检索结果-南通市图书馆

有氧运动对心肌梗死患者内皮祖细胞动员和功能的影响

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国组织工程研究 2025年第23期29卷 4947-4955页

作者：赵鹏王聪聪王晨宇郑州澍青医学高等专科学校河南省郑州市450064 中国人民武装警察部队后勤学院卫生勤务系天津市300309 郑州航空工业管理学院河南省郑州市450015

背景:运动康复是心肌梗死患者非药物治疗的重要手段,能够改善心肌灌注和心血管功能,其机制可能与血管内皮细胞介导的血管新生与修复有关,而内皮祖细胞是血管内皮细胞的前体细胞。目的:探讨12周有氧运动对心肌梗死患者内皮祖细胞动员和... 详细信息

背景:运动康复是心肌梗死患者非药物治疗的重要手段,能够改善心肌灌注和心血管功能,其机制可能与血管内皮细胞介导的血管新生与修复有关,而内皮祖细胞是血管内皮细胞的前体细胞。目的:探讨12周有氧运动对心肌梗死患者内皮祖细胞动员和功能的影响。方法:(1)选择2022年1-10月在郑州大学第一附属医院接受经皮冠状动脉介入治疗后的急性心肌梗死患者66例,按照随机数字表法分为运动组(n=33)和对照组(n=33),对照组患者接受常规心脏康复治疗12周,运动组患者接受常规心脏康复+12周有氧运动干预。干预前及干预结束后72 h,检测患者心肺适能、纽约心脏协会分级、左心室射血分数、血清肌钙蛋白Ⅰ和脑钠肽水平及外周血内皮祖细胞数量。(2)干预前及干预结束后72 h,从两组患者外周血中分离提取内皮组细胞,检测内皮组细胞的增殖、黏附和迁移能力。结果与结论:(1)干预结束后72 h,运动组患者的纽约心脏协会分级、血清肌钙蛋白Ⅰ和脑钠肽水平均低于干预前、对照组(P<0.05),峰值摄氧量、最大功率、递增负荷试验完成时间、峰值运动时左心室射血分数高于干预前、对照组(P<0.05),平均心率和平均主观疲劳感觉评分低于干预前、对照组(P<0.05),外周血内皮组细胞数量多于干预前、对照组(P<0.05);(2)干预结束后72 h,运动组患者外周血内皮祖细胞的增殖、黏附与迁移能力均高于干预前、对照组(P<0.05);(3)结果表明,规律有氧运动能够促进内皮祖细胞动员并增强其增殖、黏附和迁移能力,进而改善心肌梗死患者临床病情、心功能和心肺适能。

关键词：心肌梗死有氧运动内皮祖细胞血管生成心功能心肺适能

α-secretase ADAM IO physically interacts with β-secretase BACE1 in neurons and regulates CHL1 proteolysis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2018年第5期10卷 411-422页

作者： Xin wang congcong wang Gang Pei State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai 200031 China Shanghai Key Laboratory of Signaling and Disease Research Collaborative Innovation Center for Brain Science School of Life Sciences and Technology Tongji University Shanghai 200092 China

α-secretase and β-secretase are known to compete for amyloid precursor protein （APP） processing and thus play a vital role in Alzheimer＇s disease pathogenesis. A disintegrin and metaUoproteinase 10 （ADAM10） and β-site APP cleaving enzyme 1 （BACE1） mediate the major activities of α-secretase and β-secretase in brain and share various common substrates. However, whether they function separately or together is poorly understood. Here, we show that ADAM10 and BACE1 co-localize in the neurites of mouse primary neurons. Co-immunoprecipitation and fluorescence resonance energy transfer analysis revealed that ADAM10 and BACE1 interact with each other under both endogenous and exogenous conditions. In addition, we found that ADAMIO enhances the proteolysis of neural cell adhesion molecule close homolog of L1 （CHL1） by BACE1. Further studies found that ADAM10-BACE1 interaction interfering peptide LT52 attenuates the regulation of ADAM10 on BACEl-mediated cleavage of CHL1. Our data indicate that ADAM10-BACE1 interaction regulates the proteolysis of some specific substrates and may play a potential role in brain function.

关键词： secretase Alzheimer's disease ADAM10 BACE1 interact APP CHL1

Scale-space effect and scale hybridization in image intelligent recognition of geological discontinuities on rock slopes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1315-1336页

作者： Mingyang wang Enzhi wang Xiaoli Liu congcong wang State Key Laboratory of Hydro-science and Engineering Tsinghua UniversityBeijing100084China

Geological discontinuity(GD)plays a pivotal role in determining the catastrophic mechanical failure of jointed rock *** and efficient acquisition of GD networks is essential for characterizing and understanding the progressive damage mechanisms of slopes based on monitoring image *** by recent advances in computer vision,deep learning(DL)models have been widely utilized for image-based fracture *** multi-scale characteristics,image resolution and annotation quality of images will cause a scale-space effect(SSE)that makes features indistinguishable from noise,directly affecting the ***,this effect has not received adequate ***,we try to address this gap by collecting slope images at various proportional scales and constructing multi-scale datasets using image processing ***,we quantify the intensity of feature signals using metrics such as peak signal-to-noise ratio(PSNR)and structural similarity(SSIM).Combining these metrics with the scale-space theory,we investigate the influence of the SSE on the differentiation of multi-scale features and the accuracy of *** is found that augmenting the image's detail capacity does not always yield benefits for vision-based recognition *** light of these observations,we propose a scale hybridization approach based on the diffusion mechanism of scale-space *** results show that scale hybridization strengthens the tolerance of multi-scale feature recognition under complex environmental noise interference and significantly enhances the recognition accuracy of *** also facilitates the objective understanding,description and analysis of the rock behavior and stability of slopes from the perspective of image data.

关键词： Image processing Geological discontinuities Deep learning Multi-scale Scale-space theory Scale hybridization

Graph theoretical analysis of limestone fracture network damage patterns based on uniaxial compression test

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3485-3510页

作者： Mingyang wang congcong wang Enzhi wang Xiaoli Liu Xiao Li State Key Laboratory of Hydro-science and Engineering Tsinghua UniversityBeijing100084China Department of Automation Tsinghua UniversityBeijing100084China Beijing Huairou Laboratory Beijing101400China Institute of Geology and Geophysics Chinese Academy of ScienceBeijing100029China

The topological attributes of fracture networks in limestone,subject to intense hydrodynamics and intricate geological discontinuities,substantially influence the mechanical and hydraulic characteristics of the rock *** dynamical evolution of fracture networks under stress is crucial for unveiling the interaction patterns among ***,existing models are undirected graphs focused on stationary topology,which need optimization to depict fractures'dynamic development and rupture *** compensate for the time and destruction terms,we propose the damage network model,which defines the physical interpretation of fractures through the ternary *** focus primarily on the evolution of node types,topological attributes,and motifs of the fracture network in limestone under uniaxial *** expose the varying behavior of the nodes'self-dynamics and neighbors'adjacent dynamics in the fracture *** approach elucidates the impact of micro-crack behaviors on large brittle shear fractures from a topological perspective and further subdivides the progressive failure stage into four distinct phases(isolated crack growth phase,crack splay phase,damage coalescence phase,and mechanical failure phase)based on the significance profile of the *** analysis reveals a positive linear and negative power correlation between fracture network density and branch number to the rock damage resistance,*** damage network model introduces a novel methodology for depicting the interaction of two-dimensional(2D)projected fractures,considering the dynamic spatiotemporal development characteristics and fracture geometric *** helps dynamically characterize properties such as connectivity,permeability,and damage factors while comprehensively assessing damage in rock mass fracture networks.

关键词： Motif Fracture network Topological property Damage resistance Limestone

Practical consideration for design and optimization of the step feed process

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2013年第1期7卷 135-142页

作者： Shijian GE Yongzhen PENG congcong LU Shuying wang College of Environmental and Energy Engineering Key Laboratory of Beijing Water Quality Science and Water Environment Recovery Engineering Beijing University of Technology Beijing 100124 China

Based on the anoxic/oxic (A/O) step feed process, a modified University of Cape Town (UCT) step feed process was developed by adding an anaerobic zone and adjusting sludge return pipeline. Performance evaluation of these two types of processes was investigated by optimizing operational parameters, such as the anaerobic/anoxic/oxic volumes, internal recycle ratios, and sludge retention times, for removal of chemical oxygen demanding (COD), nitrogen, and phosphorus. Results showed high removal efficiencies of COD of (85.0±1.7)%, ammonium of (99.7±0.2)%, total nitrogen (TN) of (85.5±1.7)%, phosphorus of (95.1±3.3)%, as well as excellent sludge settleability with average sludge volume index of (83.7±9.5) L·mg?1 in the modified UCT process. Moreover, (61.5±6.0)% of influent COD was efficiently involved in denitrification or phosphorus release process. As much as 35.3% of TN was eliminated through simultaneous nitrification and denitrification process in aerobic zones. In addition, the presence of denitrifying phosphorus accumulating organisms (DNPAOs), accounting for approximately 39.2% of PAOs, was also greatly beneficial to the nitrogen and phosphorus removal. Consequently, the modified UCT step feed process was more attractive for the wastewater treatment plant, because it had extremely competitive advantages such as higher nutrient removal efficiencies, lower energy and dosages consumption, excellent settling sludge and operational assurance.

关键词： step feed anoxic/oxic (A/O) University of Cape Town (UCT) simultaneous nitrification and denitrification (SND) denitrifying phosphorus removal biological nutrient removal (BNR)

Effects of nano-silicon and common silicon on lead uptake and translocation in two rice cultivars

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2015年第5期9卷 905-911页

作者： Jianguo LIU Hui CAI congcong MEI Mingxin wang School of Environmental and Safety Engineering Changzhou University Changzhou 213164 China

The current study investigated the effects of nano-silicon （Si） and common Si on lead （Pb） toxicity, uptake, translocation, and accumulation in the rice cultivars Yangdao 6 and Yu 44 grown in soil containing two different Pb levels （500 ***-1 and 1000 ***）. The results showed that Si application alleviated the toxic effects of Pb on rice growth. Under soil Pb treatments of 500 and ***-1, the biomasses of plants supplied with common Si and nano-Si were 1.8%-5.2% and 3.3%- 11.8% higher, respectively, than those of plants with no Si supply （control）. Compared to the control, Pb concentra- tions in rice shoots supplied with common Si and nano-Si were reduced by 14.3%-31.4% and 27.6%-54.0%, respectively. Pb concentrations in rice grains treated with common Si and nano-Si decreased by 21.3%-40.9% and 38.6%--64.8%, respectively. Pb translocation factors （TFs） from roots to shoots decreased by 15.0%-29.3% and 25.6%-50.8%, respectively. The TFs from shoots to grains reduced by 8.3 %--13.7% and 15.3%-21.1%, respectively, after Si application. The magnitudes of the effects observed on plants decreased in the following order： nano-Si treatment 〉 common Si treatment and high-grain- Pb-accumulating cultivar （Yangdao 6）〉 low-grain-Pb- accumulatir~ cultivar （Yu 44） and heavy Pb stress （1000 ***-1）〉 moderate Pb stress （500 mg-kg-1）〉 no Pb treatment. The results of the study indicate that nano-Si is more efficient than common Si in ameliorating the toxic effects of Pb on rice growth, preventing Pb transfer from rice roots to aboveground parts, and blocking Pb accumulation in rice grains, especially in high-Pb- accumulating rice cultivars and in heavily Pb-polluted soils.

关键词： silicon (Si) lead (Pb) rice (Oryza sativa L.),toxicity accumulation

Identification of Weather Phenomena Based on Lightweight Convolutional Neural Networks

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2020年第9期64卷 2043-2055页

作者： congcong wang Pengyu Liu Kebin Jia Xiaowei Jia Yaoyao Li Faculty of Information Technology Beijing University of TechnologyBeijing100124China Beijing Laboratory of Advanced Information Networks Beijing100124China Beijing Key Laboratory of Computational Intelligence and Intelligent System Beijing University of TechnologyBeijing100124China Department of Computer Science and Engineering University of MinnesotaTwin CitiesUSA

Weather phenomenon recognition plays an important role in the field of ***,weather radars and weathers sensor have been widely used for weather ***,given the high cost in deploying and maintaining the devices,it is difficult to apply them to intensive weather phenomenon ***,advanced machine learning models such as Convolutional Neural Networks(CNNs)have shown a lot of promise in meteorology,but these models also require intensive computation and large memory,which make it difficult to use them in *** practice,lightweight models are often used to solve such ***,lightweight models often result in significant performance *** this end,after taking a deep dive into a large number of lightweight models and summarizing their shortcomings,we propose a novel lightweight CNNs model which is constructed based on new building *** experimental results show that the model proposed in this paper has comparable performance with the mainstream non-lightweight model while also saving 25 times of memory *** memory reduction is even better than that of existing lightweight models.

关键词： Deep learning convolution neural networks lightweight models weather identification

Hydrodynamic and trophic variations reshape macroinvertebrate food webs in urban ecosystems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Environmental Science and Ecotechnology 2024年第6期22卷 314-326页

作者： Xiongdong Zhou congcong wang Giri Kattel Jiahao Zhang Mengzhen Xu Institute of Hydrobiology Chinese Academy of SciencesWuhan430072China State Key Laboratory of Hydroscience and Engineering Department of Hydraulic EngineeringTsinghua UniversityBeijing100084China Department of Infrastructure Engineering University of MelbourneMelbourneVIC 3010Australia School of Geographical Sciences Nanjing University of Information Science and TechnologyNanjing210044China National Inland Waterway Regulation Engineering Research Center Chongqing Jiaotong UniversityChongqing400074China

Urbanization is modifying aquatic ecosystems,with hydrodynamic and trophic variations altering biotic assemblages in rapidly expanding cities *** the fundamental bioenergetic role of food webs within these assemblages,their responding mechanism to the hydrodynamic and trophic variations remains largely *** we show that hydrodynamic and trophic loss,coupled with the weakening of cascade controls by key trophic guilds,leads to a significant decline in the structure,function and stability of macroinvertebrate food *** the allometric diet breadth model and biomass balance model,we established representative food webs for macroinvertebrate groups under varying hydrodynamic and trophic *** found that such losses have reduced∼75%trophic guild richness,∼85%biomass flux,and∼80%biomass *** reductions promote trophic guild specialization,further destabilizing food web,eroding interactive strength asymmetry,and diminishing the control of trophic ***,macroinvertebrate food webs show divergent stability responses under similar stress levels,mainly driven by differences in the cascade controls exerted by key trophic *** results underscore the critical role of hydrodynamic and trophic variations in shaping urban aquatic ecosystems and highlight the significance of both external environmental revitalization and internal food web dynamics enhancement in restoring the ecological stability in urban settings.

关键词： UrbanizationAllometric diet breadth modelBiomass balance modelTrophic complexityTrophic stability

Low Li ion diffusion barrier on low-crystalline FeOOH nanosheets and high performance of energy storage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2020年第3期13卷 759-767页

作者： Jien Li Shuang Luo congcong wang Qian Tang Yanwei wang Xiangyu Han Hao Ran Jing Wan Xiao Gu Xue wang Chenguo Hu Department of Applied Physics State Key Laboratory of Power Transmission Equipment&System Security and New TechnologyChongqing UniversityChongqing400044China Faculty of Science Ningbo UniversityNingbo315211China

To obtain symmetric supercapacitors(SCs)with high energy density,it is critical to fabricate an electrode with wide potential window and excellent capacitive ***,by using the strong double hydrolysis reaction between anions and cations,the FeOOH nanosheets on the surface of activated carbon cloth(FeOOH@AC)are prepared through a simple hydrothermal *** FeOOH@AC electrode exhibits maximum capacitance of 4,090 mF·cm^−2 at wider potential window-1–0 V and 3,250 mF·cm^−2 at 0–1 V versus SCE in 2 M LiNO3 *** two pieces of FeOOH@AC electrodes the obtained symmetric SC can operate at the voltage window of 2 *** FeOOH symmetric SC shows high energy density of 13.261 mWh·cm^−3 at a power density of 14.824 mW·cm^−3 and maintains 4.175 mWh·cm^−3 at a maximum power density of 118.564 mW·cm^−3,as well as excellent charge storage capacity and cyclic *** ion adsorption and diffusion mechanism on the(200)facets of FeOOH are explained by the density functional theory(DFT)*** simple synthesis process and excellent capacitance performance of the FeOOH@AC composite make it a very promising candidate for high performance symmetric SC electrodes.

关键词： low-crystalline nanosheets FeOOH density functional theory supercapacitor