Physiology and Pharmacology School of MedicineFederal University of CearáFortaleza 60430-170CearaBrazil Department of Pathology and Legal Medicine School of MedicineFederal University of CearaFortaleza 60430-170CearaBrazil Department of Morphology(UFc) Federal University of CearaFortaleza 60430-170CearaBrazil Department of Anatomy Institute of Biomedical SciencesUniversity of São PauloSao Paulo 05508-270Brazil Department of Morphology Federal University of CearaFortaleza 60140-170CearaBrazil

clostridioides difficile(***)is the most common pathogen causing health care-associated *** TcdA and TcdB have been shown to activate enteric neurons;however,what population of these cells is more profoundly influenced and the mechanism underlying these effects remain *** To characterize a specific population of TcdA-affected myenteric neurons and investigate the role of the P2X7 receptor in TcdA-induced ileal inflammation,cell death,and the changes in the enteric nervous system in *** Swiss mice were used to model TcdA-induced ileitis in ileal loops exposed to TcdA(50μg/Loop)for 4 *** investigate the role of the P2X7 receptor,Brilliant Blue G(50 mg/kg,i.p.),which is a nonspecific P2X7 receptor antagonist,or A438079(0.7μg/mouse,i.p.),which is a competitive P2X7 receptor antagonist,were injected one hour prior to TcdA *** samples were collected to analyze the expression of the P2X7 receptor(by quantitative real-time polymerase chain reaction and immunohistochemistry),the population of myenteric enteric neurons(immunofluorescence),histological damage,intestinal inflammation,cell death(terminal deoxynucleotidyltransferasemediated dUTP-biotin nick end labeling),neuronal loss,and S100B synthesis(immunohistochemistry).RESULTS TcdA upregulated(Pceptor gene in the ileal tissues,increasing the level of this receptor in myenteric neurons compared to that in control *** with the control mice indicated that TcdA promoted(Pc calretinin+(calr)and choline acetyltransferase+neurons and increased the number of nitrergic+and calr+neurons expressing the P2X7 *** of the P2X7 receptor decreased TcdAinduced intestinal damage,cytokine release[interleukin(IL)-1β,IL-6,IL-8,and tumor necrosis factor-α],cell death,enteric neuron loss,and S100B synthesis in the mouse *** Our findings demonstrated that TcdA induced the upregulation of the P

关键词： clostridioides difficile clostridioides difficile toxin A P2X7 receptor Enteric nervous system Enteric neuron Enteric glia

compounds from Stevia rebaudiana Bertoni leaves: An overview of non-conventional extraction methods and challenges

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Food Bioscience 2022年第2期46卷 108-121页

作者： Dj´essica Tatiane Raspe camila da Silva Silvio cl´audio da costa ograma de P´os-Graduaç˜ao em ciˆencia de Alimentos Universidade Estadual de Maring´aAv.Colombo579087020-900Maring´aPRBrazil Departamento de Tecnologia Universidade Estadual de Maring´aAv.ˆAngelo Moreira da Fonseca180087506-370UmuaramaPRBrazil Departamento de Bioquímica Universidade Estadual de Maring´aAv.Colombo579087020-900Maring´aPRBrazil

To overcome the inconveniences related to its conventional obtainment of natural sweeteners and active compounds from Stevia rebaudiana Bertoni,methods involving application of technology,such as ultrasound assisted extraction,microwave assisted extraction,extraction under pressurized conditions by means of pressurized liquid extraction,subcritical water extraction and supercritical fluid extraction have been *** this review,these emerging techniques were analyzed and discussed,the process variables and operational strategies,their impacts on the extraction and their comparison against the conventional techniques were *** and the possibility of operational automation,the use of less energy and solvents,in addition to the reduced complexity of the subsequent purification steps,make up viable alternatives suitable for a possible industrial *** processes leverage the concept of green chemistry,but still suffer limitations related to acquisition and maintenance costs,in addition to the effects of the action of some of these technologies remaining unexplored.

关键词： Active compounds Natural sweeteners Steviol glycosides Technology application

Delay Times and clinical Outcomes in Acute Myocardial Infarction: comparison of Periods before and during the cOVID-19 Pandemic—Myocardial Infarction and the Pandemic

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World Journal of cardiovascular Diseases 2024年第6期14卷 392-400页

作者： clarice Teixeira Silva Araújo Arnon Salviato Mameri Thúlio carrera Guarçoni Venturini Marcus Tadeu Aguilar constantino Matos Igor Morais Araujo Lopes Luiz Gustavo Ribeiro de carvalho Murad cleberson Duartes Ovani Guilherme Vassalo Morais Fernanda Venturini de castro Danielle Lopes Rocha Lucas crespo de Barros Rodolfo costa.Sylvestre Luiz Fernando Machado Barbosa Roberto Ramos Barbosa Internal Medicine Universidade Federal do Esprito Santo (UFES) Vitria Brazil Hospital Santa casa de Misericrdia de Vitria Vitria Brazil Hospital Santa Rita de cssia Vitria Brazil Hospital Estadual Dr. Jayme Santos Neves Serra Brazil Grupo Kora Sade Vitria Brazil Hospital Estadual Infantil e Maternidade Alzir Bernardino Alves (HIMABA) Vila Velha Brazil

Introduction: At the beginning of the cOVID-19 pandemic, a drop in the number of patients treated for cardiac emergencies raised concern about cardiovascular mortality in that period. An increase in care delay for patients with ST-segment elevation myocardial infarction (STEMI) may have affected clinical outcomes. Objectives: To analyze delay times and clinical outcomes of patients with STEMI undergoing primary percutaneous coronary intervention (PPcI), before and during the cOVID-19 pandemic. Methods: Retrospective observational study that included patients with STEMI undergoing PPcI from December 2018 to July 2021. The cOVID-19 pandemic cases were divided into two groups: pandemic I—from March to August 2020;and pandemic II—from September 2020 to July 2021. Patients were compared according to the period of hospitalization. Primary outcomes were delay times in assistance and clinical outcomes (acute kidney injury [AKI], post-procedural vascular complications and in-hospital mortality). Results: 108 patients were included, 39 (36.1%) in the pre-pandemic period, 13 (12.1%) in pandemic I and 56 (51.8%) in pandemic II. Time from onset of symptoms to arrival at the service and door-to-balloon time did not differ significantly among groups. Vascular complications were more frequent during the pandemic (I and II) than in the pre-pandemic period (2.5% pre-pandemic vs 15.4% pandemic vs 12.5% pandemic II;p = 0.03). AKI incidence was similar in all three periods. There was a non-significant increase in in-hospital mortality during the cOVID-19 pandemic. conclusion: In patients with STEMI, there was an increase in vascular complications and a trend toward increased mortality during the cOVID-19 pandemic. Delay times to admission and reperfusion did not differ significantly between before and during the pandemic.

关键词： Myocardial Infarction Primary Percutaneous coronary Intervention coronary Reperfusion Pandemic cOVID-19