检索结果-南通市图书馆

生理学报 2008年第5期60卷 603-604页

作者： grant D.Nicol Department of Pharmacology and Toxicology Indiana University School of MedicineIndianapolisIN46202USA

Because nerve growth factor(NGF)is elevated during inflammation,plays a causal role in the initiation of

关键词：敏感性感觉神经元临床分析神经生长因子

Detection and monitoring prostate specific antigen using nanotechnology approaches to biosensing

在线全文

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2020年第1期14卷 4-18页

作者： grant Perry Fernando Cortezon-Tamarit Sofia I.Pascu Department of Chemistry University of BathClaverton DownBath BA27AYUK

Prostate cancer has a high incidence in men and remains the second cause of mortality due to cancer *** the development of the disease is greatly correlated to age,the identification of novel detection methods reliable,efficient,and cost effective is a matter of significant importance in the ageing population of western *** detection of the prostate specific antigen(PSA)in blood samples has been the preferred method for the detection and monitoring of prostate cancer over the past *** the indications against its use in massive population screening,PSA still remains the best studied biomarker for prostate cancer and the detection of its different forms and incorporation in multiplexed designs with other biomarkers still remains a highly valuable indicator in the theranostics of prostate *** latest developments in the use of nanomaterials towards the construction of PSA biosensors are reviewed *** incorporation of gold nanoparticles,silica nanoparticles and graphene nanostructures to biosensing devices has represented a big leap forward in terms of sensitivity,stability and *** electrochemical and optical detection methods for the detection of PSA will be reviewed herein.

关键词： biosensing immunosensor PSA prostate cancer fluorescence

Impact of COVID-19 on Safety Performance for Motorcycles:Pre- and during-Pandemic Conditions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The genetic reference population “Collaborative Cross”is a powerful resource for genetic discoveries and understanding complex genetic traits

Journal of Transportation Technologies（交通科技期刊） 2024年第3期 390页

作者： Hongyun Chen Amelia Lawson Charles Hurda Madalyn Smith Tate grant

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

中国比较医学杂志 2016年第7期26卷 1-10页

作者： grant Morahan Centre for Diabetes Research The Harry Perkins Institute of Medical ResearchCentre for Medical ResearchUniversity of Western Australia

The Collaborative Cross( CC) is a powerful genetic resource with a wide range of applications in medical research. It is a multiparental genetic reference population,composed of 200 recombinant inbred mouse strains. It was designed to be a resource for rapid mapping of genes that mediate complex traits. The CC has been produced following an intense breeding program that had taken over ten years to complete. It is now becoming available to the research community. While advances in human genetic technologies over the last decade have been substantial,the CC provides the ability to make discoveries not possible with other methods or resources. It can be applied to any subject that can be measured or modelled in the mouse. Here,we discuss a range of applications for which the CC can be used,with examples taken from the early characterization of this powerful resource.

关键词：实验动物基因工程小鼠

Recruitment and functionality traits as bioindicators of ecological restoration success in the Lurg Hills district,Victoria,Australia

在线全文

学校读者我要写书评

暂无评论

Ecological Processes 2013年第1期2卷 286-296页

作者： Kristin Monie Singarayer Florentine grant Palmer Centre for Environmental Management School of ScienceInformation Technology and EngineeringUniversity of BallaratPO Box 663BallaratVictoriaAustralia

Introduction:The Regent Honeyeater Project commenced ecological restoration in the Lurg district in 1994,with an aim to restore habitats for the critically endangered Regent Honeyeater Anthochaera phrygia and a range of other threatened and declining *** this context,our study aimed to explore whether plant reproduction can be an effective measure of ecological restoration ***:Evaluation involved comparing attributes at unrestored,restored and remnant sites to establish whether sites displayed evidence of a clear restoration *** age classes(unrestored,4–6 years old,8–10 years old,12–14 years old and remnant areas)and two landforms(upper hills and lower hills)were *** diversity of woody plant species—which have easily recognisable reproductive material and which all recruit seedlings—provides easily measured parameters that have the potential to allow the determination of early establishment success and long-term ecological development of restored ***:Restoration plantings developed in a hybrid state towards a benchmark in the lower hills;seedling species composition differed significantly among age classes,increasing in similarity with time since restoration,with some divergence from the target *** of functional groups with reproductive outputs was also significantly different among age classes;however,a restoration trajectory was only evident in the upper hills where sites converged towards the target ***:Divergence or deviation from the restoration trajectory was not deemed to be a restoration failure,as the variety of functional groups with fruits and diversity of seedlings recruiting indicated a potential increase in resilience in the future due to greater variability across the *** recruitment was effective in detecting development trends towards a restoration target in this study and therefore may be a useful measure that contributes to determining ecological

关键词： Restoration Assessment Ecological development Trajectory Monitoring

Olfaction and reaction: The role of olfactory and hypothalamic investment in the antipredator responses to chemical alarm cues by northern redbelly dace

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2023年第6期69卷 738-746页

作者： Brendan J.Joyce grant E.Brown Department of Biology Concordia UniversityMontrealQuebecCanada

Neuroplasticity enables teleosts to promote or downregulate the growth of their brains *** compensate for the effects of predation pressure,teleosts may alter their brain morphology and behavioral responses to mitigate its impact on individual ***-predation environ-ments often promote specific patterns of brain growth and produce bolder and more proactive *** to the expense of maintaining neural tissue,relative size indicates the regions most relied *** northern redbelly dace Chrosomus eos,as little as 2 weeks of elevated predation pressure,resulted in increased investment in their olfactory bulbs and optic tecta,while the imposition of captivity produced smaller,less symmetric *** together,these results suggest that an individual could potentially become better able to detect a threat,and simultaneously less inclined to react to it,making the impact of either change in isolation is difficult to ***,we compared interindividual variation in gross brain morphology,risk-taking tactics in a novel arena(shy-bold personality),and responding to olfactory cues(proactive/reac-tive stress-coping style).We hypothesized that olfactory investment would positively correlate with response intensity to predator cue concen-tration and respond across a wider range of cue concentrations,while hypothalamus size would correlate with shyness and *** to heightened risk produced more bold/proactive individuals,with larger olfactory bulbs and smaller ***,the direction of the correlation between hypothalamus size and behavior varied by treatment,and olfactory investment only corresponded with response intensity amongst proactive *** findings illustrate the potential pitfalls of relating gross brain morphology to complex behavior and suggest that stress-coping style is a relevant consideration in future studies.

关键词： boldness brainmorphology neuroplasticity predation proactivity stress-coping style

Elevated CO_2 Accelerates Phosphorus Depletion by Common Bean(Phaseolus vulgaris) in Association with Altered Leaf Biochemical Properties

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pedosphere 2018年第3期28卷 422-429页

作者： Zhong MA Jennifer FLYNN grant LIBRA Zechuan SHI Department of Biology Truman State University

Phosphorus （P） is a major limiting factor for plant productivity in many ecosystems and agriculture. The projected increase in atmospheric CO2 is likely to result in changes in plant mineral consumption and growth. We studied P depletion by common bean （Phaseolus vulgaris） cultured hydroponically under ambient （377±77μmol mol^-1） or elevated （650±32 μmol mol^-1） CO2 in media of low or high P. Under elevated CO2 compared to ambient CO2, the maximum P depletion rate increased by 98% at low P and 250% at high P, and P was depleted about 2-5 weeks sooner; leaf acid phosphatase （APase） activity and chlorophyll content both increased significantly; root-to-shoot ratio increased significantly at high P, although it was unaffected at low P; lateral root respiration rate showed no change, suggesting that COs did not affect P depletion via metabolic changes to the roots; the total biomass at final harvest was significantly higher at both low and high P. Our data showed that the increased rate and amount of P depletion during plant growth under elevated CO2 occurred in association with alterations in leaf biochemical properties, i.e., enhanced activities of leaf APase and increased leaf chlorophyll content.

关键词： acid phosphatase biomass partitioning chlorophyll climate change dry matter accumulation mineral nutrition

Multipotent pancreas progenitors: Inconclusive but pivotal topic

在线全文

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2015年第11期7卷 1251-1261页

作者： Fang-Xu Jiang grant Morahan Islet Cell Development Program Harry Perkins Institute of Medical Research Centre for Medical Research the University of Western Australia Centre for Diabetes Research Harry Perkins Institute of Medical Research

The establishment of multipotent pancreas progenitors(MPP) should have a significant impact not only on the ontology of the pancreas, but also for the translational research of glucose-responding endocrine b-cells. Deficiency of the latter may lead to the pandemic type 1 or type 2 diabetes mellitus, a metabolic disorder. An ideal treatment of which would potentially be the replacement of destroyed or failed b-cells, by restoring function of endogenous pancreatic endocrine cells or by transplantation of donor islets or in vitro generated insulin-secreting cells. Thus, considerable research efforts have been devoted to identify MPP candidates in the preand post-natal pancreas for the endogenous neogenesis or regeneration of endocrine insulin-secreting cells. In order to advance this inconclusive but critical field, we here review the emerging concepts, recent literature and newest developments of potential MPP and propose measures that would assist its forward progression.

关键词： Multipotent pancreas progenitors Regeneration Self-renewal Clonogenesis Differentiation

Fabrication of Superhydrophobic Surfaces on Aluminum Alloy Via Electrodeposition of Copper Followed by Electrochemical Modification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2011年第3期3卷 160-165页

作者： Ying Huang D.K.Sarkar X-grant Chen University Research Center on Aluminum (CURAL) University of Qubec at Chicoutimi

Superhydrophobic aluminum surfaces have been prepared by means of electrodeposition of copper on aluminum surfaces, followed by electrochemical modification using stearic acid organic molecules. Scanning electron microscopy(SEM) images show that the electrodeposited copper films follow "island growth mode" in the form of microdots and their number densities increase with the rise of the negative deposition potentials. At an electrodeposition potential of-0.2 V the number density of the copper microdots are found to be 4.5×104cm^(-2)that are increased to 2.9×105cm^(-2)at a potential of-0.8 V. Systematically, the distances between the microdots are found to be reduced from 26.6 μm to 11.03 μm with the increase of negative electrochemical potential from-0.2 V to-0.8 V. X-ray diffraction(XRD) analyses have confirmed the formation of copper stearate on the stearic acid modified copper films. The roughness of the stearic acid modified electrodeposited copper films is found to increase with the increase in the density of the copper microdots. A critical copper deposition potential of-0.6 V in conjunction with the stearic acid modification provides a surface roughness of 6.2 μm with a water contact angle of 157?, resulting in superhydrophobic properties on the aluminum substrates.

关键词： Superhydrophobic aluminum surface Water contact angle Copper microdots Surface roughness Electrochemical modification

Surgical management in pediatric neuroblastoma diagnosis and treatment:a 20-year,single-center experience

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2022年第2期18卷 120-125页

作者： Brianna Spencer Akshilkumar Patel Robert Cilley Christa N.grant Department of Surgery Penn State Health Milton SHershey Medical Center500 University DriveHersheyPA 17033USA Pennsylvania State University College of Medicine HersheyPAUSA Division of Pediatric Surgery Penn State Health Milton SHershey Medical CenterHersheyPAUSA

Background The currently utilized International Neuroblastoma Risk Group(INRG)staging system developed in 2009 uses image-defined risk factors as a measure of surgical risk,separating resectable neuroblastoma from those best preceded by *** previous International Neuroblastoma Staging System was based primarily on surgical *** hypothesized there would be a change to the role of the surgeon in neuroblastoma treatment in the more recent *** This is a single center 20-year retrospective analysis of 104 patients with International Classification of Diseases-9 and-10 codes for *** demographics,tumor site,cancer treatment modality,survival,biopsy technique,surgical intervention,and pathology staging were *** was analyzed by analysis of variance(ANOVA)and Student’s t *** There was a decrease in open surgeries for extra-adrenal neuroblastomas in the later decade(77%,31%,P=0.01).There was a narrowing of the time interval to surgery in the later cohort,likely as a result of uniformity in surgical timing on treatment protocols relying on INRG *** Our findings mirror changes in practice patterns *** found an increase in minimally invasive approaches but did not find a difference in the role of the surgeon under the INRG staging system.

关键词： International Neuroblastoma Risk Group International Neuroblastoma Staging System MYCN Neuroblastoma Resection