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Dispersion and Filler Network Structure of Fibrillar Silicates in Elastomers

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Chinese Journal of Polymer Science 2016年第7期34卷 858-872页

作者： Zhao li Hai-bin Sun cong-yi li Yong-lai Lu Wang Qiao 宁南英 li-qun Zhang 田明 Aeolus Tyre Co. Ltd State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology Petro China Sichuan Petrochemical Co. Ltd Office of Scientific Research and Development Beijing University of Chemical Technology

The dispersion and filler network of fibrillar silicate（FS） in elastomers were studied. The results showed that a good dispersion of FS in matrix during mechanical blending in unvulcanized composites contributed to a strong FS filler network, different from that of traditional reinforcing fillers. Meanwhile, the filler re-aggregation during vulcanization caused by the overlapping and intertwining of FS further strengthened the filler network. The factors including Mooney viscosity and molecular polarity of elastomer, type and amount of silane coupling agents used for filler modification, that may influence the filler network, were studied. Our study helps us to understand the mechanism for the formation of filler network of FS in elastomers and provides guidance for the preparation of high performance FS/elastomer composites.

关键词： Fibrillar silicates Dispersion Filler network Elastomers

Assessment of intraocular pressure measured by Reichert Ocular Response Analyzer,Goldmann Applanation Tonometry,and Dynamic Contour Tonometry in healthy individuals

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International Journal of Ophthalmology(English edition) 2012年第1期5卷 102-107页

作者： Ping-Bo Ouyang cong-yi li Xiao-Hua Zhu and Xuan-Chu Duan Department of Ophthalmology the Second Xiangya Hospital of Central South University Changsha 410011 Hunan Province China

AIM: To investigate the accuracy of intraocular pressure (IOP) as measured by a Reichert Ocular Response Analyzer (ORA), as well as the relationship between central corneal thickness (CCT) and IOP as measured by ORA, Goldmann applanation tonometry (GAD, and dynamic contour tonometry (DCT). METHODS: A total of 158 healthy individuals (296 eyes) were chosen randomly for measurement of IOP. After CCT was measured using A-ultrasound (A-US), IOP was measured by ORA, GAT, and DCT devices in a randomized order. The IOP values acquired using each of the three tonometries were compared, and the relationship between CCT and IOP values were analyzed separately. Two IOP values, Goldmann-correlated IOP value (IOPg) and corneal-compensated intraocular pressure (IOPcc), were got using ORA. Three groups were defined according to CCT: 1) thin cornea (CCT580 mu m) groups. RESULTS: In normal subjects, IOP measurements were 14.95 2.99mmHg with ORA (IOPg), 15.21+/- 2.77mmHg with ORA(IOPcc),1522+/- 2.77mmHg with GAT,and 15.49+/- 2.56mmHg with DCT. Mean differences were 0.01+/- 2.29mmHg between IOPcc and GAT (P >0.05) and 0.28+/- 2.20mmHg between IOPcc and DC (P >0.05). There was a greater correlation between IOPcc and DCT (r =0.946, P =0.000) than that between IOPcc and GAT (r=0.845, P=0.000). DCT had a significant correlation with GAT (r=0.854, P=0.000). GAT was moderately correlated with CCT (r=0.296, P580 mu m) showed the least significant correlation between IOPcc and GAT (r=0.859, 0.000); while the thin cornea group (CCT< 520 mu m) had the most significant correlation between IOP

关键词： intraocular pressure tonometry central corneal thickness

Rapid response to lipids profile and leukocyte gene expression after rosuvastatin administration in Chinese healthy volunteers

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Chinese Medical Journal 2008年第13期121卷 1215-1219页

作者： HUA cong-xiao li yi-shi liU Yu-qing liU Hong li Na WU ying XU li HUANG yi-ling Key Laboratory of Clinical Trial Research in Cardiovascular Drugs Ministry of Health Beijing Fuwai Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100037 China

Background Statins are potent lipid-lowering agents widely used in medical practice. There has been growing evidence suggesting the pleiotropic effects of statins in addition to the lipid-lowering effect. However, it is still unclear how rapidly the beneficial effects of statins occur. The transcriptome of peripheral blood cells can be used as a sensor to drug therapy. The purpose of the study was to investigate the acute effects of rosuvastatin both on lipids profile and gene expression of peripheral leukocytes following therapy with a single dose of rosuvastatin. Methods Thirty healthy Chinese male volunteers were enrolled. The serum lipids, high-sensitivity C-reactive protein, and plasma fibrinogen were determined before and 72 hours after administration of 20 mg of rosuvastatin. The differentially expressed genes of peripheral leukocytes after administration of rosuvastatin were screened using human oligonucleotide microarray gene expression chips. Then four of the differentially expressed genes including ATM, CASP8 IL8RB and SIOOB were verified by real-time polymerase chain reaction （PCR）. Results Rosuvastatin decreased both serum total cholesterol and low-density lipoprotein cholesterol significantly 72 hours after administration of a single dose of 20 mg rosuvastatin. However, no significant changes occurred in blood high-density lipoprotein cholesterol, triglycerides, C-reactive protein and fibrinogen after the treatment. A total of 24 genes were differentially expressed after the treatment. They were involved in important cell biological processes such as cytokine-cytokine receptor interaction, apoptosis signaling, etc. Conclusions Rosuvastatin rapidly modulates the serum lipids and affects the gene expression of peripheral leukocytes in healthy volunteers. This finding provides some new clues for further studies on its potential pleiotrooic effects.

关键词： rosuvastatin leukocytes microarray analysis gene expression

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ORA眼反应分析仪的临床应用价值

国际眼科杂志 2009年第5期9卷 934-937页

作者：李从谊段宣初中南大学湘雅二医院眼科中国湖南省长沙市410011

眼反应分析仪(reichert ocular response analyzer,ORA)是一种新型非接触喷气式眼压计。它利用一种动态双向压平过程测量眼压,不仅使测得的眼压值真实可靠,免受中央角膜厚度和硬度的影响,而且可得到反应角膜生物力学特性的新指标:角膜... 详细信息

眼反应分析仪(reichert ocular response analyzer,ORA)是一种新型非接触喷气式眼压计。它利用一种动态双向压平过程测量眼压,不仅使测得的眼压值真实可靠,免受中央角膜厚度和硬度的影响,而且可得到反应角膜生物力学特性的新指标:角膜滞后量和角膜阻力因素。其操作简单,能自动显示眼压读数及角膜生物力学特性。该仪器精确度高,可重复性好,非接触特性,因此可广泛用于临床监测眼压,尤其适用于已行准分子激光角膜屈光手术后的患者,但仍需进一步明确其对青光眼诊断和治疗的指导作用。

关键词：眼反应分析仪眼压中央角膜厚度角膜滞后量

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NAG7基因转染对鼻咽癌细胞生长的影响

生物化学与生物物理进展 2002年第3期29卷 372-377页

作者：谭琛李江王洁如彭聪谢奕曹利李小玲李桂源中南大学湘雅医学院肿瘤研究所长沙410078

为了探讨鼻咽癌表达下调基因NAG7对鼻咽癌细胞系HNE1生长的影响 ,构建了NAG7基因的真核表达载体pcDNA3 1(+) /NAG7,并采用脂质体转染技术将真核重组体pcDNA3 1(+) /NAG7质粒和真核空载体pcDNA3 1(+)质粒分别导入HNE1细胞 ,经G4 18筛选... 详细信息

为了探讨鼻咽癌表达下调基因NAG7对鼻咽癌细胞系HNE1生长的影响 ,构建了NAG7基因的真核表达载体pcDNA3 1(+) /NAG7,并采用脂质体转染技术将真核重组体pcDNA3 1(+) /NAG7质粒和真核空载体pcDNA3 1(+)质粒分别导入HNE1细胞 ,经G4 18筛选后获得稳定转染细胞克隆 ,RT PCR和RNA印迹检测NAG7基因的表达 ,并通过细胞生长曲线、裸鼠接种和流式细胞等方法对转染细胞的生物学行为进行检测 .结果显示 :转染NAG7基因后 ,基因表达增加 ,细胞生长倍增时间较空载体转染和HNE1明显延长 ,流式细胞技术检测表明 ,NAG7可延缓细胞由G0～G1期进入S期 ;裸鼠接种实验显示转染NAG7基因后的HNE1细胞致瘤性受到抑制 .上述结果表明 :NAG7基因转染后鼻咽癌细胞生长受到抑制。

关键词： NAG7 基因转染鼻咽癌细胞细胞转染基因表达裸鼠癌细胞生长

Overview of in-situ oxygen production technologies for lunar resources

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 233-255页

作者： Youpeng Xu Sheng Pang liangwei cong Guoyu Qian Dong Wang Laishi li Yusheng Wu Zhi Wang College of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China CAS Key Laboratory of Green Process and Engineering National Engineering Research Center for Green Recycling of Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

The rich resources and unique environment of the Moon make it an ideal location for human expansion and the utilization of extraterrestrial ***,crucial for supporting human life on the Moon,can be extracted from lunar regolith,which is highly rich in oxygen and contains polymetallic *** oxygen and metal extraction can be achieved using existing metallurgical ***,the ample reserves of water ice on the Moon offer another means for oxygen *** paper offers a detailed overview of the leading technologies for achieving oxygen production on the Moon,drawing from an analysis of lunar resources and environmental *** delves into the principles,processes,advantages,and drawbacks of water-ice electrolysis,two-step oxygen production from lunar regolith,and one-step oxygen production from lunar *** two-step methods involve hydrogen reduction,carbothermal reduction,and hydrometallurgy,while the one-step methods encompass fluorination/chlorination,high-temperature decomposition,molten salt electrolysis,and molten regolith electrolysis(MOE).Following a thorough comparison of raw materials,equipment,technology,and economic viability,MOE is identified as the most promising approach for future in-situ oxygen production on the *** the corrosion characteristics of molten lunar regolith at high temperatures,along with the Moon's low-gravity environment,the development of inexpensive and stable inert anodes and electrolysis devices that can easily collect oxygen is critical for promoting MOE technology on the *** review significantly contributes to our understanding of in-situ oxygen production technologies on the Moon and supports upcoming lunar exploration initiatives.

关键词： lunar resources in-situ oxygen production space metallurgy molten lunar regolith electrolysis

Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

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Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye cong Duan Jiaxin Han Jinrong Chen Ning Sun Yuan li Tifei Yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： Chen li Leilei liang Baoshan Zhang yi Yang Guangbin Ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

Application of the improved dung beetle optimizer,muti-head attention and hybrid deep learning algorithms to groundwater depth prediction in the Ningxia area,China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 18-23页

作者： Jiarui Cai Bo Sun Huijun Wang yi Zheng Siyu Zhou Huixin li Yanyan Huang Peishu Zong Collaborative Innovation Center on forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjingChina Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiChina China Meteorological Administration Key Laboratory of Transportation MeteorologyNanjingChina Jiangsu Meteorological Observatory NanjingChina

Due to the lack of accurate data and complex parameterization,the prediction of groundwater depth is a chal-lenge for numerical *** learning can effectively solve this issue and has been proven useful in the prediction of groundwater depth in many *** this study,two new models are applied to the prediction of groundwater depth in the Ningxia area,*** two models combine the improved dung beetle optimizer(DBO)algorithm with two deep learning models:The Multi-head Attention-Convolution Neural Network-Long Short Term Memory networks(MH-CNN-LSTM)and the Multi-head Attention-Convolution Neural Network-Gated Recurrent Unit(MH-CNN-GRU).The models with DBO show better prediction performance,with larger R(correlation coefficient),RPD(residual prediction deviation),and lower RMSE(root-mean-square error).Com-pared with the models with the original DBO,the R and RPD of models with the improved DBO increase by over 1.5%,and the RMSE decreases by over 1.8%,indicating better prediction *** addition,compared with the multiple linear regression model,a traditional statistical model,deep learning models have better prediction performance.

关键词： Groundwater depth Multi-head attention Improved dung beetle optimizer CNN-LSTM CNN-GRU Ningxia