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In situ tumor vaccine with optimized nanoadjuvants and lymph node targeting capacity to treat ovarian cancer and metastases

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4102-4117页

作者： Yuan Li Fan Tong Yufan wang Jing wang Manqi Wu Hanmei Li Hongyan Guo Huile Gao Department of Obstetrics and Gynecology National Clinical Research Center for Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of PharmacySichuan UniversityChengdu 610041China School of Food and Biological Engineering Chengdu UniversityChengdu 610106China

Tumor vaccine,a promising modality of tumor immunotherapy,needs to go through the process of tumor antigen generation and loading,antigen drainage to lymph nodes(LNs),antigen internalization by dendritic cells(DCs),DC maturation,and antigen cross-presentation to activate ***,tumor vaccines are often unable to satisfy all the steps,leading to the limitation of their application and ***,based on a smart nanogel system,an in situ nano-vaccine(CpG@Man-P/Tra/Gel)targeting LNs was constructed to induce potent anti-tumor immune effects and inhibit the recurrence and metastasis of ovarian *** CpG@Man-P/Tra/Gel exhibited MMP-2-sensitive release of trametinib(Tra)and nano-adjuvant CPG@Man-P,which generated abundant in situ depot of whole-cell tumor antigens and formed in situ nano-vaccines with CpG@*** from mannose(Man)modification,the nano-vaccines targeted to LNs,promoted the uptake of antigens by DCs,further inducing the maturation of DCs and activation of T ***,CpG@Man-P with different particle sizes were prepared and the effective size was selected to evaluate the antitumor effect and immune response in ***,combined with PD-1 blocking,the vaccine effectively inhibited primary tumor growth and induced tumor-specific immune response against tumor recurrence and metastasis of ovarian cancer.

关键词： In situ nano-vaccine Lymph node targeting MMP-2 responsive PD-1 Combination therapy CpG Ovarian cancer Metastases

Severe bacteremia community-acquired methicillinresistant Staphylococcus aureus pneumonia in a young adult

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World Journal of Emergency Medicine 2020年第4期11卷 263-266页

作者： Dan-li Cai Xia-qing Zhou Ye-song wang Ling-cong wang Department of ICU the First Affi liated Hospital of Zhejiang Chinese Medical UniversityHangzhouChina Department of Critical Care Medicine the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhouChina

Dear editor,Adults with community-acquired methicillin-resistant Staphylococcus aureus(CA-MRSA)are prone to necrotizing pneumonia,bacteremia,and high *** studies have reported the disease worldwide,but only a few cases of CA-MRSA pneumonia in children and adolescents have been reported in China.[1]No CA-MRSA was detected in the pathogens of community-acquired respiratory tract infections in Chinese adults from 2009 to *** the influenza epidemic,such as COVID-19,viral infections are followed by repeated bacterial infections,and methicillin-sensitive Staphylococcus aureus(MSSA)and MRSA pneumonia are known complications.[2]Thus,identifying and treating these infections is a tricky clinical issue.A case of CA-MRSA pneumonia with bloodstream infection and pneumothorax was successfully treated in our hospital in January ***,we presented a case report based on previous studies.

关键词： pneumonia methicillin mortality

Neural Circuitry Involving Substance P in Male Sexual Behavior

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Neuroscience Bulletin 2024年第4期40卷 544-546页

作者： Xinrong wang Junqiang Zheng Han Xu Department of Neurobiology and Department of Neurology of the Second Affiliated Hospital and School of Brain Science and Brain Medicine Zhejiang University School of MedicineHangzhou310058China Nanhu Brain-Computer Interface Institute Hangzhou311100China Liangzhu Laboratory MOE Frontier Science Center for Brain Science and Brain-machine IntegrationState Key Laboratory of Brain-Machine IntelligenceZhejiang UniversityHangzhou311121China NHC and CAMS Key Laboratory of Medical Neurobiology Zhejiang UniversityHangzhou310058China Lingang Laboratory Shanghai200031China

Male sexual behavior is an innate social behavior crucial for reproduction[1].Previous studies have identified several brain regions crucial for the control of both sexual and aggressive behaviors in ***,molecularly specified neural circuits that specifically control male sexual behavior remain *** with the inherently rewarding nature of sexual behavior,previous research has implicated the role of the dopamine system in regulating sexual desire[2].However,the interaction between reward and copulation at the circuit level remains largely ***,it is unclear if the associated neural pathways are specific in modulating sexual reward.

关键词： behavior neural specified

Pectin methylesterase inhibitors GhPMEI53 and AtPMEI19 improve seed germination by modulating cell wall plasticity in cotton and Arabidopsis

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Journal of Integrative Agriculture 2024年第10期23卷 3487-3505页

作者： Yayue Pei Yakong wang Zhenzhen Wei Ji Liu Yonghui Li Shuya Ma Ye wang Fuguang Li Jun Peng Zhi wang Zhengzhou Research Base State Key Laboratory of Cotton Bio-breeding and Integrated UtilizationZhengzhou UniversityZhengzhou 450001China National Nanfan Research Institute(Sanya) Chinese Academy of Agricultural SciencesSanya 572024China National Key Laboratory of Cotton Bio-breeding and Integrated Utilization/Institute of Cotton Research Chinese Academy ofAgricultural SciencesAnyang 455000China

The germination process of seeds is influenced by the interplay between two opposing factors,pectin methylesterase(PME)and pectin methylesterase inhibitor(PMEI),which collectively regulate patterns of pectin *** the recognized importance of pectin methylesterification in seed germination,the specific mechanisms that govern this process remain *** this study,we demonstrated that the overexpression of GhPMEI53is associated with a decrease in PME activity and an increase in pectin *** leads to seed cell wall softening,which positively regulates cotton seed ***19,the homologue in Arabidopsis thaliana,plays a similar role in seed germination to GhPMEI53,indicating a conserved function and mechanism of PMEI in seed germination *** studies revealed that GhPMEI53 and AtPMEI19 directly contribute to promoting radicle protrusion and seed germination by inducing cell wall softening and reducing mechanical ***,the pathways of abscicic acid(ABA)and gibberellin(GA)in the transgenic materials showed significant changes,suggesting that GhPMEI53/AtPMEI19-mediated pectin methylesterification serves as a regulatory signal for the related phytohormones involved in seed *** summary,GhPMEI53 and its homologs alter the mechanical properties of cell walls,which influence the mechanical resistance of the endosperm or ***,they impact cellular phytohormone pathways(e.g.,ABA and GA)to regulate seed *** findings enhance our understanding of pectin methylesterification in cellular morphological dynamics and signaling transduction,and contribute to a more comprehensive understanding of the PME/PMEI gene superfamily in plants.

关键词： cotton seed germination cell wall pectin demethylesterification PMEI ABA

Transition-Metal-Free Catalyzed Dehydrative Coupling of Quinoline and Isoquinoline N-Oxides with Propargylic Alcohols

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Chinese Journal of Chemistry 2022年第1期40卷 71-78页

作者： Zhao-Nan Cai Xiang-Xuan Feng Yuecheng Zhang cong-cong Lu Ya-Ping Han Jiquan Zhao School of Chemical Engineering and Technology Hebei University of TechnologyTianjin 300130China

A novel,green,and transition-metal-free protocol for the facile modification of quinoline and isoquinoline derivatives is introduced,starting from readily available and environmentally benign quinoline and isoquinoline N-oxides with propargylic alcohols in the presence of Na_(2)S_(2)O_(8) or K_(2)S_(2)O_(8) at 100℃.The one-pot transformation features the advantages of good functional group compatibility,short reaction time,operational simplicity,and highly efficient reaction *** protocol,which produces water as the only byproduct,provides efficient and atom-economical access to a class of fascinating quinoline and isoquinoline products in satisfactory *** method is effective on the gram scale,thus highlighting the inherent practicality of this methodology.

关键词： Synthetic methods Alcohols Nitrogen heterocycles Transition-metal-free Solvent-free

An envelope-based machine learning workflow for locating earthquakes in the southern Sichuan Basin

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Earthquake Research Advances 2024年第2期4卷 45-54页

作者： Kang wang Jie Zhang Ji Zhang Zhangyu wang Ziyu Li School of Earth and Space Sciences University of Science and Technology of ChinaHefei230026China

The development of machine learning technology enables more robust real-time earthquake monitoring through automated implementations. However, the application of machine learning to earthquake location problems faces challenges in regions with limited available training data. To address the issues of sparse event distribution and inaccurate ground truth in historical seismic datasets, we expand the training dataset by using a large number of synthetic envelopes that closely resemble real data and build an earthquake location model named ENVloc. We propose an envelope-based machine learning workflow for simultaneously determining earthquake location and origin time. The method eliminates the need for phase picking and avoids the accumulation of location errors resulting from inaccurate picking results. In practical application, ENVloc is applied to several data intercepted at different starting points. We take the starting point of the time window corresponding to the highest prediction probability value as the origin time and save the predicted result as the earthquake location. We apply ENVloc to observed data acquired in the southern Sichuan Basin, China, between September 2018 and March 2019. The results show that the average difference with the catalog in latitude, longitude, depth, and origin time is 0.02°,0.02°, 2 km, and 1.25 s, respectively. These suggest that our envelope-based method provides an efficient and robust way to locate earthquakes without phase picking, and can be used in earthquake monitoring in near-real time.

关键词： Waveform envelope Earthquake location Local seismicity Synthetic data Sparse stations

计及共享储能与光伏的园区多用户综合收益优化

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电力工程技术 2024年第1期43卷 60-67页

作者：马佳伊刘海涛仲聪袁宇波张效诚南京工程学院电力工程学院江苏南京211167 江苏省配电网智能技术与装备协同创新中心江苏南京211167 国网江苏省电力有限公司电力科学研究院江苏南京211103

针对含共享储能与户用光伏的园区场景,文中提出一种用户侧综合收益双层优化方法,充分挖掘共享储能灵活性及用户用电需求差异性,在实现用户整体经济效益最优的同时提升光伏消纳能力。模型上层为月前优化阶段,以用户月度用电成本最低为目... 详细信息

针对含共享储能与户用光伏的园区场景,文中提出一种用户侧综合收益双层优化方法,充分挖掘共享储能灵活性及用户用电需求差异性,在实现用户整体经济效益最优的同时提升光伏消纳能力。模型上层为月前优化阶段,以用户月度用电成本最低为目标,考虑系统能量平衡、储能充放电约束以及储能荷电状态约束,优化工业用户最大用电功率,降低需量电费;模型下层为日前优化阶段,综合考虑用户综合收益及光伏消纳能力,以上层优化结果为约束条件,兼顾功率、储能等约束,提出共享储能充放电功率及用户与电网交互功率等日前优化策略,在用户月度整体经济性最优的前提下,实现用户侧每日经济效益的优化。最后,以南方某实际园区作为算例验证了文中所提方法的有效性。

关键词：共享储能户用光伏双层优化用户综合收益光伏消纳能力需量电费

一体化压裂液对佳县区块致密气储层伤害实验研究

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油气井测试 2024年第2期33卷 9-14页

作者：卢军凯曾祺俊李云子罗成孙宏晶卢聪中国石油冀东油田分公司钻采工艺研究院河北唐山063000 西南石油大学“油气藏地质及开发工程”全国重点实验室四川成都610500

为分析压裂液对J区块致密气储层的伤害,采用压裂液评价实验方法,从压裂液性能参数、对储层基质的伤害、对填砂裂缝伤害三个方面进行实验评价,研究了压裂液基液对致密储层基质和填砂裂缝的影响。结果表明,鄂尔多斯盆地J区块现场所用的一... 详细信息

为分析压裂液对J区块致密气储层的伤害,采用压裂液评价实验方法,从压裂液性能参数、对储层基质的伤害、对填砂裂缝伤害三个方面进行实验评价,研究了压裂液基液对致密储层基质和填砂裂缝的影响。结果表明,鄂尔多斯盆地J区块现场所用的一体化变黏压裂液对致密气储层的伤害率为19.83%~29.32%,伤害还表现出渗透率越低岩心损害率越大的特征;随着返排压差的增大,压裂液对岩心的伤害程度明显降低,返排压差大于6 MPa时,损害率降低缓慢,最大可降低至10.96%;裂缝导流能力伤害率随着闭合应力逐渐增加,在高闭合应力条件下裂缝导流能力伤害程度大于低闭合应力条件;低铺砂浓度的裂缝导流能力对压裂液敏感性较强,相同条件下低铺砂浓度导流能力伤害率更大。研究为鄂尔多斯盆地J区块致密储层改造压裂液体系优化有一定实际意义。

关键词：鄂尔多斯盆地致密气储层一体化压裂液渗透率储层伤害导流能力返排压差

外耳再造耳后皮肤软组织扩张器植入后并发症现状及危险因素分析

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中国医疗美容 2024年第3期14卷 14-18页

作者：周聪代文意尚蕾南阳市中心医院河南南阳473000

目的探讨外耳再造耳后皮肤软组织扩张器植入后并发症现状及危险因素,为临床干预措施的制定提供参考。方法对2020年1月至2023年3月在我院接受耳后皮肤软组织扩张器植入的151例(163耳)外耳再造患者临床资料进行回顾性分析,了解其并发症发... 详细信息

目的探讨外耳再造耳后皮肤软组织扩张器植入后并发症现状及危险因素,为临床干预措施的制定提供参考。方法对2020年1月至2023年3月在我院接受耳后皮肤软组织扩张器植入的151例(163耳)外耳再造患者临床资料进行回顾性分析,了解其并发症发生现状;根据耳后皮肤软组织扩张器植入后是否发生并发症,将其分为并发症组和无并发症组,并运用多因素Logistic回归分析外耳再造耳后皮肤软组织扩张器植入后并发症的危险因素。结果本研究163耳有37耳发生并发症,并发症总发生率为22.69%,其中血肿18例,占总并发症的48.65%,感染10耳,占比27.03%,切口裂开4耳,占比10.81%,扩张器外漏3耳,占比8.11%,扩张器不张1耳,占比2.70%,皮瓣坏死1耳,占比2.70%;并发症发生平均时间为扩张器植入后(6.82±1.65)天。单因素分析结果显示,并发症组和无并发症组在年龄、居住地、引流管放置方式、扩张器容量、注水速度等方面存在组间差异,具有统计学意义(P﹤0.05);多因素Logistic回归分析显示,居住在农村(OR=2.079,95%CI:1.166~3.707,P=0.013)、引流管平位放置(OR=1.898,95%CI::0.962~3.748,P=0.065)、扩张器容量﹥100ml(OR=2.092,95%CI:1.128~3.878,P=0.019)、注水速度每周≥3次(OR=1.962,95%CI:1.049~3.667,P=0.035)是耳后皮肤软组织扩张器植入后并发症发生的危险因素。结论外耳再造耳后皮肤软组织扩张器植入后并发症发生率较高,居住在农村、引流管平位放置、扩张器容量>100 ml、注水速度每周≥3次是并发症发生的危险因素,临床应根据患者实际情况选择合适的引流方式、扩张器容量,并实施科学的注射速度,以降低并发症发生率,为外耳再造提供充足皮瓣。

关键词：外耳再造耳后皮肤软组织扩张器并发症危险因素