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Immunological tolerance of human hepatocyte xenograft induced by adenovirus vector-mediated CTLA4Ig gene transfer

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Hepatobiliary & Pancreatic Diseases International 2012年第2期11卷 148-153页

作者： Yao-Kai Chen,Xiao-cong liu,jun-Gang Li,Guo-Dong liu,Yan Guo,Ling Cheng and Yu-Ming Wang Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China and Department of Digestive Diseases, General Hospital of Chengdu Military Command, Chengdu 610083, China Institute of Infectious Diseases Southwest Hospital Third Military Medical University Chongqing 400038 China Department of Digestive Diseases General Hospital of Chengdu Military Command Chengdu 610083 China

BACKGROUND:Systemic administration of CTLA4Ig has been applied in inducing immunological tolerance of hepatocyte implants,but has potential for systemic immune *** study was designed to induce hepatocyte immunological tolerance by locally expressing CTLA4Ig in an attempt to improve the effectiveness of cell ***:A normal human liver cell line(L02) was transfected with adenovirus vector containing the CTLA4Ig gene(Ad-CTLA4Ig-EGFP) in vitro,and the expression of CTLA4Ig by transfected cells was assessed by fluorescent imaging and immunocytochemical *** cells then were injected into the spleen of Sprague-Dawley rats,the survival of cells was determined by immunohistochemistry,and the immune status was examined through CD4 + and CD69 + T cellcounts and ELISA detection of IL-2 in peripheral ***:L02 cells expressed CTLA4Ig in the cytoplasm for >4 *** L02 cells were observed in the experimental group at 3 and 4 weeks post-transplantation,while none was detected in the control ***,the percentages of CD4 + and CD4 + CD69 + T cells in the CTLA4-transfected group were 24.5% and 45.1%,markedly lower than those in the control group at 4 weeks post-transplantation(P<0.01).Furthermore,the IL-2 level was also lower in the CTLA4transfected group than in the control ***:Adenovirus-mediated CTLA4Ig gene transfer into human hepatocytes has the potential to become an effective method of inducing immunological tolerance in hepatocyte transplantation.

关键词： CTLA4Ig adenovirus vectors hepatocyte transplantation immune tolerance graft rejection

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Ultra-Wideband Bandpass Filter With Dual Notched Bands Using Hybrid Microstrip/CPW Structure

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Ultra-Wideband Bandpass Filter With Dual Notched Bands Using...

Language specificity in the neural processing of auditory feedback during vocal production

2011 3rd International Conference on Computer Research and Development(ICCRD 2011)

作者： cong-liu and jun-Xu School of Physical Electronics UESTC Chengdu P.R.China

A novel ultra-wideband （UWB） bandpass filter （BPF） with dual notched bands using the hybrid microstrip and coplanar waveguide （CPW） structure is proposed,to prevent interference problems between the UWB radio system and existing radio systems.A multiple-mode resonator on a CPW is formed to allocate its first three resonant modes around the lower-end,centre and upper-end of the 3.1 to 10.6 GHz UWB *** two sides are fed by two microstrip-to-CPW transitions with enhanced frequency-dispersive coupling *** dual narrow notched bands are introduced by embedding a open stub in the CPW line and etching two Ushaped slots on the ground plane to form defected ground structures （DGSs） in each side of the microstrip ***,dual-band rejected filtering properties in the C-band （3.7-4.2 GHz） and WLAN （5.15-5.825 GHz） are *** UWB bandpass filter with notched bands has been carried out by designs and related simulations to demonstrate the notchband-included and upper-stopband-improved performances.

关键词： bandpass filter (BPF) ultra-wideband (UWB) hybrid microstrip/coplanar waveguide notched band defected ground structure (DGS)

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Language specificity in the neural processing of auditory fe...

Anomalous quality factor evolution of induced transparency in a virtualized coupled-oscillator system

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Zhao-cong CHEN,Han-jun liu~* Department of Rehabilitation Medicine,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080, China

＜正＞Objective Auditory feedback has been demonstrated to play an important role in the control of voice fundamental frequency（FO）,but neural mechanisms underlying this control process are poorly *** present cross-language study was to examine whether there is a language-dependent neural processing of auditory feedback by measuring event-related potentials（ERPs） to pitch perturbations during sustained vocalizations of Cantonese and Mandarin *** Native speakers of Cantonese and Mandarin participated in this *** were asked to sustain a vocalization of a vowel sound /u/ at their comfortable habitual FO level for about 5 s,during which their voice pitch feedback was unexpectedly shifted 5 times（- 50,- 100,- 200,or - 500 cents,200 ms duration） and fed back instantaneously to them over *** ERPs to these pitch-shifted stimuli were measured and analyzed across *** Significantly larger amplitudes of P2 were produced by Cantonese speakers as compared to Mandarin speakers when voice pitch feedback was shifted from 200 to 500 cents,while no significant differences were found in P2 amplitude between them in the case of 50 and 100 cents *** addition,a systematic change of P2 amplitude across pitch perturbation magnitude was found for Cantonese speakers but not for Mandarin *** Neural representations of pitch errors in voice FO control can be modulated by subjects’ exposure to different languages,and differential effects of pitch perturbation magnitude on the cortical processing of auditory feedback between Mandarin and Cantonese speakers may be related to the specific tonal features of these two languages.

关键词： auditory feedback pitch perturbation event-related potential tonal language

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 148-155页

作者： Yunhan Yang Han Jia Tuo liu Yuzhen Yang jun Yang Key Laboratory of Noise and Vibration Research Institute of Acoustics Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Acoustics Institute of Acoustics Chinese Academy of Sciences

The phenomenon of induced transparency, characterized by a high quality(Q) factor, holds significant importance in the fields of high-precision sensing, energy storage and wave manipulation. Conventional transparency systems are often constrained by the limited experimentally accessible parameter space and the lack of independent control over intrinsic parameters, thereby hindering advanced research on high-Q effects. Here we propose a virtualized coupled-oscillator system that enables reconfigurable induced transparency in the reflection spectrum. By virtually incorporating a pair of coupled oscillators into an individual acoustic meta-atom, we achieve the manipulation of induced transparency in a decoupled, wide-ranging, and elaborate manner. Exploiting the diverse evolutions across the intrinsic parameter space, we show experimentally a counter-intuitive increase in the Q-factor of the transparency window, which is attributed to the enhanced dissipation of the bright ***, a constant group delay at the center frequency is observed accompanying this evolution. Our work demonstrates an intriguing platform as well as a novel strategy to engineer high-Q induced transparency phenomenon, and paves the way towards applications in programmable acoustic sensors, filters and slow-wave devices.

关键词： induced transparency acoustic meta-atom high quality-factor scattering programmable intrinsic parameter

Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-Chao Chen Xie liu Changqing Xu Da-Jian Wu Ying Cheng Xiao-jun liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure

Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Guan Cailing Chen Chao Wu Xiaoling liu Biao Meng Tao Chen Yu Han jun Wang Shibo Xi Yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis

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金融法制定中的基本范畴与体系结构研究

新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 17-29,F0002页

作者：刘少军中国政法大学民商经济法学院北京102249 中国政法大学金融法研究中心北京102249

党的十八届三中全会以来,党和政府高度重视金融立法和修法工作。全国人大常委会立法工作计划的预备审议项目要求研究包括金融监管制度在内的金融方面的综合性法律,党的二十届三中全会提出制定金融法,是落实党的二十大报告和2023年中央... 详细信息

党的十八届三中全会以来,党和政府高度重视金融立法和修法工作。全国人大常委会立法工作计划的预备审议项目要求研究包括金融监管制度在内的金融方面的综合性法律,党的二十届三中全会提出制定金融法,是落实党的二十大报告和2023年中央金融工作会议精神、实现建设金融强国目标的重要步骤。制定金融法的核心工作是对现行金融法规进行全面整合,实现金融规范和金融监管的全面覆盖。这就需要对金融法的基本范畴进行研究阐释,对其调整的范围,即金融、金融业及其机构、工具、市场、业务、行为等进行严格界定;必须构建逻辑清晰、结构严谨的金融法体系结构,明晰其目标与原则、要素法体系、行业法体系、体例与结构等问题。

关键词：金融的界定金融业界定目标与原则要素法体系行业法体系体例与结构

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Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders:Present trends and future directions

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World Journal of Psychiatry 2025年第1期15卷 153-167页

作者： Bo-Fan Chen Li liu Fang-Zhen Lin Hai-Min Zeng Hai-Qiang Huang Chun-Fang Zhang cong-cong liu Xiang Chen Jie Peng Yun-Fa Wang Zhi-Lin Wang Bin Chen De-Le liu Yun liu Zheng-Zheng Li Xin-Xing Zeng The Second Affiliated Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Second Clinical Medical College Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Rehabilitation Medicine The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Provincial People’s Hospital The First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006Jiangxi ProvinceChina Department of Psychiatry Jiangxi Mental HospitalHospital of Nanchang UniversityNanchang UniversityNanchang 330029Jiangxi ProvinceChina

BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood *** drug treatment modalities are crucial for managing *** To analyze the current status and future trends of global research on BD drug treatment over the last *** The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment.A total of 2624 articles were *** visualization and analysis were conducted using CiteSpace,VOSviewer,Pajek,Scimago Graphica,and R-studio bibliometrix to identify RESULTS The United States,China,and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration *** University of Pittsburgh,Massachusetts General Hospital,and the University of Michigan have been identified as the major research institutions in this *** Journal of Affective Disorders is the most influential journal.A keyword analysis revealed research hotspots related to clinical symptoms,drug efficacy,and genetic mechanisms.A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited *** This study provides a detailed overview of the field of BD drug treatment,highlighting key contributors,research hotspots,and future *** study findings can be employed as a reference for future research and policymaking,which may enable further development and optimization of BD pharmacotherapy.

关键词： Bipolar disorder Drug treatment Bibliometric analysis Visualization Mental disorder

Engineering of Fe d-band center in Fe_(3)O_(4)/CeO_(2)hetero-nanoparticles via orbital coupling for high-efficiency oxygen reduction electrocatalysis

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Nano Research 2025年第1期18卷 129-139页

作者： Jiayi liu Jingwen Yin Yingzi Lin Mingxin Pang Huan Pang Songtao Zhang Lin Xu jun Yang Yawen Tang Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Center of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023Chin a 2 State Key Laboratory of Multiphase Complex Systems Center of MesoscienceInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225009China Testing Center Yangzhou UniversityYangzhou 225009China

The deliberate engineering of the d-band center of metal site represents an effective strategy to boost the intrinsic electrocatalytic performance toward the oxygen reduction reaction(ORR).Herein,following a heterointerfaceinduced orbital coupling rationale,we report a judicious design of an efficient ORR electrocatalyst consisting of Fe_(3)O_(4)/CeO_(2)hetero-nanoparticles in-situ encased into N-doped carbon nanofibers(abbreviated as Fe_(3)O_(4)/CeO_(2)@N-CNFs hereafter).The theoretic calculations uncover that the Fe_(3)O_(4)/CeO_(2)heterointerface-triggered orbital coupling can cause the down shift of the d-band center positions of Fe sites,which leads to the weakened chemisorption of oxygenated groups and lowered energy barrier for the potential-determining step,ultimately dramatically boosting the ORR intrinsic *** a consequence,the well-designed Fe_(3)O_(4)/CeO_(2)@N-CNFs display admirable ORR activity with a half-wave potential of 0.84 V and outstanding structural/electrochemical stability in an alkaline electrolyte,surpassing the commercial Pt/C benchmark and a majority of recently reported Fe_(3)O_(4)-based *** encouragingly,the Fe_(3)O_(4)/CeO_(2)@N-CNFsincorporated Zn-air battery outperforms the Pt/C-assembled counterpart with higher power density,larger energy density,and excellent cycling stability,serving as a competent candidate for ORR-involved renewable energy *** study offers an innovative approach for the rational manipulation of the d-band center and interfacial electron behavior of active sites toward the optimization of electrocatalytic performance.

关键词： hetero-nanoparticles electrospinning interfacial engineering orbital coupling oxygen reduction reaction