检索结果-南通市图书馆

CCS Research Development and Deployment in a Clean Energy Future： Lessons from Australia over the Past Two Decades

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering 2017年第4期3卷 477-484页

作者： Peter j. cook CO2CRC Ltd.& Peter cook Centre for Carbon Capture and Storage Research The University of Melbourne Melbourne VIC 2010 Australia

碳捕集和封存(CCS)技术作为一种碳减排手段,虽未得到全方位认可,但其重要性已得到人们的广泛认可。但是,若要将全球温度上升幅度控制在低于2℃,则此技术的推广应用速度并不能满足相关的需求。虽然大规模推广CCS技术所面临的困难尚无法... 详细信息

碳捕集和封存(CCS)技术作为一种碳减排手段,虽未得到全方位认可,但其重要性已得到人们的广泛认可。但是,若要将全球温度上升幅度控制在低于2℃,则此技术的推广应用速度并不能满足相关的需求。虽然大规模推广CCS技术所面临的困难尚无法全部克服,但通过不断的研究、交流和规划,目前CCS技术已得到了极大丰富。我们知道如何进行相关操作,并自信能安全有效地完成相关操作;我们知道相关的成本情况,也知道目前成本正在不断降低,而且未来会继续降低。同时,我们也知道,只要各个国家、公司、团体继续将化石燃料用作能源及用于各种工业过程,则世界就会一直需要碳捕集和封存技术。我们缺少的是必要的政策驱动和技术上呈中性(不会增加二氧化碳排放)的方法,以达到及时、低成本地降低CO_2排放,并维持稳定的、安全的电力供应以保证能源密集型工业产品的生产和使用。我们以澳大利亚为例来说明过去20年内人们对碳捕集和封存技术所做的各种努力,尤其是在碳捕集和封存技术研究和示范工程以及国际合作方面所做的各种努力。在澳大利亚国内,碳捕集和封存技术的大规模推广进展非常慢。但全球最大的碳捕集和封存项目将作为Gorgon液化天然气项目的一部分,很快在澳大利亚国内投入运营,另外还有数个大规模的碳捕集和封存的旗舰级项目正在考察中。CO2CRC Otway项目是澳大利亚国内目前唯一一个运行中的二氧化碳封存项目。该项目目前正在进行一些细节方面的组织和推进工作。需要指出的是,如果要推广Otway项目,还需对地下岩石对封存CO_2的影响开展大量研究。如果要在全球范围广泛使用碳捕集和封存技术,国际能源机构和国际气候变化委员会等机构都认为我们面临很大的挑战,还有很多重大问题需要解决。要解决这些问题,全球各方必须紧密协作。

关键词：二氧化碳碳捕集和封存技术 Otway 澳大利亚

Detecting subtle yet fast skeletal muscle contractions with ultrasoft and durable graphene-based cellular materials

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

National Science Review 2022年第4期9卷 105-115页

作者： Zijun He Zheng Qi Huichao Liu Kangyan Wang Leslie Roberts jefferson Z.Liu Yilun Liu Stephen j.Wang Mark j.cook George P.Simon Ling Qiu Dan Li Department of Chemical Engineering The University of Melbourne Department of Materials Science and Engineering Monash University Department of Chemical Engineering Monash University State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi'an Jiaotong University Neurophysiology Department Department of Neurology and Neurological ResearchSt Vincent's Hospital Department of Medicine St.Vincent's HospitalUniversity of Melbourne Department of Mechanical Engineering University of Melbourne Department of Design Monash University School of Design The Hong Kong Polytechnic University Shenzhen Geim Graphene Center Tsinghua-Berkeley Shenzhen InstituteTsinghua University

Human bodily movements are primarily controlled by the contractions of skeletal muscles. Unlike joint or skeletal movements that are generally performed in the large displacement range, the contractions of the skeletal muscles that underpin these movements are subtle in intensity yet high in frequency. This subtlety of movement makes it a formidable challenge to develop wearable and durable so?t materials to electrically monitor such motions with high fidelity for the purpose of, for example, muscle/neuromuscular disease diagnosis. Here we report that an intrinsically fragile ultralow-density graphene-based cellular monolith sandwiched between silicone rubbers can exhibit a highly effective stress and strain transfer mechanism at its interface with the rubber, with a remarkable improvement in stretchability(>100%). In particular, this hybrid also exhibits a highly sensitive, broadband-frequency electrical response(up to 180 Hz) for a wide range of strains. By correlating the mechanical signal of muscle movements obtained from this hybrid material with electromyography, we demonstrate that the strain sensor based on this hybrid material may provide a new, so?t and wearable mechanomyography approach for real-time monitoring of complex neuromuscular–skeletal interactions in a broad range of healthcare and human–machine interface applications. This work also provides a new architecture-enabled functional so?t material platform for wearable electronics.

关键词： cellular graphene strain sensors high-frequency electromechanical property surface mechanomyography skeletal muscle activity

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

急性髓系白血病的诊疗进展

英国医学杂志中文版 2022年第3期25卷 150-164页

作者： Laura F Newell Rachel j cook 林之光(译) 陈波斌(校) Knight Cancer Institute Hematology and Medical OncologyOregon Health&Science UniversityPortlandORUSA 上海复旦大学附属华山医院血液科

急性髓系白血病(AML)是一种罕见但有潜在危害性的疾病,具有较高病死率。其标准治疗方案数十年未变;然而,近期发现的与白血病发生和疾病进展相关的分子因素,促成了新疗法的出现。目前正在进行的研究和临床试验致力于通过明确靶点、发现... 详细信息

急性髓系白血病(AML)是一种罕见但有潜在危害性的疾病,具有较高病死率。其标准治疗方案数十年未变;然而,近期发现的与白血病发生和疾病进展相关的分子因素,促成了新疗法的出现。目前正在进行的研究和临床试验致力于通过明确靶点、发现疾病或患者特异性危险因素,以及研发有效的联合治疗方案和药物来寻找个体化治疗方案。本综述重点关注AML诊断与疾病分类的重要更新,这些更新反映了对AML生物学、基因突变异质性、重要遗传和环境危险因素以及包括细胞毒性化疗、新型靶向药物和细胞疗法在内的新型治疗方案的新认识。

关键词：急性髓系白血病白血病发生疾病分类标准治疗方案疾病进展诊疗进展临床试验基因突变

Estimates for Lyme borreliosis infections based on models using sentinel canine and human seroprevalence data

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Disease Modelling 2020年第1期5卷 871-888页

作者： Michael j.cook Basant K.Puri Vis a Vis Symposiums Bury St EdmundsUK CAR CambridgeUK

Two models were developed to estimate Lyme borreliosis(LB)*** was based on the seroprevalence of Borrelia infections in human *** model used corrections for false negative and false positive results from published test sensitivity and specificity measures.A second model based on Borrelia infections in sentinel dogs was used to quantify the prevalence of Lyme disease Borrelia infections in humans;the reference baseline for this model was human and canine infections in Germany.A comparison of the two models is shown and differences *** relationships between incidence,prevalence and total infection burden for LB were derived from published data and these were used in both models to calculate annual incidence,prevalence and total LB *** modelling was conservative and based on medical insurance records coded for erythema *** model growth rates were used in place of the commonly adopted exponential *** mean of the two models was used to create estimates for various countries and *** from the analyses for LB estimated for 2018 include:incidence e USA 473,000/year,Germany 471,000/year,France 434,000/year and UK 132,000/year;prevalence e USA 2.4 million,Germany 2.4 million,France 2.2 million and UK 667,000;total infections e USA 10.1 million,Germany 10.0 million,France 9.3 million and UK 2.8 *** for the world for 2018 are:incidence 12.3 million/year;prevalence 62.1 million;and total infection burden 262.0 *** figures are far higher than officially published data and reflect not only the underestimation of diagnosed cases,which is acknowledged by health agencies,but also undiagnosed and misdiagnosed cases.

关键词： Lyme disease Borreliosis Linear regression models Seropositive Companion animals Sentinel animals

Resistance to ERK1/2 pathway inhibitors;sweet spots,fitness deficits and drug addiction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Drug Resistance 2019年第2期2卷 365-380页

作者： Matthew j.Sale Kathryn Balmanno Simon j.cook Signalling Programme The Babraham InstituteBabraham Research CampusCambridge CB223ATUK

MEK1/2 inhibitors are clinically approved for the treatment of BRAF-mutant melanoma,where they are used in combination with BRAF inhibitors,and are undergoing evaluation in other *** resistance to MEK1/2 inhibitors,including selumetinib(AZD6244/ARRY-142866),can arise through amplification of BRAF^(V600E) or KRAS^(G13D) to reinstate ERK1/2 *** have found that BRAF^(V600E) amplification and selumetinib resistance are fully reversible following drug *** is because resistant cells with BRAF^(V600E) amplification become addicted to selumetinib to maintain a precise level of ERK1/2 signalling(2%-3%of total ERK1/2 active),that is optimal for cell proliferation and *** withdrawal drives ERK1/2 activation outside of this critical“sweet spot”(~20%-30%of ERK1/2 active)resulting in a p57^(KIP2)-dependent G1 cell cycle arrest and senescence or expression of NOXA and cell death with features of autophagy;these terminal responses select against cells with amplified BRAF^(V600E).ERK1/2-dependent p57^(KIP2) expression is required for loss of BRAF^(V600E) amplification and determines the rate of reversal of selumetinib *** of selumetinib-resistant cells with BRAF^(V600E) amplification as tumour xenografts also requires the presence of selumetinib to“clamp”ERK1/2 activity within the sweet ***,BRAF^(V600E) amplification confers a selective disadvantage or“fitness deficit”during drug withdrawal,providing a rationale for intermittent dosing to forestall ***,selumetinib resistance driven by KRAS^(G13D) amplification/upregulation is not *** these cells ERK1/2 reactivation does not inhibit proliferation but drives a ZEB1-dependent epithelial-to-mesenchymal transition that increases cell motility and promotes resistance to traditional chemotherapy *** results reveal that the emergence of drug-addicted,MEKi-resistant cells,and the opportunity this may afford for intermittent dosing

关键词： BRAF CDKN1C/p57^(KIP2) EMT ERK KRAS MEK MEK inhibitor resistance selumetinib

Evaluation of an automated spike-and-wave complex detection algorithm in the EEG from a rat model of absence epilepsy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2015年第5期31卷 601-610页

作者： Sebastien H.Bauquier Alan Lai jonathan L.jiang Yi Sui Mark j.cook Faculty of Veterinary and Agricultural Sciences The University of Melbourne Department of Electrical and Electronic Engineering The University of Melbourne Department of Clinical Neurosciences St Vincent's Hospital Faculty of Medicine The University of Melbourne Department of Neurology Shenyang First People's Hospital

The aim of this prospective blinded study was to evaluate an automated algorithm for spike-andwave discharge（SWD） detection applied to EEGs from genetic absence epilepsy rats from Strasbourg（GAERS）.Five GAERS underwent four sessions of 20-min EEG *** EEG was manually analyzed for SWDs longer than one second by two investigators and automatically using an algorithm developed in MATLAB（？）.The sensitivity,specificity,positive predictive value（PPV）,and negative predictive value（NPV） were calculated for the manual（reference） versus the automatic（test） *** results showed that the algorithm had specificity,sensitivity,PPV and NPV 〉94%,comparable to published methods that are based on analyzing EEG changes in the frequency *** provides a good alternative as a method designed to mimic human manual marking in the time domain.

关键词： GAERS seizure detection epilepsy

Factor analysis identifies subgroups of constipation

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2011年第11期17卷 1468-1474页

作者： Philip G Dinning Mike jones Linda Hunt Sergio E Fuentealba jamshid Kalanter Denis W King David Z Lubowski Nicholas j Talley Ian j cook Department of Gastroenterology St.George HospitalUniversity of New South WalesKogarahNSW 2217Australia Department of Psychology Macquarie UniversityNSW 2109Australia Gastroenterology Research Unit Nepean HospitalUniversity of SydneySydneyNSW 2050Australia Department of Colorecta Surgery St.George HospitalKogarahNSW 2217Australia Gastroenterology and Hepatology Mayo ClinicJacksonvilleFL 32224United States

AIM:To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic ***:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport *** hundred of these patients had colonic transit measured *** analysis determined whether constipation-related symptoms grouped into distinct aspects of *** analysis was used to determine whether indi-vidual patients naturally group into distinct ***:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main *** all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool *** majority of patients with these characteristics also reported regular laxative ***:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated ***,clear stratification into clinically identifiable groups remains imprecise.

关键词：大便秘结因子分析识别亚群润肠通便聚类分析病理生理功能紊乱

Muscadine or amla extracts standardized to ellagic acid content ameliorate glucolipotoxicity associatedβ-cell dysfunction via inhibition of IL-1βand improved insulin secretion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

食物生产加工与营养(英文) 2020年第1期2卷 91-101页

作者： Srikanth Earpina Karen McDonough Millicent Yeboah-Awudzi Kristina j.cook Sita Aggarwal jack N.Losso Chronic Degenerative Disease Prevention Laboratory School of Nutrition and Food ScienceLouisiana State University AgCenterLouisiana State University SystemBaton RougeLA 70803USA School of Animal Science Louisiana State University AgCenterLouisiana State University SystemBaton RougeLA 70803USA William Hansel Cancer Prevention Pennington Biomedical Research CenterLouisiana State University SystemBaton RougeLA 70808USA Louisiana State University System Baton RougeLA 70803USA

Glucolipotocixity induces IL-1βsecretion which impairs pancreaticβ-cell insulin *** acid and urolithin A have strong anti-inflammatory effect on *** and amla are very good sources of ellagic *** present study examined the effect of ellagic acid,ellagic acid-rich muscadine or amla extract,or urolothin A on inflammation inβcells under glucolipotoxic *** NIT-1βcells were incubated in glucolipotoxic conditions(33.3 mM glucose,250μM palmitic acid or 33.3 mM glucose+250μM palmitic acid with or without ellagic acid,ellagic acid-rich muscadine or amla extracts standardized to its ellagic acid content,or urolithin A).Inflammatory status was evidenced by ELISA analysis of insulin and IL-1β*** acid-rich muscadine or amla extracts dose-dependently stimulated insulin secretion and down-regulated IL-1βbetter than pure ellagic acid,or urolithin *** A did not statistically stimulate insulin secretion and did not inhibit IL-1β.

关键词： Muscadine Amla Ellagic acid NIT-1 pancreaticβ-cells glucose,Palmitic acid Glucolipotoxicity IL-1β Inflammation Inflammasome Insulin secretion

Listening to People and Places teacher's tapescript V j cook.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Listening to People and Places teacher's tapescript V J COOK...