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IEEE/CAA Journal of Automatica Sinica 2020年第1期7卷 57-69页

作者： Laura Menini corrado possieri Antonio Tornambè Dipartimento di Ingegneria Industriale Universitàdi Roma Tor VergataRoma 00133Italy Istituto di Analisi dei Sistemi ed Informatica“A.Ruberti ”Consiglio Nazionale delle Ricerche(IASI-CNR)Roma 00185Italy Dipartimento di Ingegneria Civile e Ingegneria Informatica Universitàdi Roma Tor VergataRoma 00133Italy

In this paper, some computational tools are proposed to determine the largest invariant set, with respect to either a continuous-time or a discrete-time system, that is contained in an algebraic set. In particular, it is shown that if the vector field governing the dynamics of the system is polynomial and the considered analytic set is a variety, then algorithms from algebraic geometry can be used to solve the considered problem. Examples of applications of the method(spanning from the characterization of the stability to the computation of the zero dynamics) are given all throughout the paper.

关键词： Asymptotic stability discrete-time systems invariance nonlinear systems

On “Over-Sized” High-Gain Practical Observers for Nonlinear Systems

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IEEE/CAA Journal of Automatica Sinica 2018年第3期5卷 691-698页

作者： Daniele Carnevale corrado possieri Antonio Tornambè Dipartimento di Ingegneria Civile e Ingegneria Informatica Universita di Roma Tor Vergata

In this paper,it is shown that the performances of a class of high-gain practical observers can be improved by estimating the time derivatives of the output up to an order that is greater than the dimension of the system, which is assumed to be in observability form and, possibly, time-varying. Such an improvement is achieved without increasing the gain of the observers, thus allowing their use in a wide variety of control and identification applications.

关键词： Filtering properties nonlinear systems observability observer design

TWENTY-EIGHT YEARS WITH “HYPERBOLIC CONSERVATION LAWS WITH RELAXATION”

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Acta Mathematica Scientia 2015年第4期35卷 807-831页

作者： corrado MASCIA Dipartimento di Matematica "G. Castelnuovo" Sapienza Università di Roma P.le Aldo Moro

This paper is a review on the results inspired by the publication “Hyperbolic conservation laws with relaxation” by Tai-Ping Liu [1], with emphasis on the topic of nonlinear waves （specifically, rarefaction and shock waves）. The aim is twofold： firstly, to report in details the impact of the article on the subsequent research in the area; secondly, to detect research trends which merit attention in the （near） future.

关键词： conservation laws relaxation nonlinear waves stability

Chronic proctalgia and chronic pelvic pain syndromes:New etiologic insights and treatment options

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World Journal of Gastroenterology 2011年第40期17卷 4447-4455页

作者： Giuseppe Chiarioni corrado Asteria William E Whitehead Division of Gastroenterology of the University of Verona Azienda Ospedaliera Universitaria Integrata di Verona Valeggio sul Mincio Hospital 37067 Valeggio sul Mincio Verona Italy Department of Surgery and Orthopedics General Surgery Unit Azienda Ospedaliera Carlo Poma di Mantova Asola General Hospital 46041 Asola Mantova Italy Division of Gastroenterology and Hepatology Division of Urogynecology and Center for Functional Gastrointestinal and Motility Disorders University of North Carolina at Chapel Hill Chapel Hill NC 27599-7080 United States

This systematic review addresses the pathophysiology, diagnostic evaluation, and treatment of several chronic pain syndromes affecting the pelvic organs:chronic proctalgia, coccygodynia, pudendal neuralgia, and chronic pelvic pain. Chronic or recurrent pain in the anal canal, rectum, or other pelvic organs occurs in 7% to 24% of the population and is associated with impaired quality of life and high health care costs. However, these pain syndromes are poorly understood, with little research evidence available to guide their diagnosis and treatment. This situation appears to be changing:A recently published large randomized,controlled trial by our group comparing biofeedback, electrogalvanic stimulation, and massage for the treatment of chronic proctalgia has shown success rates of 85% for biofeedback when patients are selected based on physical examination evidence of tenderness in response to traction on the levator ani muscle-a physical sign suggestive of striated muscle tension. Excessive tension (spasm) in the striated muscles of the pelvic floor appears to be common to most of the pelvic pain syndromes. This suggests the possibility that similar approaches to diagnostic assessment and treatment may improve outcomes in other pelvic pain disorders.

关键词： Biofeedback Chronic pelvic pain Chronicproctalgia Coccygodynia Levator ani syndrome Pudendal neuralgia

Tidal drag and westward drift of the lithosphere

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Geoscience Frontiers 2023年第6期14卷 102-116页

作者： Vincenzo Nesi Oscar Bruno Davide Zaccagnino corrado Mascia Carlo Doglioni Dipartimento di Matematica Guido Castelnuovo Piazzale Aldo Moro5Roma 00185Italy Istituto Nazionale di Geofisica e Vulcanologia Via di Vigna Murata605Roma 00143Italy Computing and Mathematical Sciences Department Caltech1200 E.California Blvd.MC 305-16Pasadena 91125CAUSA Dipartimento di Scienze della Terra Piazzale Aldo Moro5Roma 00185Italy

Tidal forces are generally neglected in the discussion about the mechanisms driving plate tectonics despite a worldwide geodynamic asymmetry also observed at subduction and rift *** tidal drag could theoretically explain the westerly shift of the lithosphere relative to the underlying ***,viscosity in the asthenosphere is apparently too high to allow mechanical decoupling produced by tidal ***,we propose a model for global scale geodynamics accompanied by numerical simulations of the tidal interaction of the Earth with the Moon and the *** provide for the first time a theoretical proof that the tidal drag can produce a westerly motion of the lithosphere,also compatible with the slowing of the Earth’s rotational *** results suggest a westerly rotation of the lithosphere with a lower bound ofω≈(0.1-0.2)°/Myr in the presence of a basal effective shear viscosityη≈10^(16)Pa-s,but it may rise toω>1°/Myr with a viscosity ofη≈≤3×10^(14)Pa-s within the Low-Velocity Zone(LVZ)atop the *** faster velocity would be more compatible with the mainstream of plate motion and the global asymmetry at plate *** on these computations,we suggest that the super-adiabatic asthenosphere,being vigorously convecting,may further reduce the viscous coupling within the LVZ Therefore,the combination of solid Earth tides,ultra-low viscosity LVZ and asthenospheric polarized small-scale convection may mechanically satisfy the large-scale decoupling of the lithosphere relative to the underlying *** plate motions are explained because of lateral viscosity heterogeneities at the base of the lithosphere,which determine variable lithosphere-asthenosphere decoupling and plate interactions,hence plate tectonics.

关键词： Tidal drag Plate motions Polarized plate tectonics Lithosphere-asthenosphere interaction

NKG2A and COVID-19: another brick in the wall

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Cellular & Molecular Immunology 2020年第6期17卷 672-674页

作者： Luca Antonioli Matteo Fornai Carolina Pellegrini corrado Blandizzi Department of Clinical and Experimental Medicine University of Pisa56126 PisaItaly Department of Pharmacy University of Pisa56126 PisaItaly

Coronavirus disease 2019(COVID-19)is a viral infection caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2;formerly designated as 2019-nCoV),a novel betacoronavirus firstly identified during a burst of respiratory illness cases in Wuhan City,Hubei Province,China.1 Unfortunately,within a few weeks,the SARS-COV2 virus started to spread globally,producing a pandemic of an extremely spreadable and potentially fatal disease,becoming a cause of great concern for global public health.1 Despite the current estimates of COVID-19 case fatality rate suggest that this coronavirus is less deadly than other pathogens driving other large-scale outbreaks,such as SARS,Middle East respiratory syndrome,or Ebola,the main concern is that this infection is able to spread more easily than other diseases,including seasonal influenza.

关键词： becoming driving globally

Fetal Bradyarrhythmias:Etiopathogenesis,Diagnosis and Treatment:Between Literature Review and Experience of a Tertiary Center

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Congenital Heart Disease 2021年第4期16卷 309-331页

作者： Elio Caruso Silvia Farruggio Salvatore Agati corrado Di Mambro Mediterranean Pediatric Cardiology Center“Bambino Gesù”San Vincenzo Hospital Contrada SirinaTaormina98039Italy

Fetal arrhythmias reach up around 10%of the total third-level perinatal cardiology *** bradycardia is defined as a baseline fetal heart rate(FHR)of less than 110 bpm sustained for at least 10 *** overall incidence of malignant fetal bradyarrhythmias,such as complete atrioventricular block(AVB)and channellopathies,is relatively rare,1:5000 pregnancies,but represents a serious emergency for the gynecologist,neonatologists,and pediatric *** complete AVB is strongly associated with maternal connective tissue disease,but it can be also associated with congenital heart disease and usually with a poorer prognosis with high risk of fetal hydrops and ***,the treatment of severe fetal bradyarrhythmias is principally pharmacological and aims to increase the FHR,besides an early resolution of underlying causes,when possible,and a promptly management of fetal heart *** electrostimulation nowadays is an experimental pioneering method,reserved for limited selected cases.

关键词： Fetal arrhythmias hydrops bradyarrhythmia atrioventricular block

Updates on abdominal desmoid tumors

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World Journal of Gastroenterology 2007年第45期13卷 5985-5988页

作者： Bernardino Rampone corrado Pedrazzani Daniele Marrelli Enrico Pinto Franco Roviello Department of General Surgery and Surgical Oncology Unit of Surgical Oncology University of Siena Italy

Desmoid tumor is a monoclonal, f ibroblastic proliferation arising in musculoaponeurotic structures. This connective tissue hyperplasia inf iltrates locally, recurs frequently after resection but does not metastasize. Abdominal desmoid occurs sporadically, in association with some familial syndromes and often represents a clinical dilemma for surgeons. The enigmatic biology and anatomical location of abdominal desmoids make treatment recommendations diff icult. This distinct pathological entity is reviewed with a specif ic focus on aetiology and management.

关键词： Desmoid Abdomen Fibromatosis Familialadenomatous polyposis Gardner's syndrome

Identification of BRAF V600E mutation in odontogenic tumors by high-performance MALDI-TOF analysis

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International Journal of Oral Science 2022年第2期14卷 212-219页

作者： Lucrezia Togni Antonio Zizzi Roberta Mazzucchelli Andrea Santarelli corrado Rubini Marco Mascitti Department of Clinical Specialistic and Dental Sciences Marche Polytechnic Universityvia Tronto 10AnconaItaly Department of Biomedical Sciences and Public Health Marche Polytechnic Universityvia Tronto 10AnconaItaly Dentistry Clinic National Institute of Health and Science of AgingIRCCS INRCAvia Tronto 10AnconaItaly

Odontogenic tumors are rare lesions with unknown *** of them are benign,but local aggressiveness,infiltrative potential,and high recurrence rate characterize some *** MAP-kinase pathway activation can represent a primary critical event in odontogenic ***,the BRAF V600E mutation has been involved in 80%–90%of ameloblastic lesions,offering a biological rationale for developing new targeted *** study aims to evaluate the BRAF V600E mutation in odontogenic lesions,comparing three different detection methods and focusing on the Sequenom MassARRAY System.81 surgical samples of odontogenic lesions were subjected to immunohistochemical analysis,Sanger Sequencing,and Matrix-Assisted Laser Desorption/Ionization-Time of Flight mass spectrometry(Sequenom).The BRAF V600E mutation was revealed only in ameloblastoma ***,the presence of BRAF V600E was significantly associated with the mandibular site(ρ=0.627;P value<0.001)and the unicystic histotype(ρ=0.299,P value<0.001).However,any significant difference of 10-years disease-free survival time was not ***,Sequenom showed to be a 100%sensitive and 98.1%specific,suggesting its high-performance diagnostic *** results suggest the MAP-kinase pathway could contribute to ameloblastic ***,they could indicate the anatomical specificity of the driving mutations of mandibular ameloblastomas,providing a biological rational for developing new targeted ***,the high diagnostic accuracy of Sequenom was confirmed.

关键词： V600E BRAF specificity

Effects of freeze-thaw cycles on sandstone in sunny and shady slopes

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2503-2515页

作者： Dian Xiao Xiaoyan Zhao corrado Fidelibus Roberto Tomás Qiu Lu Hongwei Liu Academy of Railway Sciences Corporation Limited BeijingChina Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengduChina Department of Civil Engineering University of AlicanteAlicanteSpain Department of Innovation Engineering University of SalentoLecceItaly Department of Earth and Environmental Sciences University of Milano BicoccaMilanItaly

A growing rock engineering activity in cold regions is facing the threat of freeze-thaw(FT)weathering,especially in high mountains where the sunny-shady slope effects strongly control the difference in weathering behavior of *** this paper,an investigation of the degradation of petrophysical characteristics of sandstone specimens subjected to FT cycle tests to simulate the sunny-shady slope effects is *** this aim,non-destructive and repeatable testing techniques including weight,ultrasonic waves,and nuclear magnetic resonance methods on standard specimens were *** the sunny slope specimens,accompanied by the enlargement of small pores,100 FT cycles caused a significant decrease in P-wave velocity with an average of 23%,but a consistent rise of 0.18%in mass loss,34%in porosity,67%in pore geometrical mean radius,and a remarkable 14.5-fold increase in ***,slight changes with some abnormal trends in physical parameters of the shady slope specimens were observed during FT cycling,which can be attributed to superficial granular disaggregation and pore throat *** shocks enhance rock weathering on sunny slopes during FT cycles,while FT weathering on shady slopes is restricted to the small pores and the superficial *** two factors are primarily responsible for the differences in FT weathering intensity between sunny and shady *** conclusions derived from the interpretation of the experimental results may provide theoretical guidance for the design of slope-failure prevention measures and the selection of transportation routes in cold mountainous regions.

关键词： Sunny-shady slope Freeze and thaw Pore structure Tight rocks Talus slope Cold regions