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Management and outcomes of gastric volvulus in children: a systematic review

World Journal of Pediatrics 2019年第3期15卷 226-234页

作者： Karina Miura da costa Amulya K.Saxena Department of Pediatric Surgery Chelsea Children’s HospitalChelsea and Westminster NHS Foundation TrustImperial College LondonLondonUnited Kingdom Division of Pediatric Surgery Department of Anatomy and SurgeryRibeirao Preto Medical SchoolUniversity of Sao Paulo.Ribeirao Pr&o.Brazil

Background Gastric volvulus (GV) in children is a rare *** study reviewed management and outcomes of GV in the pediatric *** MEDLINE/PubMed,Embase,and Google Scholar databases were searched for studies in English regarding GV in patients < 18 years old between 2008 and 2017,selected by two *** were presented as percentages and ***'s exact test was used to evaluate categorical variables,and Bonferroni correction was applied for multiple *** Ninety-seven papers with 125 patients were *** median age was 24 months,with slightly female *** was the most common symptom and acute presentation occurred in the majority of *** of previous surgery/abdominal trauma was described in 12 and 3 children,*** was diagnostic for GV in most *** initial management was surgical in the majority of cases,with most of them including gastropexy,gastrostomy,or gastric *** GV was associated with acute presentation (P =0.004) and the latter with ischemia (P < 0.01).Complications occurred in 23 (18.9%) children,esophageal stenosis being the most *** were eight (6.4%) deaths,and only one recurrence 6 months after endoscopic *** median follow-up period was 12 *** inclusion of only case reports/case series,the incomplete reporting from papers,and the short followup were limitations of the *** GV occurs at a median age of 24 months and requires high suspicion and prompt management,as mortality is *** preferred surgical approach for GV includes variations of *** stenosis is the most common morbidity post-GV management.

关键词： Gastrectomy Gastric volvulus Gastropexy Gastrostomy Volvulus

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The Use of Triancinolone for the Treatment of Keloid Scars

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第3期14卷 270-275页

作者： José Humberto Cardoso Resende Luís Otávio Torres Anderson Alves Brandão Delma dos Santos Assis Mercadante Jessyka Oliveira Barbosa Batista William Felix de Oliveira Pacheco Elisangelo Aparecido costa Da Silva Douglas Henrique Farias de Oliveira Nébia Maria Almeida de Figueiredo UNIFAN-Centro Universitrio Alfredo Nasser Aparecida de Goinia Brazil UNIRIO Rio de Janeiro Brazil

Scars, when in good evolution, result in a smooth, thin and discreet tissue. Keloid scars, however, are a type of abnormal and exacerbated repair response to tissue injury, whether in surgical interventions or in various injuries, which present in a prominent and gross way. In this context, there is an excess of collagen deposition in the tissue repair process, which can lead to the formation of keloids. The diagnosis of the condition presented is made by the medical professional or by the patient himself after the surgical intervention or skin injury. Under this analysis, protruding, rough and bad-looking scars are identified. In addition, we highlight the existence of keloids similar to large tumors, described as Jorge Lobo disease. The treatment encompasses massages, compressions, corticosteroids, chemotherapy, collagenase and cryotherapy. At first, we used corticosteroid-based massages, and then we started using compressive dressings until we started intrakeloid infiltrations with injectable triamcinolone. Triamcinolone 10 mg injectable—1/10—in 0.9% saline, with syringe and fixed needle 0.3 mm × 8 mm, intralesional infiltrate, in this context, proved to be effective for its treatment when applied sequentially and linearly. In cases where the medication was applied, there was an improvement after 21 days of application and a definitive improvement 2 months after the injury. In comparison, on the other hand, patients who were not subjected to the application of the medication may improve after 4 months of the injury or worsen compared to the initial case. We have come to the conclusion that this procedure may be one of the chosen ones for the treatment of keloid scars, being one of the most recommended for cases of keloid already installed.

关键词： Keloid Scar Hypertrophy Collagen Affection

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Long-term response to avelumab and management of oligoprogression in Merkel cell carcinoma:A case report

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World Journal of Clinical Cases 2021年第18期9卷 4829-4836页

作者： Inês Leão Joana Marinho Telma costa Department of Oncology Centro Hospitalar Vila Nova de Gaia/EspinhoVila Nova de Gaia 4434-502Portugal

BACKGROUND Merkel cell carcinoma(MCC)is a rare and aggressive cutaneous neuroendocrine neoplasia,with high risk of recurrence and metastasis and poor *** checkpoint inhibitors,like the anti-programmed death-ligand 1 agent avelumab,were recently approved for the treatment of advanced ***,herein,report the first case of advanced MCC with oligoprogression managed with avelumab and local radical *** SUMMARY A 61-year-old man was presented to the hospital with sporadic fever and an exudative malodorous mass(10 cm of diameter),located on the right gluteal *** final diagnosis was MCC,cT4N3M1c(AJCC,TNM staging 8th edition,2017),with invasion of adjacent muscle,in-transit metastasis,and bone *** started chemotherapy(cisplatin and etoposide),and after six cycles,the main tumor increased,evidencing disease *** months later,the patient started second line treatment with avelumab(under an early access program).After two cycles of treatment,the lesion started to decrease,achieving a major *** progression was documented after 16 ***,as the tumor became resectable,salvage surgery was performed,while keeping the systemic treatment with *** the patient developed bilateral pneumonia,immunotherapy was *** than 2.5 years after surgery(last 19 mo without systemic therapy),the patient maintains complete local response and stable bone *** This report highlights the efficacy and long-term response of avelumab on the management of a chemotherapy resistant advanced MCC,with evidence of oligoprogression,in combination with local radical treatment.

关键词： Merkel cell carcinoma Unresectable tumor Avelumab Oligoprogression Surgery Chemotherapy Case report

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Risk Governance,Assessment,and Economic Impacts

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International Journal of Disaster Risk Science 2017年第3期8卷 235-236页

作者： Paula Teves-costa JoséManuel Mendes Instituto Dom Luiz Faculdade de Ciências Universidade de Lisboa European Center on Urban Risks (CERU) Center for Social Studies Faculty of Economics University of Coimbra

Due to climate change,growing urbanization,and population migration the social and economic impacts of natural hazards have been increasing *** challenge for risk science,both methodologically and conceptually,is to i... 详细信息

关键词： Risk Governance,Assessment,and Economic Impacts

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Cognitive training in neurodegenerative diseases: a way to boost neuroprotective molecules?

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Neural Regeneration Research 2015年第11期10卷 1754-1755页

作者： Francesco Angelucci Carlo Caltagirone Alberto costa IRCCS Santa Lucia Foundation Department of Clinical and Behavioural Neurology Department of Systemic Medicine Rome University Tor Vergata Niccolò Cusano University

Neurotrophins,and growth factors in general,are proteins which exert many actions in central nervous system *** promote the survival and neuronal function of neurons and exert neuroprotective effects in pathological models of neurodegenerative *** humans several clinical trials based on the use of these proteins have been carried out. Among them, it is worth to mention gene ther- apy especially in Parkinson＇s disease （PD）（Kordower and Bjorklund, 2013）, and a series of experiments using vectors capable of carrying neurotrophins in the selected target re- gion where they can exert their beneficial action （Ghosh et al., 2014）.

关键词： BDNF a way to boost neuroprotective molecules Cognitive training in neurodegenerative diseases

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Open data in spatial data infrastructure:the practices and experiences of Poland

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International Journal of Digital Earth 2021年第11期14卷 1547-1560页

作者： Waldemar Izdebski Agnieszka Zwirowicz-Rutkowska Joanna Nowak da costa Warsaw University of Technology WarsawPoland Military University of Technology WarsawPoland

As an important facilitator in e-government and society in general,Open SDI merits an assessment of its characteristics and the monitoring of its *** aim of the study was the proposal of the SDI openness assessment approach based on existing openness assessment frameworks,as well as the presentation of the Polish Spatial Data Infrastructure(PSDI)development towards *** results indicated that ten geodetic and cartographic databases fulfilled ten out of eleven criteria of data openness,according to the methodological assumptions,and reached a 3-star level of *** need for further development of the infrastructure towards sharing public administration data is recognized,as well as non-governmental data that meet the open data criteria,thus contributing to the openness of the *** proposed assessment method,referenced to a five-level data openness system and providing clear scoring benchmarking for assessing SDI openness,may be used for comparative analysis of SDI openness in different countries,including EU Member States that draw on the experience of the implementation of the INSPIRE Directive.

关键词： Open government data(OGD) openness assessment geospatial data information society open spatial data infrastructure(open SDI)impact

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Cell membrane and bioactive factors derived from mesenchymal stromal cells: Cell-free based therapy for inflammatory bowel diseases

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World Journal of Stem Cells 2019年第9期11卷 618-633页

作者： Fabiany da costa Goncalves Ana Helena Paz Nephrology and Transplantation Internal MedicineErasmus Medical CenterRotterdamGD 3015Netherlands Experimental Research Center Hospital de Clínicas de Porto AlegrePorto AlegreRS 90035-903Brazil

Inflammatory bowel diseases(IBD)are chronic inflammatory disorders of the gastrointestinal tract associated with multifactorial conditions such as ulcerative colitis and Crohn’s *** the underlying mechanisms of IBD remain unclear,growing evidence has shown that dysregulated immune system reactions in genetically susceptible individuals contribute to mucosal ***,conventional treatments have been effective in inducing remission of IBD but not in preventing the relapse of *** this way,mesenchymal stromal cells(MSC)therapy has been recognized as a promising treatment for IBD due to their immunomodulatory properties,ability to differentiate into several tissues,and homing to inflammatory *** so,literature is conflicted regarding the location and persistence of MSC in the body after *** this reason,recent studies have focused on the paracrine effect of the biofactors secreted by MSC,especially in relation to the immunomodulatory potential of soluble factors(cytokines,chemokines,and growth factors)and extracellular vehicles that are involved in cell communication and in the transfer of cellular material,such as proteins,lipids,and nucleic ***,treatment with interferon-γ,tumor necrosis factor-α,and interleukin-1βcauses MSC to express immunomodulatory molecules that mediate the suppression via cell-contact dependent *** together,we present an overview of the role of bioactive factors and cell membrane proteins derived from MSC as a cell-free therapy that can improve IBD treatment.

关键词： Bioactive factors Cell membrane Mesenchymal stem cells Cell-free therapy Inflammatory bowel diseases

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Heme as an inducer of cerebral damage in hemorrhagic stroke:potential therapeutic implications

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Neural Regeneration Research 2022年第9期17卷 1961-1962页

作者： Luiz Ricardo da costa Vasconcellos Pedro Moreno Pimentel-Coelho Cellular Signalling and Cytoskeletal Function Laboratory The Francis Crick InstituteLondonUK Instituto de Biofísica Carlos Chagas Filho Universidade Federal do Rio de JaneiroInstituto Nacional de Ciência e Tecnologia em Medicina RegenerativaRio de JaneiroRJBrazil

Intracerebral hemorrhage(ICH)consists of the rupture of a cerebral artery leading to bleeding into the surrounding *** event has a primary phase of brain injury consisting of mechanical tissue damage due to the mass effect,followed by a secondary phase of brain injury triggered by the presence of blood components released at the site of bleeding(Bulters et al.,2018).Despite the high rates of mortality and morbidity from ICH,no effective treatment is available so far.

关键词： cerebral damage rupture

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Experimental and Numerical Analysis of Cavity/Mean-Flow Interaction in Low Pressure Axial Flow Turbines

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Journal of Thermal Science 2021年第6期30卷 2178-2185页

作者： BARSI Dario costa Carlo LENGANI Davide SIMONI Daniele VENTURINO Giulio ZUNINO Pietro DIME-Universita di Genova Via Montallegro 11-16145 Genova

The increasing performance of modern aeroengines led the research towards the optimization of machine components not deeply analyzed in the *** this context,the mechanisms driving the interaction process between the secondary flows evolving at the hub of low-pressure turbines with the rotor-stator cavity systems have been poorly investigated in the *** this work,an experimental and numerical analysis of the interaction between the endwall near wall flow and the leakage flow of a real cavity system is *** experimental results were carried out in the annular low-pressure axial flow turbine of the University of *** blade loading and pressure distributions into the cavity,as well as the measured total pressure loss coefficient,have been used for a proper validation of CFD *** steady and unsteady calculations were carried out through the commercial solver ***,several numerical approaches have been tested into this work:RANS,Non Linear Harmonic(NLH),and *** most promising CFD techniques have been firstly identified by comparison with experimental results and then systematically employed to extend the analysis of secondary flow-cavity flow interaction to positions and quantities not available from the *** characterizing the mean flow-cavity flow interaction process will be shown to cover a great amount of the overall stage losses and should be properly accounted for the design of future optimized cavity configurations.

关键词： axial flow turbine cavity mean-flow interaction experimental analysis CFD

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Improved dark ambient degradation of organic pollutants by cerium strontium cobalt perovskite

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Journal of Environmental Sciences 2020年第4期32卷 110-118页

作者： Huihuang Chen Julius Motuzas Wayde Martens Joao C.Diniz da costa The University of Queensland FIM^2 Lab-Functional Interfacial Materials and Membranes LaboratorySchool of Chemical EngineeringBrisbaneQld 4072Australia Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaAnhui 230026China Science and Engineering Faculty Queensland University of TechnologyBrisbaneQld 4000Australia LAQV-REQUIMTE (Bio)Chemical Process EngineeringDepartment of ChemistryFaculty of Science and TechnologyUniversidade NOVA de LisboaCaparica 2829-516Portugal

This work investigates the effect of cerium substation into strontium cobalt perovskites(CeSrCoO)for the oxidative degradation of OrangeⅡ(OII)in dark ambient conditions without the aid of any external stimulants such as light,heating or chemical *** OII degradation rate by CeSrCoO reached 65%in the first hour,whilst for the blank sample without cerium(SrCoO)took over 2 hr to reach the same level of OII ***,the cerium substitution improved the catalytic activity of the perovskite material,mainly associated with the Ce0.1Sr0.9CoO3 perovskite *** contacting CeSrCoO,the-N=Nazo bonds of the OII molecules broke down resulting in electron donation and the formation of *** electrons are injected into the CeSrCoO and resulted in a redox pair of Co3+/Co2+,establishing a bridge for the electron transfer between OII and the ***,the electrons also formed reactive species(·OH)responsible for OII degradation as evidenced by radical trapping *** species were formed via the reaction between 02 and donated electrons from OII with the aid of cobalt redox *** the prepared materials dispensed with the need for light irradiation and additional oxidants,it opens a window of environmental applications for treating contaminated wastewaters.

关键词： Dark catalysis Acid orange degradation Cerium substituted perovskite Catalytic activity

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