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The emerging roles of transplanted radial glial cells in regenerating the central nervous system

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Neural Regeneration Research 2015年第10期10卷 1548-1551页

作者： Robin E.White Denis s.barry Biology Department Westfield State University Department of Anatomy Trinity Biomedical Sciences Institute Trinity College Dublin University of Dublin

scientists conclude that a combination of treatments involving rehabilitation,drug delivery,surgery and cell transplantation are necessary to achieve significant progress in regenerating the injured central nervous sy... 详细信息

关键词： cell The emerging roles of transplanted radial glial cells in regenerating the central nervous system

Machine learning in solid organ transplantation:Charting the evolving landscape

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World Journal of Transplantation 2025年第1期15卷 165-177页

作者： Badi Rawashdeh Haneen Al-abdallat Emre Arpali Beje Thomas Ty B Dunn Matthew cooper Division of Transplant surgery Medical College of WisconsinMilwaukeeWI 53202United States Department of Medicine Jordan University HospitalAmman 11263Jordan Department of Nephrology Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUND Machine learning(ML),a major branch of artificial intelligence,has not only demonstrated the potential to significantly improve numerous sectors of healthcare but has also made significant contributions to the field of solid organ *** provides revolutionary opportunities in areas such as donorrecipient matching,post-transplant monitoring,and patient care by automatically analyzing large amounts of data,identifying patterns,and forecasting *** To conduct a comprehensive bibliometric analysis of publications on the use of ML in transplantation to understand current research trends and their *** On July 18,a thorough search strategy was used with the Web of science *** and transplantation-related keywords were *** the aid of the VOs viewer application,the identified articles were subjected to bibliometric variable analysis in order to determine publication counts,citation counts,contributing countries,and institutions,among other *** Of the 529 articles that were first identified,427 were deemed relevant for bibliometric analysis.A surge in publications was observed over the last four years,especially after 2018,signifying growing interest in this *** 209 publications,the United states emerged as the top ***,the"Journal of Heart and Lung Transplantation"and the"American Journal of Transplantation"emerged as the leading journals,publishing the highest number of relevant *** keyword searches revealed that patient survival,mortality,outcomes,allocation,and risk assessment were significant themes of *** The growing body of pertinent publications highlights ML's growing presence in the field of solid organ *** bibliometric analysis highlights the growing importance of ML in transplant research and highlights its exciting potential to change medical practices and enhance patient *** collaboration between signific

关键词： Machine learning Artificial Intelligence solid organ transplantation Bibliometric analysis

C. H. Pander＇s introduction to conodonts, 1856

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Episodes 2008年第4期31卷 429-432页

作者： sweet, Walter C. cooper, barry J. school of Earth sciences The Ohio State University Columbus OH 43210 United States Primary Industries and Resources south Australia Adelaide SA 5001 GPO Box 1671 Australia

It is rare in the annals of science for a single publication to provide a definitive introduction to a previously unknown group of animals. Yet this was the case with the monograph that included the initial descriptions of an important, extinct group of fossil animals： the conodonts. The publication, by Christian Heinrich Pander, appeared in st Petersburg in 1856. The volume of ninety-one pages, written in German and accompanied by seven beautifully executed plates, was issued by the Imperial Academy of sciences as part of a series entitled Geognostische Beschreibung der Russisch-Baltischen Gouvernements.

关键词：动物科学动物化石牙形石科学研究

Natural parasites in conjunction with behavioral and color traits explain male agonistic behaviors in a lizard

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Current Zoology 2024年第1期70卷 59-69页

作者： Rodrigo Megia-Palma Dhanashree Paranjpe Robert D.cooper Pauline Blaimont barry sinervo Department of Biomedicine and Biotechnology Parasitology UnitUniversidad de Alcala(UAH)E-28805Alcala de HenaresSpain CIBio Centro de Investigagao em Biodiversidade e Recursos GeneticosInBIO Laboratorio AssociadoCampus de VairaoUniversidade do PortoP-4485-661 VairaoPortugal BIOPOLIs Program in Genomics Biodiversity and Land PlanningCIBIOCampus de VairaoP-4485-661 VairaoPortugal Rupa Rahul Bajaj Center for Environment and Art Empress Botanical GardensKavade MalaPuneIndia Department of Ecology and Evolutionary Biology University of CaliforniaLos AngelesCA 90095USA Department of Biology University of Houston Downtown1Main St.HoustonTX 77002USA Department of Ecology and Evolutionary Biology University of CaliforniaSanta CruzCA 95064USA

Male competition conforms to a cost-benefit model,because while aggression may increase reproductive prospects,it can also increase the risk of *** hypothesize that an additional cost in aggressive males would be an increase in parasite load associated with a high energy investment into sexual *** of these infections,in turn,may downmodulate the level of host aggression via energetic *** staged dyadic male contests in the lab to investigate the relationships of multiple parasites with the agonistic behavior of lizard hosts,sceloporus *** also included both color and behavioral traits from opponents in the analyses because(1)color patches of lizards may serve as intraspecific signals used by conspecifics to assess the quality of opponents,and(2)contests between male lizards fit classical models of escalated aggression,where lizards increase aggression displays in response to an opponent's *** results conform to our hypothesis because male lizards displayed more pushups when they had more ***,some parasites may modulate the levels of aggression because lizards infected by hematic coccidians performed fewer ***,lizards also displayed fewer pushups when both the chroma and size of the opponent's blue patch were *** results thus also supported the role of the blue patch of *** as a sexual armament,because it contributed to the deterrence of aggression from opponent *** revealed that natural parasitic infections in lizard hosts can contribute to their agonistic *** encourage future studies to account for parasites in behavioral testswithlizards.

关键词： Ixodes pacificus Lankesterella sexual selection social interactions ticks

Multiple color patches and parasites in sceloporus occidentalis:differential relationships by sex and infection

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Current Zoology 2018年第6期64卷 703-711页

作者： Rodrigo MEGIA-PALMA Dhanashree PARANJPE senda REGUERA Javier MARTINEZ Robert D cooper Pauline BLAIMONT santiago MERINO barry sINERVO Department of Ecologia Evolutiva Museo Nacional de Ciencias Naturales-CSICJose Gutierrez Abascal 2.Madrid E-28006Spain Departrnent of Ecology and Evolutionary Biology University of CaliforniaSanta Cruz1156High StSanta CruzCA 95064USA Department of Zoologia Facultad de CienciasUniversidad de GranadaGranada E-18071Spain Area Parasitologia Department of Biomedicina y BiotecnologiaArea de ParasitologiaFacultad de FarmaciaUniversidad de Alcala de HenaresAlcala de HenaresMadrid E-28871Spain

Parasites generally have a negative influence on the color expression of their *** selection theory predicts resistant high-quality individuals should show intense coloration,whereas susceptible low-quality individuals would show poor ***,intensely colored males of different species of Oid and New World lizards were more often infected by *** results suggest that high-quality males,with intense coloration,would suffer higher susceptibility to *** hypothesis remains poorly understood and contradicts general theories on sexual *** surveyed a population of sceloporus occidentalis for parasites and found infections by the parasite genera Lankesterella and *** this population,both males and females express ventral blue and yellow color *** was almost exclusively infecting *** body size of the males significantly predicted the coloration of both blue and yellow *** males showed darker (lower lightness)blue ventral patches and more saturated yellow patches that were also ***,these males were more often infected by Lankesterella than smaller *** intestinal parasite Acroeimeria infected both males and *** infection by intestinal parasites of the genus Acroeimeria was the best predictor for the chroma in the blue patch of the males and for hue in the yellow patch of the *** males infected by Acroeimeria expressed blue patches with significantly lower chroma than the uninfected ***,the hue of the yellow patch was not significantly different between infected and uninfected *** results suggest a different effect of Lankesterella and Acroeimeria on the *** the one hand,the intense coloration of male lizards infected by Lankesterella suggested high-quality male lizards may tolerate *** the other hand,the low chroma of the blue coloration of the infected males suggested that this coloration could honest

关键词： animal communication coloration Hamilton and Zuk parasites sexual selection

Maturation of sperm volume regulation in the rat epididymis

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Asian Journal of Andrology 2010年第4期12卷 578-590页

作者： Oliver s. Damm Trevor G. cooper Centre of Reproductive Medicine and Andrology of the University Miinster D-48149 Miinster Germany

sperm maturation in the epididymis may involve differences between mature and immature spermatozoa in their volume regulatory osmolyte response. spermatozoa obtained from the rat caput and cauda epididymidis were examined for their ability to regulate volume after transfer from in situ epididymal osmolality （measured to be 343 ± 13 and 365 ± 19 mmol kg^-1, respectively） to that of the female tract in single- and multiple-step protocols. Cells withstood the single-step treatment better than the multistep protocol. sperm volume estimates by flow cytometric measure- ments of forward scatter of cells with intact head membranes was more sensitive than those by assessing cell coiling microscopically. At osmolalites below 210 mmol kg l both caput and cauda cells ruptured, limiting the use of flow cytometry. Above this critical value, the use of quinine showed that both caput and cauda cells could regulate volume, but cauda cells were the more effective. Of several organic osmolytes studied, myo-inositol, glutamate and KCl caused only temporary and slight swelling of spermatozoa cells in hypotonic medium. spermatozoa of both maturities seemed to use potassium as the preferred osmolyte for regulating volume.

关键词： rat sperm sperm maturation volume regulation

The human application of gene therapy to re-program T-cell specificity using chimeric antigen receptors

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Chinese Journal of Cancer 2014年第9期33卷 421-433页

作者： Alan D Guerrero Judy s Moyes Laurence JN cooper Division of Pediatrics The University of Texas MD Anderson Cancer Center The University of Texas Graduate school of Biomedical sciences

The adoptive transfer of T cells is a promising approach to treat cancers. Primary human T cells can be modified using viral and non-viral vectors to promote the specific targeting of cancer cells via the introduction of exogenous T-cell receptors(TCRs) or chimeric antigen receptors(CARs). This gene transfer displays the potential to increase the specificity and potency of the anticancer response while decreasing the systemic adverse effects that arise from conventional treatments that target both cancerous and healthy cells. This review highlights the generation of clinical-grade T cells expressing CARs for immunotherapy, the use of these cells to target B-cell malignancies and, particularly, the first clinical trials deploying the sleeping Beauty gene transfer system, which engineers T cells to target CD19+ leukemia and non-Hodgkin's lymphoma.

关键词： T细胞受体基因治疗异性重新编程抗原嵌合基因转移系统非病毒载体

Colorectal cancer surveillance:What's new and what's next?

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World Journal of Gastroenterology 2014年第8期20卷 1887-1897页

作者： Johnie Rose Knut Magne Augestad Gregory s cooper Department of Family Medicine and Community Health Case Western Reserve University School of MedicineClevelandOH 44106United States Case Comprehensive Cancer Center Case Western Reserve UniversityClevelandOH 44106United States Norwegian National Centre of Telemedicine and Integrated Care University Hospitals North NorwayN-9038 Troms?Norway seidman Cancer Center University Hospitals Case Medical CenterClevelandOH 44106United States Division of Gastroenterology and Liver Disease University Hospitals Case Medical CenterClevelandOH 44106United States

The accumulated evidence from two decades of randomized controlled trials has not yet resolved the question of how best to monitor colorectal cancer(CRC)survivors for early detection of recurrent and metachronous disease or even whether doing so has its intended effect.A new wave of trial data in the coming years and an evolving knowledge of relevant biomarkers may bring us closer to understanding what surveillance strategies are most effective for a given subset of *** best apply these insights,a number of important research questions need to be addressed,and new decision making tools must be *** this review,we summarize available randomized controlled trial evidence comparing alternative surveillance testing strategies,describe ongoing trials in the area,and compare professional society recommendations for *** addition,we discuss innovations relevant to CRC surveillance and outline a research agenda which will inform a more risk-stratified and personalized approach to follow-up.

关键词： Colorectal cancer surveillance Follow-up Recurrence Relapse survivorship

Relationship of functional gastrointestinal disorders and psychiatric disorders: Implications for treatment

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World Journal of Gastroenterology 2007年第14期13卷 2020-2027页

作者： Carol s North barry A Hong David H Alpers Department of Psychiatry The University of Texas southwestern Medical Center at Dallas and North Texas VA Health Care system DallasTXUnited States Department of Psychiatry Washington University school of Medicine St. LouisMOUnited States Department of Internal Medicine Division of Gastroenterology Washington University School of MedicineSt. LouisMOUnited States

This article revisits the links between psychopathology and functional gastrointestinal disorders such as irritable bowel syndrome （IBs）, discusses the rational use of antidepressants as well as non-pharmacological approaches to the management of IBs, and suggests guidelines for the treatment of IBs based on an interdisciplinary perspective from the present state of knowledge. Relevant published literature on psychiatric disorders, especially somatization disorder, in the context of [Bs, and literature providing direction for management is reviewed, and new directions are provided from findings in the literature. IBs is a heterogeneous syndrome with various potential mechanisms responsible for its clinical presentations. IBs is typically complicated with psychiatric issues, unexplained symptoms, and functional syndromes in other organ systems. Most IBs patients have multiple complaints without demonstrated cause, and that these symptoms can involve systems other than the intestine, e.g. bones and joints （fibromyalgia, temporomandibular joint syndrome）, heart （non-cardiac chest pain）, vascular （post-menopausal syndrome）, and brain （anxiety, depression）. Host IBs patients do not have psychiatric illness per se, but a range of psychoform （psychological complaints in the absence of psychiatric disorder） symptoms that accompany their somatoform （physical symptoms in the absence of medical disorder） complaints. It is not correct to label IBs patients as psychiatric patients （except those more difficult patients with true somatization disorder）. One mode of treatment is unlikely to be universally effective or to resolve most symptoms. The techniques of psychotherapy or cognitive-behavioral therapy can allow IBs patients to cope more readily with their illness. specific episodes of depressive or anxiety disorders can be managed as appropriate for those conditions. Medications designed to improve anxiety or depression are not uniformly useful for psychiatric complaints in IB

关键词： Irritiable bowel syndrome Functionadisorders Gastrointestinal disease somatization disordersomatoform Psychoform Psychotropic medicationPsychotherapy symptoms Psychiatric disorder