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Ink-structing the future of vascular tissue engineering:a review of the physiological bioink design

Bio-Design and Manufacturing 2024年第2期7卷 181-205页

作者： Judith Synofzik Sebastian Heene Rebecca Jonczyk cornelia Blume Institute for Technical Chemistry Leibniz University Hannover30167 HannoverGermany

Three-dimensional(3D)printing and bioprinting have come into view for a plannable and standardizable generation of implantable tissue-engineered constructs that can substitute native tissues and *** tissue-engineered structures are intended to integrate with the patient’s *** tissue engineering(TE)is relevant in TE because it supports the sustained oxygenization and nutrition of all tissue-engineered *** have a specific role,representingthenecessarymedium for printability and vascular cell *** review aims to understand the requirements for the design of vascular ***,an in-depth analysis of vascular cell interaction with their native environment must be gained.A physiological bioink suitable for a tissue-engineered vascular graft(TEVG)must not only ensure good printability but also induce cells to behave like in a native vascular vessel,including self-regenerative and growth *** review describes the general structure of vascular walls with wall-speciﬁc cell and extracellular matrix(ECM)components and biomechanical properties and ***,the physiological role of vascular ECM components for their interaction with vascular cells and the mode of interaction is *** currently available or imaginable bioinks are described from physiological matrix proteins to nonphysiologically occurring but natural chemical compounds useful for vascular *** physiological performance of these bioinks is evaluated with regard to biomechanical properties postprinting,with a view to current animal studies of 3D printed vascular ***,the main challenges for further bioink development,suitable bioink components to create a self-assembly bioink concept,and future bioprinting strategies are *** concepts are discussed in terms of their suitability to be part of a TEVG with a high potential for later clinical use.

关键词： Vascular wall histology Vascular cells Microenvironment Extracellular matrix Cell–matrix interaction Bioink Printability

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含液晶成分的掺杂共聚物和胆甾醇基棕榈酸盐(或酯)掺合物(英文)

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光散射学报 2005年第3期 43-45页

作者： Maria-Cristina Popescu,cornelia vasile,Daniela Filip,Doina Macocinschi,Gh. Singurel Romanian Academy “Petru Poni" Institute of Macromolecular Chemistry 41 A Grigore Ghica Voda Alley Iasi Romania Romanian Academy “Petru Poni" Institute of Macromolecular Chemistry 41 A Grigore Ghica Voda Alley Iasi Romania Romanian Academy “Petru Poni" Institute of Macromolecular Chemistry 41 A Grigore Ghica Voda Alley Iasi Romania Romanian Academy “Petru Poni" Institute of Macromolecular Chemistry 41 A Grigore Ghica Voda Alley Iasi Romania “Al. I.Cuza" University Faculty of Physics Optics and Spectroscopy Department 11 Blvd. Carol I Iasi Romania

Physical blends containing macromolecular compounds and low molecular weight liquid crystals (LCs) have important applications. LCs are used as reinforcements for amorphous polymers or in display devices. The addition of LCs to amorphous polymers determines improvements in the mechanical properties of polymeric composites. Due to their mechanical anisotropy, which results from molecular alignment, the LC molecules may orient themselves in the shear field of a processing operation. Upon cooling, this orientation may impart to the composites some improvements in the mechanical properties similar with that found with fibrous reinforcements, but with the advantage that the additive acts also as a plasticizer. The glass transition temperature and the viscosity of the blend are lower than those of the starting polymer.

关键词： PEA CP cm

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Prospective cohort study on facial profile changes in infants with Robin sequence and healthy controls

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World Journal of Pediatrics 2024年第6期20卷 581-589页

作者： cornelia Wiechers Julian Sowula Karen Kreutzer Christoph E.Schwarz Christina Weismann Michael Krimmel Christian F.Poets Bernd Koos Department of Neonatology Tuebingen University HospitalCalwerstrasse 772076 TuebingenGermany Center for Cleft Lip Palate and Craniofacial MalformationsTuebingen University HospitalTuebingenGermany Department of Orthodontics Tuebingen University HospitalTuebingenGermany Department of Oral and Maxillofacial Surgery Tuebingen University HospitalTuebingenGermany

Background Various conservative and surgical approaches exist to treat Robin sequence(RS),but their effects on facial profile and mandibular catch-up growth are unclear.A functional treatment concept,used in our centre for 25 years,includes an individualized palatal plate with a velo-pharyngeal extension and intensive feeding *** We performed a prospective study to objectively describe facial profiles in infants with RS treated with the above *** with isolated RS were admitted to our tertiary perinatal and national referral centre for craniofacial malformations between May 2018 and Nov *** with RS received 3D-photographs during clinically indicated *** controls were recruited from Dec 2018 to Sep 2019 and received 3D-photographs every 3 *** digitally measured jaw index(JI),defined as alveolar overjet(O)x maxillary arch(U)/mandibular arch(L),and the soft tissue reference points A’-point,Nasion’,B’-point angle(ANB’),describing the relative position of maxilla to mandible,were *** mixed models were used to examine time trajectories in JI and ANB’.Results A total of 2073D images,obtained in 19 infants with RS and 32 controls,were *** and ANB’decreased over time in both groups[for JI−0.18(95%CI−0.25 to−0.10);for ANB’:−0.40°per month[(95%CI−0.48 to−0.32)]]but remained lower in controls[for JI−2.5(95%CI−3.2 to−1.8);for ANB’-1.7°(95%CI−2.4 to−1.0)].Also,the ANB’model showed a significant effect of the interaction term diagnosis x *** Based on longitudinal 3D images,we describe changes in objective parameters of facial profile in infants with and without RS during the first year of *** findings indicate catch-up growth in infants treated for RS.

关键词： Infant Mandibular catch-up growth Pre-epiglottic Baton Plate Robin sequence Three-dimensional photography

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Evaluation of the Controlled Release Ability of Theophylline from Xanthan/Chondroitin Sulfate Hydrogels

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Journal of Biomaterials and Nanobiotechnology 2013年第2期4卷 123-131页

作者： Ana-Maria Oprea Manuela-Tatiana Nistor Lenuta Profire Marcel Ionel Popa Catalina Elena Lupusoru cornelia vasile Department of Pharmacology and Algesiology “Gr. T. Popa” Medicine and Pharmacy University Iasi Romania Department of Physical Chemistry of Polymers Romanian Academy “P. Poni” Institute of Macromolecular Chemistry Iasi Romania Faculty of Chemical Engineering and Environmental Protection “Gh. Asachi” Technical University Iasi Romania

The xanthan/chondroitin sulfate (X/CS) hydrogels, obtained by a crosslinking technique, were evaluated in vitro and in vivo as matrices for theophylline release. The influence of pH of simulated physiological media on the X/CS swelling behaviour at 37°C was investigated. The hydrogels theophylline loading degree was evaluated by near infrared chemical imaging (NIR-CI) technique and confirmed also by FT-IR spectroscopy;the drug loading was about 77.5% based on PLS-DA prediction (Partial least squares-Discriminate Analysis). The release profiles of theophylline from X/CS hydrogels in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) depend on CS content. The release mechanisms were controlled by the drug solubility and ionic properties of the polymers. In vivo theophylline delivery was done by oral administration. Pharmacokinetic analysis revealed sustained-release characteristics for 50/50 X/CS theophylline-loaded formulation compared with raw theophylline which was rapidly absorbed, distributed and eliminated. A good in vitro-in vivo correlation was found.

关键词： Polysaccharide Hydrogels Theophylline Swelling In Vitro/In Vivo Release Pharmacokinetics

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A novel homozygous missense variant in ARSK causes MPS X,a new subtype of mucopolysaccharidosis

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Genes & Diseases 2024年第3期11卷 87-90页

作者： Miao Sun cornelia K.Kaminsky Philip Deppe Mai-Brittllse Frederic M.Vaz Barbara Plecko Torben Lubke Linda M.Randolph Division of Genomic Medicine Department of Pathology and Laboratory MedicineChildren's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA Department of Radiology Children's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA Department of Chemistry BiochemistryBielefeld UniversityBielefeld 33615Germany Amsterdam UMC Location University of Amsterdam Department of Clinical Chemistry and PediatricsLaboratory Genetic Metabolic DiseasesEmma Children's HospitalMeibergdreef 9Amsterdam 1100 DEthe Netherlands Amsterdam Gastroenterology Endocrinology Metabolism Inborn Errors of MetabolismAmsterdam 1105 BKthe Netherlands Core Facility Metabolomics Amsterdam UMC Location University of AmsterdamAmsterdam 1100DDthe Netherlands Department of Pediatrics Division of General PediatricsMedical Universityof GrazGraz8036Austria Division of Medical Genetics Department of PediatricsChildren's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA

Mucopolysaccharidoses(MPS)are a group of rare inborn errors of metabolism caused by defective lysosomal enzymes which prevent cells from degrading and recycling certain carbohydrates and fats,resulting in the storage of glycosaminoglycans in cells throughout the *** leads to multisystem abnormalities involving bone,connective tissues,brain,blood,spinal cord,skin,and other tissues.

关键词： metabolism doses polys

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Eight of ten patients return to daily activities, work, and sports after total knee arthroplasty

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World Journal of Orthopedics 2024年第7期15卷 608-617页

作者： Maud cornelia Wilhelmina Maria Peters Yvette Pronk Justus-Martijn Brinkman Department of Research Kliniek ViaSanaMill 5451 AANetherlands Department of Orthopedic Surgery Kliniek ViaSanaMill 5451 AANetherlands

BACKGROUND Besides return to work(RTW)and return to sports(RTS),patients also prefer to return to daily activities(RTA)such as walking,sleeping,grocery shopping,and domestic work following total knee arthroplasty(TKA).However,evidence on the timelines and probability of patients’RTA is *** To assess the percentage of patients able to RTA,RTW,and RTS after TKA,as well as the timeframe and influencing factors of this *** A retrospective cohort study with prospectively collected data was conducted at a medium-sized Dutch orthopedic *** of RTA,RTW,and RTS were performed at 3 mo and/or 6 mo following *** factors en-compassed patient characteristics,surgical characteristics,and preoperative patient-reported *** TKA patients[n=2063;66 years old(interquartile range[IQR]:7 years);47%male;28 kg/m2(IQR:4 kg/m2)]showed RTA ranging from 28%for kneeling to 94%for grocery shopping,with 20 d(IQR:27 d)spent for putting on shoes to 74 d(IQR:57 d)for *** rates varied from 62%for medium-impact work to 87%for low-impact work,taking 33 d(IQR:29 d)to 78 d(IQR:55 d).RTS ranged from 48%for medium-impact sports to 90%for low-impact sports,occurring within 43 d(IQR:24 d)to 90 d(IQR:60 d).One or more of the investigated factors influenced the return to each of the 14 activities examined,with R²values ranging from 0.013 to *** Approximately 80%of patients can RTA,RTW,and RTS within 6 mo after *** is not consistently in-fluenced by predictive *** help set realistic pre-and postoperative expectations.

关键词： Knee Arthroplasty Replacement Return to work Return to daily activities Return to sports

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含液晶成分的掺杂共聚物和胆甾醇基棕榈酸盐(或酯)掺合物(英文)

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光散射学报 2005年第3期17卷 231-233页

作者： Maria-Cristina Popescu cornelia vasile Daniela Filip Doina Macocinschi Gh. Singurel Romanian Academy "Petru Poni" Institute of Macromolecular Chemistry41 A Grigore Ghica Voda Alley Iasi RomaniaRomanian Academy "Petru Poni" Institute of Macromolecular Chemistry41 A Grigore Ghica Voda Alley Iasi RomaniaRomanian Academy "Petru Poni" Institute of Macromolecular Chemistry41 A Grigore Ghica Voda Alley Iasi RomaniaRomanian Academy "Petru Poni" Institute of Macromolecular Chemistry41 A Grigore Ghica Voda Alley Iasi Romania"Al. I.Cuza" University Faculty of Physics Optics and Spectroscopy Department 11 Blvd. Carol I Iasi Romania

关键词：掺杂共聚物胆甾醇基棕榈酸盐掺合物液晶成分微观分子结构显示装置

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Pseudospin-2 in photonic chiral borophene

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Photonics Research 2023年第5期11卷 869-877页

作者： PHILIP MENZ HAISSAM HANAFI DANIEL LEYKAM JÖRG IMBROCK cornelia DENZ Institute of Applied Physics University of MuensterMuenster 48149Germany Centre for Quantum Technologies National University of SingaporeSingapore 117543Singapore Physikalisch-Technische Bundesanstalt(PTB) 38116 BraunschweigGermany

Pseudospin is an angular momentum degree of freedom introduced in analogy to the real electron spin in the effective massless Dirac-like equation used to describe wave evolution at conical intersections such as the Dirac cones of ***,we study a photonic implementation of a chiral borophene allotrope hosting a pseudospin-2 conical intersection in its energy-momentum *** presence of this fivefold spectral degeneracy gives rise to quasiparticles with pseudospin up to±*** report on conical diffraction and pseudospin-orbit interaction of light in photonic chiral borophene,which,as a result of topological charge conversion,leads to the generation of highly charged optical phase vortices.

关键词： spectrum chiral momentum

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Oxaliplatin-induced neuropathy and colo-rectal cancer patient's quality of life:Practical lessons from a prospective cross-sectional,real-world study

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World Journal of Clinical Cases 2022年第10期10卷 3101-3112页

作者： Iulian Prutianu Teodora Alexa-Stratulat Elena Octaviana Cristea Andrei Nicolau Diana cornelia Moisuc Alina Alexandra Covrig Karina Ivanov Adina Emilia Croitoru Monica Ionela Miron Mihaela Ioana Dinu Anca Viorica Ivanov Mihai vasile Marinca Iulian Radu Bogdan Gafton SC MNT Healthcare Europe SRL Iasi 700021Romania University of Medicine and Pharmacy Grigore T Popa Iasi Iasi 700483Romania Regional Oncology Institute Iasi Iasi 700483Romania Oral and Maxillo-facial Surgery University of Medicine and Pharmacy Grigore T Popa IasiIasi 700021Romania Department of Medical Oncology Fundeni Clinical InstituteBucuresti 022328Romania University of Medicine and Pharmacy“Grigore T Popa” Iasi 700021Romania Department of Surgery Department of Surgical OncologyUniversity of Medicine and Pharmacy“Grigore T Popa”Regional Institute of OncologyIasi 700021Romania

BACKGROUND Colon cancer is one the most common forms of cancer in both *** to important progress in the field of early detection and effective treatment,colon and rectal cancer survivors currently account for 10%of cancer survivors ***,the effects of anti-cancer treatments,especially oxaliplatinbased chemotherapy,on the quality of life(QoL)have been less *** the incidence of severe chemotherapy-induced neuropathy(CIPN)in clinical studies is below 20%,data from real-world studies is scarce,and CIPN is probably under-reported due to patient selection and the patients’fear that reporting side-effects might lead to treatment *** To determine the impact of CIPN on QoL in colorectal cancer patients with a recent history of oxaliplatin-based *** We performed a prospective cross-sectional study in two major Romanian oncology tertiary hospitals—the Regional Institute of Oncology Ia?i(Iasi,Romania)and the Fundeni Clinical Oncology Institute(Bucharest,Romania).All consecutive patients with colon or rectal cancer,undergoing Oxaliplatin-based chemotherapy that consented to enroll in the study,were assessed by means of two questionnaires—the EORTC QQ-CR29(quality of life in colon and rectal cancer patients)and the QLQ-CIPN20(assessment of neuropathy).Several demographical,social,clinical and treatment data were also *** analysis was performed by means of SPSS *** student t test was used to assess the relationship between the QLQ-CIPN20 and QLQ-CR29 *** Meyer-curves were used to report 3-year progression-free survival(PFS)in patients that discontinued chemotherapy vs those that completed the recommended *** Of the 267 patients that fulfilled the inclusion criteria in the pre-specified time frame,101(37.8%)agreed to participate in the clinical *** the time of the enrolment in the study,over 50%of the patients had recently interrupted their oxaliplatin-based chemotherapy,mo

关键词： Colorectal cancer Oxaliplatin Neuropathy Quality of Life Recurrence-free survival Cross-sectional study

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Artificial intelligence as a noninvasive tool for pancreatic cancer prediction and diagnosis

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World Journal of Gastroenterology 2023年第12期29卷 1811-1823页

作者： Alexandra Corina Faur Daniela cornelia Lazar Laura Andreea Ghenciu Department of Anatomy and Embriology “Victor Babeș”University of Medicine and Pharmacy TimișoaraTimișoara 300041TimișRomania Department V of Internal Medicine I Discipline of Internal Medicine IVUniversity of Medicine and Pharmacy“Victor Babes”TimișoaraTimișoara 300041TimișRomania DepartmentⅢ Discipline of Pathophysiology“Victor Babeș”University of Medicine and PharmacyTimișoara 300041TimișRomania

Pancreatic cancer(PC)has a low incidence rate but a high mortality,with patients often in the advanced stage of the disease at the time of the first *** detected,early neoplastic lesions are ideal for surgery,offering the best *** lesions of the pancreas include pancreatic intraepithelial neoplasia and mucinous cystic neoplasms,with intraductal papillary mucinous neoplasms being the most commonly *** study focused on predicting PC by identifying early signs using noninvasive techniques and artificial intelligence(AI).A systematic English literature search was conducted on the PubMed electronic database and other *** obtained a total of 97 studies on the subject of pancreatic *** final number of articles included in our study was 44,34 of which focused on the use of AI algorithms in the early diagnosis and prediction of pancreatic *** algorithms can facilitate diagnosis by analyzing massive amounts of data in a short period of *** can be made through AI algorithms by expanding image and electronic medical records databases,which can later be used as part of a screening program for the general ***-based screening models should involve a combination of biomarkers and medical and imaging data from different *** requires large numbers of resources,collaboration between medical practitioners,and investment in medical infrastructures.

关键词： Pancreatic cancer Early pancreatic lesions Pancreatic neoplasia Artificial intelligence Deep learning Machine learning Radiomics Diagnosis Pancreas

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