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Discovery of Key Molecular Pathways of C1 Metabolism and Formaldehyde Detoxification in Maize through a Systematic Bioinformatics Literature Review

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Agricultural Sciences 2015年第5期6卷 571-585页

作者： P. Deonikar S. Kothandaram M. Mohan cori kollin Phoebe Konecky Rachael Olovyanniko Zachary Zamore Brian Carey V. A. S. Ayyadurai International Center for Integrative Systems Cambridge MA USA Livingston High School Livingston NJ USA

Computational systems biology approaches provide insights to understand complex molecular phenomena in living systems. Such understanding demands the need to systematically interrogate and review existing literature to refine and distil key molecular pathways. This paper explores a methodological process to identify key molecular pathways from systematic bioinformatics literature review. This process is used to identify molecular pathways for a ubiquitous molecular process in all plant biological systems: C1 metabolism and formaldehyde detoxification, specific to maize. The C1 metabolism is essential for all organisms to provide one-carbon units for methylation and other types of modifications, as well as for nucleic acid, amino acid, and other biomolecule syntheses. Formaldehyde is a toxic one-carbon molecule which is produced endogenously and found in the environment, and whose detoxification is an important part of C1 metabolism. This systematic review involves a five-part process: 1) framing of the research question;2) literature collection based on a parallel search strategy;3) relevant study selection based on search refinement;4) molecular pathway identification;and 5) integration of key molecular pathway mechanisms to yield a well-defined set molecular systems associated with a particular biochemical function. Findings from this systematic review produced three main molecular systems: a) methionine biosynthesis;b) the methylation cycle;and c) formaldehyde detoxification. Specific insights from the resulting molecular pathways indicate that normal C1 metabolism involves the transfer of a carbon group from serine through a folate-mediated pathway to methionine, and eventually the methylation of a biomolecule. In photosynthetic tissues, C1 metabolism often proceeds in reverse towards serine biosynthesis and formate oxidation. C1 metabolism, in maize, appears to be present in the developing embryo and endosperm indicating that these cells are vulnerable to pertu

关键词： Systematic Review Bioinformatics Molecular Pathway C1 Metabolism Formaldehyde Detoxification Maize Methionine Biosynthesis Methylation Cycle Folate-Mediated Pathways

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Sustainable Development and Health:Recent International Developments,Policies and Projects

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Chinese Journal of Population,Resources and Environment 2006年第4期4卷 3-8页

作者： Liliana cori Italian Environmental Authority for EU Structural Funds Ministry for the Environment and Territory Italy

Environment and health have been more and more jointly addressed in recent years,thanks to the efforts of several public and private *** this scenario,a leading role has been played by the World Heath Organisation(WHO).A specific attention was devoted to the issue by the European Union(EU)EU institutions and the WHO Office for Europe,which lists 52 countries(including Europe,Eastern European Countries and Turkey, former Yugoslavia and part of the former Soviet Union).The objectives of the present paper are to give an overview of the main developments in this area,and to underline the progress made towards a common understanding of health and environment issues,the advantages and limits of these developments and the challenges for the future,to be tackled at a global level.

关键词： environment and health sustainable development

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DNA metabarcoding the diet of Podarcis lizards endemic to the Balearic Islands

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Current Zoology 2023年第5期69卷 514-526页

作者： Iris Alemany Ana Pérez-Cembranos Valentín Pérez-Mellado JoséAurelio Castro Antònia Picornell cori Ramon JoséA Jurado-Rivera Deptartment of Biology Universitat de les Illes BalearsCtra.Valldemossa km 7’5Palma de Mallorca07122Balearic IslandsSpain and Department of Animal Biology Universidad de SalamancaCampus Miguel de Unamuno s/n37007SalamancaSpain

Dietary studies are essential to unravel the functioning of ecosystems and ultimately to understand *** task,which at first may seem simple,becomes especially complex in those cases of omnivorous species with highly variable *** this regard,the emergence of next-generation DNA sequencing methodologies represents a powerful tool to address the *** we implement a high-throughput metabarcoding strategy based on the analysis of four molecular markers aimed at sequencing both mitochondrial(animal prey)and chloroplast(diet plants)genome fragments from fecal samples of two lizard species endemic to the Balearic Archipelago(Podarcis lilfordi and ***)obtained through non-invasive *** results allowed for the characterization of their diets with a high degree of taxonomic detail and have contributed a large number of new trophic *** reported diets are based mainly on the consumption of arthropods,mollusks and plants from a diversity of taxonomic orders,as well as carrion and marine *** analyses also reveal inter-and intra-specific differences both in terms of seasonality and geographical distribution of the sampled lizard *** molecular findings provide new insights into the trophic interactions of these threatened endemic lizards in their unique and isolated ecosystems.

关键词： Balearic archipelago COI metabarcoding Podarcis lilfordi Podarcis pityusensis psbA-trnH rbcL trophic ecology

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Utilization of Hot Spotting to Identify Community Needs and Coordinate Care for High-Cost Patients in Memphis, TN

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Journal of Geographic Information System 2014年第1期6卷 23-29页

作者： Teresa Cutts Edward Rafalski cori Grant Razvan Marinescu Methodist Le Bonheur Healthcare University of Memphis School of Public Health Memphis USA Methodist Le Bonheur Healthcare University of Memphis School of Public Health Memphis USA University of Tennessee Health Science Center Knoxville USA University of Illinois School of Public Health Chicago USA Qsource & University of Memphis School of Public Health Memphis Memphis USA Wake School of Medicine Division of Public Health Sciences Winston Salem USA

In 2006, Methodist Le Bonheur Healthcare (MLH) created the Congregational Health Network (CHN, TM pending) which works closely with clergy in the most under-served zip codes of the city to improve access to care and overall health status of the population. To best coordinate CHN resources around high-utilization and address the largest health needs in the community, MLH applied hot spotting and geographic information system (GIS) spatial analysis techniques. These techniques were coupled with the community health needs assessment process at MLH and qualitative, participatory research findings captured in collaboration with church and other community partners. The methodology, which we call “participatory hot spotting,” is based upon the Camden Model, which leverages hot spotting to assess and prioritize community need in the provision of charity care, but adds a participatory, qualitative layer. In this study, spatial analysis was employed to evaluate hospital-based inpatient and outpatient utilization and define costs of charity care for the health system by area of residence. Ten zip codes accounted for 56% of total system charity care costs. Among these, the largest zip code, as defined by a percentage of total charity costs, contributed 18% of the inpatient utilization and 17% of the cost. Further, this zip code (38109) contributed 69% of the inpatient and 76% of the outpatient charity care volume and accounted for 75% of inpatient and 76% of outpatient charity care costs for the system. These findings were combined with grassroots intelligence that enabled a partnership with clergy and community members and Cigna Healthcare to better coordinate care in a place-based population health management strategy. Presentations of the analytics have subsequently been made to HHS and the CDC, referred to by some as the “Memphis Model”.