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Machine learning model-based prediction of postpancreatectomy acute pancreatitis following pancreaticoduodenectomy:A retrospective cohort study

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World Journal of Gastroenterology 2025年第8期31卷 9-23页

作者： Ji-Ming Ma Peng-Fei Wang liu-Qing Yang jun-Kai Wang Jian-Ping Song Yu-Mei Li Yan Wen Bing-jun Tang Xue-Dong Wang Hepatopancreatobiliary Center Beijing Tsinghua Changgung HospitalBeijing 102218China Department of Information Administration Beijing Tsinghua Changgung HospitalBeijing 102218China Department of Radiology Beijing Tsinghua Changgung HospitalBeijing 102218China Organ Transplantation Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina Department of Otorhinolaryngology Xiangyang No.1 People’s HospitalXiangyang 441000Hubei ProvinceChina

BACKGROUND The International Study Group of Pancreatic Surgery has established the defi-nition and grading system for postpancreatectomy acute pancreatitis(PPAP).There are no established machine learning models for predicting PPAP following pancreaticoduodenectomy(PD).AIM To explore the predictive model of PPAP,and test its predictive efficacy to guide the clinical *** Clinical data from consecutive patients who underwent PD between 2016 and 2024 were retrospectively *** analysis of PPAP risk factors was performed,various machine learning algorithms[logistic regression,random forest,gradient boosting decision tree,extreme gradient boosting,light gradient boosting machine,and category boosting(CatBoost)]were utilized to develop predictive *** feature elimination was employed to select several variables to achieve the optimal machine *** The study included 381 patients,of whom 88(23.09%)developed *** patients exhibited a significantly higher incidence of postoperative pancreatic fistula(55.68%vs 14.68%,P<0.001),grade C postoperative pancreatic fistula(9.09%vs 1.37%,P=0.001).The CatBoost algorithm outperformed other algorithms with a mean area under the receiver operating characteristic curve of 0.859[95%confidence interval(CI):0.814-0.905]in the training cohort and 0.822(95%CI:0.717-0.927)in the testing *** to shapley additive explanations analysis,pancreatic texture,main pancreatic duct diameter,body mass index,estimated blood loss,and surgery time were the most important variables based on recursive feature *** CatBoost algorithm based on selected variables demonstrated superior performance,with an area under the receiver operating characteristic curve of 0.837(95%CI:0.788-0.886)in the training cohort and 0.812(95%CI:0.697-0.927)in the testing *** We developed the first machine learning-based predictive model for PPAP following *** predictive model can assist surgeons in an

关键词： Pancreaticoduodenectomy Postoperative complication Acute pancreatitis Machine learning Predictive value

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数据驱动的未知线性离散系统双模模型预测控制

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控制与决策 2025年第3期40卷 813-821页

作者：刘鑫严爱军北京工业大学信息科学技术学院数字社区教育部工程研究中心城市轨道交通北京实验室

针对模型参数未知的线性离散系统,提出一种数据驱动的双模模型预测控制方法,无需预先对系统进行建模,能够实现在约束条件下对目标设定点的最优跟踪控制.首先,根据有限的系统历史运行数据预测系统未来一段时间的运行轨迹,并在代价函数中... 详细信息

针对模型参数未知的线性离散系统,提出一种数据驱动的双模模型预测控制方法,无需预先对系统进行建模,能够实现在约束条件下对目标设定点的最优跟踪控制.首先,根据有限的系统历史运行数据预测系统未来一段时间的运行轨迹,并在代价函数中加入实时优化的人工平衡点,通过在线求解滚动优化问题来获得控制输入,进而平稳地驱动系统进入一个控制不变集内;然后,在控制不变集内,基于系统历史运行数据,采用策略迭代的方法求解动态反馈控制器,同时可得到静态前馈控制器,实现驱动系统收敛至平衡点的局部最优跟踪控制;最后,验证所提出方法的稳定性,并将其应用于一个线性化的四容水箱系统.实验结果表明,所提出方法有效可行,具有更小的超调量和更好的收敛性能.

关键词：模型预测控制线性离散系统约束系统数据驱动最优控制稳定性分析

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Positron annihilation study of defect formation and evolution in matrix graphite under He ion irradiation

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Nuclear Science and Techniques 2025年第1期36卷 13-21页

作者： Hong-Xia Xu Jian-Dang liu Bang-Jiao Ye Zi-Wen Pan jun Lin Jin-Liang Song Jian-Qing Cao Chao Yan Ying-Ping Hao Jin-Xing Cheng Qing-Bo Wang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025China Beijing Institute of High Technology Beijing 100094China

The stability of matrix graphite under neutron irradiation and in corrosive environments is crucial for the safe operation of molten salt reactors(MSRs).Raman spectroscopy and a slow positron beam were employed to investigate the effects of He ion irradiation fluences and subsequent annealing on the microstructure and defects of the matrix *** ions with 500 keV energy and fluences ranging from 1.1×10^(15)ions∕cm^(2)to 3.5×10^(17)ions∕cm^(2)were used to simulate neutron irradiation at 300 *** samples with an irradiation fluence of 3.5×10^(16)ions∕cm^(2)were subjected to isochronal annealing at different temperatures(573 K,873 K and 1173 K)for 3 *** Raman results revealed that the D peak gradually increased,whereas the intrinsic G peak decreased with increasing irradiation *** the same irradiation fluence,the D peak gradually decreased,whereas the intrinsic G peak increased with increasing annealing *** positron beam analysis demonstrated that the density or size of irradiation defects(vacancy type)increased with higher irradiation fluence,but decreased rapidly with increasing annealing *** Raman spectral analysis of sample cross sections subjected to high irradiation fluences revealed the emergence of amorphization precisely at the depth where ion damage was most pronounced,whereas the surface retained its crystalline *** and positron annihilation analyses indicated that the matrix graphite exhibited good irradiation resistance to He ions at 300 ***,vacancy-type defects induced by He ion irradiation exhibit poor thermal stability and can be easily removed during annealing.

关键词： Graphite Positron annihilation Irradiation Raman spectrum

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To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 270-290页

作者： Zhuo-cong Bao Zhao-Dong liu Ye Zhang Hui-jun Dai Hui Jia Fu Ren Ning Li Lu Zhao Yi-Wei Wang Shang-Yu Lv Yan Zhang Graduate School Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Guangxi Medical University Cancer Hospital Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina School of Traditional Chinese Medicine Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Key Laboratory of Human Ethnic Specificity and Phenomics of Critical Illness in Liaoning Province Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Key Laboratory of Phenomics in Shenyang Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Department of Biochemistry School of Basic MedicineShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Molecular Morphology Laboratory College of Basic Medical SciencesShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Batch 2022 Clinical MedicineShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina International Education School International Exchange and Cooperation OfficeShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina

BACKGROUND Liver cancer has a high incidence and mortality worldwide,especially in ***,we investigated the therapeutic effect and mechanism of tetrahydrocurcumin against hepatocellular carcinoma(HCC),with a focus on the of phosphoinositide 3-kinases(PI3K)/AKT signaling *** To investigate the effects and mechanism of tetrahydrocurcumin in HCC cell lines HepG2 and *** Using Metascape,we analyzed the potential targets of tetrahydrocurcumin in *** docking validation was performed using *** Counting Kit-8,wound healing,and transwell assays were performed to evaluate the effects of tetrahydrocurcumin on HepG2 and Huh7 cell migration,invasion,and *** expression of PI3K/AKT signaling pathway-related proteins was detected by western *** Network pharmacology and molecular docking showed that tetrahydrocurcumin has high binding affinity for phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit *** vitro experiments demonstrated that tetrahydrocurcumin suppressed the migration and invasion of liver cancer cells,promoted their apoptosis,and downregulated the expression of p-PI3K,p-AKT,and B cell leukemia/lymphoma 2,while upregulating caspase-3,p53,and B cell leukemia/lymphoma 2 associated *** In summary,tetrahydrocurcumin suppresses PI3K/AKT signaling,promotes apoptosis,and prevents the migration and invasion of liver cancer cells.

关键词： Hepatocellular carcinoma Tetrahydrocurcumin Network pharmacology Molecular docking PI3K/AKT signaling pathway

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Facile formation of Mg-containing interphase on nanosilicon from Agar/MgCO3 precursor for lithium-ion battery anodes

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Progress in Natural Science:Materials International 2025年第01期 177-186页

作者： Ke Zhang Jianhua Zhou Haoran liu Xiaoyang Wang Jie Gao jun-Liang Chen Haiqing Qin Wenping liu Xiaoxu Lei Lei Miao Guangxi Key Laboratory of Information Materials Guangxi Collaborative Innovation Center of Structure and Property for New Energy Materials School of Material Science and Engineering Guilin University of Electronic Technology Novel Battery Materials Research Center of Engineering Technology State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite StructuresSchool of Physical Science and Technology Guangxi University Guangxi Key Laboratory of Superhard Material Guangxi Technology Innovation Center for Special Mineral Material China Nonferrous Metal (Guilin) Geology and Mining Co. Ltd.

The ultra-high theoretical capacity(4200 mAh g-1) of Silicon anode materials for lithium-ion batteries while which is one of the ideal replacement materials for graphite anodes. However, the poor electrical conductivity and greatly reduces the cycle life of the battery of Silicon material, which suffers from severe volume expansion during charge/discharge cycling leading to electrode pulverization. In this work, Agar/magnesium carbonate-coated silicon nanocomposites were synthesized by utilizing the "self-solidifying" property of agar. The magnesium oxide formed by the decomposition of magnesium carbonate at high temperatures mitigates the volume expansion of nanosilicon together with the derived carbon layer. Moreover, the lithium-magnesium alloy electronconducting interface layer generated by the reaction between lithium ions and magnesium oxide, which greatly shortens the diffusion length of lithium ions and electrons inside the electrode during the charge-discharge cycle. The first discharge specific capacity was 2060.2 mAh g-1, the Coulombic efficiency as high as 86.28 %, and still possesses a reversible specific capacity of 801.5 mAh g-1after cycling 200 cycles at a high current of 500 mA g-1of Agar/magnesium@Si with optimal ratio composite. The composite material used in this work largely suppresses the volume expansion of the silicon anode and contributes to the design of low-cost and high Coulombic efficiency lithium-ion batteries.

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Capsaicin(CAP) exerts a protective effect against ethanol-induced oxidative gastric mucosal injury by modulating the chemokine receptor 4 (CCR4)/Src/p47phox signaling pathway both in vitro and in vivo

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Chinese Journal of Natural Medicines 2025年第2期23卷 191-202页

作者： Zhiru Yang Haolin Guo Pengfei Zhang Kairui liu junli Ba Xue Bai Shiti Shama Bo Zhang Xiaoning Gao jun Kang School of Life Sciences Tianjin University School of Traditional Chinese Medicine Beijing University of Chinese Medicine Tianjin Pharmaceutical and Cosmetic Evaluation and Inspection Center Institute for TCM-X MOE Key Laboratory of Bioinformatics Bioinformatics Division BNRist Department of Automation Tsinghua University Institute of Biomedical Research Henan Academy of Sciences

Ethanol(EtOH) is a common trigger for gastric mucosal diseases, and mitigating oxidative stress is essential for attenuating gastric mucosal damage. Capsaicin(CAP) has been identified as a potential agent to counteract oxidative damage in the gastric mucosa; however, its precise mechanism remains unclear. This study demonstrates that CAP alleviates EtOH-induced gastric mucosal injuries through two primary pathways: by suppressing the chemokine receptor 4(CCR4)/Src/p47phox axis, thereby reducing oxidative stress, and by inhibiting the phosphorylation and nuclear translocation of nuclear factor-κB p65(NF-κB) p65, resulting in diminished inflammatory responses. These findings elucidate the mechanistic pathways of CAP and provide a theoretical foundation for its potential therapeutic application in the treatment of gastric mucosal injuries.

关键词： Capsaicin Chemokine signaling Gastric mucosal damage NF-κB p65

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Research on Energy Mutual Assistance Control Strategy between Low-Voltage Stations Using Micro-Pumped Storage System with Common Reservoir Mode

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Energy Engineering 2025年第3期122卷 1093-1112页

作者： Yunzhao Wu Guanglin Sha Qing Duan Xinwei cong Lu liu Ning Zhou Yingjie Zhou Power Distribution Department China Electric Power Research InstituteBeijing100192China Electric Power Research Institute State Grid Henan Electric Power Co.Ltd.Zhengzhou450052China School of Electrical and Control Engineering North China University of TechnologyShijingshan DistrictBeijing100144China

To enhance energy interaction among low-voltage stations(LVSs)and reduce the line loss of the distribution network,a novel operation mode of the micro-pumped storage system(mPSS)has been proposed based on the common ***,some operation modes of mPSS are analyzed,which include the separated reservoir mode(SRM)and common reservoir mode(CRM).Then,based on the SRM,and CRM,an energy mutual assistance control model between LVSs has been built to optimize energy ***,in the simulation,compared to the model without pumped storage in the LVS,the SRMand CLRMcan decrease the total energy loss by 294.377 and 432.578 kWh,*** configuration of mPSS can improve the utilization rate of the new energy source generation system,and relieve the pressure of transformer capacity in the *** with the SRM,the proposed CRM has reduced the total energy loss by 138.201 kWh,increased the new energy consumption by 161.642 kWh,and decreased the line loss by 7.271 *** the efficiency of the mPSS improving,the total energy loss reduction of CRM will be 3.5 times that of ***,the CRMcan significantly reduce the reservoir capacity construction of mPSS and ismore suitable for scenarios where the capacity configuration of mPSS is limited.

关键词： Micro pumped storage system common reservoir mode low-voltage substation area energy interaction operating mode

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Molecular fluorination strategy for regulating NIR AIEgens to boost phototheranostics of nasopharyngeal carcinoma

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Science China Chemistry 2025年

作者： Ping Zheng Yuxun Ding Alim Abdurahman jun Zhu Leyuan Tian Yi liu Qian liu Lei Wang Dong Wang Ben Zhong Tang Center for Aggregation-Induced Emission (AIE) Research Guangdong Provincial Key Laboratory of New Energy Materials Service SafetyCollege of Materials Science and Engineering Shenzhen University College of Physics and Optoelectronic Engineering Shenzhen University State Key Laboratory of Integrated Optoelectronics College of Electronic Science and Engineering Jilin University Department of Urology Tianjin First Central Hospital School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong

Light-driven theranostics, so-called phototheranostics, represents one of the most momentous advances for cancer treatment, of particular interest is fluorescence imaging（FLI）-navigated photodynamic therapy（PDT）. Development of prominent phototheranostic agent synchronously sharing high reactive oxygen species（ROS） production and conspicuous absorption/emission performance in terms of wavelength and intensity, still remains an appealing yet significantly challenging task. Herein, a molecular fluorination strategy was tactfully exploited to subtly regulate aggregation-induced emission（AIE）-featured photosensitizers, and the optimized agent FPIBT was obtained. The integration of beneficial fluorine results in extended emission wavelength tailing in the second near-infrared region and enhanced molar extinction coefficient, and promotes the intersystem crossing process by reducing energy gap between the S1and T_nand increasing spin-orbit coupling constant, thus significantly improves ROS production capacity. By employing FPIBT nanoparticles, the unprecedented performance on NIR-II FLI-guided PDT towards nasopharyngeal carcinoma in mouse model is witnessed by the precise tumor diagnosis and efficient tumor elimination outcomes.

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The Stereocomplex Crystallites Improve the Stability of Biodegradable Poly(L-lactic acid)/Poly(D-lactic acid)Melt-Blown Nonwovens

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Chinese Journal of Polymer Science 2025年第2期43卷 368-379页

作者： Jin-Shuo Yu Yue-Wei Huan Hong-Wei Pan Zhi-Gang liu Yan Zhao Zhi-Yong Tan jun-Jia Bian Hui-Li Yang Hui-Liang Zhang Key Laboratory of Polymer Ecomaterials Chinese Academy of SciencesChangchun Institute of Applied ChemistryChangchun130022China College of Material and Engineering School of Chemical EngineeringEngineering Research Center of Synthetic Resin and Special FiberMinistry of EducationChangchun University of TechnologyChangchun130012China Shandong Fufeng Fermentation Co. Ltd.Shandong276600China National Engineering Research Center of Corn Deep Processing Jilin COFCO Biochemistry Co.Ltd.Changchun130033China

Poly(lactic acid)(PLA)is a biodegradable and eco-friendly polymer that is increasingly being incorporated into various applications in contemporary ***,the limited stability of PLA-based products remains a significant challenge for their broader use in various *** this study,poly(L-lactic acid)(PLLA)/poly(D-lactic acid)(PDLA)melt-blown nonwovens were prepared by melt *** structure,thermal properties,thermal stability,biodegradability and crystalline morphology of the melt-blown nonwovens were *** and WAXD confirmed the formation of stereocomplex(SC)crystallites in the PLLA *** storage modulus(G′),loss modulus(G″),and complex viscosity(∣η^(*)∣)of the PLLA/PDLA blend increased with an increase in SC crystallite *** thermal degradation temperatures of PLLA/PDLA melt-blown nonwovens increased with the incorporation of SC crystallites,and the maximum rate of decomposition increased to 385.5℃,thus enhancing the thermal *** with neat PLLA melt-blown nonwovens,the hydrophobicity of PLLA/PDLA melt-blown nonwovens was improved,and WCA increased to 139.7°.The SC crystallites were more resistant to degradation by proteinase K compared to neat ***,the degradation rate of PLLA/PDLA melt-blown nonwovens remained at a high *** work provides an effective strategy to obtain high-performance PLLA melt-blown nonwovens.

关键词： PLLA PDLA Melt-blown nonwovens Stereocomplex crystallites Thermal stability Enzymatic degradation

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金融法制定中的基本范畴与体系结构研究

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 17-29,F0002页

作者：刘少军中国政法大学民商经济法学院北京102249 中国政法大学金融法研究中心北京102249

党的十八届三中全会以来,党和政府高度重视金融立法和修法工作。全国人大常委会立法工作计划的预备审议项目要求研究包括金融监管制度在内的金融方面的综合性法律,党的二十届三中全会提出制定金融法,是落实党的二十大报告和2023年中央... 详细信息

党的十八届三中全会以来,党和政府高度重视金融立法和修法工作。全国人大常委会立法工作计划的预备审议项目要求研究包括金融监管制度在内的金融方面的综合性法律,党的二十届三中全会提出制定金融法,是落实党的二十大报告和2023年中央金融工作会议精神、实现建设金融强国目标的重要步骤。制定金融法的核心工作是对现行金融法规进行全面整合,实现金融规范和金融监管的全面覆盖。这就需要对金融法的基本范畴进行研究阐释,对其调整的范围,即金融、金融业及其机构、工具、市场、业务、行为等进行严格界定;必须构建逻辑清晰、结构严谨的金融法体系结构,明晰其目标与原则、要素法体系、行业法体系、体例与结构等问题。

关键词：金融的界定金融业界定目标与原则要素法体系行业法体系体例与结构

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