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Analysis of Cartilage Creep Recovery Using a Highly Dynamic Closed-loop Test System

Journal of Bionic Engineering 2018年第6期15卷 1057-1066页

作者： Josef Stolberg-Stolberg Peter Foehr Iris Pflieger Lara Kuntz constantin von deimling Andreas Obermeier Peter M. Prodinger Christian U. Grosse Rainer Burgkart Department of Orthopaedics and Sports Orthopaedics Klinikum rechts der Isar Technical University of Munich Munich 81675 Germany Department of Trauma Hand and Reconstructive Surgery University Hospital Muenster Albert-Schweitzer-Campus 1 Muenster 48149 Germany Chair of Non-destructive Testing Technical University of Munieh Munich 81245 Germany Department of Trauma Surgery Trauma Center Murnau Murnau 82418 Germany

The aim of this study was to analyze cartilage creep and creep recovery after static and cyclic loading. Up to now technical limitations have hindered the measurement of creep recovery. For this reason, we developed a closed loop micro creep and creep-recovery indentation test system with active force control. Bovine osteochondral explants were tested under static （110 kPa） and cyclic （100 cycles, 350 kPa/35 kPa, 1 Hz） loading conditions and subsequently creep recovery was measured. The cartilage thickness was determined using needle indentation. For static loading, the creep and creep-recovery rates were significantly different during the first 60 seconds （p 〈 0.05）. Cyclic loading was assessed for the medial and lateral patella and resulted in a physiological patellar cartilage strain of 7.7% ± 2.6% and 8.2% ± 2.7%, respectively. We recorded a creep recovery of 97.8% ±2.1% for the medial and 98.3% ± 2.4% for the lateral patella. The advantage of this study over earlier in vitro studies is that we recorded creep-recovery profiles with an actively controlled setup. This allowed us to analyze creep recovery immediately after removing the creep load, in contrast to MRI-based in vivo studies. In future, the presented method will enable us to quantify spatial variations within articular joints.

关键词： articular cartilage indentation creep recovery arthritis regenerative tissue

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Demonstrating grating-based phase-contrast imaging of laser-driven shock waves

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Matter and Radiation at Extremes 2024年第4期9卷 90-97页

作者： Leonard Wegert Stephan Schreiner constantin Rauch Bruno Albertazzi Paulina Bleuel Eric Frojdh Michel Koenig Veronika Ludwig Artem SMartynenko Pascal Meyer Aldo Mozzanica Michael Müller Paul Neumayer Markus Schneider Angelos Triantafyllidis Bernhard Zielbauer Gisela Anton Thilo Michel Stefan Funk Plasma Physics Department GSI Helmholtzzentrum fur SchwerionenforschungPlanckstraBe 164291 DarmstadtGermany Erlangen Centre for Astroparticle Physics(ECAP) Friedrich-Alexander-Universität Erlangen-NurnbergNikolaus-Fiebiger-StraBe 291058 ErlangenGermany LULI-CNRS CEASorbonne UniversitésEcole PolytechniqueInstitut Polytechnique de ParisF-91120 Palaiseau CedexFrance Paul Scherrer Institut(Psi) Forschungsstrasse 1115232VilligenSwitzerland Karlsruhe Institute of Technology Institute of Microstructure TechnologyHermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany

Single-shot X-ray phase-contrast imaging is used to take high-resolution images of laser-driven strong shock *** a two-grating Talbot interferometer,we successfully acquire standard absorption,differential phase-contrast,and dark-field images of the shocked *** agreement is demonstrated between experimental data and the results of two-dimensional radiation hydrodynamics simulations of the laser-plasma *** main sources of image noise are identified through a thorough assessment of the interferometer’s *** acquired images demonstrate that grating-based phase-contrast imaging is a powerful diagnostic tool for high-energy-density *** addition,we make a novel attempt at using the dark-field image as a signal modality of Talbot interferometry to identify the microstructure of a foam target.

关键词： interaction shock phase

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Achieving high union rates after first metatarsophalangeal joint arthrodesis:Radiographic outcomes and technical pitfalls

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World Journal of Orthopedics 2023年第6期14卷 436-442页

作者： Christian von deimling Timo Tondelli Samuel Brunner Octavian Andronic Alexander David Graf Department of Orthopedic Surgery and Traumatology Bürgerspital SolothurnSolothurn 4500Switzerland

BACKGROUND Fusion of the first metatarsophalangeal(MTP1)joint is a common surgery performed to correct hallux rigidus,hallux rigidus et valgus and other painful degenerative diseases of the *** To assess outcomes of our surgical technique including non-union rates,accuracy and aims of *** Between September 2011 and November 2020 a total 72 of MTP1 fusions were performed using a low profile,pre-contoured dorsal locking plate and a plantar compression *** and revision rates were analyzed with a minimum clinical and radiological follow up of at least 3 mo(range 3-18 mo).The following parameters were evaluated on pre-and postoperative conventional radiographs:Intermetatarsal angle,Hallux-valgus angle,dorsal extension of the proximal phalanx(P1)in relation to the floor and the angle between the Metatarsal 1 and the P1(MT1-P1 angle).Descriptive statistical analysis was *** analysis was used to assess for correlations between radiographic parameters and achievement of *** An overall union rate of 98.6%(71/72)was *** out of 72 patients did not primarily fuse with one patient suffering from a non-union,whilst the other demonstrating a radiological delayed union without clinical symptoms,with eventually complete fusion after 18 *** was no correlation between the measured radiographic parameters and the achievement of *** believe the reason for the non-union was mainly attributed to the patient’s incompliance without wearing the therapeutic shoe leading to a fracture of the ***,we didn`t find any correlation between fusion and the degree of *** With our surgical technique,high union rates(98%)can be achieved using a compression screw and a dorsal variable-angle locking plate to treat degenerative diseases of the MTP1.

关键词： Arthrodesis First metatarsophalangeal joint Dorsal plate Arthrodesis

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评估高能效洗衣机对制造成本的影响

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家电科技 2003年第1期 61-64页

作者： Stephen Mariano constantin von Wentzel 吴婉婷

本文是美国能源部支持的一项研究课题,研究了高能效洗衣机给制造成本带来的影响。文章通过将普通洗衣机与高效洗衣机进行对比,将8个具有代表性的不同能效水平的洗衣机进行了分解,运用技术成本模型,对提高洗衣机能效造成的制造成本增加... 详细信息

本文是美国能源部支持的一项研究课题,研究了高能效洗衣机给制造成本带来的影响。文章通过将普通洗衣机与高效洗衣机进行对比,将8个具有代表性的不同能效水平的洗衣机进行了分解,运用技术成本模型,对提高洗衣机能效造成的制造成本增加进行了评估。为避免涉及到制造商的商业秘密,本文采用随机分析的方法,以成本范围的形式给出了结论。

关键词：评估高能效洗衣机制造成本能效标准洗衣模式

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Electrical programmable multilevel nonvolatile photonic random-access memory

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Light(Science & Applications) 2023年第11期12卷 2325-2334页

作者： Jiawei Meng Yaliang Gui Behrouz Movahhed Nouri Xiaoxuan Ma Yifei Zhang Cosmin-constantin Popescu Myungkoo Kang Mario Miscuglio Nicola Peserico Kathleen Richardson Juejun Hu Hamed Dalir Volker J.Sorger Department of Electrical and Computer Engineering George Washington UniversityWashington DC 20052USA Florida Semiconductor Institute University of FloridaGainesvilleFL 32603USA Department of Electrical and Computer Engineering University of FloridaGainesvilleFL 32603USA Department of Materials Science&Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA CREOL The College of Optics&PhotonicsUniversity of Central FloridaOrlandoFL 32816USA

Photonic Random-Access Memories(P-RAM)are an essential component for the on-chip non-von Neumann photonic computing by eliminating optoelectronic conversion losses in data *** Phase-Change Materials(PCMs)have been showed multilevel memory capability,but demonstrations still yield relatively high optical loss and require cumbersome WRITE-ERASE approaches increasing power consumption and system package *** we demonstrate a multistate electrically programmed low-loss nonvolatile photonic memory based on a broadband transparent phase-change material(Ge2Sb2Se5,GSSe)with ultralow absorption in the amorphous state.A zero-staticpower and electrically programmed multi-bit P-RAM is demonstrated on a silicon-on-insulator platform,featuring efficient amplitude modulation up to 0.2 dB/μm and an ultralow insertion loss of total 0.12 dB for a 4-bit memory showing a 100×improved signal to loss ratio compared to other phase-change-materials based photonic *** further optimize the positioning of dual microheaters validating performance *** we demonstrate a half-a-million cyclability test showcasing the robust approach of this material and ***-loss photonic retention-of-state adds a key feature for photonic functional and programmable circuits impacting many applications including neural networks,LiDAR,and sensors for example.

关键词： retention random eliminating

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幽门螺杆菌在皮肤病中的意义

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德国医学 2000年第4期17卷 230-231页

作者： BeateTebbe Jrg-Dieter Schulzke Michael Radenhausen constantin E.Orfanos 田德安 Klinik und Poliklinik fr Dermatologie Universittsklinikum Benjamin FranklinFreie Universitt BerlinHindenburgdamm 30D-12200 BerlinGermany 同济医科大学附属同济医院

80年代初澳大利亚人Warren和Marshall成功地从人胃中培养出螺旋样细菌,由于与空肠弯曲菌相似而称为幽门弯曲菌,之后根据其生物学特性命名为幽门螺杆菌。目前可以肯定,幽门螺杆菌(Hp)可引起慢性B型胃及胃、十二指肠溃疡。此外,Hp感染为... 详细信息

80年代初澳大利亚人Warren和Marshall成功地从人胃中培养出螺旋样细菌,由于与空肠弯曲菌相似而称为幽门弯曲菌,之后根据其生物学特性命名为幽门螺杆菌。目前可以肯定,幽门螺杆菌(Hp)可引起慢性B型胃及胃、十二指肠溃疡。此外,Hp感染为胃腺癌及淋巴瘤的易患因素之一。近年来,许多研究提示,Hp与荨麻疹有关。亦有少数研究显示,Hp与红斑痤疮(Rosazea)、干燥综合征、雷诺综合征、系统性硬皮病、Schonlein-Henoch紫癜及Sweet综合征、萎缩性皮炎有关。值得注意的是,这些疾病都与胃肠道有某种共同联系,这些器官系统中存在原发疾病的临床免疫表现或伴随局灶感染症状。

关键词：皮肤病幽门螺杆菌荨麻疹红斑痤疮雷诺病

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