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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of british columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMbASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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Artificial neural network approach for rheological characteristics of coal-water slurry using microwave pre-treatment

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International Journal of Mining Science and Technology 2017年第2期27卷 379-386页

作者： b.K.Sahoo S.de b.c.Meikap department of chemical Engineering Indian Institute of Technology Research and development centre for Iron and Steel Steel Authority of India Limited chemical Engineering School of Engineering Howard College University of Kwazulu-Natal

detailed experimental investigations were carried out for microwave pre-treatment of high ash Indian coal at high power level(900 W) in microwave oven. The microwave exposure times were fixed at60 s and 120 s. A rheology characteristic for microwave pre-treatment of coal-water slurry(cWS) was performed in an online bohlin viscometer. The non-Newtonian character of the slurry follows the rheological model of Ostwald de Waele. The values of n and k vary from 0.31 to 0.64 and 0.19 to 0.81 Pa·sn,respectively. This paper presents an artificial neural network(ANN) model to predict the effects of operational parameters on apparent viscosity of cWS. A 4-2-1 topology with Levenberg-Marquardt training algorithm(trainlm) was selected as the controlled ANN. Mean squared error(MSE) of 0.002 and coefficient of multiple determinations(R^2) of 0.99 were obtained for the outperforming model. The promising values of correlation coefficient further confirm the robustness and satisfactory performance of the proposed ANN model.

关键词： Microwave pre-treatment coal-water slurry Apparent viscosity Artificial neural network back propagation algorithm

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controlling Excitation Inversion of a cooper Pair box Interacting with a Nanomechanical Resonator

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chinese Physics Letters 2012年第8期29卷 20-24页

作者： c.Valverde H.c.b.de Oliveira A.T.Avelar b.baseia Instituto de Química Universidade de Brasília70919-970BrasíliaDFBrazil Universidade Estadual de Goiás Rod.BR 15375132-903 AnápolisGOBrazil Universidade Paulista Rod.BR 153km 774845-090 GoianiaGOBrazil Instituto de Física Universidade Federal de Goiás74001-970 GoianiaGOBrazil

We investigate the action of time-dependent detunings upon the excitation inversion of a cooper pair box interacting with a nanomechanical *** method employs the Jaynes–cummings model with damping,assuming different decay rates of the cooper pair box and various fixed and time-dependent *** is shown that,when the presence of damping plus constant detunings destroys the collapse/revival effects,convenient choices of time-dependent detunings allow one to reconstruct such events in a perfect *** is also shown that the mean excitation of the nanomechanical resonator is more robust against damping of the cooper pair box for convenient values of time-dependent detunings.

关键词： cooper tuning excitation

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Lightweight Al-Nb-Ti-V-cr high entropy alloys with high hardness and enhanced mechanical properties via doping co

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china Foundry 2025年

作者： Fang-dong Xu de-zhi chen Rui-run chen bin Gan Jing-yue Yu National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of Technology Suzhou Laboratory

To develop high-hardness and high-strength lightweight high entropy alloys （LHEAs）,a series of coxAlNbTiVcr alloys were *** phase constitution,distribution,and crystal structure of the Laves phase in alloys can be altered by adjusting the composition of HEAs,which in turn influences their mechanical *** Nb Ti Vcr （x=0,0.5,1,1.5,and 2,atomic ratio percentage） LHEAs were designed and prepared to characterize the microstructure and tailor the mechanical *** introduction of co changes the microstructure of LHEAs from a single b2 structure to a mixture dendrite structure,which consists of b2 phase,c14 and c15 Laves *** the c14 and c15 Laves phases exhibit coupled *** parameters including mixing enthalpy (ΔHmix),valence electron concentration （VEc）,atomic radius size （δ）,mixing entropy （ΔS）,and electronegativity difference （Δχ） are used to predict the formation of b2 and Laves phase in *** the co content increases from 0 to 1.5at.%,Laves phase volume fraction gradually increases,which leads to an enhancement in the compressive strength from 1,520.8 MPa to 1,844.4 ***1.5Al Nb Ti Vcr alloy exhibits the maximum Vickers hardness of 699.4 *** improvement of mechanical properties mainly originates from solid solution strengthening and second phase strengthening.

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Monthly and seasonal streamflow forecasting of large dryland catchments in brazil

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Journal of Arid Land 2021年第3期13卷 205-223页

作者： Alexandre c cOSTA Alvson b S ESTAcIO Francisco de A de SOUZA FILHO Iran E LIMA NETO Institute of Engineering and Sustainable development University of International Integration of the Afro-Brazilian LusophonyRedençãoCEP 62.790-970Brazil department of Hydraulic Engineering and Environment Federal University of CearáFortalezaCEP 60.451-970Brazil

Streamflow forecasting in drylands is *** are scarce,catchments are highly humanmodified and streamflow exhibits strong nonlinear responses to *** goal of this study was to evaluate the monthly and seasonal streamflow forecasting in two large catchments in the Jaguaribe River basin in the brazilian semi-arid *** adopted four different lead times:one month ahead for monthly scale and two,three and four months ahead for seasonal *** gaps of the historic streamflow series were filled up by using rainfall-runoff ***,time series model techniques were applied,i.e.,the locally constant,the locally averaged,the k-nearest-neighbours algorithm(k-NN)and the autoregressive(AR)*** criterion of reliability of the validation results is that the forecast is more skillful than streamflow *** approach outperformed the streamflow climatology for all monthly *** average,the former was 25%better than the *** seasonal streamflow forecasting(SSF)was also reliable(on average,20%better than the climatology),failing slightly only for the high flow season of one catchment(6%worse than the climatology).considering an uncertainty envelope(probabilistic forecasting),which was considerably narrower than the data standard deviation,the streamflow forecasting performance increased by about 50%at both *** forecast errors were mainly driven by the streamflow intra-seasonality at monthly scale,while they were by the forecast lead time at seasonal *** best-fit and worst-fit time series model were the k-NN approach and the AR model,*** rainfall-runoff modelling outputs played an important role in improving streamflow forecasting for one streamgauge that showed 35%of data *** developed data-driven approach is mathematical and computationally very simple,demands few resources to accomplish its operational implementation and is applicable to other dryland *** findings may be part of drou

关键词： nonlinear time series analysis probabilistic streamflow forecasting reconstructed streamflow data dryland hydrology rainfall-runoff modelling stochastic dynamical systems

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植物系统发生海报——以演化视角介绍植物多样性的科教资料项目

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生物多样性 2025年

作者：蒋陈焜郁文彬饶广远黎怀成 Julien b.bachelier Hartmut H.Hilger Theodor c.H.cole 北京大学生命科学学院蛋白质与植物基因研究国家重点实验室北京大学前沿交叉学科研究院北京大学-清华大学生命科学联合中心中国科学院西双版纳热带植物园综合保护中心/云南省热带雨林与亚洲象保护重点实验室 Dahlem centre of Plant Sciences (DcPS)， Institute of biology， Structural and Functional Plant Diversity， Freie Universit?t berlin

中国的植物多样性保护行动虽然提升了公众对多样性的认识，但这些努力往往未能深入到理解植物多样性演化及其保护的深层意义。从演化的视角进行植物多样性宣传教育，有利于促进对多样性的综合理解，增进对多样性保护的认可。然而， ... 详细信息

中国的植物多样性保护行动虽然提升了公众对多样性的认识，但这些努力往往未能深入到理解植物多样性演化及其保护的深层意义。从演化的视角进行植物多样性宣传教育，有利于促进对多样性的综合理解，增进对多样性保护的认可。然而，现有资料多集中于物种的识别、鉴定与分类，缺乏从生物演化角度对植物多样性进行系统性介绍的内容。本文介绍了一个具有全球影响力的科教资料案例——由美裔德国植物学家Theodor c. H. cole发起的植物系统发生海报(Plant Phylogeny Posters)项目。该项目通过整合最新的系统与演化植物学研究成果，以系统发生为线索介绍植物多样性及其亲缘关系，旨在利用系统发生树所蕴含的丰富演化思想内涵，启发读者理解植物多样性与演化。海报以系统发生树结合植物类群的形态、地理分布、物种数量等数据信息，直观展示了多个分类等级的重要类群的演化历史。在数十所大学和科研机构的45位研究人员的努力下， 70张系统发生海报已被翻译成中文，并向所有人免费开放获取。这一科教项目有望为增进公众深入理解植物多样性及其保护行动提供宝贵的资源和帮助。

关键词：植物多样性演化系统发生科教资料

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Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

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Estimation of aboveground biomass of arboreal species in the semi-arid region of brazil using SAR(synthetic aperture radar)images

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Journal of Arid Land 2023年第6期15卷 695-709页

作者： Janisson b de JESUS Tatiana M KUPLIcH Íkaro D de c bARRETO Fernando L HILLEbRAND cristiano N da ROSA Postgraduate Program in Remote Sensing Federal University of Rio Grande do SulCampus ValePorto Alegre 91501970Brazil National Institute for Space Research(INPE) COESU(Southern Spatial Coordination)Santa Maria 97105970Brazil Postgraduate Program biometry and Applied Statistics Rural Federal University of PernambucoRecife 52171900Brazil Federal Institute of Education Science and Technology of Rio Grande do Sul(IFRS)Campus RolanteRolante 95690000Brazil Postgraduate Program in Remote Sensing Polar and Climate CenterFederal University of Rio Grande do SulPorto Alegre 91501970Brazil

The caatinga biome is an important ecosystem in the semi-arid region of *** has significantly degraded due to human activities and is currently a region undergoing ***,monitoring the variation in the caatinga biome has become essential for its sustainable ***,traditional methods for estimating aboveground biomass(AGb)are time-consuming and *** sensing,such as optical and radar imaging,can estimate and correlate with ***,radar imaging is still a novelty to be applied in estimating the AGb of this biome,which is an area with little ***,this study aimed to use Sentinel-1 images to estimate the AGb of the caatinga biome in Sergipe State(northeastern brazil)and to verify its influencing *** sample plots(30 m×30 m)were selected,and the stems of individuals with a circumference at breast height(1.3 m above the ground)equal to or greater than 6.0 cm were measured,and the AGb through an allometric equation was *** Sentinel-1 images from 3 different periods(green,intermediate,and dry periods)were used to consider the phenological conditions of the caatinga *** the pre-processing and extraction of attributes(co-polarized VV(vertical transmit and vertical receive),cross-polarized VH(vertical transmit and horizontal receive),and band ratio VH/VV backscatter,radar vegetation index,dual polarization synthetic aperture radar(SAR)vegetation index(DPSVI),entropy(H),and alpha angle(α))were performed with Sentinel’s Application *** attributes were used to estimate the AGb through simple and multiple linear regressions and evaluated by the coefficients of determination(R2),correlation(r),and root mean squared error(RMSE).The results showed that the attributes individually had little ability to estimate the AGb of the caatinga biome in the three *** with multiple regression,we found that the intermediate period presented the equation with the best

关键词： caatinga tropical dry forest coherent and incoherent attributes c-band Sentinel-1

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Machine learning empowers efficient design of ternary organic solar cells with PM6 donor

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Journal of Energy chemistry 2025年第1期100卷 337-347页

作者： Kiran A.Nirmal Tukaram D.Dongale Santosh S.Sutar Atul c.Khot Tae Geun Kim School of Electrical Engineering Korea University computational Electronics and Nanoscience Research Laboratory School of Nanoscience and Biotechnology Shivaji University Yashwantrao chavan School of Rural development Shivaji University

Organic solar cells(OScs) hold great potential as a photovoltaic technology for practical ***, the traditional experimental trial-and-error method for designing and engineering OScs can be complex, expensive, and time-consuming. Machine learning(ML) techniques enable the proficient extraction of information from datasets, allowing the development of realistic models that are capable of predicting the efficacy of materials with commendable accuracy. The PM6 donor has great potential for high-performance OScs. However, it is crucial for the rational design of a ternary blend to accurately forecast the power conversion efficiency(PcE) of ternary OScs(TOScs) based on a PM6 ***, we collected the device parameters of PM6-based TOScs and evaluated the feature importance of their molecule descriptors to develop predictive models. In this study, we used five different ML algorithms for analysis and prediction. For the analysis, the classification and regression tree provided different rules, heuristics, and patterns from the heterogeneous dataset. The random forest algorithm outperforms other prediction ML algorithms in predicting the output performance of PM6-based TOScs. Finally, we validated the ML outcomes by fabricating PM6-based TOScs. Our study presents a rapid strategy for assessing a high PcE while elucidating the substantial influence of diverse descriptors.

关键词： Random forests

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Reviewing perovskite oxide sites influence on electrocatalytic reactions for high energy density devices

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Journal of Energy chemistry 2023年第6期81卷 1-19,I0002页

作者： Lorrane c.c.b.Oliveira Raissa Venâncio Paulo V.F.de Azevedo chayene G.Anchieta Thayane c.M.Nepel cristiane b.Rodella Hudson Zanin Gustavo Doubek Advanced Energy Storage Division Laboratory of Advanced Batteries(LAB)Center for Innovation on New Energies(CINE)School of Chemical EngineeringUniversity of Campinas(Unicamp)CampinasSao Paulo 13083-852Brazil Advanced Energy Storage Division Center for Innovation on New Energies(CINE)Brazilian Renewable Energies(BREnergies)groupManufacturing GroupSchool of Electrical and Computer EngineeringUniversity of Campinas(UNICAMP)CampinasSão Paulo 13083-852Brazil Paul Scherrer Institut(PSI) Swiss Light Source(SLS)Forschungsstrasse 1115232 Villigen PSIAargauSwitzerland brazilian center for Research in Energy and Materials(cNPEM)/brazilian Synchrotron Light Laboratory(LNLS) CampinasSão Paulo 13083-100Brazil

batteries,fuel cells,and supercapacitors are electrochemical devices already on the market and still need a boost in kinetics to match the high energy density demand of *** have attracted the scientific community's attention in the last decade due to their electrocatalytic activity,chemical and structural properties,tunability,low cost,and *** have been made to understand the active sites and the operational mechanisms in perovskite oxides to shape them as an electrocatalyst in advanced energy *** the role of perovskites is the key to engineering more controlled and efficient electrocatalysts via chemical synthesis,and there is still much to *** review highlights the use of perovskites in different energy storage and conversion *** A,b,and A&b doping-site effects are analyzed to understand the opportunities and challenges related to this class of *** addition,the synthesis methods and the properties related to the doping site are described and summarized.

关键词： Perovskites Energy storage systems Electrocatalysts battery Oxide fuel cells capacitors

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