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Numerical Simulation of Surrounding Rock Deformation and Grouting Reinforcement of Cross-Fault Tunnel under Different Excavation Methods

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2445-2470页

作者： Duan Zhu Zhende Zhu cong Zhang LunDai Baotian wang Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing210098China Jiangsu Research Center for Geotechnical Engineering Technology Hohai UniversityNanjing210098China

Tunnel construction is susceptible to accidents such as loosening, deformation, collapse, and water inrush, especiallyunder complex geological conditions like dense fault areas. These accidents can cause instability and damageto the tunnel. As a result, it is essential to conduct research on tunnel construction and grouting reinforcementtechnology in fault fracture zones to address these issues and ensure the safety of tunnel excavation projects. Thisstudy utilized the Xianglushan cross-fault tunnel to conduct a comprehensive analysis on the construction, support,and reinforcement of a tunnel crossing a fault fracture zone using the three-dimensional finite element numericalmethod. The study yielded the following research conclusions: The excavation conditions of the cross-fault tunnelarray were analyzed to determine the optimal construction method for excavation while controlling deformationand stress in the surrounding rock. The middle partition method (CD method) was found to be the most ***, the effects of advanced reinforcement grouting on the cross-fault fracture zone tunnel were studied,and the optimal combination of grouting reinforcement range (140°) and grouting thickness (1m) was *** stress and deformation data obtained fromon-site monitoring of the surrounding rock was slightly lower thanthe numerical simulation results. However, the change trend of both sets of data was found to be consistent. Theseresearch findings provide technical analysis and data support for the construction and design of cross-fault tunnels.

关键词： Cross-fault tunnel finite element analysis excavation methods surrounding rock deformation grouting reinforcement

Evolution of the porous structure for phosphoric acid etching carbon as cathodes in Li–O_(2) batteries:Pyrolysis temperature-induced characteristics changes

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Carbon Energy 2024年第1期6卷 172-181页

作者： Feiyang Yang Ying Yao Yunkai Xu cong wang Meiling wang Jingjie Ren Cunzhong Zhang Feng Wu Jun Lu Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijingChina Beijing Institute of Technology Chongqing Innovation Center ChongqingChina College of Chemical and Biological Engineering Zhejiang UniversityHangzhouChina

Although biomass-derived carbon(biochar)has been widely used in the energy field,the relation between the carbonization condition and the physical/chemical property of the product remains ***,we revealed the carbonization condition's effect on the morphology,surface property,and electrochemical performance of the obtained *** open slit pore structure with shower-puff-like nanoparticles can be obtained by finely tuning the carbonization temperature,and its unique pore structure and surface properties enable the Li–O_(2) battery with cycling longevity(221 cycles with 99.8%Coulombic efficiency at 0.2 mA cm^(−2) and controlled discharge–charge depths of 500 mAh g^(−1))and high capacity(16,334 mAh g^(−1) at 0.02 mA cm^(−2)).This work provides a greater understanding of the mechanism of the biochar carbonization procedure under various pyrolysis conditions,paving the way for future study of energy storage devices.

关键词： biomass Li-O_(2) battery oxygen catalysts porous carbon temperature parameters

Debris flow runout behaviors considering the influences of densely populated buildings

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Journal of Mountain Science 2024年第8期21卷 2696-2712页

作者： ZHANG Shuai FANG Zhe DAI cong wang Shuairong PENG Jingyu ZHOU Yiling SHEN Ping MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering Zhejiang UniversityHangzhou 310058China State Key Laboratory of Internet of Things for Smart City and Department of Ocean Science and Technology University of MacaoMacao SAR 999078China

Debris flows pose serious risks to communities in mountainous areas,often resulting in large losses of human life and *** impeding presence of urban buildings often affects the runout behavior and deposition of debris *** the impact of different building densities and sizes on debris flow dynamics has yet to be quantified to guide urban planning in debris flow risk *** study focused on a debris flow that occurred in Zhouqu County,Gansu Province,China on August 7th,2010,which was catastrophic and destroyed many *** FLO-2D software was used to simulate this debris flow in two scenarios,*** presence and the absence of buildings,to obtain debris-flow intensity *** developed model was then used to further analyze the influence of large buildings and narrow channels within the urban *** simulation results show that considering the presence of buildings in the simulation is essential for accurate assessment of debris flow intensity and deposition *** layout of buildings in the upstream urban area,such as large buildings or parallel buildings which form narrow channels,can affect the flow velocity and depth of debris flow heading towards downstream *** mitigate damage to downstream buildings,the relative spacing(d/a)between upstream and downstream buildings should not exceed a value of two and should ideally be even *** findings provide valuable insights for improving the resistance of mountainous cities to urban debris flows.

关键词： Debris flow Risk Building blockage effect Zhouqu Urban layout

Underwater RGB-D imaging system with millimetric precision

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Science China(Information Sciences) 2024年第10期67卷 383-385页

作者： Yajun GAO Yang cong Xu TANG Mingxue LI State Key Laboratory of Robotics Shenyang Institute of Automation Chinese Academy of Sciences Institutes for Robotics and Intelligent Manufacturing Chinese Academy of Sciences University of Chinese Academy of Sciences College of Automation Science and Engineering South China University of Technology

In recent years, underwater fine three-dimensional reconstruction technology has emerged as a focal point in research, exhibiting extensive potential applications, particularly in underwater archaeology and resource e... 详细信息

关键词： SINGLE CAMERA

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Overcoming neutrophil-induced immunosuppression in postoperative cancer therapy: Combined sialic acid-modified liposomes with scaffold-based vaccines

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 153-169页

作者： cong Li Lihong wang Kexin Zhang Zeyu wang Zhihang Li Zehao Li Lijiang Chen School of Pharmaceutical Science Liaoning UniversityShenyang 110036China

Immunotherapy is a promising approach for preventing postoperative tumor recurrence and metastasis. However, inflammatory neutrophils, recruited to the postoperative tumor site, have been shown to exacerbate tumor regeneration and limit the efficacy of cancer vaccines. Consequently, addressing postoperative immunosuppression caused by neutrophils is crucial for improving treatment outcomes. This study presents a combined chemoimmunotherapeutic strategy that employs a biocompatible macroporous scaffold-based cancer vaccine (S-CV) and a sialic acid (SA)-modified, doxorubicin (DOX)-loaded liposomal platform (DOX@SAL). The S-CV contains whole tumor lysates as antigens and imiquimod (R837, Toll-like receptor 7 activator)-loaded PLGA nanoparticles as immune adjuvants for cancer, which enhance dendritic cell activation and cytotoxic T cell proliferation upon localized implantation. When administered intravenously, DOX@SAL specifically targets and delivers drugs to activated neutrophils in vivo, mitigating neutrophil infiltration and suppressing postoperative inflammatory responses. In vivo and vitro experiments have demonstrated that S-CV plus DOX@SAL, a combined chemo-immunotherapeutic strategy, has a remarkable potential to inhibit postoperative local tumor recurrence and distant tumor progression, with minimal systemic toxicity, providing a new concept for postoperative treatment of tumors.

关键词： Postoperative tumor treatment Immunotherapy Scaffold-based cancer vaccine Inflammatory neutrophils Sialic acid-modied liposome

Navigating Epstein–Barr virus autoimmunity:role of NK cells and T cells in multiple sclerosis

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Signal Transduction and Targeted Therapy 2024年第3期9卷 833-835页

作者： Chu Xie cong Sun Mu-Sheng Zeng State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouP.R.China

In a recent study published in Cell,Vietzen and colleagues discovered the novel role of natural killer(NK)cells and EBVspecific CD8+T cell response in controlling EBV-inducing autoimmune response and collectively def... 详细信息

关键词： Epstein sclerosis killer

An Efficient Task Scheduling Algorithm in the Cloud and Edge Collaborative Environment

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Chinese Journal of Electronics 2024年第5期33卷 1296-1307页

作者： Saiqin LONG cong wang Weifan LONG Haolin LIU Qingyong DENG Zhetao LI Jinan University School of Computer Science Xiangtan University Guangxi Normal University

With the advent of the 5G era and the accelerated development of edge computing and Internet of Things technologies, the number of tasks to be processed by mobile devices continues to increase. Edge nodes become incapable of facing massive tasks due to their own limited computing capabilities, and thus the cloud and edge collaborative environment is produced. In order to complete as many tasks as possible while meeting the deadline constraints, we consider the task scheduling problem in the cloud-edge and edge-edge collaboration scenarios. As the number of tasks on edge nodes increases, the solution space becomes larger. Considering that each edge node has its own communication range, we design an edge node based clustering algorithm(ENCA), which can reduce the feasible region while dividing the edge node set. We transform the edge nodes inside the cluster into a bipartite graph,and then propose a task scheduling algorithm based on maximum matching(SAMM). Our ENCA and SAMM are used to solve the task scheduling problem. Compared with the other benchmark algorithms, experimental results show that our algorithms increase the number of the tasks which can be completed and meet the latest deadline constraints by 32%–47.2% under high load conditions.

关键词： Bipartite matching Node clustering Edge-edge collaboration Cloud-edge collaboration Task scheduling Bipartite matching Node clustering Edge-edge collaboration Cloud-edge collaboration Task scheduling COMPUTATION ASSIGNMENT

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Hydrophobic modification of polysaccharides and the construction and properties of their micelles:a review of applications in the field of biomedicine

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Science China Chemistry 2024年第6期67卷 1881-1903页

作者： Dayang wang Xiaohua Li Huanchen Yao Xin Liu Yan Gao Hailin cong Bing Yu Youqing Shen College of Chemistry and Chemical Engineering College of Life SciencesCollege of Materials Science and EngineeringInstitute of Biomedical Materials and EngineeringQingdao UniversityQingdao266071China State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdao266071China School of Materials Science and Engineering Shandong University of TechnologyZibo255000China Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for Bionanoengineeringand Department of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China

Nanomedicine delivery technology plays an important role in modern medicine and has shown good therapeutic effects in scientific *** have the characteristics of wide sources,excellent biocompatibility,and *** addition,there are multifunctional groups on the main chain of polysaccharides,which can be surface-modified or functionalized to have targeting ability through specific sugar *** polysaccharide micelles with good biocompatibility,degradability,high safety,easy structural modification,and special core-shell structure are regarded as ideal carriers for ***,this review is focused on the hydrophobic modification designs of polysaccharides,the preparation methods and characteristics of micelles,and the applications of amphiphilic polysaccharide micelles in the field of *** is expected to provide some ideas and inspiration for the design of polysaccharide drug carriers.

关键词： polysaccharide hydrophobic modification micelle drug delivery biomedicine

Ferromagnetism and insulating behavior with a logarithmic temperature dependence of resistivity in Pb_(10-x)Cux(PO_(4))_(6)O

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 106-111页

作者： Yuhang Zhang cong Liu Xiyu Zhu Hai-Hu Wen Center for Superconducting Physics and Materials National Laboratory of Solid State Microstructures and Department of PhysicsNational Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

Recent claim of discovering above-room-temperature superconductivity(Tc≈400 K)at ambient pressure in copper doped apatite Pb10(PO_(4))_(6)O has stimulated world-wide enthusiasm and impulse of motion.A lot of follow-up works have been carried out with controversial *** check whether superconductivity is really present or absent in the material,we need samples which should have a rather pure phase of Pb_(10-x)Cux(PO_(4))_(6)*** we report the characterization results from the Pb_(10-x)Cux(PO_(4))_(6)O with a fraction of about 97 wt.%inferred from the fitting to the X-ray diffraction pattern,if assuming Cu2S as the only *** resistivity measurements show that it is a semiconductor characterized roughly by a ln(1/T)temperature dependence in wide temperature region without trace of *** measurements show that it has a general ferromagnetic signal with a weak superparamagnetic *** grains of the sample show clear interactions with a Nb Fe B *** detected Cu concentration is much lower than the expected nominal *** results show the absence of metallicity and superconductivity in Pb_(10-x)Cux(PO_(4))_(6)O at ambient pressure,and suggest the presence of strong correlation effect.

关键词： superconductivity Pb10(PO4)6O ferromagnetic correlation effect