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Engineering high-performance chemiluminescent probes via enzymatic pocket targeting: high-throughput screening for ultralong afterglow imaging of orthotopic hepatocellular carcinoma

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Science China Chemistry 2025年

作者： Shuai huang Shuaige Bai Ting Luo Bin Feng Min Liu Fan Zheng Shuang huang Yanpeng Fang Dan Ding Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South University College of Life Sciences Nankai University

Hepatocellular carcinoma （HCC） is a highly aggressive liver malignancy and the main form of liver cancer. Early diagnosis and treatment of HCC can effectively reduce mortality. Carboxylesterase （CE）-specific detection and imaging can be used for early diagnosis and image-guided surgical of HCC. However, traditional optical probes suffer from poor selectivity and low imaging signal-to-noise ratio. Here, we have constructed a series of chemiluminescent probes for carboxylesterase detection based on the strategy of enzymatic pocket-oriented steric tailoring techniques. The probes with different unique and excellent properties have been obtained through the structure-based steric hindrance adjustment on the recognition site. Here, CE-2 has been successfully used for high-throughput screening of rapid carboxylesterase inhibitors due to its extremely low detection limit (2.5×10-4U mL-1) and fast recognition ability. CE-3 has been successfully used for image-guided surgery of orthotopic hepatocellular carcinoma due to its ultra-long chemiluminescence imaging （over 12 h） of hepatocellular carcinoma. This study may promote advances in the rapid detection and screening of inhibitory drugs for CE and the field of surgical navigation in HCC.

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Livability assessment of 101,630 communities in China's major cities: A remote sensing perspective

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Science China Earth Sciences 2022年第6期65卷 1073-1087页

作者： xin huang Yue LIU School of Remote Sensing and Information Engineering Wuhan UniversityWuhan 430079China State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan 430079China

Some of China's major cities have entered the middle and late stages of urbanization, and the development focus of these cities has gradually shifted from outward expansion to inward renewal. The community, as the basic unit of a city, is undoubtedly the main object of urban renewal. In order to efficiently and effectively address the problems in current community construction, it is necessary to conduct a large-scale in-depth assessment of the community livability, which can directly imply the satisfaction of residents with their quality of life. This study achieved the first comprehensive livability assessment at the individual community scale for 42 major cities of China from the perspective of remotely sensed and crowd-sourced geographic information. Specifically, we produced abundant fine-grained datasets for 42 cities, including high-resolution land cover maps interpreted from Ziyuan-3 satellites(ZY-3, 2.1 m), building height, point-of-interest, and boundaries of 101,630 *** designed in our proposed framework, the community livability was evaluated by 5 level-1 indicators, 27 level-2 indicators and an integrated community livability index(CLI). A number of interesting findings were obtained from this assessment:(1)According to the expert questionnaires, living comfort was considered as the most important livability factor for residents with the highest weight, while the building environment was rated the least. The negative factors(e.g., the factories around the community) impacted more on livability than the positive ones.(2) Most communities in major Chinese cities were characterized by dense buildings and sparse green spaces.(3) In these cities, community security construction was severely insufficient,particularly in less developed regions.(4) Imbalanced community livability development was prevalent across cities, and simultaneously, the CLI distribution within cities also exhibited significant spatial aggregation and heterogeneity. This resear

关键词： Community Livability Living comfort Building environment Security Remote sensing

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Learning-Based Switched Reliable Control of Cyber-Physical Systems With Intermittent Communication Faults

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IEEE/CAA Journal of Automatica Sinica 2020年第3期7卷 711-724页

作者： xin huang Jiuxiang Dong College of Information Science and Engineering Northeastern UniversityShenyang 110819China State Key Laboratory of Synthetical Automation of Process Industries Northeastern UniversityShenyang 110819China Key Laboratory of Vibration and Control of Aero-Propulsion System Ministry of Education Northeastern UniversityShenyang 110819China IEEE

This study deals with reliable control problems in data-driven cyber-physical systems(CPSs) with intermittent communication faults, where the faults may be caused by bad or broken communication devices and/or cyber attackers. To solve them, a watermark-based anomaly detector is proposed, where the faults are divided to be either detectable or ***, the fault's intermittent characteristic is described by the average dwell-time(ADT)-like concept, and then the reliable control issues, under the undetectable faults to the detector, are converted into stabilization issues of switched systems. Furthermore,based on the identifier-critic-structure learning algorithm, a datadriven switched controller with a prescribed-performance-based switching law is proposed, and by the ADT approach, a tolerated fault set is given. Additionally, it is shown that the presented switching laws can improve the system performance degradation in asynchronous intervals, where the degradation is caused by the fault-maker-triggered switching rule, which is unknown for CPS operators. Finally, an illustrative example validates the proposed method.

关键词： Adaptive dynamic programming(ADP) communication fault cyber-physical systems(CPSs) data-driven control reliable control

Effects of Self-gravity on Mass-loss of the Post-impact Super-Earths

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Research in Astronomy and Astrophysics 2022年第4期22卷 36-41页

作者： Jiang huang Wei Zhong cong Yu School of Physics and Astronomy Sun Yat-Sen UniversityZhuhai 519082China CSST Science Center for the Guangdong-Hong Kong-Macao Greater Bay Area Zhuhai 519082China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacaoChina

Kepler’s observations show most of the exoplanets are *** formation of a super-Earth is generally related to the atmospheric mass loss that is crucial in the planetary structure and *** shock driven by the giant impact will heat the planet,resulting in the atmosphere *** focus on whether self-gravity changes the efficiency of mass *** self-gravity,if the impactor mass is comparable to the envelope mass,there is a significant *** radiative-convective boundary will shift inward by *** the temperature and envelope mass increase,the situation becomes more prominent,resulting in a heavier ***,the impactor mass will increase to motivate the significant mass loss,as the self-gravity is *** the increase of envelope mass,the self-gravity is particularly important.

关键词： planets and satellites:atmospheres planets and satellites:physical evolution methods:numerical

超碱NLi_(4)团簇修饰DHQ石墨烯的储氢性能研究

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原子与分子物理学报 2025年第5期42卷 95-101页

作者：戴小乐王允辉黄欣南京邮电大学电子与光学工程学院柔性电子(未来技术)学院南京210023 南京邮电大学理学院南京210023

基于第一性原理计算,系统研究了超碱NLi_(4)团簇修饰在DHQ石墨烯表面上的几何结构及吸附能等性质,并深入探索了其储氢性能.研究结果表明:超碱NLi_(4)团簇可以稳定均匀地吸附在DHQ石墨烯表面,Li原子与N原子的强结合能有效避免了Li原子发... 详细信息

基于第一性原理计算,系统研究了超碱NLi_(4)团簇修饰在DHQ石墨烯表面上的几何结构及吸附能等性质,并深入探索了其储氢性能.研究结果表明:超碱NLi_(4)团簇可以稳定均匀地吸附在DHQ石墨烯表面,Li原子与N原子的强结合能有效避免了Li原子发生团聚.每个NLi_(4)团簇周围最多可吸附11个氢气分子,平均吸附能为0.20 eV,最大储氢容量为12.05 wt%,达到美国能源部制定的2025年储氢目标5.5 wt%.最后,基于相对能量计算,发现当压强大于84 bar时,该储氢体系可以在室温下稳定存在.以上结果表明经超碱NLi_(4)团簇修饰的DHQ石墨烯是一种有潜力的储氢材料.

关键词：多孔材料储氢超碱NLi_(4)团簇 DHQ石墨烯第一性原理计算

东江河口典型河段溶解氧时空动态及低氧成因解析

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湖泊科学 2025年第1期37卷 112-121页

作者：黄广灵黄本胜刘达邱静黄国如华南理工大学土木与交通学院广州510640 广东省水利水电科学研究院广州510635 广东省流域水环境治理与水生态修复重点实验室广州510635 华南理工大学亚热带建筑与城市科学全国重点实验室广州510640

为解析东江南支流低氧现象的成因,并为水环境治理提供科学依据,本研究分别于2019年春季和夏季对该河流的主要断面进行了水质监测。监测结果显示,东江南支流的溶解氧(DO)水平从中游道滘镇的6.93 mg/L降至出海口处的4.08 mg/L。DO与影响... 详细信息

为解析东江南支流低氧现象的成因,并为水环境治理提供科学依据,本研究分别于2019年春季和夏季对该河流的主要断面进行了水质监测。监测结果显示,东江南支流的溶解氧(DO)水平从中游道滘镇的6.93 mg/L降至出海口处的4.08 mg/L。DO与影响因子的相关性分析显示,DO与水温呈显著负相关,与盐度呈正相关,而与氨氮和总磷等营养物质呈显著负相关。这些营养物质的增加与DO的降低在空间上呈显著重叠,特别是在夏季。研究结果表明,东江南支流低氧现象受物理、化学和生物因素的共同影响,其中温度升高和营养物质浓度增加使得中下游水体的氧气消耗加快,河道汇流处的断面缩窄和下游水体的透光性差引起DO补给不足,从而导致下游沙田泗盛断面经常性出现氧亏(低氧)现象。

关键词：东江南支流溶解氧低氧营养物珠江

Evaluation of Auto-Ignition Characteristics of Diesel Surrogate Fuels with the Same Derived Cetane Numbers at Changed Thermodynamic Environments

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Journal of Thermal Science 2024年第4期33卷 1590-1606页

作者： ZHANG cong GUAN Yuanhang huang Zhen HAN Dong Key Laboratory for Power Machinery and Engineering Ministry of EducationShanghai Jiao Tong UniversityShanghai200240China College of Smart Energy Shanghai Jiao Tong UniversityShanghai200240China Shanghai Non-carbon Energy Conversion and Utilization Institute Shanghai200240China

The ignition tendency of diesel fuels is highly sensitive to ambient conditions and fuel *** this study,the ignition characteristics of different diesel surrogate fuels with the same derived cetane numbers(DCN)were measured and compared in varied thermodynamic and oxidizing *** combustion pressures,heat release rates,ignition delays,and combustion delays of the test fuels were *** experimental results showed that the diesel surrogate fuels with the same DCNs exhibit similar ignition propensity at standard DCN test ***,for the test conditions of high cetane fuels,high ambient temperatures,and suficient oxygen concentrations,surrogate fuels with the same DCN have similar ignition behaviors,and using the DCN to evaluate fuel ignition tendency is ***,for the test conditions of low cetane fuels,low ambient temperatures,and reduced oxygen concentrations,different ignition behaviors are observed for the surrogate fuels with the same DCN,so at these conditions using DCN as the evaluation index for fuel ignition tendency may lead to higher uncertainty.

关键词： diesel fuels surrogate fuels derived cetane numbers constant volume combustion chamber

Microstructure Evolution and Mechanism of Strength Development of Fly Ash Paste

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 152-163页

作者： MA Shuzhao WU Shunchuan huang Mingqing CHENG Haiyong JIANG Guanzhao NIU Yonghui LIU Zemin SUN Wei Faculty of Land Resources Engineering Kunming University of Science and TechnologyKunming 650093China Zijin School of Ge-ology and Mining Fuzhou UniversityFuzhou 350108China

Three types of activators such as sodium hydroxide,calcium oxide and triethanolamine(TEA)are used to establish different activation environments to address the problems associated with the process of activating fly ash *** conducted mechanical tests and numerical simulations to understand the evolution of microstructure,and used environmental scanning electron microscopy(ESEM)and energy dispersive spectroscopy(EDS)techniques to analyze the microenvironments of the *** mechanical properties of fly ash paste under different activation conditions and the changes in the microstructure and composition were *** results revealed that under conditions of low NaOH content(1%-3%),the strength of the sample increased *** the content exceeded 4%,the rate of increase in strength *** on the results,the optimal NaOH content was identified,which was about 4%.A good activation effect,especially for short-term activation(3-7 d),was achieved using TEA under high doping *** activation effect was poor for long-term strength after 28 *** CaO content did not significantly affect the degree of activation *** maximum effect was exerted when the content of CaO was 2%.The virtual cement and concrete testing laboratory(VCCTL)was used to simulate the hydration process,and the results revealed that the use of the three types of activators accelerated the formation of Ca(OH)_(2) in the *** activators also corroded the surface of the fly ash particles,resulting in a pozzolanic *** active substances in fly ash were released efficiently,and hydration was *** pores were filled with hydration products,and the microstructure changed to form a new frame of paste filling that helped improve the strength of fly ash paste.

关键词： paste filling fly ash activator unconfined compressive strength microstructure hydration simulation

Interference Suppression and Jitter Elimination Ability-Based Adaption Tracking Guidance for Robotic Fishes

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 126-137页

作者： Dongfang Li Jie huang Rob Law xin Xu Limin Zhu Edmond Q.Wu IEEE the School of Electrical Engineering and Automation Fuzhou University the Key Laboratory of System Control and Information Processing Ministry of Education the School of Electrical Engineering and Automation Fuzhou University 5G+Industrial Internet Institute Fuzhou University the University of Macau the College of Mechatronics and Automation National University of Defense Technology the School of Mechanical Engineering Shanghai Jiao Tong University the Department of Computer Science and Engineering Shanghai Jiao Tong University

This work presents an adaptive tracking guidance method for robotic fishes. The scheme enables robots to suppress external interference and eliminate motion jitter. An adaptive integral surge line-of-sight guidance rule is designed to eliminate dynamics interference and sideslip issues. Limited-time yaw and surge speed observers are reported to fit disturbance variables in the model. The approximation values can compensate for the system's control input and improve the robots' tracking ***, this work develops a terminal sliding mode controller and third-order differential processor to determine the rotational torque and reduce the robots' run jitter. Then, Lyapunov's theory proves the uniform ultimate boundedness of the proposed method. Simulation and physical experiments confirm that the technology improves the tracking error convergence speed and stability of robotic fishes.

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