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Computed tomography-based radiomics diagnostic approach for differential diagnosis between early-and late-stage pancreatic ductal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1256-1267页

作者： Shuai Ren Li-Chao Qian Ying-Ying Cao Marcus J daniels Li-Na Song Ying Tian Zhong-Qiu Wang Department of Radiology Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Geratology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Department of Radiology NYU Langone HealthNew YorkNY 10016United States

BACKGROUND One of the primary reasons for the dismal survival rates in pancreatic ductal adenocarcinoma(PDAC)is that most patients are usually diagnosed at late *** is an urgent unmet clinical need to identify and develop diagnostic methods that could precisely detect PDAC at its earliest *** A total of 71 patients with pathologically proved PDAC based on surgical resection who underwent contrast-enhanced computed tomography(CT)within 30 d prior to surgery were included in the *** staging was performed in accordance with the 8th edition of the American Joint Committee on Cancer staging *** features were extracted from the region of interest(ROI)for each patient using Analysis Kit *** most important and predictive radiomics features were selected using Mann-Whitney U test,univar-iate logistic regression analysis,and minimum redundancy maximum relevance(MRMR)*** forest(RF)method was used to construct the radiomics model,and 10-times leave group out cross-validation(LGOCV)method was used to validate the robustness and reproducibility of the *** A total of 792 radiomics features(396 from late arterial phase and 396 from portal venous phase)were extracted from the ROI for each patient using Analysis Kit *** most important and predictive features were selected using Mann-Whitney U test,univariate logistic regression analysis,and MRMR *** method was used to construct the radiomics model with the nine most predictive radiomics features,which showed a high discriminative ability with 97.7%accuracy,97.6%sensitivity,97.8%specificity,98.4%positive predictive value,and 96.8%negative predictive *** radiomics model was proved to be robust and reproducible using 10-times LGOCV method with an average area under the curve of 0.75 by the average performance of the 10 newly built *** The radiomics model based on CT could serve as a promising non-invasive method in differential diag

关键词： Pancreatic ductal adenocarcinoma Radiomics Computed tomography American Joint Committee on Cancer staging

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Changes in physical activity and sleep following the COVID-19 pandemic on a university campus:Perception versus reality

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Sports Medicine and Health Science 2024年第3期6卷 246-251页

作者： Bryce T.daniels Samantha Robinson Ivan Vargas Jamie I.Baum Erin K.Howie University of Arkansas FayettevilleARUnited States Rush University Medical Center ChicagoIllinoisUnited States1 University of Arkansas System Division of Agriculture FayettevilleARUnited States

It has been hypothesized that key lifestyle behaviors of physical activity and sleep worsened in response to the Coronavirus disease(COVID-19)***,there have been inconsistencies in findings of changes in these key lifestyle behaviors across populations likely due to the wide variety of assessment *** purpose of the study was to compare physical activity and sleep before and after the COVID-19 pandemic using accelerometers and self-reported behaviors.A longitudinal follow-up was conducted on students,faculty,and staff at a university campus in the United *** the periods before March 2020(covering the academic years of 2018–2019 or 2019–2020)and again in April–June 2021,participants completed surveys to evaluate their physical activity and sleep behaviors and wore an accelerometer.A total of 44 participants completed the survey at both timepoints and 32 completed accelerometer assessment at both ***-seven percent of participants reported a perceived decline in physical activity,while 30%reported a worsening in *** selfreported data,overall physical activity did not change,but there was a decrease in active transport(p<0.001)and increase in domestic physical activity(p?0.012).Sleep quality decreased as evidenced by an increase in Pittsburgh Sleep Quality Index scores(p?0.045).There were no changes in accelerometer measured physical activity or *** were no changes in physical or mental *** perceptions of physical activity declined from prior to the COVID-19 pandemic,there were no changes in device-measured physical activity,and changes in self-reported physical activity differed by domain.

关键词： Movement Longitudinal Measurement

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Near-Surface Soil Chemical Properties as Affected by Cover Crops Over Time in the Lower Mississippi River Valley

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Agricultural Sciences 2024年第9期15卷 1035-1056页

作者： Cooper Fanning Kristofor R. Brye Michael B. daniels Trenton L. Roberts Samuel Fernandes Lisa S. Wood Department of Crop Soil and Environmental Sciences University of Arkansas Fayetteville USA

Typical row-crop agricultural practices can potentially be harmful to soil health and future sustainability. The use of cover crops (CC) as a mechanism to improve soil health on a wide scale remains underutilized. Soil health remains a major concern for the sustainability of agricultural productivity, therefore, research into CC implementation as a mean to preserve or improve soil health is warranted. The objective of this study was to evaluate the effects of CC on the soils in the eastern Arkansas portion of the Lower Mississippi River Valley (LMRV) over time for various chemical soil parameters, including pH, soil organic matter (SOM), soil elemental contents (i.e., P, K, Ca, Mg, S, Na, Fe, Mn, Zn, Cu, and B), soil respiration, and a generalized soil health score index. Soil pH decreased over time under both CC and no-cover-crop (NCC) treatments, by −0.3 and −0.2, respectively. Soil OM decreased over time under NCC by −0.1%, but did not differ between CC treatments. Soil N availability decreased over time under NCC (−22.6 kg·ha−1), but did not change over time under CC. Soil respiration decreased over time under both CC and NCC, by −76.1 mg·L−1 and −77.3 mg·L−1, respectively, though there was no effect of CC treatment. The Haney soil health score index decreased under CC (−7.0) and NCC (−6.8) without an effect from CC treatment. Results of the study place emphasis on the temporal nature of soil health as influenced by cover crops and their potential to improve soil health.

关键词： Arkansas Cover Crops Soil Properties Soil Organic Matter Soil Health Score

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Kodak＇s Magic Marker

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空中英语教室（高级版．彭蒙惠英语） 2009年第4期 20-21页

作者： cora.daniels

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Comparison between solid pseudopapillary neoplasms of the pancreas and pancreatic ductal adenocarcinoma with cystic changes using computed tomography

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World Journal of Radiology 2024年第6期16卷 211-220页

作者： Shuai Ren Li-Chao Qian Xiao-Jing Lv Ying-Ying Cao Marcus J daniels Zhong-Qiu Wang Li-Na Song Ying Tian Department of Radiology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Geratology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Department of Radiology NYU Langone HealthNew YorkNY 10016United States

BACKGROUND Solid pseudopapillary neoplasms of the pancreas(SPN)share similar imaging findings with pancreatic ductal adenocarcinoma with cystic changes(PDAC with cystic changes),which may result in unnecessary *** To investigate the value of computed tomography(CT)in differentiation of SPN from PDAC with cystic *** This study retrospectively analyzed the clinical and imaging findings of 32 patients diagnosed with SPN and 14 patients diagnosed with PDAC exhibiting cystic changes,confirmed through pathological *** and qualitative analysis was performed,including assessment of age,sex,tumor size,shape,margin,density,enhancement pattern,CT values of tumors,CT contrast enhancement ratios,“floating cloud sign,”calcification,main pancreatic duct dilatation,pancreatic atrophy,and peripancreatic invasion or distal *** logistic regression analysis was used to identify relevant features to differentiate between SPN and PDAC with cystic changes,and receiver operating characteristic curves were obtained to evaluate the diagnostic performance of each variable and their *** When compared to PDAC with cystic changes,SPN had a lower age(32 years vs 64 years,P0.05).The area under the receiver operating characteristic curve of the combination was 0.833(95%confidence interval:0.708-0.957)with 78.6%sensitivity,81.3%specificity,and 80.4%accuracy in differentiation of SPN from PDAC with cystic *** A larger tumor size,“floating cloud sign,”and peri

关键词： Solid pseudopapillary neoplasm Pancreas Pancreatic ductal adenocarcinoma Computed tomography Differential diagnosis

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“我们永远都是道德主义者”——艾瑞斯·默多克、事实及价值

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当代中国价值观研究 2024年第4期9卷 95-115页

作者：科拉·戴蒙德卢俊豪(译) 弗吉尼亚大学中山大学哲学系

通过重构默多克对黑尔等分析哲学家的批判,本文深入分析了默多克的道德哲学理论以及她对事实与价值区分的不同理解方式,阐明了道德价值与个体认知活动的关系。在默多克看来,个体在感知世界、对待事物时带有一种“一般观念态度”,因此,... 详细信息

通过重构默多克对黑尔等分析哲学家的批判,本文深入分析了默多克的道德哲学理论以及她对事实与价值区分的不同理解方式,阐明了道德价值与个体认知活动的关系。在默多克看来,个体在感知世界、对待事物时带有一种“一般观念态度”,因此,我们观看外部的视角和注意力始终受到道德的指引;我们的道德本质是无处不在的,不仅渗透在我们的日常意识中,而且表现在我们的所有意识模式中。我们天生就是道德存在者,永远受道德价值的引导,这些道德价值不仅影响着我们的一切认知,而且塑造着我们的“境界”与“选择”。

关键词：事实价值境界道德主义道德语言认知活动

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VARIATIONAL DISCRETIZATION OF A CONTROL-CONSTRAINED PARABOLIC BANG-BANG OPTIMAL CONTROL PROBLEM

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Journal of Computational Mathematics 2020年第1期38卷 14-40页

作者： Nikolaus von daniels Michael Hinze Schwerpunkt Optimierung und Approximation Universitat HamburgBundesstrase 5520146 HamburgGermany

We consider a control-constrained parabolic optimal control problem without Tikhonov term in the tracking *** the numerical treatment,we use variational discretization of its Tikhonov regularization:For the state and the adjoint equation,we apply Petrov-Galerkin schemes in time and usual conforming finite elements in *** prove a-priori estimates for the error between the discretized regularized problem and the limit *** these estimates are not robust if the regularization parameter tends to zero,we establish robust estimates,which--depending on the problem's regularity——enhance the previous *** the special case of bang-bang solutions,these estimates are further improved.A numerical example confirms our analytical findings.

关键词： Optimal control Heat equation Control constraints Finite elements A-priori error estimates Bang-bang controls

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可控热膨胀聚合物复合材料的挑战和机遇(英文)

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硅酸盐学报 2009年第5期37卷 689-695页

作者： LIND cora 托利多大学化学系美国托利多OH43606

负热膨胀(negative thermal expansion,NTE)材料可作为填料制备可控热膨胀复合材料。高质量聚合物复合材料的研发面临诸多挑战,包括 NTE填料与基体材料的相容性,NTE相的稳定性,颗料形貌和尺寸的控制及其对混合程度的影响。本文对影响聚... 详细信息

负热膨胀(negative thermal expansion,NTE)材料可作为填料制备可控热膨胀复合材料。高质量聚合物复合材料的研发面临诸多挑战,包括 NTE填料与基体材料的相容性,NTE相的稳定性,颗料形貌和尺寸的控制及其对混合程度的影响。本文对影响聚合物复合材料成型中存在的诸多可能存在的问题进行了述评,讨论了对有望用作填料的 NTE材料的要求,即对NTE填料颗粒尺寸和相容性进行合成控制。通过晶体前驱体到目标NTE相的拓扑转变,可实现对颗粒尺寸的最优控制。

关键词：负热膨胀材料纳米颗粒聚合物复合材料钨酸锆钼酸锆钒酸锆

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Forkhead box protein P1, a key player in neuronal development?

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Neural Regeneration Research 2018年第5期13卷 801-802页

作者： Luca Braccioli cora H.Nijboer Paul J.Coffer Laboratory of Neuroimmunology and Developmental Origins of Disease (NIDOD) University Medical Center Utrecht University Regenerative Medicine Center University Medical Center Utrecht Utrecht University Center for Molecular Medicine and Division of Pediatrics University Medical Center Utrecht Utrecht University

Forkhead box protein P1（FOXP1）is a transcription factor belonging to the forkhead box（FOX）proteins,a family of transcriptional regulators sharing a highly conserved forkhead DNA-binding domain（Bacon and Rappold,2012）.Previous reports have proposed a role for FOXP1 in functionally regulating the central nervous system（CNS）,while mutations in FOXP1 have been implicated in cognitive abnormalities（Bacon and Rappold, 2012）.

关键词： a key player in neuronal development Forkhead box protein P1

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A 15-year-Long catalog of seismicity in the Eastern Tennessee Seismic Zone(ETSZ)using matched filter detection

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Earthquake Research Advances 2023年第1期3卷 92-105页

作者： Clara daniels Zhigang Peng School of Earth and Atmospheric Sciences Georgia Institute of TechnologyAtlanta311 Ferst DrAtlantaGA30318USA Applied Research Associates BurlingtonMAUSA

We present a detailed catalog of 13671 earthquakes in the Eastern Tennessee Seismic Zone(ETSZ)that spans January 1,2005 to July 31,*** apply a matched filter detection technique on over 15 years of continuous data,resulting in arguably the most complete catalog of seismicity in the ETSZ *** magnitudes of newly detected events are determined by computing the amplitude ratio between the detections and templates using a principal component *** also compute the b-value for the new catalog and comparatively relocate a subset of newly detected events using XCORLOC and hypoDD,which shows a more defined structure at *** find the greatest concentration along and to the east of the New York-Alabama Lineament,as defined by the magnetic anomaly,supporting the argument that this feature likely is related to the generation of seismicity in the *** examine seismicity in the vicinity of the Watts Bar Reservoir,which is located about 5 km from the epicenter of the M_(W) 4.4 December 12,2018 Decatur,Tennessee earthquake,and find possible evidence for reservoir modulated seismicity in this *** also examine seismicity in the entire ETSZ to search for a correlation between shallow earthquakes and seasonal hydrologic *** results show limited evidence for hydrologicallydriven shallow seismicity due to seasonal groundwater levels in the ETSZ,which contradicts previous studies hypothesizing that most intraplate earthquakes are associated with the dynamics of hydrologic cycles.

关键词： Eastern Tennessee Seismic Zone Matched filter detection Intraplate earthquakes Reservoir modulated seismicity

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