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npj Computational Materials 2020年第1期6卷 971-981页

作者： Andrea Gayon-Lombardo Lukas Mosser Nigel P.Brandon samuel J.cooper Department of Earth science and Engineering Imperial College LondonLondon SW72BPUK Earth science Analytics AsA Professor Olav Hanssens vei 7AStavanger 4021Norge Dyson school of Design Engineering Imperial College LondonLondon SW72DBUK

The generation of multiphase porous electrode microstructures is a critical step in the optimisation of electrochemical energy storage *** work implements a deep convolutional generative adversarial network(DC-GAN)for generating realistic nphase microstructural *** same network architecture is successfully applied to two very different three-phase microstructures:A lithium-ion battery cathode and a solid oxide fuel cell anode.A comparison between the real and synthetic data is performed in terms of the morphological properties(volume fraction,specific surface area,triple-phase boundary)and transport properties(relative diffusivity),as well as the two-point correlation *** results show excellent agreement between datasets and they are also visually *** modifying the input to the generator,we show that it is possible to generate microstructure with periodic boundaries in all three *** has the potential to significantly reduce the simulated volume required to be considered“representative”and therefore massively reduce the computational cost of the electrochemical simulations necessary to predict the performance of a particular microstructure during optimisation.

关键词： microstructure electrode phase

A preliminary study of sperm identification in microdissection testicular sperm extraction samples with deep convolutional neural networks

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Asian Journal of Andrology 2021年第2期23卷 135-139页

作者： Daniel J Wu Odgerel Badamjav Vikrant V Reddy Michael Eisenberg barry Behr Department of Computer science Stanford UniversityStanfordCA 94305USA Department of Urology University of Utah HealthSalt Lake CityUT 84108USA Department of Obstetrics and Gynecology Stanford Children’s HealthStanfordCA 94305USA Department of Urology Stanford University School of MedicineStanfordCA 94305USA

sperm identification and selection is an essential task when processing human testicular samples for in vitro *** and identifying sperm cell(s)in human testicular biopsy samples is labor intensive and time *** developed a new computer-aided sperm analysis(CAsA)system,which utilizes deep learning for near human-level performance on testicular sperm extraction(TEsE),trained on a custom *** system automates the identification of sperm in testicular biopsy samples.A dataset of 702 de-identified images from testicular biopsy samples of 30 patients was *** image was normalized and passed through glare filters and diffraction *** data were split 80%,10%,and 10%into training,validation,and test sets,***,a deep object detection network,composed of a feature extraction network and object detection network,was trained on this *** model was benchmarked against embryologists’performance on the detection *** deep learning CAsA system achieved a mean average precision(mAP)of 0.741,with an average recall(AR)of 0.376 on our *** proposed method can work in real time;its speed is effectively limited only by the imaging speed of the *** results indicate that deep learning-based technologies can improve the efficiency of finding sperm in testicular biopsy samples.

关键词： artificial intelligence computer vision male infertility microdissection testicular sperm extraction sperm

second generation biorefining in Ecuador:Circular bioeconomy,zero waste technology,environment and sustainable development:The nexus

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Journal of Bioresources and Bioproducts 2021年第2期6卷 83-107页

作者： Lourdes M.Orejuela-Escobar Andrea C.Landázuri barry Goodell Universidad san Francisco de Quito UsFQ Colegio de Ciencias e IngenieríasInstituto de Ingeniería CircularEngineeringApplied Sciences&Simulation Group(GICAS)Chemical Engineering DepartmentDiego de Robles y Vía InteroceánicaP.O.Box 17-0901QuitoEcuador Universidad san Francisco de Quito UsFQ Instituto de Investigaciones Biológicas y Ambientales BIÓSFERADiego de Robles y Vía InteroceánicaP.O.Box 17-0901QuitoEcuador University of Massachusetts Department of MicrobiologyAmherstMA 01003United States

The projection of world population growth with concurrent generation of large volumes of agroindustrial waste that negatively affect the environment is of great ***,this review article describes the nexus between concepts of Circular Bioeconomy,Zero Waste Technology,sustainable Development,Biorefineries,and alternatives and research efforts to generate less environmental impact.A brief analysis of the Ecuadorian industry and exports is described,emphasizing the fact that,to improve the Ecuadorian trade balance,it is necessary to increase industrial *** is important to have emerging technologies and innovation in order to promote the replacement of fossil-derived raw materials with renewable raw materials and develop more environmentally friendly processes and *** paper analyses the state of biomass research and its transformation in Ecuador,together with current pretreatment research on biomass to obtain bioproducts and biofuels in a biorefinery that promotes clean production for the extraction of phytochemicals using green solvents,such as deep eutectic solvents;and technologies to recover high-value added materials with enhanced *** conclusion,the need to develop technologies and markets to commercialize high value-added products coming from biorefineries is highlighted,as this will increase the income both in rural and urban areas and will strengthen the productivity and profitability of the Ecuadorian *** goal through this analysis is to improve Ecuador’s trade balance while also contributing to the circular bioeconomy that promotes sustainable development.

关键词： Biorefinery Circular bioeconomy Agro-industrial by-products High-added-value products sustainable development

八十年代的图书馆员和图书馆学教育者的新关系——扩大合作共同受益

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图书与情报 1991年第2期 54-59,44页

作者： M.cooper s.Kaufmann 刘华

图书馆学专业教师和实际工作者有必要进行广泛的合作和交流。但是,几十年来,有限的合作还夹杂着一定程度的紧张关系,一直反映在图书馆事业上。图书馆学教师和图书馆工作者分属于两个不同的部门。在高校中,担负着不同的使命,各自有着不... 详细信息

图书馆学专业教师和实际工作者有必要进行广泛的合作和交流。但是,几十年来,有限的合作还夹杂着一定程度的紧张关系,一直反映在图书馆事业上。图书馆学教师和图书馆工作者分属于两个不同的部门。在高校中,担负着不同的使命,各自有着不同的要求。同时,它们之间又有明显的联系,——在学术界又被视为一体。近年来,由于各自需求的扩大,两部门之间的鸿沟也进一步加深。大量的文献表明,对图书馆工作者和教育者之间关系的某些方面已进行了调研。

关键词：图书馆图书馆学院合作

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Turing之后的不可计算性

数学译林 2014年第4期33卷 296-306页

作者： s. barry cooper 张晓强陈小光吴宏锋利兹(Leeds)大学不详

1．生活在可计算的世界那些上了年纪的人也许还记得，大家曾痴迷于George Gamow的有关数学与科学的畅销书，其中最著名的一本书叫《从一到无穷大（One Two Three…Infinity）》．Gamow让仅有二维平面体验的我们设想生活在一个二维气球... 详细信息

1．生活在可计算的世界那些上了年纪的人也许还记得，大家曾痴迷于George Gamow的有关数学与科学的畅销书，其中最著名的一本书叫《从一到无穷大（One Two Three…Infinity）》．Gamow让仅有二维平面体验的我们设想生活在一个二维气球的表面．然后，他告诉我们如何通过纯粹的二维观察来发现它的三维曲面特征．图1是他在1961年版的该书的p．103给出的示意图．

关键词：不可计算性曲面特征无穷大二维平面体示意图生活

survival in men older than 75 years with low- and intermediate-grade prostate cancer managed with watchful waiting with active surveillance

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Family Medicine and Community Health 2015年第3期3卷 25-36页

作者： Tzuyung D.Kou siran M.Koroukian Pingfu Fu Derek Raghavan Gregory s.cooper Li Li Department of Epidemiology and Biostatistics Case Western Reserve University School of MedicineClevelandOHUSA Case Comprehensive Cancer Center Case Western Reserve University School of MedicineClevelandOHUSA Levine Cancer Institute Carolinas Healthcare SystemCharlotteNCUSA Department of Family Medicine-Research Division Case Western Reserve University School of MedicineClevelandOHUSA

Objective:Recent studies have reported the underuse of active surveillance or watchful wait-ing for low-risk prostate cancer in the United *** study examined prostate cancer-specific and all-cause death in elderly patients older than 75 years with low-risk tumors managed with active treatment versus watchful waiting with active surveillance(WWAs).Methods:We performed survival analysis in a cohort of 18,599 men with low-risk tumors(early and localized tumors)who were 75 years or older at the time of prostate cancer diagnosis in the linked surveillance,Epidemiology,and End Results(sEER)-Medicare database(from 1992 to 1998)and who were followed up through December *** was defined as having an-nual screening for prostate-specific antigen and/or digital rectal examination during the follow-up *** risks of prostate cancer-specific and all-cause death were compared by Cox regression *** propensity score matching technique was used to address potential selection ***:In patients with well-differentiated(Gleason score 2-4)and localized disease,those managed with WWAs without delayed treatment had higher risk of all-cause death(hazard ratio 1.20,95%confidence interval 1.13-1.28)but a substantially lower risk of prostate cancer-specific death(hazard ratio 0.62,confidence interval 0.51-0.75)than patients undergoing active *** managed with WWAs with delayed treatment had comparable mortality ***-tivity analyses based on propensity score matching yielded similar ***:In men older than 75 years with well-differentiated and localized prostate cancer,WWAs without delayed treatment had a lower risk of prostate cancer-specific death and compa-rable all-cause death as compared with active *** patients in whom treatment was delayed had comparable mortality *** results support WWAs as an initial management option for older men with well-differentiated and localized prostate cancer.

关键词： Epidemiology watchful waiting prostate cancer

Environmental and landscape influences on the spatial and temporal distribution of a cattle herd in a south Texas rangeland

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Ecological Processes 2020年第1期9卷 443-460页

作者： Christopher Cheleuitte-Nieves Humberto L.Perotto-Baldivieso XBen Wu susan M.cooper Department of Ecosystem science and Management Texas A&M University2120 TAMU320 WFES BuildingCollege StationTX 77843-2138USA Present address:Center of Comparative Medicine and Pathology Memorial Sloan Kettering Cancer CenterWeill Cornell Medicineand Hospital for Special Surgery408 East 69th StreetZ-913New YorkNY 10021USA Caesar Kleberg Wildlife Research Institute Texas A&M University-Kingsville700 University Blvd.MSC 218KingsvilleTX 78363USA Texas A&M AgriLife Research 1619 Garner Field RoadUvaldeTX 78801USA

The multiple spatial and temporal parameters affecting cattle herd distribution and activity dynamics can significantly affect resource utilization but are not fully *** aim of this study was to determine whether current animal tracking technology and spatio-temporal analysis tools can be used to integrate multi-scale information on herd distribution patterns as a function of seasonal forage production,periods of the day,animal activity,and landscape *** and activity information of 11 free-ranging cows within a 31-member herd was obtained at 5-min intervals by using GPs collars for 1 year within a 457-ha ranch in the semi-arid rangelands of south *** biomass was calculated with satellite *** analysis of cattle distribution and landscape features was conducted with *** spread was greatest during the growing *** the year,during midday,the herd showed smaller spread and greater use of shade patches than any other time of *** also aggregated under trees in winter,particularly during the *** was no statistically significant overall pattern of seasonal changes in the use of water and supplemental feeding areas,but a trend toward highest use during the ***,significantly different diurnal patterns in the use of supplemental feed and water were observed within each *** study found a strong influence of shade patches relative to the influence of water and supplemental feeding areas on the diurnal and seasonal movement patterns of cattle in shrub-dominated *** this study used only 11 tracked cows in a 31-member herd,the results indicated that techniques such as seasonal and diurnal GPs tracking,GIs,and remote sensing data enable evaluation of multiple spatial and temporal dynamics of cattle distribution and activity *** smaller spread during the dry winter season associated with the observed aggregation of individuals in water and supplemental feeding ar

关键词： Cattle behavior Cross-scale interactions GPs collars Group dispersion Normalized difference vegetation index(NDVI) Thermoregulation Ungulate grazing patterns

Rapunzel syndrome is not just a mere surgical problem: A case report and review of current management

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World Journal of Clinical Cases 2017年第2期5卷 50-55页

作者： Obinna Obinwa David cooper Faraz Khan James M O'Riordan Department of surgery the Adelaide and Meath Hospital Dublin Incorporating the National Children’s Hospital

Recurrent Rapunzel syndrome(RRs) is a rare clinical presentation with fewer than six cases reported in the Pub Med literature. A report of RRs and literature review is presented. A 25-year-old female was admitted to hospital with a 4-wk history of epigastric pain and swelling. she had a known history of trichophagia with a previous admission for Rapunzel syndrome requiring a laparotomy nine years earlier, aged 16. Psychological treatment had been successfully achieved for nine years with outpatient hypnotherapy sessions only, but she defaulted on her last session due to stressors at home. The abdominal examination demonstrated an epigastric mass. Computer tomography scan revealed a large gastric bezoar and features of aspiration pneumonia. The patient underwent emergency open surgical laparotomy for removal as the bezoar could not be removed endoscopically. The bezoar was cast in a shape that mimicked the contours of the stomach and proximal small bowel, hence the diagnosis of RRs. The patient was seen by a psychiatrist and was commenced on Quetiapine before discharge. she continues to attend follow-up.

关键词： Trichobezoars Rapunzel syndrome Recurrence Obsessive compulsive disorders Case report

Branched hybridization chain reaction-using highly dimensional DNA nanostructures for label-free,reagent-less,multiplexed molecular diagnostics

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Microsystems & Nanoengineering 2019年第1期5卷 316-322页

作者： Gaolian Xu Mingliang Lai Rab Wilson Andrew Glidle Julien Reboud Jonathan M.cooper Division of Biomedical Engineering James Watt School of EngineeringUniversity of GlasgowOakfield AvenueGlasgow G128LTUK

The specific and multiplexed detection of DNA underpins many analytical methods,including the detection of microorganisms that are important in the medical,veterinary,and environmental *** achieve such measurements generally requires enzyme-mediated amplification of the low concentrations of the target nucleic acid sequences present,together with the precise control of temperature,as well as the use of enzyme-compatible *** inevitably leads to compromises between analytical performance and the complexity of the *** hybridization chain reaction(HCR)provides an attractive alternative,as a route to enzyme-free DNA *** date,the linear nucleic acid products,produced during amplification,have not enabled the development of efficient multiplexing strategies,nor the use of label-free ***,we show that by designing new DNA nanoconstructs,we are able,for the first time,to increase the molecular dimensionality of HCR products,creating highly branched amplification products,which can be readily detected on label-free *** show that this new,branching HCR system offers a route for enzyme-free,label-free DNA detection,we demonstrate the multiplexed detection of a target sequence(as the initiator)in whole *** the future,this technology will enable rapid point-of-care multiplexed clinical analysis or in-the-field environmental monitoring.

关键词： reagent attractive branching

A Co-Evolution Model for Dynamic social Network and Behavior

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Open Journal of statistics 2014年第9期4卷 765-775页

作者： Liping Tong David shoham Richard s. cooper Department of Public Health sciences Loyola University Medical School Maywood USA

Individual behaviors, such as drinking, smoking, screen time, and physical activity, can be strongly influenced by the behavior of friends. At the same time, the choice of friends can be influenced by shared behavioral preferences. The actor-based stochastic models (ABsM) are developed to study the interdependence of social networks and behavior. These methods are efficient and useful for analysis of discrete behaviors, such as drinking and smoking;however, since the behavior evolution function is in an exponential format, the ABsM can generate inconsistent and unrealistic results when the behavior variable is continuous or has a large range, such as hours of television watched or body mass index. To more realistically model continuous behavior variables, we propose a co-evolution process based on a linear model which is consistent over time and has an intuitive interpretation. In the simulation study, we applied the expectation maximization (EM) and Markov chain Monte Carlo (MCMC) algorithms to find the maximum likelihood estimate (MLE) of parameter values. Additionally, we show that our assumptions are reasonable using data from the National Longitudinal study of Adolescent Health (Add Health).

关键词： social Network social Behavior Co-Evolution Markov Chain stationary Distribution